WO2017018686A3 - 마나산틴 a 또는 마나산틴 b를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물 - Google Patents

마나산틴 a 또는 마나산틴 b를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2017018686A3
WO2017018686A3 PCT/KR2016/007395 KR2016007395W WO2017018686A3 WO 2017018686 A3 WO2017018686 A3 WO 2017018686A3 KR 2016007395 W KR2016007395 W KR 2016007395W WO 2017018686 A3 WO2017018686 A3 WO 2017018686A3
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WO
WIPO (PCT)
Prior art keywords
manassantin
fatty liver
alcoholic fatty
treatment
liver disease
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Ceased
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PCT/KR2016/007395
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English (en)
French (fr)
Other versions
WO2017018686A2 (ko
Inventor
한신희
박춘근
최애진
차선우
박충범
제이 산얄에이런
민해기
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Korea Rural Development Administration
Virginia Commonwealth University
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Korea Rural Development Administration
Virginia Commonwealth University
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Application filed by Korea Rural Development Administration, Virginia Commonwealth University filed Critical Korea Rural Development Administration
Publication of WO2017018686A2 publication Critical patent/WO2017018686A2/ko
Publication of WO2017018686A3 publication Critical patent/WO2017018686A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

본 발명은 마나산틴 A(manassantin A) 또는 마나산틴 B(manassantin B)을 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물에 관한 것으로, 본 발명의 마나산틴 A(manassantin A) 또는 마나산틴 B(manassantin B)을 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물은 종래 합성 약제 조성물이 유발하는 심혈관작용, 중추작용, 간장장애 및 신장장애 등 여러 부작용이 없으며, 비알코올성 지방간 질환에 의한 염증 감소, 비알코올성 지방간 진행 및 전이 억제, 간 내 지질축적 억제, 항 세포사멸효과 및 세포의 자식작용(autophagy) 활성촉진 효과를 가지고 있으므로, 비알코올성 지방간 예방 및/또는 치료용 약학적 조성물 또는 비알코올성 지방간 및/또는 개선용 건강기능성 식품 조성물로 유용하게 활용될 수 있다.
PCT/KR2016/007395 2015-07-27 2016-07-07 마나산틴 a 또는 마나산틴 b를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물 Ceased WO2017018686A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0106051 2015-07-27
KR1020150106051A KR20170013086A (ko) 2015-07-27 2015-07-27 마나산틴 a 또는 마나산틴 b를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물

Publications (2)

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WO2017018686A2 WO2017018686A2 (ko) 2017-02-02
WO2017018686A3 true WO2017018686A3 (ko) 2017-04-06

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PCT/KR2016/007395 Ceased WO2017018686A2 (ko) 2015-07-27 2016-07-07 마나산틴 a 또는 마나산틴 b를 포함하는 비알코올성 지방간 질환 예방 또는 치료용 조성물

Country Status (2)

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KR (1) KR20170013086A (ko)
WO (1) WO2017018686A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102106991B1 (ko) * 2019-06-07 2020-05-06 충북대학교 산학협력단 아스타잔틴을 유효 성분으로 포함하는 알코올성 간 질환의 치료 또는 예방용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327368A (zh) * 2010-09-06 2012-01-25 成都地奥制药集团有限公司 三白草根茎总有效部位及其制备方法和用途
KR20150026972A (ko) * 2013-08-30 2015-03-11 한국생명공학연구원 삼백초 추출물 및 이의 분획물로부터 분리된 화합물을 유효성분으로 함유하는 항바이러스용 약학적 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327368A (zh) * 2010-09-06 2012-01-25 成都地奥制药集团有限公司 三白草根茎总有效部位及其制备方法和用途
KR20150026972A (ko) * 2013-08-30 2015-03-11 한국생명공학연구원 삼백초 추출물 및 이의 분획물로부터 분리된 화합물을 유효성분으로 함유하는 항바이러스용 약학적 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHANG, J. S. ET AL.: "Manassant in A and B From Saururus Chinensis Inhibit Interleukin-6-induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 115, no. 1, 2011, pages 84 - 88, XP055374660 *
KIM, J. Y. ET AL.: "Inhibition of Phenotypic and Functional Maturation of Dendritic Cells by Manassant in A", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 109, no. 4, 2009, pages 583 - 592, XP055374662 *
LEE, M. K. ET AL.: "Antifibrotic Activity of Manassant in B from Saururus Chinensis in HSC-T6 Hepatic Stellate Cells", NATURAL PRODUCT SCIENCES, vol. 14, no. 2, 2008, pages 118 - 121, XP053005995 *

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WO2017018686A2 (ko) 2017-02-02
KR20170013086A (ko) 2017-02-06

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