WO2015010666A3 - Dérivé de phénol et son utilisation - Google Patents

Dérivé de phénol et son utilisation Download PDF

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Publication number
WO2015010666A3
WO2015010666A3 PCT/CN2014/087448 CN2014087448W WO2015010666A3 WO 2015010666 A3 WO2015010666 A3 WO 2015010666A3 CN 2014087448 W CN2014087448 W CN 2014087448W WO 2015010666 A3 WO2015010666 A3 WO 2015010666A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
phenol derivative
aralkyl
cycloalkyl
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2014/087448
Other languages
English (en)
Chinese (zh)
Other versions
WO2015010666A2 (fr
Inventor
李健雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WUHAN INNERSE PHARMACEUTICAL Inc
Original Assignee
WUHAN INNERSE PHARMACEUTICAL Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WUHAN INNERSE PHARMACEUTICAL Inc filed Critical WUHAN INNERSE PHARMACEUTICAL Inc
Publication of WO2015010666A2 publication Critical patent/WO2015010666A2/fr
Publication of WO2015010666A3 publication Critical patent/WO2015010666A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un dérivé de phénol et une utilisation de ce dernier. Le dérivé de phénol comprend un composé tel que représenté par les formules développées (I), (II) ou (III) ou un sel, ester et amide pharmaceutiquement acceptables de celui-ci. Dans les formules développées (I), (II) ou (III), R1 est choisi parmi un groupe alkyle, un groupe cycloalkyle, un groupe alcényle, un groupe alcynyle, un groupe aryle, un groupe aralkyle, halogène ou un groupe acyle; R2 et R3 sont choisis chacun indépendamment parmi hydrogène, un groupe alkyle, un groupe cycloalkyle, un groupe aryle, un groupe aralkyle ou un groupe acyle; et R4, R5, R6 et R7 sont choisis chacun indépendamment parmi hydrogène, un groupe alkyle, un groupe cycloalkyle, un groupe aryle ou un groupe aralkyle. L'invention concerne également l'utilisation du composé ou du sel, de l'ester et de l'amide pharmaceutiquement acceptables de celui-ci dans la préparation de médicaments utilisés pour traiter une maladie immunitaire, une inflammation ou une maladie auto-immune.
PCT/CN2014/087448 2013-07-25 2014-09-25 Dérivé de phénol et son utilisation Ceased WO2015010666A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310317062.0A CN103467281B (zh) 2013-07-25 2013-07-25 一种苯酚衍生物及其应用
CN201310317062.0 2013-07-25

Publications (2)

Publication Number Publication Date
WO2015010666A2 WO2015010666A2 (fr) 2015-01-29
WO2015010666A3 true WO2015010666A3 (fr) 2015-03-26

Family

ID=49792363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/087448 Ceased WO2015010666A2 (fr) 2013-07-25 2014-09-25 Dérivé de phénol et son utilisation

Country Status (2)

Country Link
CN (1) CN103467281B (fr)
WO (1) WO2015010666A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103467281B (zh) * 2013-07-25 2016-03-23 武汉英纳氏药业有限公司 一种苯酚衍生物及其应用
CN113072488A (zh) * 2021-03-30 2021-07-06 广东工业大学 一种苯乙烯衍生物及其合成方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978065A (en) * 1973-05-25 1976-08-31 Gruppo Lepetit S.P.A. Reserpine derivatives
CN102548965A (zh) * 2009-09-25 2012-07-04 安斯泰来制药株式会社 取代酰胺化合物
CN103467281A (zh) * 2013-07-25 2013-12-25 武汉英纳氏药业有限公司 一种苯酚衍生物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2663829C (fr) * 2006-09-29 2012-02-07 Celestial Pharmaceuticals (Shenzhen) Ltd. Composes de dithiolopyrrolone et leurs applications therapeutiques
CN101648851B (zh) * 2009-09-03 2012-10-10 河北科技大学 (e)-3,5-二羟基-4-异丙基二苯乙烯的清洁制备方法
CN102911309B (zh) * 2012-11-02 2015-07-08 中国海洋大学 一种水性丙烯酸高分子化合物及其制备方法与它的用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978065A (en) * 1973-05-25 1976-08-31 Gruppo Lepetit S.P.A. Reserpine derivatives
CN102548965A (zh) * 2009-09-25 2012-07-04 安斯泰来制药株式会社 取代酰胺化合物
CN103467281A (zh) * 2013-07-25 2013-12-25 武汉英纳氏药业有限公司 一种苯酚衍生物及其应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AAMER S. ET AL.: "Total Synthesis and Cytotoxic Activity of Stellatin.", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH., vol. 13, no. 2, February 2011 (2011-02-01), pages 100 *
FIUZA S. M. ET AL.: "Phenolic Acid Derivatives with Potential Anticancer Properties- a Structure-Activity Relationship Study. Part 1: Methyl, Propyl and Octyl Esters of Caffeic and Gallic Acids.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 3581 *
HOLKER ET AL.: "The Chemistry of Fungi. Part XL. Further Evidence for theStructure of Sclerotiorin.", JOURNAL OF THE CHEMICAL SOCIETY., 1962, pages 1962 *
PRATEEK S. ET AL.: "Cinnamic Acid Derivatives: A New Chapter of Various Pharmacological Activities.", J. CHEM. PHARM. RES., vol. 3, no. 2, 2011 *

Also Published As

Publication number Publication date
CN103467281B (zh) 2016-03-23
WO2015010666A2 (fr) 2015-01-29
CN103467281A (zh) 2013-12-25

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