WO2014189375A1 - Procédé pour le dépôt d'un matériau de revêtement sur un dispositif médical et dispositif médical - Google Patents

Procédé pour le dépôt d'un matériau de revêtement sur un dispositif médical et dispositif médical Download PDF

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Publication number
WO2014189375A1
WO2014189375A1 PCT/NL2014/050324 NL2014050324W WO2014189375A1 WO 2014189375 A1 WO2014189375 A1 WO 2014189375A1 NL 2014050324 W NL2014050324 W NL 2014050324W WO 2014189375 A1 WO2014189375 A1 WO 2014189375A1
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WO
WIPO (PCT)
Prior art keywords
medical device
coating material
ions
coating
spray chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2014/050324
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English (en)
Inventor
Johannes Cornelis Maria Marijnissen
Wilfred Peter Heiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALVIMEDICA VASCULAR RESEARCH BV
Original Assignee
ALVIMEDICA VASCULAR RESEARCH BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALVIMEDICA VASCULAR RESEARCH BV filed Critical ALVIMEDICA VASCULAR RESEARCH BV
Publication of WO2014189375A1 publication Critical patent/WO2014189375A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
    • B05D3/0486—Operating the coating or treatment in a controlled atmosphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B05D1/04—Processes for applying liquids or other fluent materials performed by spraying involving the use of an electrostatic field
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/14—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/02—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber

