WO2016195200A1 - Appareil d'injection de fluide pour stimulation de la peau - Google Patents

Appareil d'injection de fluide pour stimulation de la peau Download PDF

Info

Publication number
WO2016195200A1
WO2016195200A1 PCT/KR2016/000540 KR2016000540W WO2016195200A1 WO 2016195200 A1 WO2016195200 A1 WO 2016195200A1 KR 2016000540 W KR2016000540 W KR 2016000540W WO 2016195200 A1 WO2016195200 A1 WO 2016195200A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
opening
skin
microneedle
hollow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2016/000540
Other languages
English (en)
Korean (ko)
Inventor
임동호
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hail Co Ltd
Original Assignee
Hail Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hail Co Ltd filed Critical Hail Co Ltd
Publication of WO2016195200A1 publication Critical patent/WO2016195200A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a fluid stimulating device for skin irritation, and more particularly, to a fluid stimulating device for skin stimulation to more easily inject an immunoactive drug such as a therapeutic agent or a vaccine or a skin elastic drug for skin beauty into the body through the percutaneous body. It is about.
  • oral administration or injection method is used to inject into the body immune active drugs such as therapeutic agents or vaccines or skin elasticity drugs for skin beauty.
  • many drugs are not absorbed or modified directly into the bloodstream by the action of digestive enzymes in the digestive tract, so that they do not exert their full efficacy, and the injection method is that many drugs are injected into the bloodstream through the skin or vein. Because it is added immediately, it may be introduced into the bloodstream without being modified by digestive enzymes, etc., but when injected, the needle penetrates into the dermal layer of the skin and may cause pain and pathogen infection.
  • Transdermal administration method is a microneedle device administration method, in which the microneedles function to penetrate the epidermal layer including the stratum corneum of the skin without causing pain when administering the drug. Accordingly, the microneedle device may obtain an advantage of increasing the rate at which the drug is delivered to the dermal layer of the skin by penetrating the epidermal layer through a plurality of microneedles during drug administration.
  • microneedle device examples include Republic of Korea Patent Registration 10-1032298 (Registration Date: April 25, 2011), Republic of Korea Patent Registration 10-1017392 (Registration Date: February 17, 2011), Republic of Korea Patent No. 10-0972800 (registration date: July 22, 2010) has been proposed.
  • the microneedle device includes a fluid storage unit for storing various drugs, a plurality of micro needles arranged to protrude to the outside, and a plurality of micro needles for drugs stored in the fluid storage unit. It is provided with an opening and closing means for transmitting to the dermal layer of the skin when pressurized against the skin is configured to be delivered to the dermal layer of the skin along the microneedles to the drug stored in the fluid reservoir when the microneedles contact the skin
  • the drug stored in the fluid reservoir is configured to rapidly deliver the microneedle to the dermal layer of the skin.
  • microneedle device is relatively inconvenient to operate the opening and closing means for delivering the drug stored in the fluid reservoir to the plurality of microneedles or the complexity of the delivery means increases the manufacturing cost. can do.
  • Republic of Korea Patent No. 10-0972800 has a fluid selection means for selectively supplying the fluid stored in the fluid storage unit, because the user has to supply the fluid stored in the fluid storage unit by operating the fluid selection means directly. It can be inconvenient.
  • Korean Patent No. 10-1032298 has a blocking rod that is exposed to the front to open the fluid reservoir through the blocking rod when the microneedles contact the skin, through which the drug stored in the fluid reservoir is supplied to the microneedles By doing so, a user can easily supply the drug stored in the fluid storage unit to the microneedles without any manipulation, but a problem such as an increase in the manufacturing cost of the microneedle device may occur due to the complexity of the opening and closing structure using the blocking rod. have.
  • the drug stored in the fluid reservoir is administered to the dermal layer of the skin along the surface of the microneedles inserted into the skin, wherein the micro The surface of the needle is pressurized, which causes the drug delivered along the surface of the microneedles not only to the dermal layer of the skin due to the elasticity of the skin, but also the drug delivered to the dermal layer of the skin is countercurrent by the elasticity of the skin. Since the microneedle is discharged to the outside, the drug administration effect is inevitably insignificant.
