WO2017105378A1 - Tête de mise sous capsule et dispositif de fabrication de capsules - Google Patents

Tête de mise sous capsule et dispositif de fabrication de capsules Download PDF

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Publication number
WO2017105378A1
WO2017105378A1 PCT/UA2016/000146 UA2016000146W WO2017105378A1 WO 2017105378 A1 WO2017105378 A1 WO 2017105378A1 UA 2016000146 W UA2016000146 W UA 2016000146W WO 2017105378 A1 WO2017105378 A1 WO 2017105378A1
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WO
WIPO (PCT)
Prior art keywords
shell
capsule
contents
internal contents
internal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/UA2016/000146
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English (en)
Russian (ru)
Inventor
Павел Петрович ПИВОВАРОВ
Ольга Павловна НЕКЛЕСА
Александр Юрьевич НАГОРНЫЙ
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2017105378A1 publication Critical patent/WO2017105378A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Definitions

  • the invention relates to a capsule head and device for producing capsules by top-down coaxial extrusion encapsulation of a shell former and internal contents through air into a receiving liquid.
  • the invention also relates to the production of capsules with internal contents based on fats and / or hydrophobic substances by vertical top-down coaxial extrusion encapsulation of a shell former and the above-mentioned internal contents in an extrusion liquid state through air into a receiving liquid.
  • the invention can be used in medical, chemical, pharmaceutical, food industry, livestock and biotechnology.
  • the invention can also be used as equipment for the production of encapsulated products in the form of capsules that contain internal contents and a shell.
  • the invention can also be used as equipment for the production of encapsulated products in the form of capsules with internal contents based on fats and / or hydrophobic substances, for example, oils, fats, suspensions in fats, dispersions in oil, substances in the colloidal state of inverse emulsions, inverse seamless emulsions
  • capsule heads are known. See patents: NsNsUS3790492, US4162282, US4302166, in which capsules are prepared by vertical top-down coaxial extrusion encapsulation of the enveloping agent and internal contents.
  • Known capsule heads are characterized by the presence of:
  • the housing with a nozzle for supplying the shell former to the cavity of the housing
  • a nozzle for supplying internal contents with a nozzle, which is located coaxially with the outlet and installed above it, while the nozzle is installed above the outlet with the ability to control the distance between the nozzle and the outlet.
  • a design feature of the known capsule heads is that the inner contents and the shell forming agent from the reservoir for the inner contents and the shell forming tank are supplied under pressure to the capsule head, while the monodispersive decomposition necessary for capsule formation is carried out using a vibrator.
  • known capsule heads receive microcapsules with a diameter of up to 50 microns.
  • a system for receiving liquid circulation which contains a receiving tray with a receiving liquid, over which there is a capsule head with which, through the air, coaxial extrusion encapsulation of the shell-forming agent is carried out from top to bottom,
  • a design feature of the known device is the use of the above capsule heads, which are characterized by the above disadvantages.
  • Another disadvantage of the known device is that oil is used as a receiving liquid, for which it is necessary to maintain a predetermined temperature, and it is also necessary to carry out heating of the shell of the former, which makes the capsule manufacturing process energy-intensive.
  • Another disadvantage of the known device is the low productivity of capsule manufacturing, which is due to the presence of 15 use of only one capsule head in the device, which creates one capsule manufacturing stream in the receiving tray.
  • thermostable capsules Another disadvantage of this device is the inability to obtain thermostable capsules, because the design of the device only works with materials capable of thermotropic 20 gelation, which are labile to temperature.
  • the objective of the invention is to provide a capsule head and device for producing capsules, with which it is also possible:
  • the capsule head for producing capsules by top-down coaxial 15 extrusion encapsulation of the shell former and the internal contents through the air into the receiving liquid is characterized by the presence of: a housing into which the shell former, a confuser with an outlet, enters the body cavity through a pipe for supplying the shell former located at the bottom
  • a nozzle for supplying internal contents with a nozzle which is located coaxially with the outlet and installed above it, while the nozzle is installed above the outlet with the possibility of adjusting the distance between the nozzle and
  • fatty and / or hydrophobic substances are used as the basis of the internal contents, wherein a solution of an ionotropic gelling agent is used as a shell former, and the receiving liquid contains a cross-linking agent 20 for said ionotropic gelling agent.
  • the confuser is made with the possibility of removal from the housing. This allows you to install on the capsule head confusers with different outlet openings, which allows you to get capsules with different diameters.
  • the nozzle is made with the possibility of removal from the supply pipe of the internal contents, which allows you to adapt the head to a different amount of internal content and different diameter of the capsule shell.
