WO2017001676A1 - Système de pipetage muni d'un dispositif de traitement d'images - Google Patents

Système de pipetage muni d'un dispositif de traitement d'images Download PDF

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Publication number
WO2017001676A1
WO2017001676A1 PCT/EP2016/065557 EP2016065557W WO2017001676A1 WO 2017001676 A1 WO2017001676 A1 WO 2017001676A1 EP 2016065557 W EP2016065557 W EP 2016065557W WO 2017001676 A1 WO2017001676 A1 WO 2017001676A1
Authority
WO
WIPO (PCT)
Prior art keywords
pipetting
tips
camera
tip
optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2016/065557
Other languages
German (de)
English (en)
Inventor
Ingo Schwaiger
Meinrad Hofstetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Bonaduz AG
Original Assignee
Hamilton Bonaduz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamilton Bonaduz AG filed Critical Hamilton Bonaduz AG
Priority to CH01475/17A priority Critical patent/CH712782B1/de
Publication of WO2017001676A1 publication Critical patent/WO2017001676A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00545—Colours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • G01N2035/1013—Confirming presence of tip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device

Definitions

  • the present invention relates to a Pipettiervornchtung according to the preamble of claim 1.
  • the present invention relates, for example, to a pipetting device with
  • At least one pipetting channel movable relative to a frame of the pipetting device, preferably with a plurality of such pipetting channels, for aspiration and / or dispensing of a liquid
  • the at least one pipetting channel is designed for detachable coupling of a pipetting tip formed by the pipetting device and with a control device for Control the operation of the pipetting device, wherein the pipetting device
  • a camera which is designed to optically detect at least a portion of a working area of the pipetting device, and - has a processing device, which is designed for image processing of images captured by the camera.
  • the present invention also relates to a pipette tip carrier having a plurality of pipetting tips received therein for providing the above-mentioned pipetting device.
  • Pipetting devices with at least one controlled motor movable pipetting channel are well known. They are often referred to in specialist literature as "pipetting robots". Such pipetting devices are used in laboratories, inter alia, the chemical and pharmaceutical industries for the automated processing of highly accurately metered amounts of liquid, especially small amounts of liquid in the micro or milliliter range.
  • the pipetting devices aspirate a given amount of liquid in one place and transport it to another location where they dispense (release) the amount of liquid.
  • There are also pipetting devices are known which are equipped with a camera to optically detect, for example, the area below a pipetting head, so a remote along a Pipettierkanalachse of the at least one Pipettierkanals of a coupling formation of the at least one Pipettierkanals.
  • the pipetting tips which can be coupled to the pipetting device, more precisely to the at least one pipetting channel. While the pipetting device is substantially fixed in terms of apparatus, the pipetting tips, which are generally designed as disposable products, form a variable element of the pipetting device and thus a variable factor of the quality achievable by the pipetting device.
  • the object of the present invention is therefore to refine the above-mentioned pipetting device in such a way that it is improved with regard to its quality management.
  • a generic pipetting device with all features of claim 1.
  • This is, for example, a pipetting device, in which the camera is designed to optically detect at least a portion of a delivery location for a plurality of pipetting tips provided for coupling to the at least one pipetting channel, and wherein the processing device is adapted to receive an image of the camera at least to compare the portion of the place of provision with a predetermined reference image and / or a predetermined reference pattern.
  • the camera is capable of optically detecting at least a portion of the location at which pipetting tips are provided for coupling to the pipetting channels of the pipetting device.
  • the present invention offers the fundamental possibility that the pipetting tips provided for coupling optically at least in sections before being coupled to the pipetting device can be detected and this optical detection can be processed by the processing device at least for a rating.
  • the pipetting tips provided for coupling can be at least qualitatively detected and evaluated for quality-sensitive features.
  • a pipette tip carrier is provided at all, whether a pipetting tip carrier provided is completely filled with pipetting tips, if a pipetting tip carrier provided contains the correct pipetting tips for a pipetting task to be performed and even if the pipetting tips provided have undergone a possibly required quality check in a pipette tip carrier.
  • the delivery location is preferably a predetermined delivery location, which the at least one pipetting channel in accordance with preprogrammed control always moves to in order to couple an unused pipette tip.
  • this predetermined delivery location typically does not relate to a single pipetting tip alone, but to the pipette tip carrier in which a plurality of pipetting tips are provided and which are coupled sequentially from a single pipetting channel.
  • a plurality of pipetting tips may be simultaneously coupled to a plurality of pipetting channels of the multi-pipetting head.
  • the place of delivery may also be any ready-to-use location in the working area of the pipetting device, for example when the pipetting device with its processing device and optionally also with its control device is designed to recognize a pipetting tip carrier provided in its working area and after recognition thereof Coupling pipetting tips for the subsequent pipetting tasks.