  • the present invention has been proposed to solve the problems of the prior art, and the structure and operation is easy to use and easy to use, while lowering the manufacturing cost, while improving the drug dosage fluid injection device for skin irritation
  • the purpose is to provide.
  • the present invention according to one aspect for achieving the above object is a fluid reservoir containing a fluid containing a drug to be administered to the skin;
  • One side is provided with a plurality of coupling grooves are coupled to the head portion of the plurality of micro needles, the other side is provided with a first coupling groove portion is inserted into the upper portion of the fluid reservoir is inserted therein, from one side to the other side
  • a microneedle housing having a plurality of fluid passages therethrough for supplying the fluid stored in the fluid reservoir to the microneedles; It is coupled to cover one side of the microneedle housing, one side is formed with a plurality of fluid discharge holes through which the insertion portion of the microneedle is exposed to the outside, the other side is formed on one side of the microneedle housing
  • a second recess is formed to communicate with the fluid discharge holes so as to face the first recess communicating with the fluid passage, thereby forming a fluid chamber together with the first recess to temporarily receive the fluid flowing from the
  • An upper cap which is then delivered to the fluid discharge holes; A first hollow formed in the first recess of the microneedle housing and a second hollow formed in the center of the second recess of the upper cap in alignment with the first hollow, and having one end thereof outward of the upper cap.
  • An opening / closing rod which is retracted, and an opening / closing member which is coupled to the other end of the opening / closing rod and the other side is inserted into the fluid storage container to open and close the fluid passage by moving up and down in conjunction with the entrance / exit operation of the opening / closing rod, Skin irritation is provided in the interior of the first and second hollow to surround the outer surface includes a fluid transfer means including an elastic member for elastically supporting the opening and closing rods in the interior of the first and second hollow Provided is a fluid injection device.
  • the insertion portion of the microneedle may be characterized in that the fluid discharge groove of the thread shape or helical shape continuously connected to the outer peripheral surface is formed.
  • the insertion portion of the microneedles may be further formed with a hollow formed at a predetermined depth in the center of the end portion, and a communication hole connecting the hollow and the fluid discharge groove.
  • the opening and closing member is formed in a circular structure on one side corresponding to the inner peripheral surface of the first coupling groove, the outer diameter is smaller than the inner diameter of the first coupling groove so that the outer peripheral surface is not in close contact with the inner peripheral surface of the first coupling groove It may be characterized in that formed in size.
  • the second hollow is coupled to a fixing ring to surround the outer circumferential surface of the opening and closing rods to block the fluid from flowing into the second hollow along the surface of the opening and closing rods during the vertical movement of the opening and closing rods.
  • a fixing ring to surround the outer circumferential surface of the opening and closing rods to block the fluid from flowing into the second hollow along the surface of the opening and closing rods during the vertical movement of the opening and closing rods.
  • the fluid delivery means provides a fluid irritation device for skin irritation consisting of the opening and closing rod, the opening and closing member and the elastic member
  • the structure is relatively simple, the operation is easy and the manufacturing cost is lowered
  • the opening and closing member is coupled to open and close the fluid passage formed in the microneedle housing relatively smaller than the inlet of the fluid reservoir. The effect of relatively easy supply and interruption can be obtained.
  • the fluid discharge groove is formed in the outer peripheral surface of the microneedle insert portion inwardly, even when the surface is pressurized by the elasticity of the skin when the insertion portion is inserted through the skin step by step with the skin Due to the fact that the fluid delivered into the skin along the fluid discharge groove is delivered to the skin along the fluid discharge groove without being affected by the elasticity of the skin, it is possible to minimize the loss of fluid to improve drug dosage.
  • the fluid delivered along the fluid discharge groove by communicating the fluid discharge groove and the hollow through the communication hole at the end portion of the insert portion After being delivered to the hollow inside through the communication hole to be delivered into the skin through the hollow, thereby minimizing the effect of skin elasticity, thereby improving drug dosage.
