WO2014171183A1 - Corps tubulaire médical - Google Patents

Corps tubulaire médical Download PDF

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Publication number
WO2014171183A1
WO2014171183A1 PCT/JP2014/054562 JP2014054562W WO2014171183A1 WO 2014171183 A1 WO2014171183 A1 WO 2014171183A1 JP 2014054562 W JP2014054562 W JP 2014054562W WO 2014171183 A1 WO2014171183 A1 WO 2014171183A1
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WO
WIPO (PCT)
Prior art keywords
tubular body
marker
medical
diameter
markers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/054562
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English (en)
Japanese (ja)
Inventor
雄起 向井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
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Kaneka Corp
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Filing date
Publication date
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Publication of WO2014171183A1 publication Critical patent/WO2014171183A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
    • A61F2250/0063—Nested prosthetic parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • the present invention relates to a medical tubular body that can be expanded in diameter, and is used, for example, to treat a lesion where a blood vessel or other in-vivo lumen is narrowed or occluded. More specifically, the present invention relates to a medical tubular body typified by a stent placed in a lesioned part of a living body lumen, or a medical tubular body used for removing a thrombus generated in a lesioned part.
  • a medical tubular body typified by a stent is generally a medical instrument for treating various diseases caused by stenosis or occlusion of a blood vessel or other living body lumen.
  • the medical tubular body includes a lesion that is expanded from the inside, such as a stenosis or occlusion, and is placed in the lesion to maintain the inner diameter of the lumen, or a thrombus that has developed in or around the lesion. Examples include those that are removed from the entangled body and restored to the luminal inner diameter at the lesion.
  • the medical tubular body is used in the body, but once the medical tubular body is inserted into the body, its position cannot be visually confirmed. Therefore, usually, a marker including a radiopaque material is provided at a predetermined position of the medical tubular body, and the treatment is performed while confirming the exact position of the marker under fluoroscopy.
  • the marker visibility is required to be improved in terms of accurate transport to the lesion (delivery) and alignment of the exact extended range (working range) in the expanded state.
  • FIG. 14 of Patent Document 1 describes an intravascular medical instrument (medical tubular body) that can be inserted into a small-diameter delivery system by making the marker shape longer in the axial direction and shorter in the radial direction. ing.
  • Patent Document 2 describes a medical tubular body in which markers having a predetermined distance are arranged around the end of the tubular body for the purpose of facilitating the determination of the direction of the medical tubular body. Yes.
  • the present invention has excellent visibility under fluoroscopy, insertion into a catheter, and slidability within a catheter, and can suppress contact between a marker and a tubular body or adjacent markers in a reduced diameter state.
  • An object of the present invention is to provide a medical tubular body that can be reduced in diameter.
  • the present inventor has made various studies on the shape and arrangement of the markers in order to solve the above problems. As the medical tubular body is reduced in diameter, each marker formed at the end of the tubular body gathers toward the central axis of the tubular body. In the present study, the present inventor did not make the marker small because the markers gathered in one place do not contact with each other in this way, but utilized the axial dimension of the tubular body to place the marker in a different place. The present invention was completed by thinking that it could not be escaped.
  • the medical tubular body of the present invention that has solved the above-described problem has a tubular body that can be expanded in diameter, and at least two markers formed at at least one end of the tubular body.
  • the markers have different axial positions when the tubular body is reduced in diameter.
  • the two markers have different axial positions, they do not contact each other.
  • the tubular body includes a plurality of struts having different lengths, and the marker is formed at an end of each strut. If struts having different lengths are used, markers can be easily formed at different positions in the axial direction of the tubular body.
  • tubular body has a mesh structure and the mesh units are arranged in a spiral shape
  • the tubular body has a mesh structure and the mesh units are arranged in a spiral shape
  • the two markers do not contact each other when the tubular body is reduced in diameter.
  • housing In the medical tubular body, when the diameter of the tubular body is reduced, it is desirable that members (hereinafter referred to as “housing”) that are non-deformable portions included in the tubular body do not contact each other. .
  • the marker is formed inside the tubular body.
