WO2014151970A2 - Injecteur et procédé sous-conjonctival - Google Patents

Injecteur et procédé sous-conjonctival Download PDF

Info

Publication number
WO2014151970A2
WO2014151970A2 PCT/US2014/026749 US2014026749W WO2014151970A2 WO 2014151970 A2 WO2014151970 A2 WO 2014151970A2 US 2014026749 W US2014026749 W US 2014026749W WO 2014151970 A2 WO2014151970 A2 WO 2014151970A2
Authority
WO
WIPO (PCT)
Prior art keywords
injection device
forceps
needle
actuator
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/026749
Other languages
English (en)
Other versions
WO2014151970A3 (fr
Inventor
Edwin RYAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US14/777,288 priority Critical patent/US20160038680A1/en
Publication of WO2014151970A2 publication Critical patent/WO2014151970A2/fr
Publication of WO2014151970A3 publication Critical patent/WO2014151970A3/fr
Anticipated expiration legal-status Critical
Priority to US16/180,998 priority patent/US11975177B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Definitions

  • This invention relates to ophthalmological injections.
  • Ophthalmological injections such as subconjunctival injections are necessary in a number of procedures. It is desirable to increase the repeatability of injection procedures, and to increase the ease of performing injections, and to increase the safety of such injections.
  • FIG. 1 shows an injection device according to an embodiment of the invention.
  • FIG. 2 shows the injection device of claim 1 in operation according to an embodiment of the invention.
  • FIG. 3 shows individual components of an injection device according to an embodiment of the invention.
  • FIG. 4 shows another injection device according to an embodiment of the invention.
  • FIG. 5 shows a method of using an injection device according to an embodiment of the invention.
  • FIG. 6 shows another injection device according to an embodiment of the invention.
  • FIG. 7 shows another injection device according to an embodiment of the invention.
  • Figure 1 shows an injection device 100 according to an embodiment of the invention.
  • the injection device 100 of Figure 1 includes a body 102 housing a number of additional components.
  • a drug reservoir 1 18 is shown within the body 102, and a needle 112 connected to the drug reservoir 1 18.
  • a forceps 120 are also shown within the body 102.
  • a first actuator 104 is operatively coupled to the needle 1 12. When actuated, the first actuator 104 advances a tip 1 14 of the needle 1 12 forward between gripping ends 122 of the forceps 120. A range of travel of the needle 1 12 is limited by the first actuator 104 and the gripping ends 122 of the forceps 120.
  • injection devices as described in the present disclosure may be used to administer any number of different drugs.
  • the first actuator 104 is moved along arc 105.
  • the motion of the first actuator 104 is translated through a linkage 108, which is coupled to a wedge 124.
  • the wedge 124 pushes against protrusions 126 on the forceps 120 and causes the gripping ends 122 to close as indicated by arrows 123.
  • a portion 204 of tissue 202 such as a portion of a conjunctiva, is bunched up between the gripping ends 122.
  • the tip 1 14 of the needle 1 12 then penetrates into the portion 204 of tissue 202.
  • a second linkage 109 is coupled to the first linkage 108 such that in addition to actuating a clamping of the gripping ends 122, the needle 1 12 is urged in direction 1 15.
  • the linkages 108, 109 are timed such that the gripping ends 122 are clamped first, and the needle 1 12 is urged in direction 1 15 after the gripping ends 122 are clamped.
  • the gripping ends 122 and the needle 112 are actuated at the same time.
  • the first actuator 104 operates as a single actuator to move both the gripping ends 122 and the needle 1 12. In other examples, these operations may be performed by separate actuators.
  • linkages and actuator configurations are shown, the invention is not limited to any one actuation method or type of actuating lever, button, etc.
  • Other linkages and actuators such as pneumatic, hydraulic, electric motor driven operation, solenoid, etc. are within the scope of the invention.
  • other actuators apart from levers may be used without departing from the scope of the invention.
  • buttons, knobs or other effective actuators may be used to facilitate gripping of the forceps 120 and controlled motion of the needle 1 12.
  • one or more of the actuators is electrically powered, and the injection device 100 includes one or more batteries to power the one or more actuators.
  • Figure 1 further shows a second actuator 106.
  • the second actuator 106 is moved long direction 107, and is used to expel an amount of a drug into the tissue penetrated by the needle 1 12.
  • Configurations such as the example shown provide ease of use, in that the tissue is gripped and the needle consistently penetrates to the desired depth using a single control, and the drug is easily delivered when desired using the second control.
  • the drug reservoir 1 18 is part of a standard hypodermic syringe 1 10.
  • the syringe 1 10 includes a plunger 1 16 that interacts with the second actuator 106.
  • the syringe 1 10 is disposable, while the remaining components of the injection device 100 are reusable.
  • the forceps 120 are disposable, while the remaining components of the injection device 100 are reusable.
  • both the syringe 110 and the forceps 120 are disposable, while the remaining components of the injection device 100 are reusable.
  • Figure 3 illustrates one example where the syringe 110 and forceps 120 may be removed from the body 102 of the injection device 100.
  • the body 102 includes a first portion 304 and a second portion 306 that are hinged 308.
  • the portions 304, 306 are approximately halves of the body 102, although the invention is not so limited.