  • FIG. 1 is an assembled perspective view showing a fluid injection device for skin irritation according to an embodiment of the present invention.
  • Figure 2 is a view showing a state in which the main body and the protective cap shown in FIG.
  • FIG. 3 is an exploded perspective view of the main body shown in FIG.
  • FIG. 4 is a cross-sectional view of the main body shown in FIG.
  • FIG. 5 is an enlarged view for explaining the microneedle shown in FIG. 3;
  • Figure 6 is an enlarged cross-sectional view of the insertion portion of the microneedle according to another embodiment of the present invention.
  • FIG. 7 is a cross-sectional view for explaining the operating characteristics of the fluid injection device for skin irritation according to an embodiment of the present invention.
  • FIG. 8 is a cross-sectional view showing a route through which fluid is administered to the skin.
  • the present invention provides a fluid reservoir containing a fluid containing a drug to be administered to the skin;
  • One side is provided with a plurality of coupling grooves are coupled to the head portion of the plurality of micro needles, the other side is provided with a first coupling groove portion is inserted into the upper portion of the fluid reservoir is inserted therein, from one side to the other side
  • a microneedle housing having a plurality of fluid passages therethrough for supplying the fluid stored in the fluid reservoir to the microneedles;
  • one side is formed with a plurality of fluid discharge holes through which the insertion portion of the microneedle is exposed to the outside, the other side is formed on one side of the microneedle housing
  • a second recess is formed to communicate with the fluid discharge holes so as to face the first recess communicating with the fluid passage, thereby forming a fluid chamber together with the first recess to temporarily receive the fluid flowing from the fluid passage.
  • An upper cap which is then delivered to the fluid discharge holes;
  • An opening / closing rod which is retracted, and an opening / closing member which is coupled to the other end of the opening / closing rod and the other side is inserted into the fluid storage container to open and close the fluid passage by moving up and down in conjunction with the opening / closing operation of the opening / closing rod,
  • a fluid delivery means including an elastic member installed inside the first and second hollows to surround the outer surface and including an elastic member elastically supporting the opening and closing rods inside the first and second hollows; Provide the device.
  • fluid refers to a liquid or gel-like substance that is easily deformed and has a flowing property and is not defined in the present invention, and in the present invention, an immune active drug such as a therapeutic agent or a vaccine or skin elasticity for skin beauty It may include all drugs that can be administered to the skin for the treatment and beauty of the skin, such as drugs.
  • FIG. 1 is an assembled perspective view showing a fluid injection device for skin irritation according to an embodiment of the present invention
  • Figure 2 is a view showing a state in which the body and the protective cap shown in Figure 1 is separated
  • Figure 3 is Figure 2 4 is an exploded perspective view of the main body shown in FIG. 4
  • FIG. 4 is a cross-sectional view of the main body shown in FIG. 2.
  • the skin irritation fluid injection device 1 includes a main body 10, and a protective cap 20 to cover and protect the upper portion of the main body (10). .
  • the body 10 includes a fluid reservoir 11, a microneedle housing 12, a plurality of microneedles 13, an upper cap 14, and a fluid delivery means 15, as shown in FIGS. 2 to 4.
  • the fluid reservoir 11 is made of a cylinder to receive and store the fluid, one side of the inlet is inserted into the first coupling groove 121 of the microneedle housing 12 is coupled do.
  • the fluid reservoir 11 may be configured to be divided into a multi-part structure independently of each other to simultaneously receive a variety of different drugs.
  • the microneedle housing 12 is provided with a plurality of coupling grooves 122 to which a plurality of microneedles 13 are coupled to one side portion (upper portion in the figure), and the other side portion (on the figure).
  • the lower side is provided with a first coupling groove 121 to which the upper portion of the fluid reservoir 11 is coupled, and inside the micro needle 13 through the fluid stored in the fluid reservoir 11 penetrated from one side to the other side
  • It is provided with a plurality of fluid passages (123) for transferring to.
  • one side is formed with a first recess 124 in communication with the fluid passage 123.
  • the fluid passage 123 is preferably formed in a rectangular or bar shape so that the fluid supplied from the fluid reservoir 11 is delivered to the first recess 124 in large quantities.
  • FIG. 5 is an enlarged view illustrating the microneedle illustrated in FIG. 3.