  • the camera is preferably arranged such that at the point of supply - assuming a plurality of pipetting tips actually provided there - it is removed from the pipette tip A plurality of pipetting tips provided at least a portion detected.
  • the pipetting tips are usually provided oriented such that their coupling section, which interacts with the coupling formation of the at least one pipetting channel of the pipetting device for coupling the pipetting tip thereto, points to the at least one pipetting channel.
  • the coupling portion of a pipette tip unlike its pipetting opening, does not come into contact with a liquid to be dosed, the coupling portion is available as the pipetting aperture of a pipetting tip as an optically manipulatable area for image recognition.
  • the camera is particularly preferably arranged such that it detects at least the coupling section as the section of the pipetting tips.
  • the camera is arranged and designed such that it faces away from a pipetting opening in the direction of a pipetting tip axis Surface of the pipette tips recorded.
  • the pipetting device discussed herein comprises a plurality of pipetting tips provided at the delivery site in a pipette tip carrier for coupling to the at least one pipetting channel.
  • the pipetting tips received in the pipetting tip carrier have at least two optically different types of pipetting tips.
  • the at least one pipetting tip of one type may be of the at least one pipetting tip of another type, inter alia due to at least partially applied color or / and due to at least partially formed distinguish optically effective surface texture.
  • the optically effective surface texture can be enhanced by appropriate lighting in their effect and in their distinctness from another surface texture.
  • a development of the pipetting device of the present invention may therefore comprise illumination means, which are arranged and designed to illuminate the area detectable by the camera.
  • the processing device is therefore preferably designed to compare an image taken by the camera of the plurality of pipetting tips provided in the pipette tip carrier with the predetermined reference image and / or the predetermined reference pattern.
  • the pipette tip carrier preferably contains a plurality of pipetting tips of one kind and of the other type. Furthermore, it should not be ruled out that the pipette tip carrier has more than just two types of optically differing pipetting tips.
  • the pipetting tips of a pipette tip carrier are preferably functionally identical and differ only optically.
  • the use of at least two types of optically different pipetting tips can be used in a pipette tip carrier with fixed locations for placement of pipetting tips - these are usually arranged in rows and columns in an orthogonal pattern in the pipette tip carrier - for binary coding of information, for example one type of pipetting tips represents a "0" and the other type of pipetting tips represents a "1".
  • This type of information can be detected by the processing device if it is designed to determine by comparison whether or not an arrangement of optically distinguishable pipetting tips in the pipetting tip carrier relative to one another corresponds to a predetermined relative arrangement.
  • the processing device determines whether or not the pipetting tips provided for the pipetting task to be performed are actually the appropriate pipetting tips.
  • the maximum receiving volume of the pipetting tips can be coded so that the processing device recognizes or at least prepares for recognition can determine whether the pipetting tips provided have the required volume and are not too big or too small.
  • the arrangement of the pipetting tips in the pipetting tip carrier does not have to be a binary coding.
  • the optically different pipetting tips may be arranged in the pipette tip carrier in a predetermined pattern indicative of an origin of the pipetting tips from a particular manufacturer. For example, users of the pipetting device can be protected from using inferior pipetting tips of indeterminate origin.
  • the processing device is in communication with the control device. It may even be part of the control device, wherein it does not need to be physically realized by the same processor for this purpose.
  • the controller is preferably configured to perform an action, such as outputting a message, such as warning the user of the pipetting device prior to using false pipetting tips, depending on the comparison-based determination result.
  • the control device can send a message to a predetermined address, for example by e-mail, for example for warning or documentation purposes.
  • control device is designed to control the operation of the pipetting device as a function of the comparison-based determination result.
  • This includes, for example, the training to prevent coupling of at least one, preferably all, pipetting tips of the pipette tip carrier if the comparison-based determination result shows that there is no sufficient match of the actual relative arrangement of optically distinguishable pipetting tips with the predetermined relative arrangement.
  • the control device after determining that the wrong pipetting tips were provided, interrupt the further operation of the pipetting device until an operator has checked the operating situation and canceled the interruption by appropriate input action ,
  • the pipetting device of the present invention comprises a plurality of pipetting channels, which may be accommodated for common movement in a multiple pipetting head, or may be moved relative to each other singly or in groups.
  • the processing device is designed to detect whether a pipette tip carrier provided at the point of delivery has been exchanged for another pipette tip carrier. If unconsumed pipetting tips remain in the pipette tip carrier after a coupling process and are removed in a subsequent coupling process, the incomplete removal of pipetting tips from the pipette tip carrier changes the image detectable by the camera from the place of supply.