  • the gap inside the tubular body is effectively used and the marker is stored in the gap. Therefore, even if the markers do not contact each other or the marker and the tubular body, or even if they contact each other, the degree of contact is reduced as compared with the conventional case. As a result, the diameter of the tubular body when contracted can be made smaller than before.
  • the marker is formed on a flat portion on the inner surface of the tubular body.
  • the inner surface of the tubular body is a flat surface, it is easy to increase the contact area between the inner surface of the tubular body and the marker, so that the tubular body and the marker can be more firmly fixed.
  • the marker is preferably welded to the inner surface of the tubular body. It is possible to provide a medical tubular body with reduced risk of marker dropping.
  • the marker is preferably sized to be accommodated in an inner space when the tubular body is reduced in diameter.
  • a gap is formed between one end of the marker and the tubular body when the diameter of the tubular body is reduced. Since the tubular body does not necessarily have a reduced diameter as designed, it may be advantageous to reduce the diameter of the tubular body by leaving some gaps.
  • the marker can preferably be implemented such that the axial length of the tubular body is longer than the radial length of the tubular body. Even when the marker is arranged using the inner space of the tubular body, the inner space of the tubular body is naturally limited, so that the marker volume can be increased by forming it longer in the axial direction of the tubular body.
  • the marker housing has an opening, and the marker is embedded in the opening.
  • the markers are spaced apart from each other more than the length of the marker housing in the axial direction of the tubular body.
  • the marker is preferably columnar.
  • the end of the tubular body has a shape obtained by obliquely cutting a cylinder.
  • the two markers formed at the end of the medical tubular body are different in the axial direction of the tubular body, the two markers do not contact each other even when the tubular body contracts. Therefore, it is possible to reduce the diameter of the medical tubular body smaller than before while maintaining the volume per marker.
  • FIG. 1 is a development view of the medical tubular body according to the first embodiment of the present invention.
  • FIG. 2 is an enlarged view of an end of the medical tubular body according to the first embodiment of the present invention.
  • FIG. 3 is an end perspective view of the medical tubular body (when the diameter is reduced) according to the first embodiment of the present invention.
  • FIG. 4 is a development view of the medical tubular body according to the second embodiment of the present invention.
  • FIG. 5 is a development view of the medical tubular body according to the third embodiment of the present invention.
  • FIG. 6A is an end perspective view of the medical tubular body according to the third embodiment (during diameter expansion)
  • FIG. 6B is a medical tubular body according to the third embodiment (expanded diameter).
  • FIG. 7A is an end perspective view of the medical tubular body according to the third embodiment (when the diameter is reduced), and FIG. 7B is a medical tubular body according to the third embodiment (the diameter is reduced). It is the figure which looked at time from the axial direction.
  • FIG. 8 is a development view of the medical tubular body according to the fourth embodiment of the present invention.
  • FIG. 9A is an end perspective view of the medical tubular body according to the fourth embodiment (when the diameter is expanded), and FIG. 9B is a medical tubular body according to the fourth embodiment (the diameter is expanded). It is the figure which looked at time from the axial direction.
  • FIG. 10A is an end perspective view of the medical tubular body according to the fourth embodiment (when the diameter is reduced), and FIG. 10B is a medical tubular body according to the fourth embodiment (the diameter is reduced). It is the figure which looked at time from the axial direction.
  • the medical tubular body of the present invention has a tubular body that can be expanded, and at least two markers formed on at least one end of the tubular body, and the two markers are contractions of the tubular body.
  • the positions in the axial direction at the time of diameter are different from each other.
  • the two markers have different axial positions, and the markers do not come into contact with each other even when the diameter of the tubular body is reduced, so that the diameter of the medical tubular body can be further reduced.
  • the positional relationship in the axial direction of the marker may change depending on the expansion / contraction of the tubular body.
  • the fact that the axial positions of the two markers are different from each other is based on the structure of the tubular body when the diameter is reduced.
  • “Different positions in the axial direction of the tubular body” means that “positions separated by at least one marker length in the axial direction of the tubular body so that the markers do not contact each other”. Can understand. In the present specification, a configuration in which a marker is removed from a medical tubular body is referred to as a “tubular body”.
