WO2016182139A3 - 자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물 - Google Patents

자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물 Download PDF

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Publication number
WO2016182139A3
WO2016182139A3 PCT/KR2015/010333 KR2015010333W WO2016182139A3 WO 2016182139 A3 WO2016182139 A3 WO 2016182139A3 KR 2015010333 W KR2015010333 W KR 2015010333W WO 2016182139 A3 WO2016182139 A3 WO 2016182139A3
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Prior art keywords
peripheral neuropathy
alleviating
radix extract
preventing
composition
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Ceased
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PCT/KR2015/010333
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English (en)
French (fr)
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WO2016182139A2 (ko
Inventor
김노수
박종식
이진무
이유진
조은상
김진희
임채준
방옥선
김영아
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Korea Institute of Oriental Medicine KIOM
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Korea Institute of Oriental Medicine KIOM
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Priority to CN201580079986.9A priority Critical patent/CN108348563A/zh
Priority to EP15891955.5A priority patent/EP3295946B1/en
Priority to US15/572,062 priority patent/US10517913B2/en
Publication of WO2016182139A2 publication Critical patent/WO2016182139A2/ko
Publication of WO2016182139A3 publication Critical patent/WO2016182139A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 자근(Lithospermi Radix) 추출물을 유효성분으로 함유하는 말초신경병증(peripheral neuropathy), 특히 항암제로 유발된 말초신경병증(chemotherapy-induced peripheral neuropathy, CIPN) 예방, 개선 또는 치료용 조성물에 관한 것으로, 구체적으로 본 발명의 자근 추출물은 정상세포에 독성을 유발하지 않고, 인간 암세포주에서 항암제의 고유한 세포독성 효력에 영향을 주지 않으면서 동시에, 항암제에 의한 신경돌기 성장 억제를 완화하며, 항암제로 유발된 말초신경병증 동물모델에서 증가된 통증 자극에 대한 민감도를 효과적으로 감소시키는 것을 확인함으로써, 상기 자근 추출물은 항암제로 유발된 말초신경병증 예방, 개선 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.
PCT/KR2015/010333 2015-05-12 2015-09-30 자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물 Ceased WO2016182139A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201580079986.9A CN108348563A (zh) 2015-05-12 2015-09-30 含有紫草根提取物作为有效成分的用于预防、改善或治疗周围神经病变的组合物
EP15891955.5A EP3295946B1 (en) 2015-05-12 2015-09-30 Composition, containing lithospermi radix extract as active ingredient, for preventing, alleviating, or treating peripheral neuropathy
US15/572,062 US10517913B2 (en) 2015-05-12 2015-09-30 Composition for prevention, alleviation, or treatment of peripheral neuropathy comprising Lithospermi Radix extract as an effective component

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150065825 2015-05-12
KR10-2015-0065825 2015-05-12

Publications (2)

Publication Number Publication Date
WO2016182139A2 WO2016182139A2 (ko) 2016-11-17
WO2016182139A3 true WO2016182139A3 (ko) 2017-05-18

Family

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Family Applications (1)

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PCT/KR2015/010333 Ceased WO2016182139A2 (ko) 2015-05-12 2015-09-30 자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물

Country Status (5)

Country Link
US (1) US10517913B2 (ko)
EP (1) EP3295946B1 (ko)
KR (1) KR101708165B1 (ko)
CN (1) CN108348563A (ko)
WO (1) WO2016182139A2 (ko)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
KR101732483B1 (ko) 2016-07-06 2017-05-24 한국 한의학 연구원 연교 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물
KR20200144576A (ko) * 2018-05-17 2020-12-29 주식회사 헬릭스미스 화학요법-유발 말초신경병증과 관련된 신경병증성 통증의 치료
CN111973729A (zh) * 2019-05-23 2020-11-24 上海长征医院 独一味制剂在制备硼替佐米增效剂中的应用
CN114470189B (zh) * 2020-11-12 2024-01-16 达石药业(广东)有限公司 Ngf抗体在cipn性疼痛中的应用
CN112807300A (zh) * 2021-01-27 2021-05-18 西安交通大学 丹酚酸A、丹酚酸B和丹酚酸C联合抗2019-nCov病毒的制药应用及药物
KR20240132783A (ko) 2023-02-27 2024-09-04 서울대학교산학협력단 장내 유익균을 포함하는 신경병증성 통증 예방 또는 치료용 조성물
KR20250177653A (ko) 2024-06-17 2025-12-24 부산대학교병원 Glp-1 수용체 작용제를 유효성분으로 포함하는 항암제 유발 신경독성 및 말초신경병증 예방 또는 치료용 조성물

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KR20060064068A (ko) * 2004-12-07 2006-06-13 경희대학교 산학협력단 신경세포 보호활성을 갖는 아세틸시코닌을 포함하는퇴행성 뇌질환 예방 및 치료용 약학 조성물

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Also Published As

Publication number Publication date
US20180303889A1 (en) 2018-10-25
KR101708165B1 (ko) 2017-02-21
CN108348563A (zh) 2018-07-31
US10517913B2 (en) 2019-12-31
EP3295946A2 (en) 2018-03-21
WO2016182139A2 (ko) 2016-11-17
KR20160133347A (ko) 2016-11-22
EP3295946B1 (en) 2020-08-19
EP3295946A4 (en) 2018-12-26

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