  • the above-mentioned comparison of the detected image with a predetermined reference image and / or a predetermined reference pattern may in fact only work with a pipette tip carrier that is completely or at least equipped with a predetermined minimum circumference. If a suitably populated pipette tip carrier has been found to be in order by the image acquisition and evaluation described, it is advantageous if this result is stored in a data memory and remains until replacement of the already examined pipette tip carrier by a new pipette tip carrier is detected optical detection of the delivery site by the camera or be it by appropriate manual input of an operator.
  • the camera may be coupled for common movement with the at least one pipetting channel.
  • it is preferably arranged such that it detects an area which is located in the direction of a pipetting channel axis of the at least one pipetting channel under the at least one pipetting channel.
  • the camera can also be fixed to the frame on a frame of the pipetting device be provided, to which the at least one pipetting channel is provided relatively movable.
  • the camera is preferably set in such a way that it can optically capture at least such a large part of the operating range of the pipetting device that a predetermined place of provision or a plurality of possible or expected delivery locations can always be optically detected by the camera.
  • the present invention also relates to a pipetting tip carrier having a plurality of pipetting tips accommodated therein in order to achieve the above-mentioned object.
  • the pipetting tips accommodated in the pipetting tip carrier have at least two optically different types of pipetting tips.
  • the physical design of the at least two types of pipetting tips to ensure their optical distinctness reference is made to the above statements.
  • each of the pipetting tips it is preferable for each of the pipetting tips to extend along a respective pipetting tip axis.
  • the existing optical differences can be seen particularly well from an elevated camera position, if the at least one pipetting tip of one type differs from the at least one pipetting tip of another type due to optically different surface areas which form an angle, preferably one, with the respective pipetting axis Angle of greater than 60 °, more preferably a right angle include.
  • the increased camera position relative to the pipette tip carrier is given when the camera is designed to move in common with the pipetting head.
  • the increased with respect to the Pipettierspitzen umans camera position is advantageous if the camera is to be able to detect such a large part of the working range of the pipetting that all possible delivery locations are detected by her.
  • the pipette tip carrier Since the pipette tip carrier is usually placed on an opaque worktop after its provision, it is advisable to detect the plurality of pipetting tips from a camera position which is raised relative to the pipette tip carrier.
  • the camera is therefore preferably located axially with respect to the pipetting axes of the pipetting tips over the plurality of pipetting tips.
  • the pipetting tips used are then optically distinguishable from one another particularly when the at least one pipetting tip of one type differs from the at least one pipetting tip of another type due to at least one section of its end face pointing in the axial direction, preferably away from a pipetting opening, preferably at the coupling-side longitudinal end. differ.
  • This end face is always sufficiently well illuminated or at least sufficiently illuminatable with appropriate illumination means, so that a favorable signal-to-noise ratio can be obtained for the detection and evaluation of the end faces of the pipetting tips.
  • FIG. 1 shows an exemplary embodiment according to the invention of a pipetting device in the form of a pipetting robot
  • FIG. 2 shows a storage carrier for providing a plurality of inventive
  • Pipette tip carriers each having a plurality of pipette tips
  • FIG. 3 shows an embodiment according to the invention of a pipette tip carrier of the present application for use in a pipetting device, such as that of FIG. 1, or in a storage carrier, as illustrated by way of example in FIG.
  • FIG. 4 shows a detailed view of the pipetting device of FIG. 1
  • FIG. 5 shows an exemplary illustration of an image of a fully loaded pipetting tip carrier according to FIG. 3, which is captured by the camera of the pipetting device.
  • an embodiment of a pipetting device according to the invention is designated generally by 10.
  • a pipetting robot is shown as a pipetting device.
  • FIG. 3 a central region of the illustration of FIG. 1 is shown enlarged in detail.
  • the pipetting device 10 has a housing 12, on which a pipetting head 14 is received displaceably in the y-direction.
  • the pipetting head 14 can have a multiplicity of pipetting channels which can be displaced in the x-direction, from which each individual pipetting channel can be lowered in the z-direction, independently of the other pipetting channels, toward the working surface 16 of the working area 18 and raised again therefrom.
  • the adjusting motors can be accommodated in the housing 12 in the y direction in order to displace the pipetting head 14.
  • modules which can be displaced in the x-direction can be provided on the pipetting head 14, which can be displaced in the x-direction, for example by means of a spindle drive or a linear drive, and can preferably be displaced independently of one another.
  • Each module can carry a pipetting channel, which can be accommodated by a further Versteilmotor in the z direction displaced on the module.
  • a control device 15 for example in the form of a CPU, is provided which controls the operation of the pipetting device 10.
  • the operation of the pipetting device 10 includes, for example, the displacement of the pipetting head and one or more pipetting channels and the operation of a pressure changing device for aspiration and dispensing of liquid through the pipetting channels.