  • the medical tubular body is used in a living body lumen. For example, it is placed in a lesioned part of a living body lumen to maintain or expand the diameter of the living body lumen.
  • a peripheral protection device such as a peripheral protection filter, a thrombectomy device for removing a thrombus formed in a lumen in a living body, and the like.
  • the medical tubular body is used by being attached to a catheter (delivery system: delivery device) or the like having a portion where the medical tubular body is placed for delivery (delivery) to a lesioned part.
  • the medical tubular body is (i) a balloon that mounts (mounts) a medical tubular body on the outer surface of the balloon and transports it to the lesioned area, and expands the medical tubular body with the balloon at the lesioned area. It can be classified into an expandable type and (ii) a self-expandable type that expands itself by removing the member that suppresses expansion at the lesioned part by transporting to the lesioned part with a catheter having a member that suppresses expansion.
  • the medical tubular body is reduced in a direction perpendicular to the longitudinal axis of the tubular body (that is, the radial direction of the tubular body) in a state where the medical tubular body is installed in a delivery system composed of a balloon, a catheter, or the like, and the longitudinal axis direction.
  • the diameter is reduced to a cylindrical shape that is longer than the expanded state.
  • the diameter of the reduced diameter state can be reduced as compared with the balloon expansion type.
  • Tubular body A tubular body is a structure which can be expanded in diameter, for example comprised by mesh structures, such as a mesh.
  • being able to expand the diameter means that the tube can be expanded in a direction perpendicular to the major axis (radial direction) of the tubular body, and can be contracted (reduced diameter) from the expanded state.
  • the tubular body is formed, for example, from a pattern of interconnected structural elements that expand and contract in the circumferential and axial directions.
  • the tubular body in the present invention can be applied in any pattern and is therefore not limited to any particular stent shape or structural element pattern.
  • a marker including a radiopaque material is provided at a predetermined position of the medical tubular body so that the medical tubular body can be observed under X-ray fluoroscopy.
  • the marker does not need to completely block X-rays, and may have an X-ray transmittance that can detect the presence of the marker under fluoroscopy.
  • FIG. 1 is a development view of the medical tubular body according to the first embodiment of the present invention.
  • the medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102.
  • the metal mesh portion 111 is configured by a combination of continuous cells 112.
  • the metal mesh portion 111 is bent into a tubular shape with the longitudinal direction as the central axis, and the two long sides of the metal mesh portion 111 are joined to form a tubular body.
  • the medical tubular body 100 has a marker housing 161 at the distal end 101 or the proximal end 102, a marker 121 fixed to the marker housing 161, and other markers 122 to 124. is doing.
  • the marker housing 161 will be described later with reference to FIG.
  • FIG. 2 is an enlarged view of the vicinity of the marker 121 of the medical tubular body 100 according to the first embodiment of the present invention.
  • a marker housing 161 having an opening at the distal end 101 is provided, and a marker 121 is embedded in the opening.
  • the material of the marker housing 161 is preferably the same material as that of the metal mesh portion 111 in terms of strength and corrosion resistance, and preferably has an integral structure with the metal mesh portion 111.
  • FIG. 3 is a perspective view of the end portion (distal end 101) of the medical tubular body (when the diameter is reduced) 100 according to the first embodiment of the present invention. Due to the reduced diameter of the medical tubular body 100, the markers 122 to 124 are very close to the vicinity of the axis of the medical tubular body 100. However, since the markers 121 to 124 in the present embodiment have different axial positions when the tubular body is reduced in diameter, the markers 121 to 124 are in contact with each other even when the tubular body is reduced in diameter. The diameter of the medical tubular body 100 can be made smaller than before.
  • the form of fixing the markers 121 to 124 is not particularly limited. However, as shown in FIGS. 1 to 3, when the marker housing 161 is larger than the marker 121, the marker in the axial direction of the tubular body is used. It is desirable that the markers 121 to 124 be separated from each other by a length longer than the length of the housing 161.
  • the material used for the metal mesh portion 111 is not particularly limited as long as it is a material that can withstand a strong load at the time of deformation or indwelling, such as expansion or contraction, but is stainless steel for medical use.
