WO2016108331A1 - Stimulateur haute fréquence pulsatoire bio-implanté passif pour cathéter pour la stimulation du nerf rachidien épidural transsacral - Google Patents

Stimulateur haute fréquence pulsatoire bio-implanté passif pour cathéter pour la stimulation du nerf rachidien épidural transsacral Download PDF

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Publication number
WO2016108331A1
WO2016108331A1 PCT/KR2015/001112 KR2015001112W WO2016108331A1 WO 2016108331 A1 WO2016108331 A1 WO 2016108331A1 KR 2015001112 W KR2015001112 W KR 2015001112W WO 2016108331 A1 WO2016108331 A1 WO 2016108331A1
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WIPO (PCT)
Prior art keywords
high frequency
pulsatile high
pulsatile
frequency signal
treatment
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Ceased
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PCT/KR2015/001112
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English (en)
Korean (ko)
Inventor
안상호
이상학
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Research Cooperation Foundation of Yeungnam University
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Research Cooperation Foundation of Yeungnam University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data

Definitions

  • the present invention relates to a pulsatile radiofrequency stimulator for a catheter for passive biograft cervical epidural spinal nerve stimulation (hereinafter referred to as an pulsatile radiofrequency stimulator for passive catheter), in particular the generation of pulsatile radiofrequency by an appropriate algorithm according to the patient's symptoms.
  • the present invention relates to a passive extracorporeal pulsatile radiofrequency stimulator which transmits to a catheter implanted in the body so as to control pain or neuronal abnormality with the generated pulsatile radiofrequency energy.
  • Pulsatile radiofrequency has been used for the treatment of various chronic pain syndromes. Compared with persistent high frequency, there is almost no nerve damage, and it has recently emerged as a neuromodulator. It can also be seen as a tool to avoid steroid injections in elderly patients with chronic pain disorders, which can cause various complications due to repeated injections. Tricuspid neuralgia, failure syndrome after spinal surgery, complex site pain syndrome For the treatment of postherpetic neuralgia, peripheral nerve pulsatile radiofrequency therapy of spinal nerve, face and trunk and limbs is expanding. Recently, intraarticular pulsatile radiofrequency has been reported to reduce chronic joint pain. Intra-articular pulsatile radiofrequency is expected to act on intra-articular tissues rather than directly on nerve tissues to act as an anti-inflammatory and immune cell regulator.
  • Micropulmonary cells known to be important for the development of neuropathic pain in the dorsal horn, when pulsatile radiofrequency ablation is performed on the dorsal root ganglion of animals with neuropathic pain, It has been found that the activity of microglia), astrocytes, and substance P (substance P) are reduced. Peripheral nerves and joint pain, such as the central nervous system spinal cord and the pain perception of the brain becomes sensitive and central sensitization occurs, the central sensitization is involved in the activation of microglia. Central sensitization causes the pain in the local area to gradually expand, spreading the pain over a wide area, causing pain or spontaneous pain even with minor irritation and not responding well to any treatment.
  • pulsatile radiofrequency therapy that reduces the activity of microglia is required.
  • pulsatile radiofrequency treatment of the nerves over the entire length of the spinal cord is required because it does not respond well to single-time pulsatile radiotherapy for local nerves.
  • pain reduction or neuronal dysregulation effect does not last for a long time, so the pulsatile radiofrequency that can continuously control the pain or nerve abnormality of the patient by inserting a living implantable catheter A stimulation device is needed.
  • pulsatile stimulation of high frequency of 500,000Hz which is more effective than low frequency stimulation, is a biograft cervical epidural that can be stimulated throughout the spinal field to treat centralized sensitized chronic intractable pain or to control nerve abnormalities.
  • a pulsatile radiofrequency device for a catheter for spinal nerve stimulation is a biograft cervical epidural that can be stimulated throughout the spinal field to treat centralized sensitized chronic intractable pain or to control nerve abnormalities.
  • the present invention transmits the generated pulsatile high frequency and the generated pulsatile high frequency energy to the catheter implanted in the body so as to control the pain or nerve abnormality according to the patient's symptoms, thereby causing the patient's pain.