  • one portion, such as portion 306 is formed of a substantially clear material, such as clear plastic. When in use, such a configuration allows a user to see if the syringe 1 10 is full with an appropriate dose of the desired drug.
  • An advantage of an example injection device 100 where selected components are removable and disposable includes reduced cost of components, and better ability to sterilize components that will be in contact with a patient. Because a majority of the injection device 100 is reusable, and the cost of elements such as the syringe 1 10 and forceps 120 that are disposed of are at a minimum, the cost of an injection procedure is reduced. In one example, the forceps are formed from a clear plastic material. Such a configuration reduces cost, and allows the user to better see the tissue where an injection is taking place.
  • Figure 4 shows another example injection device 400 according to an embodiment of the invention.
  • the injection device 400 operates similar to examples described above.
  • a forceps 420 are included, along with a syringe 410.
  • a needle 412 may be advanced using an actuator along with clamping of tissue using the forceps 420.
  • Figure 4 further illustrates a speculum 402 that may be used to hold a patient's eyelids apart during an injection procedure.
  • the speculum 402 is disposable, while the remaining components of the injection device 400 are reusable.
  • the syringe 410 is disposable, while the remaining components of the injection device 400 are reusable.
  • the forceps 420 are disposable, while the remaining components of the injection device 400 are reusable.
  • a light 430 is included at a distal end of the injection device 400.
  • Examples of the light 430 include, but are not limited to an LED light.
  • FIG. 5 illustrates an example method of use according to an embodiment of the invention.
  • a first control on an injection device is actuated to clamp a forceps on a portion of a conjunctiva and concurrently move a needle into the clamped portion of conjunctiva, wherein a depth of the needle into the conjunctiva is limited by the injection device.
  • a second control on the injection device is actuated to expel an amount of a drug through the needle into the conjunctiva.
  • FIG. 6 shows another example injection device 600 according to an embodiment of the invention.
  • the injection device 600 includes a forceps handle 610, having a pair of paddles 612 for grasping a conjunctiva of a patient's eye.
  • At least one paddle 612 includes a number of micro-needles 614.
  • the micro-needles 614 are dimensioned to break a surface of the conjunctiva, but are not long enough to penetrate into any structure beneath.
  • the micro-needles 614 will penetrate the conjunctiva, but will not penetrate the sclera.
  • the micro-needles 614 are less than approximately 0.30 mm long. In one example, the micro-needles 614 are less than approximately 0.50 mm long.
  • the injection device 600 includes a drug delivery system 620 that is coupled to the micro-needles 614.
  • the example of Figure 6 shows a reservoir 622 coupled to a tube 624 and an actuator 626.
  • the actuator 626 includes a piston or plunger that forces a drug from the reservoir 622 through the tube 624 into the micro-needles 614.
  • the micro-needles 614 are located on only one paddle 612. In one example, both paddles 612 may include micro-needles 614.
  • the drug that is delivered includes an anesthetic.
  • FIG. 7 shows another example injection device 700 according to an embodiment of the invention.
  • a handle 710 is coupled to a plate 712 that is shaped to be places against the conjunctiva of a patient's eye.
  • a number of micro-needles 714 are located on a face of the plate 712. Similar to the example injection device 600 of Figure 6, the micro-needles 714 are dimensioned to break a surface of the conjunctiva, but are not long enough to penetrate into any structure beneath. In one example, the micro-needles 714 will penetrate the conjunctiva, but will not penetrate the sclera. In one example, the micro-needles 714 are less than approximately 0.30 mm long. In one example, the microneedles 714 are less than approximately 0.50 mm long.
  • the injection device 700 includes a drug delivery system 720 that is coupled to the micro-needles 714.
  • a reservoir (not shown) is located within the handle 710 and an actuator 724 is located on the handle 710.
  • the actuator 724 is coupled to a piston or plunger that forces a drug from the reservoir into the micro-needles 714.
  • the drug that is delivered includes an anesthetic.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif et un procédé d'injection. Les dispositifs et procédés comprennent un forceps et un mécanisme d'avancement d'aiguille pour fixer une partie de tissu et contrôler la profondeur de pénétration de l'aiguille entre les extrémités de préhension du forceps. L'invention concerne un dispositif et un procédé d'injection permettant à des composants sélectionnés, tels qu'une seringue et un forceps, du dispositif d'injection d'être jetables tandis que les parties restantes du dispositif d'injection sont réutilisables. Les dispositifs et les procédés selon l'invention utilisent des micro-aiguilles pour contrôler la profondeur de pénétration.
PCT/US2014/026749 2013-03-15 2014-03-13 Injecteur et procédé sous-conjonctival Ceased WO2014151970A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/777,288 US20160038680A1 (en) 2013-03-15 2014-03-13 Subconjunctival injector and method
US16/180,998 US11975177B2 (en) 2013-03-15 2018-11-05 Subconjunctival injector and method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361787684P 2013-03-15 2013-03-15
US61/787,684 2013-03-15
US201461935239P 2014-02-03 2014-02-03
US61/935,239 2014-02-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/777,288 A-371-Of-International US20160038680A1 (en) 2013-03-15 2014-03-13 Subconjunctival injector and method
US16/180,998 Continuation US11975177B2 (en) 2013-03-15 2018-11-05 Subconjunctival injector and method