  • 316L stainless steel, tantalum, Co—Cr (cobalt chromium) alloy, Ni—Ti (nickel-titanium) alloy and the like can be preferably used.
  • a nickel-titanium alloy can be preferably used because it has shape memory characteristics and elastic characteristics and is excellent in workability.
  • an alloy containing about 50% by mass to about 60% by mass of nickel can be preferably used.
  • the metal mesh portion 111 may include a biodegradable material such as a biodegradable polymer or metal.
  • the biodegradable material may be a composite of at least two biodegradable polymers and / or metals.
  • a laser processing method, an electric discharge processing method, a mechanical cutting method, an etching method, or the like can be suitably used.
  • a method of cutting a tubular material into a pattern of the cells 112 by a laser processing method and forming a mesh shape can be preferably used.
  • the material constituting the marker 121 is not particularly limited as long as it is a material having higher radiopacity than the constituent material of the medical tubular body 100.
  • a metal material is preferable from the viewpoint of workability such as an influence on a living body or a difficulty in deformation when attached to the marker housing 161.
  • platinum, palladium, and tantalum are preferable because they have excellent biological compatibility with the human body.
  • tantalum is preferable because it has a small difference in electrochemical potential and is difficult to corrode.
  • the size of the tubular body is not particularly limited, but in Embodiment 1, the outer diameter of the tubular body is, for example, about 0.36 to 0.46 mm when the diameter is reduced, and is about 4.0 to 4.5 mm when the diameter is expanded, for example. .
  • the marker has a thickness of about 0.05 to 0.10 mm and an outer diameter of about 0.1 to 0.3 mm, for example.
  • FIG. 4 is a development view of the medical tubular body according to the second embodiment of the present invention.
  • the medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102.
  • the metal mesh portion 111 is configured by a combination of cells 112 that are continuous in the spiral direction.
  • the medical tubular body 100 according to the second embodiment of the present invention basically has the same configuration as that of the medical tubular body 100 according to the first embodiment of the present invention. The same reference numerals are given and description thereof is omitted.
  • the medical tubular body 100 according to the second embodiment of the present invention is different from the medical tubular body 100 according to the first embodiment in that the length of the support columns 151 to 154 is different in the first embodiment.
  • the positions of the markers 121 to 124 in the body axial direction are different, in the second embodiment, as shown in FIG. 4, the cells 112 are made continuous in the spiral direction to form the metal mesh portion 111.
  • the positions of the markers 121 to 124 in the axial direction of the tubular body are different.
  • the struts 151 to 154 are formed very long, the strut may be deformed in the living body lumen.
  • the end of the tubular body is configured obliquely (that is, shaped like the tip of an injection needle) due to the configuration of the metal mesh portion 111 itself, so that the long support as in the first embodiment This is advantageous in that the rigidity of the end of the tubular body is maintained.
  • the markers 121 to 124 are aligned in a straight line with a certain angle with respect to the axial direction of the medical tubular body 100.
  • 1 and 4 are developed views, but the markers 121 to 124 can be seen in a straight line even when the metal mesh portion 111 is bent to form a tubular shape and the medical tubular body 100 is observed from the side. This is because the end of the tubular body has a shape obtained by obliquely cutting the cylinder (that is, a shape like the tip of an injection needle). As the diameter of the tubular body shrinks, the angle between the straight line in which the markers 121 to 124 are arranged and the axial direction of the tubular body becomes smaller.
  • the straight line in which the markers 121 to 124 are arranged becomes substantially parallel to the axis of the tubular body.
  • the expansion and contraction of the tubular body can be performed from the angle formed by the straight line in which the markers 121 to 124 are arranged and the axis of the tubular body. You can know the degree.
  • FIG. 5 is a development view of the medical tubular body according to the third embodiment of the present invention.
  • the medical tubular body 100 has a distal end 101 and a proximal end 102, and has a metal mesh portion 111 between the distal end 101 and the proximal end 102. Since the medical tubular body 100 according to the third embodiment of the present invention has the same configuration as the medical tubular body 100 according to the second embodiment of the present invention, the same reference numerals are given to the same configurations. The description is omitted.