  • An object of the present invention is to provide an extracorporeal pulsatile radiofrequency stimulator for a passive catheter.
  • the extracorporeal pulsatile high frequency stimulation apparatus for passive catheter allows the pulsatile high frequency signal to be selected according to the patient's condition, and converts the selected pulsatile high frequency signal information into a therapeutic pulsatile high frequency signal in a wireless form.
  • Therapeutic pulsatile high frequency signal generator for converting and transmitting through the antenna;
  • Receiving a therapeutic pulsatile high frequency signal through the implanted antenna in the body may include a passive biograft catheter to generate an electrical stimulation to the site.
  • a therapeutic pulsatile high frequency signal generator provides a service for selecting a frequency required for treatment of pain or neuropathy control, and treatment based on frequency information selected by a physical force applied from the outside. And an input unit for generating and outputting a pulsatile high frequency signal generation request signal, and generating and outputting an initial signal for treatment when a therapeutic pulsatile high frequency signal generation request signal is input from the input unit, while causing the pulsatile high frequency signal generator to generate a pulsatile high frequency signal.
  • a control unit for controlling, a pulsating high frequency signal generating unit for generating and outputting a preset pulsating high frequency signal according to the control of the control unit, an initial signal for treatment from the control unit, and receiving pulsatile high frequency signal information from the pulsating high frequency signal generating unit Receive and mix to treat electrical scene Is a pulsatile high frequency gateway that converts the signal into a therapeutic signal and outputs a therapeutic electrical signal, a pulsatile high frequency power amplifier that receives and amplifies a therapeutic electrical signal from the pulsatile high frequency gateway, and converts the amplified electrical signal into a radio frequency therapeutic pulsatile high frequency. It may be made of a wireless power control unit for converting the signal to be transmitted through the antenna.
  • two therapeutic pulsatile high frequency signal generators are inserted for stimulation synchronization of two passive biograft catheters to insert two passive biograft catheters into the body to stimulate a desired spinal cord nerve segment. You can service in synchronization mode.
  • the input unit when the input unit selects a frequency required for pain treatment, it may serve to select a duration and treatment time of the frequency.
  • control unit provides a plurality of patient state information through an input unit, and if one of the patient state information is selected, the service for selecting a corresponding treatment frequency, duration, treatment time
  • the interface screen can be provided.
  • the treatment pulsatile high frequency signal generator further comprises a storage unit for storing the duration and treatment time information linked to the plurality of patient state information and the plurality of patient state information, the control unit, Information stored in the storage may be read and provided through the input unit.
  • the input unit may be provided in the form of a touch screen.
  • the wireless power control unit may perform high frequency matching with an antenna connected to an electrode, and may monitor an output state of a therapeutic pulsatile high frequency signal transmitted through the antenna.
  • an electrical stimulation may be generated at a corresponding site by receiving a pulsatile high frequency signal through an antenna of a passive biograft catheter implanted in the body.
  • the present invention transmits the generated pulsatile radiofrequency by the appropriate algorithm and the generated pulsatile high frequency energy according to the symptoms of the patient to the implanted catheter to control the pain or nerve abnormality, thereby allowing the patient to control the pain. It is effective in relieving pain and nerve abnormalities.
  • the present invention can generate and transmit a pulsatile high frequency signal required for treatment in vitro and non-invasive, thereby eliminating unnecessary pain generated every time a high frequency needle is inserted into the patient, and appropriately according to the symptoms of the patient. It is effective in controlling pain or nerve abnormalities.