Publications (2)

Publication Number Publication Date
WO2014151970A2 true WO2014151970A2 (fr) 2014-09-25
WO2014151970A3 WO2014151970A3 (fr) 2014-12-18

Family

ID=51581664

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/026749 Ceased WO2014151970A2 (fr) 2013-03-15 2014-03-13 Injecteur et procédé sous-conjonctival

Country Status (2)

Country Link
US (2) US20160038680A1 (fr)
WO (1) WO2014151970A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11975177B2 (en) 2013-03-15 2024-05-07 Edwin Ryan Subconjunctival injector and method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7039703B2 (ja) * 2019-06-19 2022-03-22 ジウン イ ノズルアセンブリ、注射器本体、及びこれを含む無針注射器

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543096A (en) * 1983-08-05 1985-09-24 Thomas Keene Eyedrop dispenser with eyelid opening means
CN1720055A (zh) * 2002-10-04 2006-01-11 组织技术公司 视网膜上皮细胞在羊膜上的培养和移植
US20080312669A1 (en) * 2004-03-31 2008-12-18 Vries Luc De Surgical instrument and method
US8016849B2 (en) * 2004-10-18 2011-09-13 Tyco Healthcare Group Lp Apparatus for applying wound treatment material using tissue-penetrating needles
US7727177B2 (en) * 2005-06-21 2010-06-01 Inasurgica, Llc Four function surgical instrument
US8197435B2 (en) * 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8012120B2 (en) * 2007-09-13 2011-09-06 Avant Medical Corp. Device and method for the automatic initiation of an injection
US7678078B1 (en) * 2008-10-21 2010-03-16 KMG Pharma LLC Intravitreal injection device, system and method
US8221353B2 (en) * 2008-10-21 2012-07-17 KMG Pharma, Inc Intravitreal injection device and system
US8287494B2 (en) * 2009-03-23 2012-10-16 Colin Ma Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye
WO2012006677A1 (fr) * 2010-07-14 2012-01-19 The University Of Queensland Appareil d'application de timbre transdermique
EP2446866A1 (fr) * 2010-11-02 2012-05-02 Fovea Pharmaceuticals Appareil pour injection dans un oeil
US9005099B2 (en) * 2011-02-15 2015-04-14 Seros Medical, Llc Method and apparatus for the delivery of photochemical (cross-linking) treatment to scleral tissue
US20160038680A1 (en) 2013-03-15 2016-02-11 Edwin Ryan Subconjunctival injector and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11975177B2 (en) 2013-03-15 2024-05-07 Edwin Ryan Subconjunctival injector and method

Also Published As

Publication number Publication date
US20160038680A1 (en) 2016-02-11
US11975177B2 (en) 2024-05-07
WO2014151970A3 (fr) 2014-12-18
US20190070363A1 (en) 2019-03-07

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