WO2015102019A3 - Procédé de préparation de polymorphes de chlorhydrate de 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide - Google Patents

Procédé de préparation de polymorphes de chlorhydrate de 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide Download PDF

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Publication number
WO2015102019A3
WO2015102019A3 PCT/IN2014/000801 IN2014000801W WO2015102019A3 WO 2015102019 A3 WO2015102019 A3 WO 2015102019A3 IN 2014000801 W IN2014000801 W IN 2014000801W WO 2015102019 A3 WO2015102019 A3 WO 2015102019A3
Authority
WO
WIPO (PCT)
Prior art keywords
indol
piperazinyl
cyano
butyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2014/000801
Other languages
English (en)
Other versions
WO2015102019A2 (fr
Inventor
Srinivasan Thirumalai Rajan
Sajja Eswaraiah
Gogulapati Venkata Panakala Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Priority claimed from IN6150CH2013 external-priority patent/IN2013CH06150A/en
Priority claimed from IN732CH2014 external-priority patent/IN2014CH00732A/en
Publication of WO2015102019A2 publication Critical patent/WO2015102019A2/fr
Publication of WO2015102019A3 publication Critical patent/WO2015102019A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un sel d'acide formique ainsi que sa forme cristalline d'un médicament antidépresseur à savoir, un composé de 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide de formule 1a, qui est utile dans la préparation du composé de chlorhydrate de 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide de formule 1b et son procédé de préparation.
PCT/IN2014/000801 2013-12-30 2014-12-29 Procédé de préparation de polymorphes de chlorhydrate de 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide Ceased WO2015102019A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN6150/CHE/2013 2013-12-30
IN732/CHE/2014 2014-02-17
IN6150CH2013 IN2013CH06150A (fr) 2013-12-30 2014-12-29
IN732CH2014 IN2014CH00732A (fr) 2014-02-17 2014-12-29

Publications (2)

Publication Number Publication Date
WO2015102019A2 WO2015102019A2 (fr) 2015-07-09
WO2015102019A3 true WO2015102019A3 (fr) 2015-08-27

Family

ID=53494170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000801 Ceased WO2015102019A2 (fr) 2013-12-30 2014-12-29 Procédé de préparation de polymorphes de chlorhydrate de 5-[4-[4-(5-cyano-1h-indol-3-yl)butyl]-1-pipérazinyl]-2-benzofuranne carboxamide

Country Status (1)

Country Link
WO (1) WO2015102019A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (fr) * 2001-06-19 2002-12-27 Merck Patent Gmbh Formes polymorphes de chlorhydrate de 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine
US7829723B2 (en) * 2005-05-26 2010-11-09 Vertex Pharmaceuticals Incorporated Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-3-(3-methoxy-4-(oxazol-5-yl)phenyl)uriedo)phenyl)ethylcarbamate
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102794A2 (fr) * 2001-06-19 2002-12-27 Merck Patent Gmbh Formes polymorphes de chlorhydrate de 1-'4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine
US7829723B2 (en) * 2005-05-26 2010-11-09 Vertex Pharmaceuticals Incorporated Polymorphic forms of (S)-1-cyanobutan-2-yl (S)-1-(3-3-(3-methoxy-4-(oxazol-5-yl)phenyl)uriedo)phenyl)ethylcarbamate
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法

Also Published As

Publication number Publication date
WO2015102019A2 (fr) 2015-07-09

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