WO2016185931A1 - Dispositif de mesure d'informations biologiques - Google Patents

Dispositif de mesure d'informations biologiques Download PDF

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Publication number
WO2016185931A1
WO2016185931A1 PCT/JP2016/063755 JP2016063755W WO2016185931A1 WO 2016185931 A1 WO2016185931 A1 WO 2016185931A1 JP 2016063755 W JP2016063755 W JP 2016063755W WO 2016185931 A1 WO2016185931 A1 WO 2016185931A1
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WIPO (PCT)
Prior art keywords
blood pressure
pulse wave
living body
information
biological information
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Ceased
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PCT/JP2016/063755
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English (en)
Japanese (ja)
Inventor
北川　毅
新吾 山下
小椋　敏彦
広幸 木下
祐之 若宮
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Omron Healthcare Co Ltd
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Omron Healthcare Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state

Definitions

  • the present invention relates to a biological information measuring device.
  • the blood pressure value of a living body usually has a relatively large daily change. For this reason, for a diagnosis or the like, a blood pressure meter is attached to the measurement subject, and blood pressure values are measured and recorded regularly (for example, at intervals of several hours). In this case, in order to clarify the cause of the change in blood pressure value accurately and easily, the measurement of information related to the cause of the change in blood pressure value is performed together with the measurement of the blood pressure value and recorded ( (See Patent Documents 1 and 2).
  • Patent Document 2 information on an acceleration sensor attached to a living body and a blood pressure value are recorded in association with each other, and the correlation between the amount of exercise and a change in physiological function can be grasped in detail from the recorded information.
  • An apparatus that can be used for the above is described.
  • Patent Document 1 describes a device that continuously records blood pressure values, exercise intensity, and temperature, and supports the elucidation of the cause of changes in blood pressure values from the recorded information.
  • a pressure sensor is brought into direct contact with a biological site through which an artery such as the radial artery of the wrist passes.
  • a biological information measuring device capable of continuously measuring biological information such as a pulse or blood pressure value (every beat) using information on a pressure pulse wave detected by this sensor in a state (patent) Reference 3-6).
  • Patent Documents 1 and 2 are assumed to measure blood pressure values at long time intervals such as minutes, tens of minutes, or hours.
  • a doctor or the like cannot know the blood pressure change.
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a biological information measuring device that can support accurate grasp of the cause of changes in biological information.
  • the biological information measuring device of the present invention includes a pulse wave detection unit that detects a pulse wave from a living body for each beat, a biological information measurement unit that measures biological information based on the pulse wave detected by the pulse wave detection unit, A living body information different from the living body information measured by the living body information measuring unit, environmental information of a place where the living body exists, and an information measuring unit that measures at least one of the living body activity information; Biological information generated by the biological information measuring unit based on the pulse wave for each beat or every plurality of beats detected by the pulse wave detecting unit, and information measured by the information measuring unit at the detection timing of the pulse wave And a recording control unit that records them in association with each other.
  • FIG. 1 It is a figure showing the schematic structure of blood pressure measuring device 1 as a living body information measuring device for explaining one embodiment of the present invention. It is a figure which shows an example of the pressure pulse wave detected by the pulse wave detection part of FIG. 1, and the air temperature detected by the temperature sensor. It is a figure for demonstrating the matching process of the blood pressure value and temperature information by the recording control part 13 of FIG. It is a figure for demonstrating the analysis process by the server which acquired data from the blood-pressure measuring apparatus 1 of FIG. It is a figure for demonstrating the modification of the matching process of the blood pressure value and temperature information by the recording control part 13 of FIG. It is a figure which shows an example of the format of the data recorded on the recording medium 14 by the recording control part 13 of FIG.
  • FIG. 1 is a diagram showing a schematic configuration of a blood pressure measuring device 1 as a biological information measuring device for explaining an embodiment of the present invention.
  • This blood pressure measurement device 1 is a portable type, and is always used by being worn on a part of the body of a measurement subject (for example, a wrist) as a living body.
  • the blood pressure measurement device 1 includes a pulse wave detection unit 10, a blood pressure measurement unit 11, a temperature sensor 12, a recording control unit 13, a recording medium 14, a communication unit 15, and a transmission control unit 16.
  • the blood pressure measurement unit 11, the recording control unit 13, and the transmission control unit 16 are functional blocks that are expressed when the processor executes a program.
  • the pulse wave detection unit 10 detects a pulse wave non-invasively from a living body.
  • the pulse wave detection unit 10 for example, a unit that detects a pressure pulse wave as a pulse wave by a tonometry method is used.
  • the pulse wave detection unit 10 may detect a volume pulse wave as a pulse wave.
  • the pulse wave detection unit 10 may detect a pulse wave by reflected light from an artery obtained by applying light to the artery. In the following description, it is assumed that the pulse wave detector 10 detects a pressure pulse wave by the tonometry method.