  • the microneedle 13 is inserted into the coupling groove 122 of the microneedle housing 12 to be coupled to the head portion 131 and the insertion portion inserted into the skin through the skin ( 132 and a connecting portion 133 connecting the head portion 131 and the insertion portion 132.
  • the head portion 131 couples the microneedle 13 to the microneedle housing 12 stably, while being larger than the inserting portion 132 and the connecting portion 133 to prevent the microneedle 13 from being easily broken. It is formed in diameter.
  • the head part 131 may be coupled to the coupling groove 122 of the microneedle housing 12 by bonding, bonding, pressing or screwing.
  • the insertion part 132 penetrates the skin and forms fine pores in the skin so that fluid may penetrate into the skin.
  • the insertion portion 132 is preferably formed in the outer diameter of the range of about 1 ⁇ m to 100 ⁇ m in order to minimize the pain when inserted into the skin, and is cut at an angle of approximately 25 to 45 degrees toward the end portion to form a sharp shape It is formed to have.
  • a threaded or helical fluid discharge groove 132-1 may be formed continuously connected from one end to the other end.
  • the insertion part 132 has a structure recessed inward on its outer circumference, so that the surface is pressurized by the elasticity of the skin when the insertion part 132 is inserted through the skin as the fluid discharge groove 132-1 is formed.
  • the fluid delivered into the skin along the fluid discharge groove 132-1 due to the step with the skin is delivered to the skin along the fluid discharge groove 132-1 without being affected by the elasticity of the skin. The loss can be minimized to improve drug dosage.
  • FIG. 6 is an enlarged cross-sectional view of an insertion part of a microneedle according to another example of the present invention.
  • the insertion portion 132 ′ of the microneedle includes a fluid discharge groove 132-1 ′ and a hollow 132-2 ′ formed at a predetermined depth in a central portion of one end thereof. ) And a communication hole 132-3 ′ communicating the hollow 132-2 ′ and the fluid discharge groove 132-1 ′.
  • the fluid transferred into the skin along the fluid discharge groove 132-1 due to the step with the skin is discharged without being affected by the elasticity of the skin.
  • the loss of the fluid may be minimized by allowing it to be transferred into the skin along the groove 132-1.
  • the insertion part 132 is formed with a relatively small outer diameter to minimize the pain, it is virtually impossible to form the fluid discharge groove 132-1 deep in the outer circumferential surface thereof. This may affect the fluid delivered along the fluid discharge groove 132-1 according to the degree of elasticity of the skin. In particular, since the elasticity of the skin increases toward the dermal layer as compared to the epidermal layer, the fluid discharge groove 132-1 alone is limited in preventing fluid loss.
  • the hollow 132-2 ' is formed at a predetermined depth in the center of the insertion portion 132', and the fluid discharge groove 132-1 'is connected through the communication hole 132-3'.
  • the fluid delivered along the fluid discharge groove 132-1 ′ by communicating the hollows 132-2 ′ with each other passes through the communication hole 132-3 ′ at the end portion of the insertion portion 132 ′. After being delivered to (132-2 '), it is delivered to the skin through the hollow (132-2') to minimize the effect of skin elasticity.
  • the upper cap 14 is coupled to cover one side of the microneedle housing 12 through the bolt (B).
  • One side of the upper cap 14 is formed with a plurality of fluid discharge holes 141 through which the insertion portion 132 of the microneedle 13 is exposed to the outside, the microneedle housing 12 on the other side
  • a second recess 142 is formed in communication with the fluid discharge holes 141 to face the first recess 124 of the first recess 124 to form a fluid chamber together with the first recess 124 to temporarily prevent the fluid introduced therein. It receives and delivers to the fluid discharge hole 141.
  • the fluid delivery means 15 is aligned with the first hollow 125 and the first hollow 125 formed in the center of the first recess 124 of the microneedle housing 12, as shown in FIGS. 3 and 4.
  • Opening and closing rods 151 coupled to penetrate through the second hollow 143 formed in the center of the second recessed portion 142 of the upper cap 14 and one end of the upper cap 14 to the outside of the upper cap 14, one side opening and closing Opening and closing member 152 coupled to the other end of the rod 151 and the other side is inserted into the interior of the fluid reservoir 11 to move up and down in conjunction with the opening and closing operation of the opening and closing rod 151 to open and close the fluid passage 123.
  • an inner side of the first and second hollows 125 and 143 to surround the outer surface of the opening and closing rod 151 to elastically support the opening and closing rod 151 in the first and second hollows 125 and 143. It includes an elastic member 153.