Definitions

  • the invention relates to a method for depositing a coating material on a medical device.
  • a known method for depositing a material on a target, e.g. a substrate, is electrospraying.
  • the material to be deposited is provided in a nozzle.
  • a high voltage electric potential is applied to the nozzle, usually in the order of 1-30 kV. Due to this electric potential, the material in the nozzle obtains an electrical charge. In some cases, the electrical forces force the material out of the nozzle. Additionally or alternatively, the material is forced out mechanically, e.g. by using a syringe. The material then forms small droplets which repel each other due to their like charges. The result is a very fine spray.
  • the target is electrically conducting and connected to ground. Therefore, the charged particles of the coating material are drawn towards the target, where they are deposited.
  • electrospinning is the same as for electrospraying. However, whereas in electrospraying the material is formed as spray of fine particles, in electrospinning a polymer material is used which forms very fine fibers, e.g. nanofibers, when ejected from the nozzle. The target is again electrically conducting and connected to ground to draw the fibers to the target.
  • Coating an electrically conducting target with an insulating coating material using conventional methods results in a coating with cracks or openings.
  • the coating applied to a medical device i.e. a stent or other implantable device or a catheter, needs to be free of cracks.
  • these devices often comprise insulating parts, which cannot be coated using the above conventional methods.
  • a goal of the invention is to overcome these drawbacks and provide an improved method for depositing material on a medical device.
  • the method further comprises - providing ions in the spray chamber to subject said surface to be coated to ions to prevent the formation of holes or cracks in the deposited coating material.
  • back ionization sometimes called back sparking
  • back ionization occurs because the layers of coating material isolate the conducting target as they are build up on the target.
  • the layers on the target therefore obtain a high charge, which can result in an electrical discharge through the deposited layers. This leads to a coating with cracks or openings.
  • subjecting the target to ions neutralizes the charge build up in the layers of coating material. Thereby, back ionization is prevented.
  • the ions will charge the surface of the target such that the coating material is attracted by the target's surface.
  • this initial charge will be at least partially neutralized.
  • a new load of ions will attach to this first layer to again establish a net charge, on which a second layer will be deposited, and the process repeats itself.
  • some of the charged particles ejected from the nozzle may be (partially) neutralized in flight by the ions in the spray chamber.
  • the charge at the surface of the target may be (partially) released through the air, since it has a certain conductivity due to the presence of the ions.
  • the invention enables an electrospray or electrospinning process for insulating targets and/or depositing material.
  • the ions prevent back ionization.
  • the invention enables applying to an insulating or conducting medical device a coating free of holes or cracks.
  • Ejecting the material may comprise applying a high enough electric potential such that the material is ejected from the nozzle due to the electrical forces overcoming the surface tension of the liquid, i.e. without applying an additional (mechanical) force.
  • a force can be applied to eject the material.
  • the nozzle comprises a piston or syringe pump for applying a pressure to expel the material from the nozzle.
  • the nozzle is also known as the emitter.
  • the nozzle may for example comprise a capillary, such as a hollow needle.
  • a capillary promotes the formation of a Taylor cone, from which the material is ejected at a sufficiently high voltage level.
  • the material will usually be present in a liquid, such as alcohol, tetrahydrofuran (THF), dimehtylformamide (DMF) or an isopropyl alcohol.
  • a liquid such as alcohol, tetrahydrofuran (THF), dimehtylformamide (DMF) or an isopropyl alcohol.
  • THF tetrahydrofuran
  • DMF dimehtylformamide
  • the electric potential applied to the nozzle is preferably a high voltage. For example, a voltage over 1 kV, over 10 kV, over 20 kV or over 30 kV is used.
  • the electrospray device may include a counter electrode, e.g. for focusing the charged particles.
  • a counter electrode ring may be used.
  • a voltage of the same polarity as the voltage applied to the nozzle is applied to the counter electrode.
  • the spray chamber is preferably closable.
  • the outlet of the nozzle is located in the chamber.
  • the chamber comprises a door to enable placing the target inside the chamber.
  • the chamber is substantially completely closed during use.
  • the spray chamber may be any suitable enclosure for the electrospray operation.
  • the spray chamber may have any suitable size.
  • the spray chamber may comprise an entire room or a relatively small box.
  • the walls of the spray chamber are electrically insulating. This prevents the ions from being drawn towards the walls of the chamber.
  • a counter electrode is used for forming the electrospray.
  • the ions are provided to the surface to be coated.
  • the part of the surface which is to be coated is subjected to both electrospray coating and ions.
  • the surface to be coated is simultaneously subjected to electrospray coating and ions.
  • the method comprises depositing multiple layers of the coating material on the medical device.
  • the coating material is deposited evenly over the surface of the medical device.
  • the mass of coating material per surface area is substantially constant over the coated surface.
  • the even distribution of the coating material can for example be inspected visually, for example using a microscope.
  • the material comprises a combination of a drug and a polymer.
