WO2017014162A8 - アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 - Google Patents

アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 Download PDF

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WO2017014162A8
WO2017014162A8 PCT/JP2016/070902 JP2016070902W WO2017014162A8 WO 2017014162 A8 WO2017014162 A8 WO 2017014162A8 JP 2016070902 W JP2016070902 W JP 2016070902W WO 2017014162 A8 WO2017014162 A8 WO 2017014162A8
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amyloid
therapeutic
fibril
preventive
agent
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Ceased
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PCT/JP2016/070902
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English (en)
French (fr)
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WO2017014162A1 (ja
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陽一 石井
猛 岡本
さやか 石井
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Well Stone Co
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Well Stone Co
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Publication date
Priority to RU2018105718A priority Critical patent/RU2018105718A/ru
Priority to US15/577,464 priority patent/US20180147243A1/en
Priority to AU2016296962A priority patent/AU2016296962B2/en
Priority to KR1020227031896A priority patent/KR20220131357A/ko
Priority to BR112017027209A priority patent/BR112017027209A2/pt
Priority to CN201680016841.9A priority patent/CN107405366B/zh
Priority to CA2983905A priority patent/CA2983905A1/en
Priority to KR1020217028697A priority patent/KR20210114551A/ko
Priority to KR1020217014598A priority patent/KR102302013B1/ko
Application filed by Well Stone Co filed Critical Well Stone Co
Priority to EP16827722.6A priority patent/EP3326636A4/en
Priority to KR1020177030221A priority patent/KR102255146B1/ko
Publication of WO2017014162A1 publication Critical patent/WO2017014162A1/ja
Priority to PH12017501949A priority patent/PH12017501949A1/en
Publication of WO2017014162A8 publication Critical patent/WO2017014162A8/ja
Anticipated expiration legal-status Critical
Priority to AU2022200329A priority patent/AU2022200329B2/en
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23BPRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00Preservation of foods or foodstuffs, in general
    • A23B2/90Preservation of foods or foodstuffs, in general by drying or kilning; Subsequent reconstitution
    • A23B2/92Freeze drying
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L35/00Foods or foodstuffs not provided for in groups A23L5/00 - A23L33/00; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/15Inorganic Compounds
    • A23V2250/156Mineral combination
    • A23V2250/16Potassium
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/15Inorganic Compounds
    • A23V2250/156Mineral combination
    • A23V2250/161Magnesium
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00Food ingredients
    • A23V2250/15Inorganic Compounds
    • A23V2250/156Mineral combination
    • A23V2250/1614Sodium
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00Processes
    • A23V2300/18Fractionation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

天然物を有効成分として含有するアミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬または予防薬、アミロイドβの線維化に起因する疾患の治療用または予防用食品組成物を提供することにある。ミミズの乾燥粉末、摩砕物及び/又は抽出物を有効成分として含有する、アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬または予防薬、アミロイドβの線維化に起因する疾患の治療用または予防用食品組成物である。アミロイドβの線維化に起因する疾患は、アルツハイマー病であることが好ましい。
PCT/JP2016/070902 2015-07-21 2016-07-14 アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 Ceased WO2017014162A1 (ja)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1020217014598A KR102302013B1 (ko) 2015-07-21 2016-07-14 아밀로이드β 섬유 분해제, 아밀로이드β의 섬유화에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품조성물
AU2016296962A AU2016296962B2 (en) 2015-07-21 2016-07-14 Amyloid beta fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid beta fibril formation
KR1020227031896A KR20220131357A (ko) 2015-07-21 2016-07-14 아밀로이드β 섬유 분해제, 아밀로이드β의 섬유화에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품조성물
BR112017027209A BR112017027209A2 (pt) 2015-07-21 2016-07-14 agente de decomposição de fibrila beta amiloide e agente terapêutico ou de prevenção e composição alimentícia terapêutica ou de prevenção de doenças causadas pela formação de fibrila beta amiloide
CN201680016841.9A CN107405366B (zh) 2015-07-21 2016-07-14 β淀粉样蛋白纤维分解剂、由β淀粉样蛋白的纤维化引起的疾病的治疗药/预防药
CA2983905A CA2983905A1 (en) 2015-07-21 2016-07-14 Amyloid .beta. fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid .beta. fibril formation
KR1020217028697A KR20210114551A (ko) 2015-07-21 2016-07-14 아밀로이드β 섬유 분해제, 아밀로이드β의 섬유화에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품조성물
RU2018105718A RU2018105718A (ru) 2015-07-21 2016-07-14 СРЕДСТВО, РАЗРУШАЮЩЕЕ ФИБРИЛЛЫ АМИЛОИДА β, И ТЕРАПЕВТИЧЕСКИЙ ИЛИ ПРОФИЛАКТИЧЕСКИЙ АГЕНТ, И ТЕРАПЕВТИЧЕСКАЯ ИЛИ ПРОФИЛАКТИЧЕСКАЯ ПИЩЕВАЯ КОМПОЗИЦИЯ ДЛЯ ЗАБОЛЕВАНИЙ, ВЫЗВАННЫХ ОБРАЗОВАНИЕМ ФИБРИЛЛ АМИЛОИДА β
EP16827722.6A EP3326636A4 (en) 2015-07-21 2016-07-14 MEDIUM FOR THE REMOVAL OF AMYLOID BETA FIBRILLES AND A THERAPEUTIC OR PREVENTIVE AGENT AND THERAPEUTIC OR PREVENTIVE FOOD COMPOSITION FOR DISEASES CAUSED BY AMYLOID BETA FIBRILLATION
US15/577,464 US20180147243A1 (en) 2015-07-21 2016-07-14 Amyloid beta fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid beta fibril formation
KR1020177030221A KR102255146B1 (ko) 2015-07-21 2016-07-14 아밀로이드β 섬유 분해제, 아밀로이드β의 섬유화에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품조성물
PH12017501949A PH12017501949A1 (en) 2015-07-21 2017-10-25 Amyloid � fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid � fibril formation
AU2022200329A AU2022200329B2 (en) 2015-07-21 2022-01-19 Amyloid beta fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid beta fibril formation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-144319 2015-07-21
JP2015144319A JP2017025019A (ja) 2015-07-21 2015-07-21 アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物