  • the supply pipe for the shell former comprises a feed regulator for the shell former with an intermediate depressurized container. This allows you to more efficiently carry out the process of setting the flow of the shell former and the rhythm of the capsule head during its operation.
  • the pipe for supplying internal contents contains a regulator for supplying internal contents from an intermediate pressurized container. This allows you to more efficiently carry out the process of adjusting the flow of internal content and the rhythm of the capsule head during its operation.
  • a spring which is dressed on the pipe for supplying internal contents, and is located between the first lower and second upper stops,
  • the means for fixing the supply pipe of the internal contents in the housing is made in the form of a locking screw, which is located in the upper part of the housing. This simplifies the fixation of the internal content supply pipe in the housing.
  • a sealing gasket is located above the first lower stop, which presses the end of the spring to the first lower stop.
  • the presence of a sealing gasket prevents the shell-forming agent from entering the upper part of the capsule head housing.
  • the supply pipe of the internal content contains a support protrusion for controlled movement of the pipe. In the process of operation of the capsule head, the controlled movement of the internal content supply pipe in the housing is carried out by an operator, who grabs the capsule head body with his palm, and presses the supporting protrusion of the internal content supply pipe with his thumb, which simplifies the adjustment of the capsule head, which is also an advantage of the claimed invention.
  • At least one lateral tap is located in the upper part of the intermediate depressurized container for the shell former and / or in the upper part of the intermediate depressurized container, the presence of which simplifies control over maintaining the level of liquids in the pressurized containers and prevents the formation of in pressurized containers of liquid level, which will impair the rhythm of the capsule head.
  • a device for producing capsules with internal contents based on fats and / or hydrophobic substances which contains at least one of the above capsule head, and is characterized by the presence of:
  • At least one capsule receptacle At least one capsule receptacle.
  • the capsule head is installed with the possibility of regulating the distance between the receiving tray and the capsule head. This allows you to adjust the immersion of the formed drops of the capsules in the receiving liquid to prevent collision of the drops of the capsules with the bottom of the receiving tray.
  • the reservoir for the internal contents contains a heating element, the use of which allows you to translate viscous or non-flowing refractory fats into the fluid state necessary for top-down coaxial extrusion encapsulation through air into the receiving liquid.
  • the claimed invention contains at least one distributor shell-forming agent, which is connected to at least one reservoir for the shell-forming agent, while through the distribution collector of the shell-forming agent, the shell-forming agent is fed into at least two intermediate depressurized containers for a shell former.
  • the claimed invention contains at least one distribution container of the internal contents, which is connected to at least one reservoir for the internal contents, while through the distribution collector of the internal contents, the shell former is fed into at least two intermediate pressurized containers for internal contents.
  • FIG. 1 is a schematic sectional view of a capsule head according to the invention.
  • FIG. 2 - schematically shows a device for producing capsules with internal contents based on fats and / or hydrophobic substances.
  • FIG. 1 shows a section through the housing 1 of the capsule head in the lower part of which there is a confuser 2 with an outlet 3. Moreover, the confuser 2 is removable from the lower part of the housing 1.
  • a pipe for supplying internal contents 4 which is connected on one side to the housing 1 and, on the other hand, is connected to an intermediate pressurized container for internal contents 5 from which the internal content enters the pipe for supplying internal contents 4.
  • the nozzle 10 which is located coaxially with the outlet 3 and installed above it, while the nozzle 10 is installed above the outlet 3 with the possibility of adjusting the distance between the nozzle 10 and an outlet 3. Also, the nozzle 10 is mounted with the possibility of removal from the supply pipe of the internal contents 4.
  • the nozzle 10 In the upper part of the housing 1 there is a removable cover 11.
  • the first lower stop 12 which is adjacent to the inner surface case 1; the second upper stop 13, which is adjacent to the outer surface of the supply pipe of the inner contents 4 and the spring 14, which is worn on the supply pipe of the internal contents 4, and is located between the first lower 12 and the second upper 13 stops.
  • the means for fixing the pipe 15 for supplying the internal contents 4 in the housing 1 is made in the form of a locking screw, which is located in the upper part of the housing 1.
  • a sealing gasket 16 which is pressed by the spring 14 to the first lower stop 12.
  • In the upper part of the intermediate pressurized container for internal contents 5 is located lateral branch 17, and in the upper part of the intermediate depressurized container for shell former 8 there is a lateral branch 18.