  • the fluid transfer unit 15 may further include a coupling member 154 for coupling the other side of the opening and closing rod 151 into the coupling groove 152-1 provided at the center of one side of the opening and closing member 152. have. At this time, the other side of the opening and closing rod 151 is inserted into the coupling through one side of the coupling member 154.
  • Coupling member 154 is made of a cylindrical shape, the outer peripheral surface is provided with a locking groove 154-1 may be engaged with the engaging projection provided inside the coupling groove 152-1 of the opening and closing member 152.
  • the opening and closing member 152 has a circular structure on one side corresponding to the inner circumferential surface of the first coupling groove 121 as shown in FIG. 3, but the outer diameter of the opening and closing member 152 is not in close contact with the inner circumferential surface of the first coupling groove 121. It is formed to a size smaller than the inner diameter of the coupling groove 121. Accordingly, when the opening and closing member 152 is interlocked with the opening and closing rod 151 to be separated from the fluid passage 123 and the fluid passage 123 is opened, the fluid stored in the fluid reservoir 11 is the first coupling groove 121. It is transmitted to the fluid passage 123 through a space between the inner circumferential surface and the outer peripheral surface of the opening and closing member 152.
  • a rubber pad having excellent adhesion is attached to one side of the opening and closing member 152 in contact with the fluid passage 123 in order to stably seal the fluid passage 123.
  • Skin irritation fluid injection device 1 is relatively simple structure, as the fluid delivery means 15 is made of the opening and closing rod 151, opening and closing member 152 and the elastic member 153,
  • the opening / closing member 152 does not open or close the inlet of the fluid reservoir 11 having a relatively large diameter, but the fluid passage 123 formed in the microneedle housing 12 that is relatively smaller than the inlet of the fluid reservoir 11.
  • the supply and shutoff of the fluid supplied from the fluid reservoir 11 may be advantageously relatively easy.
  • a fixing ring (not shown) may be further coupled to the second hollow 125 of the microneedle housing 12 to surround the outer circumferential surface of the opening and closing rod 151.
  • the fixing ring may be fixed to the outer circumferential surface of the opening and closing rod 151, the fluid is blocked along the surface of the opening and closing rod 151 during the up and down movement of the opening and closing rod 151 into the second hollow 125 It plays a role.
  • the fixing ring may be made of a silicon material having a constant elasticity and harmless to the human body.
  • Figure 7 is a cross-sectional view for explaining the operating characteristics of the skin irritation fluid injection device according to an embodiment of the present invention
  • Figure 8 is a cross-sectional view showing a route that the fluid is administered to the skin.
  • FIG. 7A in a state where the opening and closing member 152 of the fluid delivery means 15 is in close contact with the fluid passage 123 and the fluid passage 123 is closed, as shown in FIG. 7B.
  • the opening and closing member 152 moves downward in association with the opening and closing rod 151, as shown in FIG.
  • the fluid passage 123 is opened to lead to the fluid reservoir 11, the first coupling groove 121, the fluid passage 123, the first and second recesses 124 and 142, and the fluid discharge hole 141.
  • a fluid path is formed.
  • the fluid 2 stored in the fluid reservoir 11 passes through the first coupling groove 121, the fluid passage 123, the first and second recesses 124 and 142, and the fluid discharge hole 141. After being delivered to the microneedle 13 is administered into the skin 3 along the fluid discharge groove (132-1) of the insertion portion (132).
  • the present invention can be applied to the field of the fluid injection device for skin irritation to more easily put into the body through the percutaneous immune active drugs such as therapeutic agents or vaccines or skin elasticity drugs for skin care.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un appareil d'injection de fluide pour stimulation de la peau et, plus particulièrement, un appareil d'injection de fluide pour stimulation de la peau, capable d'injecter par voie transdermique, dans le corps, un médicament actif sur le plan immunologique, tel qu'un agent thérapeutique ou un vaccin, ou un médicament traitant l'élasticité de la peau pour les soins de la peau, plus facilement.
PCT/KR2016/000540 2015-05-30 2016-01-19 Appareil d'injection de fluide pour stimulation de la peau Ceased WO2016195200A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020150076832A KR101582822B1 (ko) 2015-05-30 2015-05-30 피부 자극용 유체 주입 장치
KR10-2015-0076832 2015-05-30