  • the pulse wave detection unit 10 detects the pressure pulse wave for each beat, and transmits the detected pressure pulse wave to the blood pressure measurement unit 11. From the pulse wave detection unit 10, a continuous pressure pulse wave as illustrated in FIG. 2 is transmitted to the blood pressure measurement unit 11.
  • the blood pressure measurement unit 11 measures the blood pressure value for each beat of the living body based on the pressure pulse wave for each beat detected by the pulse wave detection unit 10. As a method for measuring the blood pressure value, a known method described in Patent Documents 3 to 6 can be used.
  • the blood pressure measurement unit 11 associates the rise time information (pressure pulse wave detection time information) of the pressure pulse wave indicating the detection timing of an arbitrary pressure pulse wave with the blood pressure value measured based on the pressure pulse wave. , To the recording control unit 13.
  • the temperature sensor 12 detects and holds the temperature (air temperature) of the place where the living body exists at a predetermined sampling period, and holds the held temperature information and time information (temperature holding time information) holding the temperature information. This is transmitted to the recording control unit 13.
  • the recording control unit 13 temporarily stores in the internal memory a set of pressure pulse wave detection time information and blood pressure value transmitted from the blood pressure measurement unit 11 and a set of temperature holding time information and temperature information transmitted from the temperature sensor 12. To do.
  • the recording control unit 13 reads out the temperature information corresponding to the time closest to each pressure pulse wave detection time information stored in the internal memory among the temperature information stored in the internal memory, and reads the read temperature information and the pressure pulses.
  • the blood pressure value corresponding to the wave detection time information is associated and recorded on the recording medium 14.
  • FIG. 3 is a diagram for explaining a process of associating a blood pressure value and temperature information by the recording control unit 13.
  • blood pressure values (white blocks in the figure) and temperature information (shaded blocks in the figure) are stored in association with the time.
  • the recording control unit 13 specifies temperature information corresponding to the time closest to the time corresponding to each blood pressure value, and records each blood pressure value and the specified temperature information in the recording medium 14 in association with each other.
  • the blood pressure value and temperature information connected by the broken-line arrows are recorded in association with each other.
  • the time corresponding to each of the blood pressure value and the temperature information connected by the broken-line arrow completely matches, but the two times may not match, so the recording control unit 13
  • the temperature information corresponding to the time closest to the time corresponding to is specified. If there are two times closest to the time corresponding to the blood pressure value, one of the two times may be selected.
  • the time corresponding to the blood pressure value is the rise time of the pressure pulse wave used for measuring the blood pressure value.
  • the relationship between the pressure pulse wave and the temperature information (air temperature) is as shown in FIG.
  • the temperature information air temperature
  • the blood pressure value increases as the blood pressure value increases. That is, by looking at the transition of the blood pressure value and the temperature information recorded in the recording medium 14, it becomes possible for a doctor or the like to grasp that the cause of the change in the blood pressure value is due to the temperature.
  • the communication unit 15 is an interface for communicating with an external device by wire or wireless.
  • the transmission control unit 16 transmits the data recorded on the recording medium 14 to the external device via the communication unit 15.
  • the external device here is, for example, a server connected to a network.
  • This server is managed by a hospital, for example.
  • the blood pressure value and temperature information data are received from the blood pressure measurement device 1, the received data is analyzed, and the analysis result is displayed on the display unit.
  • the pulse wave detector 10 starts detecting the pressure pulse wave, and the temperature sensor 12 starts detecting the temperature. Is done.
  • the blood pressure measurement unit 11 measures the blood pressure value, and the blood pressure value and the time information of the detection timing of the pressure pulse wave used to measure the blood pressure value are stored in the recording control unit 13. Recorded in internal memory.
  • the temperature information is detected, the detected temperature information and time information indicating the detection time are recorded in the internal memory of the recording control unit 13.
  • the recording control unit 13 specifies blood pressure values and temperature information corresponding to substantially the same time information as described with reference to FIG. A process of associating the value with the temperature information and recording it on the recording medium 14 is performed.
  • the person to be measured uses the blood pressure measurement device 1 for a certain period (for example, one day), then goes to the hospital, operates an operation button (not shown), and stores the blood pressure value and temperature information recorded in the recording medium 14 at the hospital management terminal. (Server) to send.
  • the management terminal calculates a difference between adjacent blood pressure values for blood pressure values arranged in time series.
  • FIG. 4 is a diagram for explaining an example of analysis processing by the management terminal.
  • blood pressure values acquired from the blood pressure measurement device 1 are shown in time series.
  • the white rectangle shown in FIG. 4 indicates the blood pressure value, and the longer the rectangle is, the larger the blood pressure value is.
  • the middle part of FIG. 4 shows the difference between the adjacent blood pressure values in the upper part.
  • the difference value between the blood pressure value corresponding to an arbitrary time and the blood pressure value corresponding to the next time of this time is recorded as a difference value corresponding to this arbitrary time.