  • FIG. 1 is a block diagram for explaining the configuration of the in vitro pulsatile high frequency stimulation apparatus for passive catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • 1 is a block diagram for explaining the configuration of the in vitro pulsatile high frequency stimulation apparatus for passive catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • the extracorporeal pulsatile high frequency stimulator for a passive catheter includes a therapeutic pulsatile high frequency signal generator 200 and a passive biograft catheter 300.
  • the pulsatile high frequency signal generator 200 for selecting a pulsatile high frequency signal according to a patient's condition converts the selected pulsatile high frequency signal into a therapeutic pulsatile high frequency signal, and transmits it through an antenna in a wireless form. .
  • Passive biograft catheter 300 is inserted into the body of the patient, and receives the therapeutic pulsatile high frequency signal through the antenna to cause electrical stimulation to occur in the site. That is, the basic implantation site is implanted in the sacral region of the pain patient.
  • two or more passive biograft catheter 300 may be implanted to determine the spinal cord region to be stimulated, and the implanted catheter may be controlled by the synchronization mode.
  • Service pulsatile high frequency signal generator 200 to select a frequency required for the treatment of pain or neurological abnormality, and requests for therapeutic pulsatile high frequency signal generation based on frequency information selected by physical force applied from the outside
  • the pulsatile high frequency generator 230 generates the pulsatile high frequency signal while generating and outputting an initial signal for treatment.
  • the control unit 220 to control the control unit, the pulsatile high frequency generator 230 generating and outputting a preset pulsatile high frequency signal according to the control of the control unit 220, and receiving the initial signal for treatment from the control unit 220
  • the pulsatile high frequency signal is input from the high frequency generator 230 and mixed into a therapeutic electrical signal, and the therapeutic electrical Pulsatile high frequency gateway 240 for outputting a signal, Pulsatile high frequency power amplifier 250 for receiving and amplifying a therapeutic electrical signal from the pulsatile high frequency gateway 240, and the amplified electrical signal for the treatment of the radio type
  • the wireless power control unit 260 converts the pulsatile high frequency signal and transmits it through the antenna 270, and the storage unit 280 storing the duration and treatment time information linked to the plurality of patient state information and the plurality of patient state information. Is made of.
  • the input unit 210 may be configured as a touch screen or a plurality of knob switches. When selecting a frequency for pain treatment, the input unit 210 serves to select a duration and treatment time of the frequency.
  • the input unit 210 when the input unit 210 forms a touch screen, the input unit 210 has the function of the output unit at the same time, and provides all menu items for generating pulsatile high frequency signals for controlling pain or nerve abnormality, and selecting menu items. To select and enter conditions.
  • the input unit 210 when the input unit 210 is composed of a plurality of knob switches, the output unit is provided separately, and the duration and treatment time can be selected by turning the knob switch on the basis of the pulsatile high frequency signal selection and the selected pulsatile high frequency signal.
  • the controller 220 recognizes this and outputs the current value of the knob switch through the output unit, so that the doctor or therapist can check and select the values while viewing it.
  • the interface unit 220 provides a plurality of patient state information through the input unit 210, and if one of the patient state information is selected, the interface screen for selecting the treatment frequency, duration, treatment time Can be provided.
  • the input unit 210 is provided in the form of a touch screen.
  • the controller 220 reads the information stored in the storage 280 to be provided through the input unit 210.
  • the wireless power control unit 260 allows high frequency matching with the antenna 310 connected to the passive biograft catheter 300 and monitors the output state of the therapeutic pulsatile high frequency signal transmitted through the antenna 270.
  • the doctor or therapist lays down the patient in the treatment bed, and then the duration of the high frequency signal and the high frequency signal suitable for treating pain or nerve abnormality of the patient through the input unit 210 of the pulsatile high frequency signal generator 200 for treatment. ), Set the treatment time (time).
  • Passive biograft catheter 300 equipped with an antenna 310 is implanted between the spine and the lumbar spine through the procedure.
