WO2017120568A8 - Compositions de peptides mimétiques de l'apoe - Google Patents

Compositions de peptides mimétiques de l'apoe Download PDF

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Publication number
WO2017120568A8
WO2017120568A8 PCT/US2017/012678 US2017012678W WO2017120568A8 WO 2017120568 A8 WO2017120568 A8 WO 2017120568A8 US 2017012678 W US2017012678 W US 2017012678W WO 2017120568 A8 WO2017120568 A8 WO 2017120568A8
Authority
WO
WIPO (PCT)
Prior art keywords
mimetic peptide
peptide compositions
apoe mimetic
apoe
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/012678
Other languages
English (en)
Other versions
WO2017120568A1 (fr
Inventor
Dennis I Goldberg
Phillip M FRIDEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LipimetiX Development LLC
Original Assignee
LipimetiX Development LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LipimetiX Development LLC filed Critical LipimetiX Development LLC
Publication of WO2017120568A1 publication Critical patent/WO2017120568A1/fr
Publication of WO2017120568A8 publication Critical patent/WO2017120568A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions aqueuses comprenant un mélange de peptides synthétiques mimétiques de l'apolipoprotéine E (ApoE) et d'un ester de polyéthylène sorbitanne, et leur utilisation pour réduire le taux de cholestérol plasmatique.
PCT/US2017/012678 2016-01-08 2017-01-09 Compositions de peptides mimétiques de l'apoe Ceased WO2017120568A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662276295P 2016-01-08 2016-01-08
US62/276,295 2016-01-08
US201662288748P 2016-01-29 2016-01-29
US62/288,748 2016-01-29

Publications (2)

Publication Number Publication Date
WO2017120568A1 WO2017120568A1 (fr) 2017-07-13
WO2017120568A8 true WO2017120568A8 (fr) 2017-08-10

Family

ID=57960820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/012678 Ceased WO2017120568A1 (fr) 2016-01-08 2017-01-09 Compositions de peptides mimétiques de l'apoe

Country Status (1)

Country Link
WO (1) WO2017120568A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018190896A1 (fr) * 2017-04-13 2018-10-18 Lipimetix Development, Inc. Compositions de peptides mimétiques de l'apoe
TW202010752A (zh) * 2018-04-11 2020-03-16 美商立畢密蒂斯發展公司 擬脂蛋白元(apoe)之肽組合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506880B2 (en) 1998-03-17 2003-01-14 The Uab Research Foundation Synthetic peptides that enhance atherogenic lipoprotein uptake and lower plasma cholesterol
WO2009032702A2 (fr) 2007-08-28 2009-03-12 Uab Research Foundation Polypeptides synthétiques analogues d'apolipoprotéine e et procédés d'utilisation
US20160002315A1 (en) * 2013-03-14 2016-01-07 Uab Research Foundation Apolipoprotein mimetics and uses thereof
WO2016018665A1 (fr) * 2014-07-31 2016-02-04 Uab Research Foundation Peptides e-mimétiques d'apo ayant une puissance supérieure afin de dégager le taux de cholestérol plasmatique

Also Published As

Publication number Publication date
WO2017120568A1 (fr) 2017-07-13

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