WO2014173635A1 - Composition topique pour la croissance des cheveux - Google Patents

Composition topique pour la croissance des cheveux Download PDF

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Publication number
WO2014173635A1
WO2014173635A1 PCT/EP2014/056410 EP2014056410W WO2014173635A1 WO 2014173635 A1 WO2014173635 A1 WO 2014173635A1 EP 2014056410 W EP2014056410 W EP 2014056410W WO 2014173635 A1 WO2014173635 A1 WO 2014173635A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
hair
extract
gallic acid
hair growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2014/056410
Other languages
English (en)
Inventor
Indu Mani
Savitha RAJKUMAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever NV
Conopco Inc
Original Assignee
Unilever NV
Conopco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever NV, Conopco Inc filed Critical Unilever NV
Publication of WO2014173635A1 publication Critical patent/WO2014173635A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)

Definitions

  • the invention relates to a topical composition for hair growth comprising synergistic combination of materials including extracts of plant source.
  • Hairs are filamentous, keratinized structures consisting of a shaft and a root.
  • the shaft is composed of specialized keratinocytes.
  • the root lies within the hair follicle and comprises the germinative matrix and the keratogenous zone.
  • the hair growth cycle is divided into three phases: an anagen phase, in which the hair is growing actively, with a very substantial level of cell proliferation occurring in the hair follicle; a catagen phase, when the follicle slows down its proliferative activity temporarily to permit hair development; and a telogen phase, in which the follicle simply stops growing and regresses, until the hair is shed, and a new anagen phase begins.
  • WO 07/084614A discloses a hair treatment composition for topical application to the skin and/or hair, comprising partially hydrolyzed fucoidan and a
  • composition for minimizing hair loss comprising 0.001 -10% by weight gallic acid or an alkyl ester of gallic acid or a mixture thereof.
  • the invention relates to a topical composition for hair growth comprising: a. 0.01 to 10% of a gallic acid ester selected from methyl, ethyl or propyl
  • a topical composition for hair growth is meant to include a composition for topical application to hair or scalp of mammals, especially humans. By topical is meant that the composition is applied to the external surface of the body.
  • compositions for achieving the desired benefits by way of ingestion into the human body are excluded from the scope of the present invention.
  • Such a composition may be generally classified as leave-on or rinse off, and includes any product applied to a human body for also improving the appearance, cleansing, odor control or general aesthetics of scalp and hair.
  • the composition of the present invention can be in the form of a liquid, lotion, cream, foam, scrub, gel, shampoo, conditioner, shower gel or bar.
  • the composition of the present invention is preferably a leave-on composition.
  • alkyl ester is selected from methyl, ethyl or propyl ester or a mixture thereof. It is particularly preferred that the ester is methyl gallate.
  • the source of methyl gallate is preferably an extract from Acacia nilotica, Mangifera indica, Anachardium oxydentale. Alternately it may be chemically synthesized from gallo tannins using reported procedures.
  • the source of gallic acid or its esters is synthetic or any gallic acid rich plant source.
  • the source of gallic acid is preferably gall nuts, Terminalia species for e.g. chebula, bellerica, arjuna etc, tea, Embelica officinalis, Mucuna pruriens and other gallic acid rich sources.
  • Sesamum indicum is also known as Sesamum orientale.
  • the common name is sesame. It is an erect, branched plant that grows to a height of about 60-180 cm. It is an annual plant. It is cultivated throughout the plains of India and also in the hills up to an altitude of about 1200 metres. It is also grown in other countries having climatic conditions like the tropical plains of India mostly as a source of oil seed. It is also used as a spice for seasonings.
  • Sesame is known as Tila, Till, Til, or Gingelli in different regions of India. There are many varieties of sesame grown in India. The varieties are based on the colour of the seed coat which ranges from white to black. There are many intermediate varieties as well. However, the black and white Sesame are two varieties largely cultivated in India.
  • the white sesame is more preferred for use in the present invention.
  • the extract of the second active is preferably present in 0.01 to 2% by weight of the composition, conveniently 0.1 to 1 .0 % by weight of the composition.
  • the extract of Sesamum indicum preferably comprises sesamin, sesamolin, sesamol and sesaminol.