  • the pipetting device 10 also has a camera head 20 on which a camera 22 is adjustably received. It is enough in the given example when the camera 22 in the x direction along the provided under the camera 22 storage carrier 24 is adjustable.
  • the storage carrier 24, which is illustrated enlarged in FIG. 2 alone, is provided on the working surface 16 in the working area 18 of the pipetting device 10 immediately below the camera 22 or the camera head 20.
  • the dosing-side longitudinal end 28a of the pipetting tips 28 has a pipetting opening in a manner known per se, the coupling-side longitudinal end 28b has a coupling formation 30 for coupling to the respective pipetting channels of the pipetting apparatus 10.
  • the pipetting tips 28 extend along a pipette tip axis P, which is preferably also a rotational symmetry axis.
  • the pipetting tips 28 are all functionally identical. They only differ visually from each other, wherein in the example shown exactly two types of optically distinguishable pipetting tips 28 are provided. These are shown in FIG.
  • FIG. 5 shows a photograph as it could be taken by camera 22 in FIGS. 1 and 4.
  • FIGS. 5a and 5b differ only in the orientation of the picked-up pipette tip carriers 26.
  • the views of FIGS. 5a and 5b are views of the camera 22 when viewed in the z direction, the camera 22 preferably being exactly above the pipette tip carrier 26 considered located.
  • the arrangement of the pipetting tips 28 is arranged as an arrangement in twelve rows and eight columns and the individual pipette tip 28 taken is addressed (row number, column number), the pipetting tip 28 in FIG. 1, 1), then the following pipetting tips 28 belong to a first type 34 of pipetting tips: (1; 1) to (2; 8), (3; 1), (3; 4) to (3; 6), (4; 2), (4; 4), (4; 5), (4; 7), (5; 1), (5; 4), (5; 5), (5; 7), (6 ; 1), (6; 2), (6; 4), (6; 5), (6; 8), (7; 1), (7; 7), (7; 8), (8; 2 ), (8; 4), (8; 5), (8; 7), (9; 2), (9; 4), (9; 5), (9; 7), (10; 1), (10; 3) to (10; 6), (10,8) and (1 1; 1) to (12; 8).
  • the following pipetting tips 28 instead belong to a second type 36 of pipetting tips optically distinguishable from the first type 34 by the camera 22: (3; 2), (3; 3), (3; 7), (3; 8), (4 ; 1), (4; 3), (4; 6), (4; 8), (5; 2), (5; 3), (5; 6), (5; 8), (6; 3 ), (6; 6), (6; 7), (7; 2) to (7; 6), (8; 1), (8; 3), (8; 6), (8; 8), (9; 1), (9; 3), (9; 6), (9; 8), (10; 2) and (10; 7).
  • the following pipetting tips 28 belong in Figure 5b to the first type 34 of pipette tips: (1; 1) to (1; 3), (1; 7), (1; 8), (1; 1 1), (2; ), (2; 2), (2; 4), (2; 5), (2; 7), (2; 9), (2; 1 1), (3; 1) to (3; 3) , (3; 7), (3; 9), (3; 1 1), (3; 12), (4; 1) to (4; 5), (4; 7), (4; 9), (4; 1 1), (5; 1) to (5; 3), (5; 10) to (5; 12), (6; 1), (6; 2), (6; 4), (6; 5), (6; 7), (6 9) to (6; 12), (7; 1) to (7; 3), (7; 6), (7; 7), (7; 9), (7; 1 1), (7; 12), (8; 1) to (8; 8) and (8; 10) to (8; 12).
  • the following pipetting tips 28 belong in FIG. 5b to the second type 36 of pipetting tips that can be differentiated optically from the first type 34 by the camera 22: (1; 4) to (1; 6), (2; 3), (2; 6) , (2; 8), (2; 10), (2; 12), (3; 4) to (3; 6), (3; 8), (3; 10), (4; 6), ( 4; 8), (4; 10), (4; 12), (5; 4) to (5; 9), (6; 3), (6; 6), (6; 8), (7; 4), (7; 5); (7; 8), (7; 10) and (8; 9).
  • the pipetting tips 28 of the types 34 and 36 in the orientation according to FIG. 5a in lines 3 to 10 form a pattern which compares a processing device, which is preferably part of the control device 15, with a predetermined pattern.
  • the control device 15 controls the further operation of the pipetting device 10 on the basis of the comparison result.
  • the different types 34 and 36 of pipette tips 28 in columns 3 to 10 form a pattern that compares the processing device with a predetermined pattern.
  • the control device 15 controls the further operation of the pipetting device 10 as a function of the result of the comparison.
  • the processing means may search the entirety of the pipetting tips 28 in a pipette tip carrier 26 for the predetermined reference pattern, and the controller 15 may take further actions depending on whether or not the processing means finds the predetermined reference pattern in the image of the pipetting tip holder 26 taken by the camera 22 or control the operation of the pipetting device 10.
  • the eight pipetting tips 28 in column 12 are used for coding, for example, the maximum volume of pipetting taken up by the present pipetting tips or the material of the pipetting tips 28.
  • the pipetting tips 28 of the first type 34 may represent a "0" and the pipetting tips 28 of the second type 36 may represent a "1".
  • the staging areas of lines 1 to 8 can be 28 in column 12 of Pipettierspitzen termes 26 of Figure 5b, for example, from top to bottom represent exponents 0 to 7 of powers of two.
  • the pipetting tips 28 arranged in column 12 can thus represent the number "1 1". In this way, by arranging two different types of pipetting tips 28 in a column or row having eight arrangement locations, 255 different states or information about the pipetting tips 28 provided in the respective pipette tip carrier 26 can be coded.
  • the processing device d. H.
  • the control device 15 may be configured to refuse a recording of a pipette tip 28 from a pipette tip carrier 26 provided, ie, for example, a further operation of the pipetting device 10, preferably issuing a warning or sending an e-mail to a predetermined Address to prevent when the predetermined reference pattern is not found in a captured by the camera 22 image of the coupling-side longitudinal ends 28 b of the provided in a pipette tip 26 pipetting tips 28.
  • This may mean, for example, that the pipetting tips did not originate from a predetermined manufacturer and did not pass through its quality control.
  • the processing device or the control device 15 can initiate the same if the evaluation of a binary coding of a line and / or a column of pipetting tips 28 by image processing in the processing device results in a value other than that expected for the respective pipetting task, ie if Thus, it is determined that incorrectly suitable pipetting tips 28 have been provided for a pipetting task to be performed.

