WO2016101280A1 - Système et procédé d'imagerie intravasculaire - Google Patents

Système et procédé d'imagerie intravasculaire Download PDF

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Publication number
WO2016101280A1
WO2016101280A1 PCT/CN2014/095213 CN2014095213W WO2016101280A1 WO 2016101280 A1 WO2016101280 A1 WO 2016101280A1 CN 2014095213 W CN2014095213 W CN 2014095213W WO 2016101280 A1 WO2016101280 A1 WO 2016101280A1
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WIPO (PCT)
Prior art keywords
signal
photoacoustic
ultrasonic
laser light
intravascular
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Ceased
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PCT/CN2014/095213
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English (en)
Chinese (zh)
Inventor
宋亮
李岩
龚小竞
林日强
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to PCT/CN2014/095213 priority Critical patent/WO2016101280A1/fr
Publication of WO2016101280A1 publication Critical patent/WO2016101280A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters

Definitions

  • the photoacoustic/ultrasound endoscopic device comprises: a multimode fiber, a flexible spring coil, a matching tube, a converging element, a reflective element, an ultrasonic transducer, a protective sleeve and a supporting element; a converging element, a transmitting element, an ultrasonic transducer and a supporting element are disposed in the protective sleeve; one end of the flexible spring coil is fixed on an inner wall of the protective sleeve, and the other end is connected to the three-dimensional scanning system; a mode fiber is passed through the inside of the matching tube and fixed to one end of the converging element, the reflective element is fixed between the other end of the converging element and the ultrasonic transducer; the ultrasonic transducer is disposed at On the support member;
  • exit surface of the ultrasonic transducer is perpendicular to the blood vessel wall or an angle between the exit surface of the ultrasonic transducer and the blood vessel wall within a predetermined angle range.
  • the frequency of the laser source is greater than or equal to 1 KHz.
  • FIG. 2 is a schematic structural view of a photoacoustic/ultrasound endoscopic device 7 according to an embodiment of the present invention
  • FIG. 3 is a schematic view showing the oblique incident relationship between a pulsed laser and a blood vessel wall according to an embodiment of the present invention
  • 4B is a schematic diagram of energy ratios of two illumination modes at different depths according to an embodiment of the present invention.
  • the coupling optical path 2 shapes, focuses, etc. the pulsed laser light emitted from the light source, and couples the pulsed laser into the multimode optical fiber of the photoacoustic/ultrasound endoscopic device 7 with high coupling efficiency.
  • the intravascular imaging system of the present invention strongly concentrates the light beam by the large numerical aperture converging lens, the spot incident on the tissue surface is very small, and in the prior art, the outgoing beam of the commonly used cardiovascular endoscopic device diverges or converges. The effect is not good, the spot on the surface of the tissue is large, so the Monte Carlo simulation method uses two different spots with diameters of 0.3mm and 1.2mm respectively, but the energy is equal.
  • the laser light source in the intravascular imaging system of the present invention can select a high repetition frequency low energy tunable pulse laser to realize intravascular photoacoustic/ultrasonic high speed imaging.
  • the tunable pulsed laser of the selected light source has a repetition frequency of 1 kHz or more.
  • S602 controlling the pulsed laser to sequentially introduce the photoacoustic/ultrasound endoscopic device through a coupling optical path and a three-dimensional scanning system, so that the pulsed laser is obliquely incident on the surface of the tissue to excite the photoacoustic signal;
  • S604 receiving, by the ultrasonic signal transceiver, the photoacoustic signal and the ultrasonic signal from the photoacoustic/ultrasound endoscopic device;

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

La présente invention concerne un système et un procédé d'imagerie intravasculaire, ledit système d'imagerie intravasculaire comprenant une source de lumière laser (1), un trajet de couplage (2) de lumière, un système (3) de collecte et de commande de signaux, un circuit de temporisation (4), un émetteur-récepteur (5) de signaux ultrasonores, un système (6) de balayage tridimensionnel et un dispositif (7) d'endoscope vasculaire opto-acoustique/ultrasonore ; le laser (31) à impulsions émis par la source de lumière laser (1) passe séquentiellement par le trajet de couplage (2) de lumière, le système (6) de balayage tridimensionnel et le dispositif (7) d'endoscope vasculaire opto-acoustique/ultrasonore, et pénètre de manière oblique dans une paroi vasculaire pour exciter un signal opto-acoustique ; un signal de déclenchement synchrone émis par la source de lumière laser (1) pénètre dans l'émetteur-récepteur (5) de signaux ultrasonores ; l'émetteur-récepteur (5) de signaux ultrasonores commande, en fonction du signal de déclenchement synchrone, le dispositif (7) d'endoscope vasculaire opto-acoustique/ultrasonore pour qu'il émette et reçoive un signal d'onde ultrasonore ; et le système (3) de collecte et de commande de signaux reçoit le signal opto-acoustique et le signal d'onde ultrasonore en provenance du dispositif (7) d'endoscope vasculaire opto-acoustique/ultrasonore par l'intermédiaire de l'émetteur-récepteur (5) de signaux ultrasonores, conduit la reconstruction tridimensionnelle en fonction du signal opto-acoustique et du signal d'onde ultrasonore, et génère une image tridimensionnelle et une image en coupe transversale d'un tissu intravasculaire. Le système d'imagerie intravasculaire améliore une vitesse d'imagerie.
PCT/CN2014/095213 2014-12-26 2014-12-26 Système et procédé d'imagerie intravasculaire Ceased WO2016101280A1 (fr)