  • a drug such as stents, other implantable devices or catheters.
  • Such invasive devices are often coated with a drug.
  • stents are provided with a coating comprising a drug to prevent restenosis of arteries.
  • the coating has to be as homogeneous as possible, i.e. free of cracks and openings.
  • the method according to the invention is in particular suitable in creating such coatings.
  • the invention enables applying the coating to non-conducting parts of the medical device as well.
  • the drug may for example comprise paclitaxel or sirolumus (rapamycin) or other limus drugs, such as temsirolimus, everolymus, deforolimus, zotarolimus or biolimus.
  • paclitaxel or sirolumus rapamycin
  • limus drugs such as temsirolimus, everolymus, deforolimus, zotarolimus or biolimus.
  • the drug eluting coating provided on a medical device by the method according to the invention is a homogenous coating, i.e. the drug is evenly distributed over the coated surface.
  • the mass of drug per surface area is substantially constant.
  • the coating will be substantially free of cracks and openings. This enables a homogenous release of the drug during use of the medical device. In other words, the invention ensures optimal release kinetics of the drug eluting coating.
  • the drug is distributed evenly over the surface of the medical device for homogeneous release of the drug during use of the medical device.
  • the ions in the spray chamber comprise ions having a polarity opposite to the polarity of the electric potential of the nozzle.
  • this contributes to the neutralization of charges on the medical device, and therefore to the homogeneous building of coating layers on the medical device.
  • the ions used are negative ions, e.g. N 2 and 0 2 .
  • both positive and negative ions are provided.
  • the ions are generated by ionizing air.
  • the ions are for example generated using a corona discharge system.
  • a corona discharge system may comprise a conductor having a sharp edge, e.g. a sharp point, to which a high voltage is applied.
  • the high electric field at the edge ionizes the air which creates a corona discharge.
  • N 2 and 0 2 are formed.
  • the medical device is electrically insulating. As described above, before the invention it was not possible to coat an electrically insulating medical device using electrospraying or electrospinning.
  • the medical device is electrically conducting.
  • the method of the invention does not require a conducting medical device to be grounded; it may as well be electrically insulated from ground.
  • the medical device is electrically conducting and electrically connected to ground.
  • grounding of the medical device is no longer necessary, it can be advantageous during the start of the coating process.
  • the grounded medical device efficiently attracts the charged coating material. After the first layer of material has been deposited on the medical device, the ions will largely take over this role of providing an active surface to attract the coating material.
  • the medical device is electrically conducting and electrically insulated from ground.
  • isolating the target from ground will lead to back ionization and consequently to the formation of cracks in the coating.
  • back ionization is prevented.
  • the coating material to be deposited on the medical device is electrically insulating.
  • the step of providing the ions in the spray chamber comprises providing the medical device in an atmosphere comprising the ions.
  • the medical device is placed in a holding means, such as a clamp or platform, and the air surrounding the medical device is ionized by using an ionization device.
  • a holding means such as a clamp or platform
  • the step of providing the ions in the spray chamber comprises creating a flow or bundle of ions directed towards the medical device.
  • the ions are provided before ejecting the material towards the medical device. This is especially advantageous in the case of an insulating medical device, as it allows building up a net charge on the surface of the medical device by means of the ions before the coating material is applied.
  • the coating material comprises a polymer such that the ejected coating material forms fibers by means of electrospinning.
  • the polymer is chosen such that a nanofiber is created.
  • the coating material to be deposited comprises a polymer selected from the group comprising polylactic acid (PLA),poly-L-lactide (PLLA), poly(lactic-co- glycolic acid) (PLGA), thermoplastic polyure thane (TPU), nylon and polyether block amide (PEBA or PEBAX).
  • PLA polylactic acid
  • PLLA poly-L-lactide
  • PLGA poly(lactic-co- glycolic acid)
  • TPU thermoplastic polyure thane
  • PEBA or PEBAX polyether block amide
  • the invention further relates to a medical device with layers of a coating material deposited on the device, wherein the coating is free of holes or cracks and the coating material comprises a combination of a drug and a polymer.
  • the coating material is deposited on the device using the method as described above.
  • the invention further relates to a medical device obtainable using the method described above.
  • the invention also relates to a depositing device configured for performing the aforementioned method for depositing a coating material on a medical device, comprising:
  • a voltage source connected to the electrospray nozzle for applying an electric potential to the electrospray nozzle
  • the spray chamber encloses both the medical device and the outlet end of the nozzle.
  • the spray chamber is closable, preferably such that it is substantially completely closed during use.
  • the chamber comprises a door for placing the medical device inside the chamber.
  • the walls of the spray chamber preferably are electrically insulating.
  • a holding means is provided in the spray chamber for holding the medical device in the path of the ejected material.
  • the holding means for example comprises a platform or a clamp.
  • the invention further relates to the use of a device according to the invention for depositing coating material on at least a part of a medical device.