  • the nozzle for supplying the internal contents 4 contains a lateral protrusion 23.
  • FIG. 2 a device for producing capsules with internal contents based on fats and / or hydrophobic substances, in which the capsule head is used is shown in FIG. 1 comprises a reservoir for a shell former 24, a reservoir for internal contents 25, and a receiver fluid circulation system 26.
  • the reservoir for the shell former 24 is connected to the distribution manifold for the shell former 27 through a nozzle 28 that includes a regulator 29.
  • the distributor manifold of the shell former 27 includes nozzles 30 with regulators 31. Through the nozzle 30, the enveloper is supplied from the distributor manifold of the enveloper 27 to an intermediate depressurized shell 8 for shell.
  • the reservoir for the inner contents 25 contains a heating element 32, while the reservoir for the inner contents 25 is connected to the distribution manifold of the inner contents 33 through the pipe 34 with the regulator 35.
  • the distribution manifold of the internal contents 33 contains the pipes 36 with regulators 37. Through the pipe 36, the internal contents are supplied into an intermediate pressurized container for internal contents 5.
  • the system for receiving fluid 26 contains a reservoir for the receiving fluid 38, which is connected to the pipe 39, on which the pump 40 and the regulator 41 are installed. At the same time, the pipe 39 is on the other hand connected to the receiving tray 42.
  • the means for separating the capsules from the receiving liquid is in the form of a collection tray 43, in the upper part of which there is a grid 44.
  • the receiving liquid from the receiving tray 42 enters through the mesh 44 to the collection tray 43, from which the receiving liquid enters the reservoir for receiving liquid 38 and the formed capsules separated by the mesh 44 from the receiving liquid enter the capsule tank 45.
  • the capsule head for producing capsules by top-down coaxial extrusion encapsulation of the shell former and the internal contents through the air into the receiving medium operates as follows, see FIG. 1 and FIG. 2.
  • the shell former From the reservoir for the shell former 24, the shell former enters a depressurized tank for the shell former 8, which is connected to the atmosphere. After the formation of the level of the shell-forming agent in the pressurized container for the shell-forming agent 8, the regulator 9 is opened, as a result of which the shell-forming agent enters the cavity of the housing 1 of the capsulator head and fills the confuser 2.
  • the inner contents enter the pressurized container for the inner contents 5.
  • the regulator 6 As a result of which, through the nozzle for supplying the inner contents 4, the inner contents are supplied through the nozzle 10 in the lower part of which the inner layer (core) of the capsule drop begins to form, which is enveloped by the shell former, as a result of which the capsule drop forms, which has two layers: the inner layer (core) in the form of inner contents, and the outer layer, which envelops the inner layer, in the form of a shell former.
  • a drop of the capsule leaves through the outlet 3 of the confuser 2 and is supplied through the air to a receiving liquid, which is located in the receiving tray 43, in which the residual processes of capsule formation take place.
  • Setting the capsule head to an effective pace of its operation is carried out by adjusting the distance between the nozzle 10 and the outlet 3 by moving the supply pipe of the internal contents 4, and adjusting the supply quantity of the shell former and the internal content using the regulators 6 and 9, which also allows you to adjust the ratio of the internal contents and shell-forming agent in a drop of capsule, and also allows you to get the required rate of encapsulation.
  • the fixing means 15 are loosened and the nozzle for supplying the internal contents 4 is moved and the necessary distance between the outlet 3 and the nozzle is set 10.
  • the presence of a spring 14 allows you to: simplify the movement of the pipe for supplying internal content 4 in the housing 1 to set the required distance between the outlet tverstiem 3 and orifice 10 and provides a tight abutment of the gasket 16 to the first lower stop 12.
  • the lateral protrusion 23 simplifies and improves the accuracy of displacement feed pipe internal contents provider 4, which directs its operation.
  • FIG. 2 A device for producing capsules, see FIG. 2, which comprises a capsule head, which is shown in FIG. 1. works as follows.
  • the enveloping agent is loaded into the reservoir for the enveloping agent 24.
  • the internal contents based on fats and / or hydrophobic substances are also loaded into the inner contents reservoir 25 cm. FIG. 2. If viscous or non-flowing refractory fats are used as internal contents, include a heating element 32 and the internal contents are heated to a temperature providing the necessary flow parameters for top-down coaxial extrusion encapsulation through air into the receiving liquid.
  • the reservoir for the receiving fluid 38 is filled with the receiving fluid.
  • the regulator 41 is opened and the pump 40 is turned on, as a result of which the receiving liquid enters the receiving tray 42, in which a laminar flow of the receiving liquid is formed.
  • the receiving liquid passes through the mesh 44 and enters the collection tray 43 of the capsule separation means. From the collection tray 43, the receiving liquid enters the reservoir for the receiving liquid 38.