  • temperature information acquired from the blood pressure measurement device 1 is shown in time series.
  • a rectangle with hatched hatching shown in FIG. 4 indicates temperature information, and the longer the length of the rectangle, the larger the temperature information.
  • the management terminal After obtaining the difference value shown in the middle part of FIG. 4, the management terminal identifies a period (a period indicated by a bidirectional arrow in the figure, a period in which the blood pressure change is large) corresponding to the difference value equal to or greater than the threshold value. The difference between the temperature information corresponding to the beginning and the temperature information corresponding to the end of this period is calculated.
  • the management terminal causes the display unit to display information indicating that the blood pressure value tends to change greatly due to a change in temperature as an analysis result. Based on the analysis result, the doctor can grasp the blood pressure change tendency of the measurement subject and can make use of the treatment policy.
  • the blood pressure value measured for each beat and the temperature information detected at the timing when the blood pressure value is measured are associated with each other and recorded on the recording medium 14. . For this reason, by using the data recorded on the recording medium 14, it is possible to support accurate grasp of the cause of the change in blood pressure value.
  • the blood pressure measurement device 1 only the temperature information measured at the detection timing of the pressure pulse wave is recorded on the recording medium 14. For this reason, compared with the case where all the temperature information sampled and hold
  • the blood pressure measurement device 1 regularly transfers data recorded on the recording medium 14 to the server
  • the amount of data transmitted from the blood pressure measurement device 1 to the server can be reduced. For this reason, power consumption for data transmission can be reduced.
  • data can be acquired in a state where the blood pressure value and the temperature information are associated with each other. For this reason, it is not necessary to extract temperature information corresponding to the detection timing of the pressure pulse wave used for measuring the blood pressure value from a large number of temperature information, and the server load can be reduced.
  • the server receives data from a large number of blood pressure measurement devices 1 and performs analysis, it is preferable that the processing load on the server is small.
  • the server only needs to perform the simple processing described with reference to FIG. 4, thereby reducing the processing load. Therefore, it is not necessary to prepare a server with high processing capacity, and the cost for system construction can be reduced.
  • the recording control unit 13 records the temperature information in association with the blood pressure value for each beat measured by the blood pressure measurement unit 11.
  • the recording control unit 13 may record the temperature information in association with the blood pressure value for each of a plurality of beats measured by the blood pressure measurement unit 11.
  • the blood pressure value is recorded in the internal memory as a value measured for each beat, but the recording control unit 13 selects 2 of the blood pressure values recorded in the internal memory. Only the blood pressure value measured for each beat (the first, third, fifth, and seventh blood pressure values from the left in FIG. 5) is the most suitable for the detection timing of the pressure pulse wave used to measure this blood pressure value. The temperature information detected at a close time is associated and recorded on the recording medium 14.
  • the measured blood pressure value is thinned out and recorded, but if the number of blood pressure values to be thinned is too large, it becomes difficult to grasp the cause of blood pressure change of the measurement subject. For this reason, in this modification, it is preferable that one blood pressure value is recorded on the recording medium 14 every 2 to 10 beats.
  • temperature information is taken as an example of information recorded on the recording medium 14 in association with the blood pressure value.
  • the humidity information of the environment where the blood pressure measurement device 1 is placed may be recorded on the recording medium 14.
  • the temperature information and the humidity information constitute environmental information of the place where the measurement subject exists.
  • the blood pressure measurement unit 11 measures the blood oxygen saturation of the subject, the state of the subject's autonomic nerve, the stress level of the subject, and the body temperature of the subject. It is good also as a structure which records the to-be-measured person's biometric information different from the biometric information to the recording medium 14. According to this configuration, for example, when the blood pressure value fluctuates greatly, it is possible to grasp how the biological information of the measurement subject has changed, which can be used for diagnosis.
  • the exercise intensity of the subject information about whether the subject is eating, information indicating that the subject has started eating, that the subject has finished eating It is good also as a structure which records on the recording medium 14 information to measure, such as the information to show, the depth of sleep of a to-be-measured person, the elapsed time from sleep of to-be-measured person, and the posture of a to-be-measured person.
  • information to measure such as the information to show, the depth of sleep of a to-be-measured person, the elapsed time from sleep of to-be-measured person, and the posture of a to-be-measured person.
  • the state of the subject's autonomic nerve (information such as which sympathetic nerve or parasympathetic nerve is dominant) and the stress level can be determined according to the measured heart rate by measuring the heart rate of the subject.
  • the exercise intensity of the measurement subject can be obtained by measuring the oxygen intake of the measurement subject and calculating the ratio of the measured oxygen intake and the maximum oxygen intake of the measurement subject. It is also possible to measure the heart rate of the person to be measured and obtain it by the ratio of the measured heart rate and the maximum heart rate of the person to be measured. Further, an acceleration sensor can be mounted on the blood pressure measurement device 1, and it can be obtained by a known method based on information on the movement of the measurement subject detected by the acceleration sensor.