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PCT/CN2014/095213 WO2016101280A1 (fr) 2014-12-26 2014-12-26 Système et procédé d'imagerie intravasculaire

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PCT/CN2014/095213 WO2016101280A1 (fr) 2014-12-26 2014-12-26 Système et procédé d'imagerie intravasculaire

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109870413A (zh) * 2019-03-05 2019-06-11 上海市同济医院 青春期大鼠精索静脉曲张模型的光声检测实验装置及方法
CN110990818A (zh) * 2019-12-20 2020-04-10 江西科技师范大学 一种基于线性阵列式迷你led的光声强度防伪识别装置及其方法
CN112515631A (zh) * 2020-10-22 2021-03-19 中国科学院深圳先进技术研究院 血管内窥成像装置
CN113057581A (zh) * 2020-01-02 2021-07-02 北京膳宜德医学研究院有限公司 体外光声扫描仪
CN115462766A (zh) * 2022-10-09 2022-12-13 深圳英美达医疗技术有限公司 信号同步采集方法、系统及可读存储介质
CN115500774A (zh) * 2022-10-22 2022-12-23 深圳市联科翰微医疗科技有限公司 一种血管内窥镜
CN115670520A (zh) * 2023-01-06 2023-02-03 深圳微创踪影医疗装备有限公司 血管内超声成像方法、装置、计算机设备、存储介质
CN116299837A (zh) * 2023-01-04 2023-06-23 华中科技大学 一种全光型侧向光致超声自发自收式光纤内窥镜制备方法
WO2025122109A1 (fr) * 2023-12-04 2025-06-12 Bilkent Universitesi Ulusal Nanoteknoloji Arastirma Merkezi Système d'endoscope photoacoustique

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CN101912250A (zh) * 2010-05-24 2010-12-15 华南师范大学 一种血管内光声超声双模成像内窥镜装置及其成像方法
US20110021924A1 (en) * 2007-02-09 2011-01-27 Shriram Sethuraman Intravascular photoacoustic and utrasound echo imaging
CN102743191A (zh) * 2012-06-28 2012-10-24 华南师范大学 聚焦式旋转扫描光声超声血管内窥成像装置及其成像方法
CN103385758A (zh) * 2013-07-22 2013-11-13 深圳先进技术研究院 一种血管内光声超声双模成像系统及其成像方法
CN103654867A (zh) * 2013-12-27 2014-03-26 深圳先进技术研究院 成像探头及具有该成像探头的成像装置
CN103690141A (zh) * 2013-12-26 2014-04-02 广州佰奥廷电子科技有限公司 直肠内光学、光声、超声多模成像内窥镜及其成像方法

Patent Citations (6)

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US20110021924A1 (en) * 2007-02-09 2011-01-27 Shriram Sethuraman Intravascular photoacoustic and utrasound echo imaging
CN101912250A (zh) * 2010-05-24 2010-12-15 华南师范大学 一种血管内光声超声双模成像内窥镜装置及其成像方法
CN102743191A (zh) * 2012-06-28 2012-10-24 华南师范大学 聚焦式旋转扫描光声超声血管内窥成像装置及其成像方法
CN103385758A (zh) * 2013-07-22 2013-11-13 深圳先进技术研究院 一种血管内光声超声双模成像系统及其成像方法
CN103690141A (zh) * 2013-12-26 2014-04-02 广州佰奥廷电子科技有限公司 直肠内光学、光声、超声多模成像内窥镜及其成像方法
CN103654867A (zh) * 2013-12-27 2014-03-26 深圳先进技术研究院 成像探头及具有该成像探头的成像装置

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109870413A (zh) * 2019-03-05 2019-06-11 上海市同济医院 青春期大鼠精索静脉曲张模型的光声检测实验装置及方法
CN110990818A (zh) * 2019-12-20 2020-04-10 江西科技师范大学 一种基于线性阵列式迷你led的光声强度防伪识别装置及其方法
CN113057581A (zh) * 2020-01-02 2021-07-02 北京膳宜德医学研究院有限公司 体外光声扫描仪
CN112515631A (zh) * 2020-10-22 2021-03-19 中国科学院深圳先进技术研究院 血管内窥成像装置
CN115462766A (zh) * 2022-10-09 2022-12-13 深圳英美达医疗技术有限公司 信号同步采集方法、系统及可读存储介质
CN115500774A (zh) * 2022-10-22 2022-12-23 深圳市联科翰微医疗科技有限公司 一种血管内窥镜
CN116299837A (zh) * 2023-01-04 2023-06-23 华中科技大学 一种全光型侧向光致超声自发自收式光纤内窥镜制备方法
CN116299837B (zh) * 2023-01-04 2024-03-15 华中科技大学 一种全光型侧向光致超声自发自收式光纤内窥镜制备方法
CN115670520A (zh) * 2023-01-06 2023-02-03 深圳微创踪影医疗装备有限公司 血管内超声成像方法、装置、计算机设备、存储介质
WO2025122109A1 (fr) * 2023-12-04 2025-06-12 Bilkent Universitesi Ulusal Nanoteknoloji Arastirma Merkezi Système d'endoscope photoacoustique

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