WO2016131202A1 - Sel de robénidine et son application dans la préparation d'un promoteur de croissance pour l'alimentation animale - Google Patents

Sel de robénidine et son application dans la préparation d'un promoteur de croissance pour l'alimentation animale Download PDF

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Publication number
WO2016131202A1
WO2016131202A1 PCT/CN2015/074459 CN2015074459W WO2016131202A1 WO 2016131202 A1 WO2016131202 A1 WO 2016131202A1 CN 2015074459 W CN2015074459 W CN 2015074459W WO 2016131202 A1 WO2016131202 A1 WO 2016131202A1
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WO
WIPO (PCT)
Prior art keywords
acid
series
chlorobenzoquinone
salts
chlorpheniramine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/074459
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English (en)
Chinese (zh)
Inventor
彭险峰
覃宗华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Insighter Biotechnology Co Ltd
Original Assignee
Guangzhou Insighter Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Insighter Biotechnology Co Ltd filed Critical Guangzhou Insighter Biotechnology Co Ltd
Publication of WO2016131202A1 publication Critical patent/WO2016131202A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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  • the invention belongs to the field of animal and animal animal feed, and particularly relates to a series of salts of chlorpheniramine and its application in preparing animal feed growth promoters.
  • Feed growth promoters include a variety of chemical structures of biologically active substances and their preparations, which play an important role in improving feed conversion ratio and improving livestock production efficiency.
  • many antibiotic growth promoters have been or will be banned due to drug resistance problems.
  • Chloroquinone hydrochloride is traditionally an anticoccidial for animals.
  • a first object of the present invention is to provide a series of salts of chlorophenyl hydrazine which are capable of promoting the growth of animals.
  • R is DL-lactic acid, methanesulfonic acid, 2-hydroxyethylsulfonic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid or oxalic acid.
  • a second object of the present invention is to provide a use of a series of salts of chlorophenylhydrazine represented by formula (1) for the preparation of an animal feed growth promoter.
  • the animals are farm animals such as ducks, pigs, and chickens at various stages of growth.
  • the feed described is a full-price compound feed.
  • the series of salts of chlorophenylhydrazine represented by formula (1) of the present invention are low-toxic or non-toxic to animals, and therefore are suitable as feed growth promoters, and have very good application prospects in the aquaculture industry.
  • the series of salts of chlorpheniramine of the present invention can be used for preparing animal feed growth promoters. Has a broad market prospects.
  • R is DL-lactic acid, methanesulfonic acid, 2-hydroxyethylsulfonic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid or oxalic acid.
  • R is DL-lactic acid, methanesulfonic acid, 2-hydroxyethylsulfonic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid or oxalic acid.
  • chlorophenyl hydrazine DL-lactate and chlorpheniramine 2-hydroxyethyl sulfonate had the most obvious improvement on broiler performance.
  • the effect is better than the hydrochloride, while the other salts are less effective than the hydrochloride.
  • test dose is based on the chlorophenyl hydrazine dosage.
  • Example 15 Effect of different doses of chlorophenyl hydrazine on performance of broilers
  • test dose is based on the dose of chlorophenyl hydrazine.
  • Example 16 Application effect of series of chlorpheniramine salts in pig feed
  • the dose is based on the content of chlorpheniramine.
  • the dose is based on the content of chlorpheniramine.

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un sel de robénidine et son application dans la préparation d'un promoteur de croissance pour l'alimentation animale. La formule développée du sel de robénidine est représentée dans la formule (I) : R est l'acide DL-lactique, l'acide méthanesulfonique, l'acide 2-iséthionique, l'acide citrique, l'acide tartrique, l'acide benzoïque, l'acide succinique, l'acide fumarique, l'acide maléique, l'acide acétique, l'acide sulfurique, l'acide phosphorique ou l'acide oxalique.
PCT/CN2015/074459 2015-02-16 2015-03-18 Sel de robénidine et son application dans la préparation d'un promoteur de croissance pour l'alimentation animale Ceased WO2016131202A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510085371.9A CN104744313A (zh) 2015-02-16 2015-02-16 氯苯胍的系列盐及其在制备动物饲用生长促进剂中的应用
CN201510085371.9 2015-02-16

Publications (1)

Publication Number Publication Date
WO2016131202A1 true WO2016131202A1 (fr) 2016-08-25

Family

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Application Number Title Priority Date Filing Date
PCT/CN2015/074459 Ceased WO2016131202A1 (fr) 2015-02-16 2015-03-18 Sel de robénidine et son application dans la préparation d'un promoteur de croissance pour l'alimentation animale

Country Status (2)

Country Link
CN (1) CN104744313A (fr)
WO (1) WO2016131202A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105030744B (zh) * 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103250882A (zh) * 2013-06-07 2013-08-21 济源市阳光兔业科技有限公司 生长肉兔配合饲料
CN104082621A (zh) * 2014-06-18 2014-10-08 广州英赛特生物技术有限公司 氯苯胍作为肉鸭饲用生长促进剂的应用
CN104082534A (zh) * 2014-06-18 2014-10-08 广州英赛特生物技术有限公司 氯苯胍作为猪饲用生长促进剂的应用
CN104543453A (zh) * 2014-12-11 2015-04-29 河北农业大学 一种抗兔断乳应激的预混料

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941825A (en) * 1973-07-27 1976-03-02 American Cyanamid Company Substituted aminobenzylideneamino guanidine compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103250882A (zh) * 2013-06-07 2013-08-21 济源市阳光兔业科技有限公司 生长肉兔配合饲料
CN104082621A (zh) * 2014-06-18 2014-10-08 广州英赛特生物技术有限公司 氯苯胍作为肉鸭饲用生长促进剂的应用
CN104082534A (zh) * 2014-06-18 2014-10-08 广州英赛特生物技术有限公司 氯苯胍作为猪饲用生长促进剂的应用
CN104543453A (zh) * 2014-12-11 2015-04-29 河北农业大学 一种抗兔断乳应激的预混料

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