  • the regulators 29 and 35 are opened, as a result, the shell former from the reservoir for the shell former 24 through the nozzle 28 enters the distribution manifold of the shell former 27, and the inner contents from the reservoir for the inner contents 25 enter through the nozzle 34 into the distribution manifold of the inner contents 33.
  • the regulators 31 and 37 are opened, as a result of which the shell former from the distribution collector of the shell former 27 enters the pressurized container for the shell former 8, and the inner contents from the distribution collector of the inner contents 33 enter the depressurized container for the inner contents 5.
  • the regulator 9 is opened, as a result of which the shell-forming agent enters the cavity of the housing 1 of the capsulator head and fills the confuser 2.
  • the regulator 6 is opened, as a result of which the internal content is supplied through the supply pipe of the internal content 4 and exits through the nozzle 10 above the outlet 3 of the confuser 2.
  • the internal content is enveloped by a shell former, no chemical interaction occurs between the components of the capsule - and the capsule is quasistable for the shell former through the outlet s 3 through the air enters the receiving tray 42 in which is formed a receiving liquid laminar flow.
  • the implementation of the top-down coaxial extrusion capsulation of the shell former and the internal contents through the air into the receiving liquid from the capsule head constantly drops drops drops of the capsule, which has two layers: the inner layer (core) in the form of inner contents, and the outer layer that envelops the inner layer, at
  • the shell former When the capsule drop contacts the receiving fluid, the shell former enters a chemical reaction. After that, the formed capsules are taken out by the receiving liquid from the receiving tray 42 into the means for separating the capsules from the receiving liquid, in which
  • the mesh 44 may have simultaneously rare-diameter openings that allow you to immediately calibrate the capsules according to dimensional characteristics.
  • the supply of the shell former to the pressurized container for the shell former 8 is carried out in drip mode using the regulator 31, which allows you to maintain a given level of the shell former in the depressurized tank for the shell former 8.
  • the internal contents are supplied to the pressurized container for the inner contents 5 in the drip mode using regulator 37, which allows you to maintain a given level of internal content in the intermediate depressurizer capacity for internal contents 5.
  • the presence of side pipes 17 and 18 on one side connects the pressurized containers 5 and 8 with air, and on the other hand allows you to remove excess fluid from the pressurized containers 5 and 8, which is also an advantage of the claimed invention .
  • Texture refers to the wall thickness of the shell and the resistance of the capsule to
  • n capsule heads makes it possible to create multichannel extrusion, which also allows to increase the production capacity of capsules using capsules by ⁇ -times (depending on the number of capsule heads), which is also an advantage of the invention.
  • all capsule heads work independently of one another, and this ensures the continuous production of capsules, and also allows you to simultaneously receive capsules with different diameters and ratios of the capsule shell and the internal contents of the capsule, which is also an advantage of the invention.
  • the inner contents, the shell-forming agent and the receiving liquid are prepared, see table ⁇ 1 for three experiments.
  • the top-down coaxial extrusion encapsulation of the shell former and the internal contents through air into the receiving liquid is carried out using five capsule heads with the help of which capsules with a diameter of 1.0 mm to 10.0 mm were obtained. During the operation of these five capsule heads, the distance between the nozzle and the outlet of the confuser was changed, the test data are listed in table Ns2. Table N ° 2
  • the inner contents, a shell-forming agent and a receiving liquid are prepared, see table Ns3 for five experiments.
  • pressurized containers for the shell-forming agent 8 and the internal contents 5 are made of a transparent material or contain a liquid level indicator, or other technical means to control the liquid level in them.
  • On the outer surface of the inner content supply pipe 4 in the area of the cover 11 of the housing 1 it is possible to arrange a graduated scale with which it is possible to more accurately establish the distance between the nozzle 10 and the outlet 3.
  • the covers 19 and 21 of the pressurized containers 5 and 8 may additionally contain a ventilation window or it is possible to use pressurized containers 5 and 8 without lids 19 and 21. It is also possible to implement when the pipe for supplying the internal contents 4 is made as one piece lehr 3.
  • the nozzle 10 may be formed integrally with the feed pipe internal contents 4. Also, the nozzle 10 can be mounted on the pipe for supplying the internal contents 4 due to threaded or other fasteners.
  • the technical result of the invention is to obtain capsules with a diameter of 1.0 mm to 10.0 mm, with a different ratio of the capsule shell to its internal contents.
  • the technical result of the invention is to obtain capsules with internal contents based on fats and / or hydrophobic substances with a diameter of 1.0 mm to 10.0 mm, with a different ratio of the capsule shell to its internal contents.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