  • the medical tubular body 100 according to the third embodiment of the present invention is different from the medical tubular body 100 according to the second embodiment in that the marker 121 and the like are embedded in the marker housing 161 in the second embodiment. However, in the third embodiment, the marker 121 and the like are formed on the marker housing 131 and on the inner surface of the tubular body.
  • the method for attaching each of the markers 121 to 124 to the marker housing is not particularly limited as long as it is a method that does not drop off during the transportation of the medical tubular body 100 or the indwelling operation in the lesioned part.
  • the method for example, welding, brazing, caulking, and the like can be mentioned. This is because, in the case of welding, a material different from a marker material such as a marker housing or a solder is not used. On the other hand, in the case of brazing, a material different from the marker housing or the marker material is used, and in the case of caulking, it is difficult to obtain the smoothness of the outer surface in the radial direction of the marker housing.
  • the inner surface of the marker housing is preferably flat, and is preferably oval, square, or rectangular because a linear length corresponding to the diameter of the welding spot is required.
  • the diameter of the welding spot is preferably 80% or less of the short side of the fixed surface of the marker, more preferably 70% or less, and still more preferably 60%, from the viewpoint of not adversely affecting the fluoroscopic image.
  • the diameter of the welding spot is preferably 20% or more of the short side of the fixed surface of the marker, more preferably 30% or more, and even more preferably 40% or more.
  • the diameter of the welding spot is preferably about 40 ⁇ m to 100 ⁇ m, more preferably about 50 ⁇ m to 90 ⁇ m.
  • FIG. 6A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the third embodiment (when the diameter is expanded), and FIG. 6B is a view of the distal end 101 viewed from the axial direction.
  • FIG. 7A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the third embodiment (when the diameter is reduced), and FIG. 7B is a view of the distal end 101 seen from the axial direction. It is a figure.
  • the markers 121 to 124 are formed at different positions in the axial direction of the tubular body as in the first and second embodiments, the markers 121 to 124 when the diameter of the tubular body is reduced. Are accommodated in the internal space of the tubular body without interfering with each other.
  • the marker of the medical tubular body 100 according to the present embodiment is formed inside the tubular body capable of expanding the diameter. ⁇ 124 fit in the void inside the tubular body. Therefore, even if a marker and a tubular body do not contact each other or contact, the degree of contact is reduced more than before.
  • the markers 121 to 124 have some gaps on the side opposite to the side fixed to the marker housings 131 to 134, and the diameter of the markers 121 to 124 is reduced. It may not be perfectly aligned with the axial direction of the tubular body. Of course, it is ideal that the markers 121 to 124 are perfectly aligned in that a marker having a large volume can be arranged by making the best use of the voids in the tubular body. However, since the tubular body does not necessarily have a reduced diameter as designed, leaving some clearance may be advantageous for reducing the diameter of the tubular body. Therefore, it is also a preferable aspect to employ a configuration in which the markers 121 to 124 are not arranged in a straight line when the diameter of the tubular body is reduced.
  • FIG. 8 is a development view of the medical tubular body according to the fourth embodiment of the present invention.
  • FIG. 9A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the fourth embodiment (when expanded in diameter), and FIG. 9B shows the distal end 101 viewed from the axial direction.
  • FIG. 10A is a perspective view of the vicinity of the distal end 101 of the medical tubular body according to the fourth embodiment (when the diameter is reduced), and FIG. 10B is a view of the distal end 101 seen from the axial direction. It is a figure.
  • the medical tubular body 100 according to the fourth embodiment of the present invention has substantially the same configuration as the medical tubular body 100 according to the third embodiment of the present invention.
  • 124 is formed in a columnar shape, but the fourth embodiment is different in that the markers 121 to 124 are formed in a prismatic shape. If the markers 121 to 124 are prismatic shapes, the contact surface with the marker housings 131 to 134 is large, which is advantageous in terms of fixing strength.