Publications (2)

Publication Number Publication Date
WO2017014162A1 WO2017014162A1 (ja) 2017-01-26
WO2017014162A8 true WO2017014162A8 (ja) 2017-11-16

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Family Applications (1)

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PCT/JP2016/070902 Ceased WO2017014162A1 (ja) 2015-07-21 2016-07-14 アミロイドβ線維分解剤、アミロイドβの線維化に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物

Country Status (12)

Country Link
US (1) US20180147243A1 (ja)
EP (1) EP3326636A4 (ja)
JP (1) JP2017025019A (ja)
KR (4) KR20220131357A (ja)
CN (1) CN107405366B (ja)
AU (2) AU2016296962B2 (ja)
BR (1) BR112017027209A2 (ja)
CA (1) CA2983905A1 (ja)
PH (1) PH12017501949A1 (ja)
RU (1) RU2018105718A (ja)
TW (1) TWI781082B (ja)
WO (1) WO2017014162A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6253837B1 (ja) * 2017-07-18 2017-12-27 エンチーム株式会社 組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08283157A (ja) 1995-02-15 1996-10-29 Takeda Chem Ind Ltd アミロイドβ蛋白産生・分泌阻害剤
JP4227245B2 (ja) 1999-04-30 2009-02-18 パナソニック株式会社 磁気ディスク用基板の製造方法
CN100571701C (zh) * 2002-12-24 2009-12-23 贝卢斯健康(国际)有限公司 治疗β淀粉样蛋白相关疾病的治疗性制品
ITRM20050045A1 (it) * 2005-02-02 2006-08-03 Consiglio Nazionale Ricerche Proteina isolata da eisenia foetida simile all'ngf umano e usi relativi.
WO2007126111A1 (ja) 2006-04-28 2007-11-08 Kagoshima University アミロイドβ線維化阻害ペプチド
JP4699974B2 (ja) * 2006-09-29 2011-06-15 Well Stone 有限会社 ミミズ乾燥粉末の製造方法
US8137701B2 (en) * 2008-03-21 2012-03-20 Well Stone Co. Method of producing a dry earthworm powder
JP2009249362A (ja) * 2008-04-09 2009-10-29 Well Stone 有限会社 無害化されたミミズ乾燥粉末の製造方法
US8137666B2 (en) * 2008-11-22 2012-03-20 Academia Sinica Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses
JP4886017B2 (ja) * 2009-10-13 2012-02-29 Well Stone 有限会社 ミミズ乾燥粉末の製造方法
JP4808822B1 (ja) * 2011-04-11 2011-11-02 Well Stone 有限会社 ミミズ乾燥粉末の製造方法
BR112014001613B1 (pt) * 2011-07-29 2019-01-22 Well Stone Co. inibidor de tirosinase produzido com o uso de pó de minhoca seco e método para produzir o mesmo
CN103550537B (zh) * 2013-11-10 2014-08-06 孟晓彬 一种治疗阿尔茨海默病的中药制剂及制备方法
KR102061183B1 (ko) * 2014-01-20 2019-12-31 웰 스톤 유겐가이샤 카테콜라민 생산 촉진제, 카테콜라민의 결핍에 기인하는 질환의 치료약·예방약 및 치료용·예방용 식품 조성물
CN104288396A (zh) * 2014-09-27 2015-01-21 隋荣玲 一种治疗老年痴呆症的中药汤剂
JP6321521B2 (ja) * 2014-11-04 2018-05-09 Well Stone 有限会社 タウ蛋白産生促進剤、タウ蛋白の欠乏に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物
CN104547388A (zh) * 2014-12-18 2015-04-29 黑龙江儒泰生物制药有限责任公司 治疗阿尔茨海默病的中药组合物、其制备方法和用途

Also Published As

Publication number Publication date
KR102302013B1 (ko) 2021-09-13
AU2022200329B2 (en) 2023-10-05
TWI781082B (zh) 2022-10-21
PH12017501949A1 (en) 2018-03-19
CN107405366A (zh) 2017-11-28
TW201716073A (zh) 2017-05-16
KR20220131357A (ko) 2022-09-27
CA2983905A1 (en) 2017-01-26
AU2022200329A1 (en) 2022-02-17
EP3326636A4 (en) 2019-03-27
CN107405366B (zh) 2022-07-22
AU2016296962A1 (en) 2018-01-04
WO2017014162A1 (ja) 2017-01-26
RU2018105718A (ru) 2019-08-22
US20180147243A1 (en) 2018-05-31
KR20210059023A (ko) 2021-05-24
EP3326636A1 (en) 2018-05-30
KR20210114551A (ko) 2021-09-23
AU2016296962B2 (en) 2021-10-28
JP2017025019A (ja) 2017-02-02
KR102255146B1 (ko) 2021-05-21
BR112017027209A2 (pt) 2018-10-30
KR20180029950A (ko) 2018-03-21

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