  • Information on whether or not the measured person is eating indicates that the measured person is eating during the period from the start of the meal to the end of the meal, for example, by performing a button operation when the measured person starts and ends the meal.
  • Information can be generated and recorded.
  • the meal has ended.
  • information indicating that a meal is in progress may be recorded.
  • the information indicating that the measurement subject has started the meal and the information indicating that the meal has been completed can be acquired by the above button operation, respectively. Or it can also acquire by receiving the signal which shows that the meal started, and the signal which shows that the meal was complete
  • the information on the depth of sleep of the measurement subject or the elapsed time since falling asleep can be obtained by a technique used for a well-known sleep meter.
  • the information on the posture of the person to be measured is information indicating whether the posture is the sitting position, the standing position, or the lying position, and can be obtained by a known method by combining an acceleration sensor or an atmospheric pressure sensor.
  • Blood pressure values can change significantly when the subject moves from a warm place to a cold place, or when the subject is performing a heavy exercise (for example, muscle training, running, climbing stairs)
  • a heavy exercise for example, muscle training, running, climbing stairs
  • the temperature information is information related to the cause of the change in blood pressure value.
  • the exercise intensity is information related to the cause of the change in blood pressure value.
  • the body temperature can be said to be information related to the cause of the change in blood pressure value.
  • the blood oxygen saturation is information related to the cause of the change in blood pressure value.
  • the blood pressure measurement device 1 is different from those measured by the blood pressure measurement unit 11 serving as a biological information measurement unit, the biological information of the measured person, the environmental information of the place where the measured person exists, and the activity information of the measured person. What is necessary is just to have the information measurement part which measures at least one.
  • a humidity sensor in addition to the temperature sensor 12 shown in FIG. 1, a humidity sensor, a sensor that measures blood oxygen saturation, a measuring unit that measures an autonomic nerve state or a stress level using a heart rate sensor, and a body temperature are measured.
  • a sensor a measurement unit that measures exercise intensity, a sleep meter, and a body posture measurement unit that measures body posture using an acceleration sensor.
  • the recording control unit 13 correlates the blood pressure value with the biological information after correcting the shift uniformly for the time information corresponding to the biological information stored in the internal memory.
  • the blood pressure measurement unit 11 is taken as an example of the biological information measurement unit, but the biological information measured by the biological information measurement unit is not limited to the blood pressure value.
  • the blood pressure measurement unit 11 of the blood pressure measurement device 1 may measure, for example, a pulse instead of a blood pressure value as biological information.
  • FIG. 6 is a diagram illustrating an example of a format of data recorded on the recording medium 14 by the recording control unit 13.
  • blood pressure value maximum blood pressure SYS, minimum blood pressure DIA
  • temperature humidity
  • stress state (1 with stress, 0 without stress)
  • meal It is data in which information indicating whether or not it is inside (0 during non-meal, 1 during meal) and body position are recorded in association with each measurement time.
  • information indicating whether or not a meal has started (1 for meal start, 0 except for the meal start timing) or information indicating whether or not the meal has ended (1 for meal end, meal) Other than the end timing, 0) may be used.
  • the disclosed biological information measuring device includes a pulse wave detection unit that detects a pulse wave from a living body for each beat, a biological information measurement unit that measures biological information based on the pulse wave detected by the pulse wave detection unit, A living body information different from the living body information measured by the living body information measuring unit, environmental information of a place where the living body exists, and an information measuring unit that measures at least one of the living body activity information; Biological information generated by the biological information measuring unit based on the pulse wave for each beat or every plurality of beats detected by the pulse wave detecting unit, and information measured by the information measuring unit at the detection timing of the pulse wave And a recording control unit that records them in association with each other.
  • the biological information measured by the information measuring unit includes the state of the autonomic nerve of the living body, the stress level of the living body, the blood oxygen saturation level of the living body, and the body temperature of the living body. Including at least one of the following.
  • the environmental information includes at least one of temperature and humidity of a place where the living body exists.
  • the activity information includes exercise intensity of the living body, information on whether the living body is eating, information indicating whether the living body has started eating, or the living body is eating It includes at least one of information indicating whether or not it has been completed, the depth of sleep of the living body, the elapsed time from falling asleep of the living body, and the body position of the living body.
  • the pulse wave detection unit detects a pressure pulse wave from the living body, and the biological information measurement unit measures a blood pressure value based on the pressure pulse wave.
  • the present invention is particularly convenient and effective when applied to a portable blood pressure monitor.