L'invention concerne une tête de mise sous capsule et un dispositif de production de capsules qui fonctionne par une mise sous capsule par extrusion coaxiales de haut en bas visant la formation d'une enveloppe et du contenu interne via l'air en direction du liquide de réception. Le résultat technique consiste à obtenir des capsules avec un contenu interne à base de lipides et/ou de substances hydrophobes ayant un diamètre de 1,0 à 10,0 mm avec un rapport de l'enveloppe de la capsule à son contenu interne.
PCT/UA2016/000146 2015-12-14 2016-12-15 Tête de mise sous capsule et dispositif de fabrication de capsules Ceased WO2017105378A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
UAA201512372A UA117927C2 (uk) 2015-12-14 2015-12-14 Капсуляторна головка та пристрій для одержання капсул
UAA201512372 2015-12-14

Publications (1)

Publication Number Publication Date
WO2017105378A1 true WO2017105378A1 (fr) 2017-06-22

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Application Number Title Priority Date Filing Date
PCT/UA2016/000146 Ceased WO2017105378A1 (fr) 2015-12-14 2016-12-15 Tête de mise sous capsule et dispositif de fabrication de capsules

Country Status (2)

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UA (1) UA117927C2 (fr)
WO (1) WO2017105378A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713283A (zh) * 2019-10-12 2020-01-21 李海洋 一种医疗废水多级处理工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1591937A1 (ru) * 1988-06-20 1990-09-15 Gpki Rybopromy Flota Капсуляторная головка для формирования зернистых пищевых продуктов
US5223185A (en) * 1991-04-19 1993-06-29 Freund Industrial Co., Ltd. Method of manufacturing seamless capsules and apparatus therefor
RU5491U1 (ru) * 1996-12-09 1997-12-16 Товарищество с ограниченной ответственностью - Межрегиональный центр "Адаптоген" Устройство для производства капсулированных продуктов

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1591937A1 (ru) * 1988-06-20 1990-09-15 Gpki Rybopromy Flota Капсуляторная головка для формирования зернистых пищевых продуктов
US5223185A (en) * 1991-04-19 1993-06-29 Freund Industrial Co., Ltd. Method of manufacturing seamless capsules and apparatus therefor
RU5491U1 (ru) * 1996-12-09 1997-12-16 Товарищество с ограниченной ответственностью - Межрегиональный центр "Адаптоген" Устройство для производства капсулированных продуктов

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713283A (zh) * 2019-10-12 2020-01-21 李海洋 一种医疗废水多级处理工艺

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