  • the controller 220 recognizes the pulsatile high frequency generator 230 and presets the pulsatile high frequency signal. While generating a signal, an initial signal for treatment is generated based on the pulsatile high frequency signal, the duration of the pulsatile high frequency signal, and the treatment time information, which is set through the input unit 210, and is output to the pulsatile high frequency gateway 240. At this time, the pulsatile high frequency generator 230 also generates a pulsatile high frequency signal and outputs the pulsatile high frequency gateway 240.
  • the pulsatile high frequency gateway 240 mixes the initial signal for treatment and the pulsatile high frequency signal of the control unit 220 and converts it into a therapeutic electrical signal and outputs the pulsatile high frequency power amplifier 250.
  • the pulsatile high frequency power amplifier 250 amplifies the input therapeutic electrical signal and outputs it to the wireless power controller 260, and the wireless power controller 260 converts the amplified therapeutic electrical signal into a wireless signal to form an antenna.
  • the electrical signal for treatment in the form of a wireless signal transmitted through the antenna 270 and transmitted through the antenna 270 is received through the antenna 310 implanted in the body of the patient and applied to the electrode 320, and the electrode 320. ) Allows electrical stimulation to be performed through a pulsatile high frequency signal inside the patient's body.
  • the electrical stimulation is to relieve pain or neurological abnormalities of the patient, and can be treated for pain or neurological abnormalities when given periodically for a period of time.
  • FIG. 2 is a passive catheter of the present invention implanted in a patient complaining of urethral pain during urination, and initially "600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done” condition through an in vitro pulsatile high frequency stimulator (FIG.
  • Pulmonary radiofrequency signals were applied to electrodes implanted in the sacral region between the spine and the lumbar vertebrae for 3 to 4 days. After one month of treatment, the pulsatile high frequency signal was removed using an in vitro pulsatile high frequency stimulator to have a "Pulsed RF 600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done" condition (see FIG. 2 (b)). It was applied to the two electrodes so that the electrical stimulation is made to the area to treat the pain, the pain was improved.
  • Figure 3 is a patient complaining of fever in the pain and back around the anus, MRI (see Fig. 3 (a)) and a picture of the present invention (see Fig. 3 (b)), the pain when sitting in a hard place
  • the patient is appealing.
  • the patient who was treated by breaking the tailbone after falling only 3m from the patient, the patient was implanted with a passive catheter of the present invention, and the pulsed RF 600sec 55V, 5Hz / 5ms, 360 ⁇ , 150mA
  • the heat sensitivity of the back improves more than 30% and then
  • the pain in the tailbone was improved by 100% and 40 ⁇ 50% after 5 days more pain after treatment using pulsatile radiofrequency signal.
  • the pain in the tailbone was 70% better than in
  • Figure 4 shows that the whole arm is missing, we complain of pain at night, it is hard to fall asleep, pain in the left arm and left hand, lose weight, hard to stretch fingers, limp walking in limp because there is no strength in the left leg (Atrophic lateral sclerosis)
  • the patient was implanted with a passive catheter of the present invention, and the pulsatile high frequency signal having the condition "Pulsed RF 600sec 55V, 5Hz / 5ms, 182ohm, 304mA done" through an in vitro pulsatile radiofrequency stimulator was applied to the site. After the electrical stimulation treatment, the pain was eliminated and relaxed, the left arm pain improved from 70% to 85%, 0.5kg of dumbbell exercise was possible, Biceps increased, and no longer lost weight. It is possible to grab paper with the left hand, reduce the dim feeling when walking, and improve to walk 4 ⁇ 5km at a time.
  • 5 to 7 is a patient who is hospitalized for continuous rehabilitation treatment with neuropathic pain, the passive catheter of the present invention to a patient complaining of pain such as popping of the hands and feet and the pain of hot feeling such as burning on the back Using a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 °C, 320 ⁇ " condition (see Fig. 5 (a)) through an in vitro pulsatile high frequency stimulator After performing the treatment to give electrical stimulation to the site as shown in Fig. 6 (a), the hand and foot and back pain after treatment fell the day after the procedure, after which there was a slight fluctuation, but appeared to be lower than before the procedure. As shown in Fig.