  • Glycyrrhiza glabra is perennial herb or under shrub attaining a height up to six feet. It is commonly called as licorice, liquorice or mulethi or sweet wood. It is cultivated in India, Spain, Iran, Russia, China, Italy and Persia. In India it is cultivated in Punjab and Sub Himalayan tracts. The root crown gives out a number of long woody stems which bear compound pinnate leaves. Liquorice is known as Jeshtamadha, Jatimadhu, Atimaduram, Atimadhuranu, or Yashtimadhukam in different parts of India. Root and rhizomes are the parts commonly used.
  • the major bio-active constituent of rhizomes are triterpenoids saponin, glycyrrhizin, glycyrrhizinic acid, glabrin A&B, glycyrrhetol, glabrolide, isoglabrolide, isoflavones, coumarins and triterpene sterols.
  • the extract of Glycyrrhiza glabra for use in the present invention, preferably comprises higher than 10% of glycyrrhizinic acid.
  • the extract of Glycyrrhiza glabra or Sesamum indicum for use in the composition of the invention preferably an aqueous extract.
  • the composition of the invention comprises a topically acceptable base.
  • the topically acceptable bases are such as to have a product in preferably a lotion, emulsion, gel, or cream form.
  • the topically acceptable base preferably comprises water.
  • the composition is preferably a gel or a cream.
  • the composition according to the invention may also comprise other diluents.
  • the diluents act as a dispersant or carrier for other materials present in the composition, so as to facilitate their distribution when the composition is applied to the skin.
  • Diluents other than water can include liquid or solid emollients, solvents, humectants, thickeners and powders.
  • compositions of the present invention can comprise a wide range of other optional components.
  • CTFA Cosmetic Ingredient Handbook Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin, scalp and hair care industry, which are suitable for use in the
  • compositions of the present invention examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, humectants, opacifying agents, conditioners, exfoliating agents, pH adjusters, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
  • Anagen hair follicles were isolated from scalp biopsies of volunteers undergoing hair transplant operations. Isolated follicles were maintained in William's E Media (Sigma # W 4128) in the absence or presence of various actives. The movement of hair bulbs from anagen (growth phase) to catagen phase (phase of hair fall) was monitored by daily photography and measurement of the size of the hair bulb.
  • Methyl gallate (MG) was purchased from Sigma and aqueous extracts of all herb samples were purchased from Phyto Concentrates. These were prepared in water as 1 % solution and stored at -20°C. Further dilutions of MG and herbs and their combinations were prepared in the media just before addition to the hair follicle culture. The actives were added fresh every time the media was changed (every alternate day) and the growth was followed for a period of 4 days. Morphology of hair bulb and change in length was recorded for every time point (Day 0, Day 2 and Day 4). Each experiment was conducted at least with 6-8 hair follicles per group and the results are averages of 3-5 experiments per active.
  • Glycyrrhiza glabra in combination with methyl gallate showed both growth and bulb retention in the invitro hair follicle.
  • the methyl gallate was tested at concentrations of 10 and 50 ppm and the herb extracts were tested at at concentrations of 125, 250 and 500 ppm.
  • the summary of the data on % hair growth and % bulbs retained in anagen ph is summarised in Table 1 .
  • the concentration of the herb and the gallic acid ester in the above experiments correspond to in-vitro hair bulb conditions.
  • the actual amount of these actives to be included in a composition for hair growth has to be orders of magnitude higher, to account for various factors including loss of active due to possible stability issues in the composition over storage and use, efficiency of spreading of the composition on the hair/ scalp, availability of the active from the bulk of the composition to the desired surface, diffusion of the active from the desired surface to the active site where the biochemical reaction occurs among various other known and unknown factors.
  • ppm levels of active in an in-vitro assay generally requires percentage levels of incorporation of the actives in a compostion.
  • the invention thus provides for a composition for hair growth comprising a judicious combination of natural materials.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition topique pour la croissance des cheveux, ladite composition comprenant une combinaison synergique d'extraits d'origine végétale. La composition permet non seulement de maintenir le bulbe pileux à l'état anagène pendant une durée plus longue, mais assure aussi une plus grande longueur des cheveux. Ceci est rendu possible par une composition qui comprend un ester de l'acide gallique et un extrait de Glycyrrhiza glabra ou Sesamum indicum qui est appliquée sur les cheveux ou le cuir chevelu pour obtenir les avantages souhaités.
PCT/EP2014/056410 2013-04-23 2014-03-31 Composition topique pour la croissance des cheveux Ceased WO2014173635A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13164912.1 2013-04-23
EP13164912 2013-04-23