Publications (1)

Publication Number Publication Date
WO2016195200A1 true WO2016195200A1 (fr) 2016-12-08

Family

ID=55169051

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/000540 Ceased WO2016195200A1 (fr) 2015-05-30 2016-01-19 Appareil d'injection de fluide pour stimulation de la peau

Country Status (2)

Country Link
KR (1) KR101582822B1 (fr)
WO (1) WO2016195200A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107758105A (zh) * 2016-08-23 2018-03-06 韩基洙 配备针部件的化妆品容器
CN109078259A (zh) * 2017-06-13 2018-12-25 韩基洙 印章式流体注入装置
CN111939454A (zh) * 2019-05-16 2020-11-17 (株)我丽美业有限公司 一种用于诱导药物吸收的皮肤刺激仪

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101582822B1 (ko) * 2015-05-30 2016-01-07 주식회사 하일 피부 자극용 유체 주입 장치
KR101745584B1 (ko) * 2016-02-26 2017-06-09 이범하 마이크로 니들형 피부자극기
KR101711350B1 (ko) * 2016-07-25 2017-03-02 김미영 피부용 수동식 인젝터기
US11266344B2 (en) 2016-09-21 2022-03-08 Samsung Electronics Co., Ltd. Method for measuring skin condition and electronic device therefor
KR101929761B1 (ko) * 2017-01-03 2018-12-17 (주)엠큐어 약물주입홀이 형성된 니들모듈
KR101938187B1 (ko) * 2017-01-03 2019-01-14 (주)엠큐어 약물주입홀의 개폐가 가능한 니들모듈
KR102025980B1 (ko) 2017-03-16 2019-09-26 이영복 약물주입용 니들장치
KR102061000B1 (ko) 2017-08-31 2019-12-31 주식회사 제이엘유 피부용 약물 주입장치
KR102470744B1 (ko) * 2022-03-02 2022-11-28 주식회사 대종메디텍 피부흡수유도장치

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027384A1 (en) * 2003-06-04 2008-01-31 Wang Ping M Drilling microneedle device
KR100941770B1 (ko) * 2007-02-09 2010-02-11 호남석유화학 주식회사 마이크로 니들 롤러
KR20100112427A (ko) * 2009-04-09 2010-10-19 한국생명공학연구원 유체전달을 조절할 수 있는 마이크로 니들 유닛
KR20110045703A (ko) * 2009-10-27 2011-05-04 (주)유 바이오메드 다종 유체 주입용 마이크로 니들장치
JP2013517889A (ja) * 2010-01-29 2013-05-20 ユーバイオメッド インク． マイクロニードル及びマイクロニードル装置
KR101582822B1 (ko) * 2015-05-30 2016-01-07 주식회사 하일 피부 자극용 유체 주입 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101017392B1 (ko) 2010-05-11 2011-02-25 (주)유 바이오메드 마이크로 니들형 적외선 피부자극기
KR101080034B1 (ko) 2010-09-14 2011-11-07 (주)유 바이오메드 마이크로 니들
KR100972800B1 (ko) 2010-01-29 2010-07-29 (주)유 바이오메드 마이크로 니들 장치