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  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un système de pipetage (10) comportant - au moins un canal de pipetage, de préférence plusieurs canaux de pipetage, déplaçables par moteur par rapport au bâti (12) du système de pipetage (10) et servant à aspirer et/ou distribuer un fluide, le ou les canaux de pipetage étant réalisés pour le raccordement amovible d'une pointe de pipetage (28) réalisée séparément du système de pipetage (10), et un dispositif de commande (15) servant à commander le fonctionnement du système de pipetage (10). Le système de pipetage (10) présente : une caméra (22) qui est conçue pour détecter de manière optique au moins une partie d'une zone de travail (18) du système de pipetage (10), et un dispositif de traitement (15) qui est conçu pour traiter des images détectées à l'aide de la caméra (22). Le système de pipetage est caractérisé en ce que la caméra (22) est conçue pour détecter de manière optique au moins une partie d'un lieu de préparation d'une pluralité de pointes de pipetage (28) préparées pour le raccordement à ou aux canaux de pipetage, et en ce que le dispositif de traitement (15) est conçu pour comparer une image, enregistrée par la caméra (22), d'au moins une partie du lieu de préparation à une image de référence prédéterminée et/ou à un modèle de référence prédéterminé.
PCT/EP2016/065557 2015-07-02 2016-07-01 Système de pipetage muni d'un dispositif de traitement d'images Ceased WO2017001676A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH01475/17A CH712782B1 (de) 2015-07-02 2016-07-01 Pipettiervorrichtung mit Bildverarbeitung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015212457.6A DE102015212457A1 (de) 2015-07-02 2015-07-02 Pipettiervorrichtung mit Bildverarbeitung
DE102015212457.6 2015-07-02