  • the invention further relates to a method for depositing a coating material on a target for the production of a battery.
  • the method is the same as describe above, except that the target is a battery component instead of a medical device.
  • the features described above with respect to preferred embodiments of the method for coating a medical device may also be applied to the method for coating a target for production of a battery.
  • the method for coating a target for production of a battery comprises the steps of:
  • the method further comprises using the coated target to produce a battery.
  • the method comprises using the battery in a medical device, such as a catheter or a pace maker, or in a medical apparatus such as a heart monitor or diagnostic apparatus.
  • the coating material comprises a polymer loaded with at least a second material, preferably in the form of nanoparticles.
  • the polymer is loaded with a metal, a ceramic or a precursor, such as chloroplatinic acid.
  • FIG. 1 shows schematically a first embodiment of a device for executing the method according to the invention
  • FIG. 2 shows schematically a second embodiment of a device for executing the method according to the invention
  • FIG. 3 shows schematically a part of a stent
  • FIG. 4 shows a detail of the stent of figure 3 when coated according to a conventional method of coating
  • FIG. 5 shows a detail of the stent of figure 3 when coated according to the method of the invention.
  • Device 2 (figure 1) comprises a spray chamber 4. Electrospray nozzle 6 has a needle shaped outlet in spray chamber 4. Nozzle 6 is connected to high voltage power supply 8. In this example, the voltage applied is a positive voltage of 10 kV.
  • Counter electrode ring 9 is positioned inside chamber 4 and connected to a high voltage, which is equal or preferably lower than the voltage of nozzle 6. In this example the voltage level of counter electrode 9 is 5 kV. A stable spray will be developed between nozzle 6 and ring 9.
  • a syringe 10 is provided.
  • Ion generating device 12 is connected to high voltage power supply 16 for generating positively charged ions.
  • Ion generating device 14 is connected to high voltage power supply 18 for generating negatively charged ions.
  • Spray chamber 4 further comprises a support (not shown) on which medical device 22 is placed.
  • medical device 22 is electrically insulating.
  • medical device 22 is connected to ground.
  • medical device 22 is a stent or a catheter.
  • a solvent e.g. alcohol, comprising the coating material, e.g. a polymer
  • Medical device 22 is placed on the support and spray chamber 4 is closed.
  • Ion generating devices 12, 14 are activated by controlling power supplies 16, 18, such that both positive and negative ions are generated inside the volume of spray chamber 4.
  • a bipolar ionization source 124 i.e. a source creating both positive and negative ions, is provided inside spray chamber 104.
  • Bipolar ionization source 124 is a source as known from air purifier systems. Source 124 is connected to a power supply via cables 126.
  • a solvent comprising the coating material is provided in syringe 110.
  • Medical device 122 is placed on the support (not shown) and spray chamber 104 is closed.
  • Source 124 is switched on, such that ions are generated inside the volume of spray chamber 104.
  • power supply 108 is activated, to charge the coating material.
  • Counter electrode ring 109 is also brought to a high voltage, which is equal to or preferably lower than the voltage level of nozzle 6.
  • the material is forced out of nozzle 106 in the form of an electrospray. The coating is thereby applied on the surface of medical device 122.
  • Stent 124 (figure 3) comprises a mesh 126.
  • mesh 126 is composed of a material comprising a metal, such as nitinol.
  • the mesh 126 forms a tubular structure of which only a part has been shown in figure 3.
  • the center line 128 and circumference 130 have been schematically indicated for illustrative purposes.
  • Figure 4 shows a detail of stent 124 when coated using a conventional method. Due to the occurrence of backsparking the coated surface shows irregularities 132, e.g. cracks or openings.
  • Figure 5 shows a detail of stent 124 when coated using the method of the invention.
  • the resulting coating shows an even surface, without cracks or openings.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Electrostatic Spraying Apparatus (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé pour le dépôt d'un matériau de revêtement sur un dispositif médical, un système de dépôt pour le dépôt d'un matériau de revêtement sur un dispositif médical et un dispositif médical revêtu. Le procédé comprend les étapes suivantes : le placement du dispositif médical dans une chambre de pulvérisation; l'alimentation du matériau de revêtement à une buse d'électro-pulvérisation; l'application d'un potentiel électrique à la buse; et l'éjection du matériau de revêtement depuis la buse d'électro-pulvérisation vers le dispositif médical pour le revêtement d'une surface du dispositif médical. L'invention est caractérisée en ce que le procédé comprend en outre : l'apport d'ions dans la chambre de pulvérisation pour soumettre ladite surface à revêtir à des ions afin d'empêcher la formation de trous ou de fissures dans le matériau de revêtement déposé.
PCT/NL2014/050324 2013-05-21 2014-05-21 Procédé pour le dépôt d'un matériau de revêtement sur un dispositif médical et dispositif médical Ceased WO2014189375A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2010830 2013-05-21
NL2010830A NL2010830C2 (en) 2013-05-21 2013-05-21 Method and device for depositing a material on a target and medical device obstainable therewith.

Publications (1)

Publication Number Publication Date
WO2014189375A1 true WO2014189375A1 (fr) 2014-11-27

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WO (1) WO2014189375A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019078719A1 (fr) 2017-10-19 2019-04-25 Innovative Mechanical Engineering Technologies B.V. Procédé et système de production électrohydrodynamique

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