Publications (1)

Publication Number Publication Date
WO2014173635A1 true WO2014173635A1 (fr) 2014-10-30

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Family Applications (1)

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PCT/EP2014/056410 Ceased WO2014173635A1 (fr) 2013-04-23 2014-03-31 Composition topique pour la croissance des cheveux

Country Status (1)

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WO (1) WO2014173635A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029080A1 (fr) 2016-08-12 2018-02-15 Unilever N.V. Composition de traitement capillaire
WO2020025257A1 (fr) 2018-07-30 2020-02-06 Unilever N.V. Compositions comprenant des ingrédients botaniques actifs
KR20220040959A (ko) * 2020-09-24 2022-03-31 주식회사 비에이치랩 두피 보호 및 모발 발색 증진을 위한 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103616A2 (fr) * 2002-06-11 2003-12-18 L'oreal Utilisation d'un agent mimetique de l'activite de la dopachrome tautomerase (trp-2) comme agent protecteur des melanocytes du follicule pileux et applications
US20070116664A1 (en) * 2005-11-21 2007-05-24 Shmuel Gonen Methods and compositions for treating hair and skin afflictions
WO2007084614A2 (fr) 2006-01-18 2007-07-26 Sakura Properties, Llc Préparation pour croissance capillaire
CN101181205A (zh) * 2006-11-14 2008-05-21 王学勤 一种洗发香波
CN101700312A (zh) * 2009-11-30 2010-05-05 王心聚 一种治疗斑秃的中药制剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103616A2 (fr) * 2002-06-11 2003-12-18 L'oreal Utilisation d'un agent mimetique de l'activite de la dopachrome tautomerase (trp-2) comme agent protecteur des melanocytes du follicule pileux et applications
US20070116664A1 (en) * 2005-11-21 2007-05-24 Shmuel Gonen Methods and compositions for treating hair and skin afflictions
WO2007084614A2 (fr) 2006-01-18 2007-07-26 Sakura Properties, Llc Préparation pour croissance capillaire
CN101181205A (zh) * 2006-11-14 2008-05-21 王学勤 一种洗发香波
CN101700312A (zh) * 2009-11-30 2010-05-05 王心聚 一种治疗斑秃的中药制剂

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Sesamum Indicum Nigrum", INTERNET CITATION, 8 April 2012 (2012-04-08), pages 1 - 2, XP007922269, Retrieved from the Internet <URL:http://www.epharmacognosy.com/2012/04/black-sesame-seedheizhima-sesamum.html> [retrieved on 20130623] *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 6 August 2008 (2008-08-06), HINDUSTAN UNILEVER LTD., INDIA: "Topical compositions for minimizing hair loss", XP002713623, Database accession no. 2008:930889 *
DATABASE WPI Week 200865, Derwent World Patents Index; AN 2008-K98389, XP002713624 *
DATABASE WPI Week 201034, Derwent World Patents Index; AN 2010-F21050, XP002713622 *
LIU: "Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats", THE JOURNAL OF NUTRITION, vol. 136, no. 4, 1 January 2006 (2006-01-01), pages 906, XP055080424, ISSN: 0022-3166 *
NISHIOKA T ET AL: "Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 61, no. 11, 1 January 1998 (1998-01-01), pages 1413 - 1415, XP003011527, ISSN: 0163-3864, DOI: 10.1021/NP980163P *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018029080A1 (fr) 2016-08-12 2018-02-15 Unilever N.V. Composition de traitement capillaire
WO2020025257A1 (fr) 2018-07-30 2020-02-06 Unilever N.V. Compositions comprenant des ingrédients botaniques actifs
US11291624B2 (en) 2018-07-30 2022-04-05 Conopco, Inc. Compositions comprising active botanical ingredients
KR20220040959A (ko) * 2020-09-24 2022-03-31 주식회사 비에이치랩 두피 보호 및 모발 발색 증진을 위한 조성물
KR102575612B1 (ko) * 2020-09-24 2023-09-06 주식회사 비에이치랩 두피 보호 및 모발 발색 증진을 위한 조성물

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