Publications (1)

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WO2017001676A1 true WO2017001676A1 (fr) 2017-01-05

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11263433B2 (en) 2016-10-28 2022-03-01 Beckman Coulter, Inc. Substance preparation evaluation system
US12280368B2 (en) 2019-11-27 2025-04-22 Corning Incorporated Connected ecosystem for laboratory environment
US12478973B2 (en) 2019-04-12 2025-11-25 Randox Laboratories Ltd Pipette tip carrier assembly
US12584089B2 (en) 2019-11-27 2026-03-24 Corning Incorporated Sensing vessels for cell cultures

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020104422A1 (de) 2020-02-19 2021-08-19 Hamilton Bonaduz Ag Verfahren zur Zuordnung einer Pipettierspitze zu einer Pipettierspitzenklasse aufgrund ihres pneumatischen Verhaltens

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069925A1 (fr) * 2010-11-23 2012-05-31 Andrew Alliance S.A Dispositifs et procédés pour manipulation programmable de pipettes
US20130205920A1 (en) * 2012-02-10 2013-08-15 Adam Perry Tow Automated visual pipetting

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069925A1 (fr) * 2010-11-23 2012-05-31 Andrew Alliance S.A Dispositifs et procédés pour manipulation programmable de pipettes
US20130205920A1 (en) * 2012-02-10 2013-08-15 Adam Perry Tow Automated visual pipetting

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11263433B2 (en) 2016-10-28 2022-03-01 Beckman Coulter, Inc. Substance preparation evaluation system
US12478973B2 (en) 2019-04-12 2025-11-25 Randox Laboratories Ltd Pipette tip carrier assembly
US12280368B2 (en) 2019-11-27 2025-04-22 Corning Incorporated Connected ecosystem for laboratory environment
US12584089B2 (en) 2019-11-27 2026-03-24 Corning Incorporated Sensing vessels for cell cultures

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DE102015212457A1 (de) 2017-01-05

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