WO2015019193A3 - Dérivés acylés de phloridzine et d'isoquercétrine en tant qu'agents thérapeutiques anticancéreux et leurs procédés d'utilisation - Google Patents

Dérivés acylés de phloridzine et d'isoquercétrine en tant qu'agents thérapeutiques anticancéreux et leurs procédés d'utilisation Download PDF

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Publication number
WO2015019193A3
WO2015019193A3 PCT/IB2014/002520 IB2014002520W WO2015019193A3 WO 2015019193 A3 WO2015019193 A3 WO 2015019193A3 IB 2014002520 W IB2014002520 W IB 2014002520W WO 2015019193 A3 WO2015019193 A3 WO 2015019193A3
Authority
WO
WIPO (PCT)
Prior art keywords
phloridzin
isoquercetrin
methods
acylated derivatives
anticancer therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2014/002520
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English (en)
Other versions
WO2015019193A2 (fr
Inventor
H.P. Vasantha RUPASINGHE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dalhousie University
Original Assignee
Dalhousie University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dalhousie University filed Critical Dalhousie University
Publication of WO2015019193A2 publication Critical patent/WO2015019193A2/fr
Publication of WO2015019193A3 publication Critical patent/WO2015019193A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un dérivé de flavonoïde acylé dérivé de flavonoïdes et d'acides gras naturels et synthétiques. Les dérivés de flavonoïdes acylés peuvent faire partie d'une composition pharmaceutique. Un procédé de diminution de la prolifération et de la viabilité de cellules cancéreuses chez un sujet comprend l'administration de la composition pharmaceutique décrite.
PCT/IB2014/002520 2013-08-08 2014-08-08 Dérivés acylés de phloridzine et d'isoquercétrine en tant qu'agents thérapeutiques anticancéreux et leurs procédés d'utilisation Ceased WO2015019193A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361863790P 2013-08-08 2013-08-08
US61/863,790 2013-08-08

Publications (2)

Publication Number Publication Date
WO2015019193A2 WO2015019193A2 (fr) 2015-02-12
WO2015019193A3 true WO2015019193A3 (fr) 2015-06-25

Family

ID=52461989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/002520 Ceased WO2015019193A2 (fr) 2013-08-08 2014-08-08 Dérivés acylés de phloridzine et d'isoquercétrine en tant qu'agents thérapeutiques anticancéreux et leurs procédés d'utilisation

Country Status (1)

Country Link
WO (1) WO2015019193A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106868077B (zh) * 2016-12-29 2019-12-31 河南科技学院 一种具有肝癌HepG2细胞抑制活性的根皮苷三乙酯的制备方法
CA3102404A1 (fr) 2018-06-05 2019-12-12 Flagship Pioneering Innovations V, Inc. Agents actifs et leurs procedes d'utilisation pour le traitement de troubles metaboliques et d'une steatose hepatique non alcoolique
WO2019236765A1 (fr) * 2018-06-05 2019-12-12 Flagship Pioneering Innovations V, Inc. Polyphénols de catéchine acylés et leurs procédés d'utilisation pour le traitement du cancer
CN109852645B (zh) * 2019-02-26 2022-12-16 山东省千佛山医院 一种槲皮素酯及其复合物
CN110302391B (zh) * 2019-07-01 2022-11-08 大连民族大学 一种葡聚糖-槲皮素聚合物载药胶束制剂及其制备方法
CN110279869B (zh) * 2019-07-01 2022-11-08 大连民族大学 一种葡聚糖-槲皮素前药聚合物的制备方法
CN110540566B (zh) * 2019-08-08 2023-03-24 云南农业大学 紫云英苷衍生物及其应用
CN110801447A (zh) * 2019-10-17 2020-02-18 南京康齐生物科技有限公司 高纯度神经酸在美白方面的应用及其制备方法
CN115181143B (zh) * 2022-06-20 2023-08-18 华南理工大学 一种增强α葡萄糖苷酶抑制活性的酚苷类化合物及其制备方法和应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NAIR ET AL.: "Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression", PLOS ONE, vol. 9, no. 9, 17 September 2014 (2014-09-17) *
SALEM ET AL.: "Effect of acyl donor chain length on isoquercitrin acylation and biological activities of corresponding esters", PROCESS BIOCHEMISTRY, vol. 45, no. 3, 2010, pages 382 - 389, XP026864643 *
ZIAULLAH ET AL.: "An efficient microwave-assisted enzyme-catalyzed regioselective synthesis of long chain acylated derivatives of flavonoid glycosides", TETRAHEDRON LETT, vol. 54, no. 15, 10 April 2013 (2013-04-10), pages 1933 - 1937, XP028998240, DOI: doi:10.1016/j.tetlet.2013.01.103 *
ZIAULLAH ET AL.: "Biocatalytic synthesis, structural elucidation, antioxidant capacity and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin", BIOORG MED CHEM, vol. 21, no. 3, 1 February 2013 (2013-02-01), pages 684 - 692, XP028975833, DOI: doi:10.1016/j.bmc.2012.11.034 *

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WO2015019193A2 (fr) 2015-02-12

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