  • the medical tubular body of the present invention can be suitably used for various medical tubular bodies such as drug-coated stents and biodegradable stents in addition to those exemplified.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un corps tubulaire médical qui présente une excellente visibilité sous fluoroscopie sous rayons X, une excellente aptitude à l'insertion dans un cathéter et une excellente aptitude au coulissement à l'intérieur du cathéter, qui puisse se contracter pour devenir encore plus petit et qui, dans un état contracté, supprime tout contact entre des marqueurs et le corps tubulaire ou entre des marqueurs adjacents. Le corps tubulaire médical selon la présente invention est pourvu d'un corps tubulaire extensible et d'au moins deux marqueurs (121, 122) formés sur au moins une extrémité du corps tubulaire, les deux marqueurs (121, 122) présentant des positions différentes entre elles dans la direction axiale lorsque le corps tubulaire est contracté.
PCT/JP2014/054562 2013-04-16 2014-02-25 Corps tubulaire médical Ceased WO2014171183A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-086134 2013-04-16
JP2013086134 2013-04-16

Publications (1)

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WO2014171183A1 true WO2014171183A1 (fr) 2014-10-23

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WO (1) WO2014171183A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016140716A (ja) * 2015-02-05 2016-08-08 オリンパス株式会社 医療用電気刺激電極
US20220061985A1 (en) * 2020-08-25 2022-03-03 Medtronic, Inc. Devices and methods for multi-alignment of implantable medical devices
US11969343B2 (en) 2020-12-07 2024-04-30 Medtronic, Inc. Transcatheter heart valve prosthesis systems and methods for rotational alignment
US12064343B2 (en) 2020-03-04 2024-08-20 Medtronic, Inc. Devices and methods for multi-alignment of implantable medical devices

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002272855A (ja) * 2001-03-14 2002-09-24 Piolax Medical Device:Kk ステント
US20040254627A1 (en) * 2003-04-04 2004-12-16 Thompson Paul J. Stent with end adapted for flaring
JP2008511423A (ja) * 2004-09-01 2008-04-17 アンギオメット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コムパニー メディツィンテヒニク コマンデイトゲゼルシャフト ステント及びステント製造方法
US20090306760A1 (en) * 2008-06-06 2009-12-10 Bay Street Medical Prosthesis and delivery system
WO2011093941A2 (fr) * 2010-01-29 2011-08-04 Dc Devices, Inc. Dispositifs et systèmes de traitement de l'insuffisance cardiaque
WO2011122444A1 (fr) * 2010-03-30 2011-10-06 テルモ株式会社 Système de pose d'endoprothèse
WO2012031748A2 (fr) * 2010-09-08 2012-03-15 Phenox Gmbh Implant destiné à influencer le débit sanguin en cas de malformations artérioveineuses

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002272855A (ja) * 2001-03-14 2002-09-24 Piolax Medical Device:Kk ステント
US20040254627A1 (en) * 2003-04-04 2004-12-16 Thompson Paul J. Stent with end adapted for flaring
JP2008511423A (ja) * 2004-09-01 2008-04-17 アンギオメット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コムパニー メディツィンテヒニク コマンデイトゲゼルシャフト ステント及びステント製造方法
US20090306760A1 (en) * 2008-06-06 2009-12-10 Bay Street Medical Prosthesis and delivery system
WO2011093941A2 (fr) * 2010-01-29 2011-08-04 Dc Devices, Inc. Dispositifs et systèmes de traitement de l'insuffisance cardiaque
WO2011122444A1 (fr) * 2010-03-30 2011-10-06 テルモ株式会社 Système de pose d'endoprothèse
WO2012031748A2 (fr) * 2010-09-08 2012-03-15 Phenox Gmbh Implant destiné à influencer le débit sanguin en cas de malformations artérioveineuses

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016140716A (ja) * 2015-02-05 2016-08-08 オリンパス株式会社 医療用電気刺激電極
US12064343B2 (en) 2020-03-04 2024-08-20 Medtronic, Inc. Devices and methods for multi-alignment of implantable medical devices
US20220061985A1 (en) * 2020-08-25 2022-03-03 Medtronic, Inc. Devices and methods for multi-alignment of implantable medical devices
US12521236B2 (en) * 2020-08-25 2026-01-13 Medtronic, Inc. Devices and methods for multi-alignment of implantable medical devices
US11969343B2 (en) 2020-12-07 2024-04-30 Medtronic, Inc. Transcatheter heart valve prosthesis systems and methods for rotational alignment

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