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Abstract

La présente invention concerne un stimulateur haute fréquence pulsatoire in vitro passif permettant la modulation de la douleur ou d'une anomalie neurologique d'un patient au moyen de, selon les symptômes du patient, la génération d'une haute fréquence pulsatoire selon un algorithme approprié, et la transmission de l'énergie haute fréquence pulsatoire à un cathéter implanté in vivo de manière à moduler la douleur ou une anomalie neurologique, la présente invention comprenant les éléments suivants : un générateur de signal haute fréquence pulsatoire pour le traitement permettant la sélection d'un signal haute fréquence pulsatoire en fonction de l'état du patient ; la conversion du signal haute fréquence pulsatoire en un signal haute fréquence pulsatoire pour le traitement, puis sa conversion en une forme sans fil et sa transmission par l'intermédiaire d'une antenne ; et une électrode recevant le signal haute fréquence pulsatoire pour le traitement à travers l'antenne d'un cathéter de type bio-implant passif inséré à l'intérieur du corps du patient, et permettant la génération d'un stimulus électrique sur un site correspondant. En outre, un mode de synchronisation peut être mis en oeuvre pour la synchronisation de stimulus de deux cathéters de type bio-implants passifs pour l'insertion des cathéters de type bio-implants passifs in vivo et la stimulation d'un intervalle souhaité de nerf rachidien. En tant que telle, la présente invention permet non seulement de soulager la douleur ou une anomalie neurologique d'un patient, mais également d'améliorer le traitement de la douleur ou le traitement de neuromodulation pour une anomalie neurologique.
PCT/KR2015/001112 2014-12-31 2015-02-03 Stimulateur haute fréquence pulsatoire bio-implanté passif pour cathéter pour la stimulation du nerf rachidien épidural transsacral Ceased WO2016108331A1 (fr)

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KR10-2014-0194940 2014-12-31
KR1020140194940A KR101653888B1 (ko) 2014-12-31 2014-12-31 수동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치

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US20110130804A1 (en) * 2009-11-30 2011-06-02 UniMed Investment Inc. Implantable pulsed-radiofrequency micro-stimulation system
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US20140142661A1 (en) * 2012-04-18 2014-05-22 Hung Wei Chiu Sympathetic ganglion stimulation apparatus for treatment of hyperhidrosis, Raynauds phenomenon, cerebral ischemia, asthma and hypertension
KR20140071661A (ko) * 2012-12-04 2014-06-12 한국전자통신연구원 무선 전기침을 통한 치료 장치 및 방법

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KR101012818B1 (ko) 2008-11-20 2011-02-08 (주)아이티시 고주파치료 및 저주파치료 기능이 부가된 체외 충격파 치료기
KR101137525B1 (ko) 2009-12-11 2012-04-20 한국과학기술연구원 통증 치료용 심부뇌자극 장치 및 방법
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Publication number Priority date Publication date Assignee Title
US20090132003A1 (en) * 2005-10-21 2009-05-21 Purdue Research Foundation Wireless Electrical Stimulation of Neural Injury
KR20120028307A (ko) * 2009-04-22 2012-03-22 네브로 코포레이션 단순화된 제어기를 포함하는, 통증을 억제하기 위한 고주파수 척수 조정을 제어하기 위한 장치, 및 관련된 시스템 및 방법
US20110130804A1 (en) * 2009-11-30 2011-06-02 UniMed Investment Inc. Implantable pulsed-radiofrequency micro-stimulation system
US20140142661A1 (en) * 2012-04-18 2014-05-22 Hung Wei Chiu Sympathetic ganglion stimulation apparatus for treatment of hyperhidrosis, Raynauds phenomenon, cerebral ischemia, asthma and hypertension
KR20140071661A (ko) * 2012-12-04 2014-06-12 한국전자통신연구원 무선 전기침을 통한 치료 장치 및 방법

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