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027384A1 (en) * 2003-06-04 2008-01-31 Wang Ping M Drilling microneedle device
KR100941770B1 (ko) * 2007-02-09 2010-02-11 호남석유화학 주식회사 마이크로 니들 롤러
KR20100112427A (ko) * 2009-04-09 2010-10-19 한국생명공학연구원 유체전달을 조절할 수 있는 마이크로 니들 유닛
KR20110045703A (ko) * 2009-10-27 2011-05-04 (주)유 바이오메드 다종 유체 주입용 마이크로 니들장치
JP2013517889A (ja) * 2010-01-29 2013-05-20 ユーバイオメッド インク． マイクロニードル及びマイクロニードル装置
KR101582822B1 (ko) * 2015-05-30 2016-01-07 주식회사 하일 피부 자극용 유체 주입 장치

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107758105A (zh) * 2016-08-23 2018-03-06 韩基洙 配备针部件的化妆品容器
CN107758105B (zh) * 2016-08-23 2019-06-21 韩基洙 配备针部件的化妆品容器
CN109078259A (zh) * 2017-06-13 2018-12-25 韩基洙 印章式流体注入装置
CN109078259B (zh) * 2017-06-13 2020-11-10 韩基洙 印章式流体注入装置
CN111939454A (zh) * 2019-05-16 2020-11-17 (株)我丽美业有限公司 一种用于诱导药物吸收的皮肤刺激仪

Also Published As

Publication number Publication date
KR101582822B1 (ko) 2016-01-07

Similar Documents

Publication Publication Date Title
WO2016195200A1 (fr) Appareil d'injection de fluide pour stimulation de la peau
WO2011016615A2 (fr) Système d'administration de médicament par micro-aiguille comprenant une capsule mobile contenant le médicament
US8197447B2 (en) Flexible IV site protector
ES2305031T3 (es) Inyector intradermico pre-rellenable.
ES2988621T3 (es) Dispositivo inclinado de inserción activado por deslizamiento para la perfusión intradérmica de fármacos
WO2015186940A1 (fr) Timbre à micro-aiguilles et procédé de production associé
WO2010117218A2 (fr) Unité à micro-aiguille permettant de commander une distribution de liquide
ES2689531T3 (es) Aparato de suministro de medicamento
ES3012786T3 (en) Needle hub assembly for a syringe and a syringe comprising such needle hub assembly
WO2010082707A1 (fr) Ensemble tube pour régler la longueur d'aiguille d'une seringue
WO2008139303A2 (fr) Nouveau dispositif d'injection intradermique
WO2022225208A1 (fr) Micro-aiguille de type seringue
WO2015142013A1 (fr) Dispositif d'injection de fluides médicinaux
CN109966636B (zh) 一种给药导入装置
KR101897958B1 (ko) 피부 자극을 위한 미용기
KR101641432B1 (ko) 무통 주사기
WO2013141446A1 (fr) Système d'administration de médicaments utilisant un implant
KR102501996B1 (ko) 뇌실포트 조립체
CN102247642A (zh) 一种携带式鼻腔持续给药装置
KR101596419B1 (ko) 약물분배체가 구비된 피부시술용 멀티 니들장치
WO2017022924A1 (fr) Support de cathéter
JPS58218967A (ja) 管内投薬器
WO2017176069A2 (fr) Micro-aiguille utilisant un métal bioabsorbable
KR101733012B1 (ko) 마이크로 니들기구
CN111632230A (zh) 一种乳房给药装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16803555

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16803555

Country of ref document: EP

Kind code of ref document: A1