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Abstract

L'invention concerne un dispositif de mesure d'informations biologiques pouvant faciliter la détermination précise de la cause d'un changement dans des informations biologiques. Un dispositif de mesure de pression artérielle 1 est pourvu de : une unité de détection d'onde sphygmique 10 pour détecter, pour chaque battement, une onde sphygmique d'un corps vivant ; une unité de mesure de pression artérielle 11 pour mesurer une valeur de pression artérielle en tant qu'information biologique sur la base de l'onde sphygmique détectée par l'unité de détection d'onde sphygmique 10 ; un capteur de température 12 pour mesurer une température de l'air, qui est une information liée à la cause d'un changement de la valeur de pression artérielle ; et une unité de commande d'enregistrement 13 pour corréler la valeur de pression artérielle générée par l'unité de mesure de pression artérielle 11 et les informations de température mesurées par le capteur de température 12 au temps de détection de l'onde sphygmique sur la base de l'onde sphygmique pour chaque battement détecté par l'unité de détection d'onde sphygmique 10, et l'enregistrement de la valeur de pression artérielle et les informations de température dans un support d'enregistrement 14.
PCT/JP2016/063755 2015-05-20 2016-05-09 Dispositif de mesure d'informations biologiques Ceased WO2016185931A1 (fr)

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JP2015102997A JP2016214563A (ja) 2015-05-20 2015-05-20 生体情報測定装置
JP2015-102997 2015-05-20

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Cited By (2)

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WO2019131243A1 (fr) * 2017-12-27 2019-07-04 オムロンヘルスケア株式会社 Dispositif, procédé et programme de traitement d'informations
WO2020195592A1 (fr) * 2019-03-25 2020-10-01 オムロンヘルスケア株式会社 Dispositif de facilitation de mesure, procédé, et programme

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JP6765998B2 (ja) * 2017-03-14 2020-10-07 オムロン株式会社 情報処理装置および情報処理プログラム
JP6851866B2 (ja) * 2017-03-14 2021-03-31 オムロン株式会社 情報処理装置および情報処理プログラム
JP7225893B2 (ja) * 2019-02-18 2023-02-21 オムロンヘルスケア株式会社 血圧値解析支援装置、血圧値解析支援システム、血圧値解析支援方法、およびプログラム

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JP2006102253A (ja) * 2004-10-06 2006-04-20 Terumo Corp 血圧測定装置及び血圧測定方法、並びに制御プログラム及びコンピュータ読取可能な記憶媒体
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JP2019115612A (ja) * 2017-12-27 2019-07-18 オムロンヘルスケア株式会社 情報処理装置、情報処理方法、及び情報処理プログラム
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CN113614838A (zh) * 2019-03-25 2021-11-05 欧姆龙健康医疗事业株式会社 测定促进装置、方法以及程序

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