WO2017133422A1 - Système de traitement de produit sanguin sur la base d'un traitement photochimique à la riboflavine - Google Patents

Système de traitement de produit sanguin sur la base d'un traitement photochimique à la riboflavine Download PDF

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Publication number
WO2017133422A1
WO2017133422A1 PCT/CN2017/071038 CN2017071038W WO2017133422A1 WO 2017133422 A1 WO2017133422 A1 WO 2017133422A1 CN 2017071038 W CN2017071038 W CN 2017071038W WO 2017133422 A1 WO2017133422 A1 WO 2017133422A1
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Prior art keywords
bag
blood
blood product
product processing
light
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PCT/CN2017/071038
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English (en)
Chinese (zh)
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汪相伯
朱立国
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Individual
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Priority claimed from CN201610070102.XA external-priority patent/CN105561359B/zh
Priority claimed from CN201620100930.9U external-priority patent/CN205322836U/zh
Priority claimed from CN201620100929.6U external-priority patent/CN205549056U/zh
Application filed by Individual filed Critical Individual
Publication of WO2017133422A1 publication Critical patent/WO2017133422A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/26—Accessories

Definitions

  • the invention belongs to the field of medical equipment, and in particular relates to a blood product processing system based on riboflavin photochemical method.
  • Blood product safety includes transfusion-associated graft-versus-host diseases caused by blood-borne pathogens (viruses, bacteria, protozoa, spirochetes, etc.), blood cells (such as lymphocytes).
  • pathogens viruses, bacteria, protozoa, spirochetes, etc.
  • blood cells such as lymphocytes.
  • Common methods for virus inactivation in plasma include pasteurization, S/D, membrane filtration, methylene blue and riboflavin photochemistry. Among them, methylene blue is widely used in China, but There are some deficiencies in this method, including the residual toxicity of methylene blue, the loss of plasma protein after treatment, and the cumbersome operation; the method of preventing transfusion-related graft-versus-host disease is to irradiate blood (inactivate lymphocytes).
  • the riboflavin photochemical inactivation of the virus is considered to be a promising method.
  • the principle is that riboflavin can be embedded in the nucleic acid of the virus due to its structural properties, and its electron transfer is stimulated under ultraviolet irradiation to oxidize the guanine on the nucleic acid. Residues, the nucleic acid of the virus is modified and damaged, can no longer be copied and repaired, so as to achieve the effect of inactivating the virus, and riboflavin is a safe drug, no toxic side effects, no need to be filtered after adding treatment.
  • riboflavin photochemical method is used for virus inactivation of platelets, and a single device can only process up to two treatment units at a time.
  • Patent CN203017432U discloses a flow plasma virus inactivation device, comprising a box body having at least two sets of symmetrically arranged ultraviolet lamp sets, and a plasma flow tube between the two sets of ultraviolet lamp sets; The plasma input end and the plasma output end of the plasma flow tube are respectively disposed outside the chamber.
  • the flow plasma inactivation device is only suitable for batch processing of mixed plasma.
  • Patent CN204582023U discloses a platelet virus inactivating device, comprising a support net for preventing blood bags and an upper inactivated ultraviolet lamp and an inactivated ultraviolet lamp respectively located on the underside and below the support net, inactivated ultraviolet lamp and inactivated
  • the distance between the ultraviolet lamp and the support net is adjustable, and the upper inactivated ultraviolet lamp and the lower inactivated ultraviolet lamp each include a light box, a plurality of ultraviolet tubes and a light shielding plate installed in the light box.
  • this patent also relates only to platelet virus inactivation devices, there is no complete supporting technology, and the inactivation process relies entirely on manual operations.
  • Patent CN204582095U discloses a leukocyte-inactivated blood collection bag, including a blood collection needle, a whole blood bag, a white blood cell filter, a leukocyte whole blood bag, a red blood cell preservation solution bag, a tee, a plasma bag, a methylene blue component, and an easy a folding member, a methylene blue filter, and a product bag, wherein the blood collection needle is connected to the inlet conduit at the upper end of the whole blood bag through a catheter, and the outlet catheter at the upper end of the whole blood bag is sequentially connected in series to the white blood cell whole blood bag through the inlet and outlet conduits. Plasma bags and product bags.
  • Patent CN201418870Y discloses a riboflavin whole blood virus inactivated blood bag, which is connected in series through a pipeline to integrate a triple collection bag for whole blood collection, and a riboflavin addition component is arranged in series on the collection bag bleeding line.
  • the design of the blood bag described above is complicated. When a single bag of light is used to inactivate the virus, too many components will affect the light effect. What is important is the UV of the bag. The transmittance is very low, and it is not suitable for ultraviolet irradiation treatment.
  • the blood bag since the blood bag is not provided with the fixing device, it must be placed on the tray of the inactivation device, and the tray will block the process of inactivating the virus, which ultimately affects the inactivation efficiency.
  • the present invention provides a riboflavin photochemical blood product processing system.
  • the invention not only solves the defect that the blood product has the effect of blocking the light due to the restriction of the blood bag support component when the single bag inactivates the pathogen, realizes the automation of the inactivation of the blood product pathogen, and improves the safety and convenience of inactivation of the blood product pathogen.
  • the invention provides a blood product processing system based on riboflavin photochemistry, comprising at least one blood product processing box and a blood bag; the blood bag comprises a blood inlet tube, a light treatment bag, and a riboflavin addition. And a finished bag, the top edge and the bottom edge of the light treatment bag are provided with connecting members; the box body is provided with an ultraviolet lamp and a light processing bag tray, and the light processing bag tray comprises a horizontally arranged frame.
  • the lighting frame fixing member is disposed on the frame; the connecting member and the light processing bag fixing member are connected to place the light processing bag in parallel with the ultraviolet lamp.
  • the blood product processing box according to the present invention is preferably a light-proof case to prevent an operator from being exposed to ultraviolet radiation.
  • the blood product processing box body is provided with a box door, and the box door is provided with a window for the entrance and exit of the light processing bag and the internal observation and maintenance.
  • the ultraviolet lamp of the present invention is located on the upper and lower sides of the casing.
  • the ultraviolet lamp is arranged in a manner of UVA combined with UVB. More preferably, the ultraviolet lamp is arranged in a pair of UVA and UVB.
  • the ultraviolet lamps have the same irradiation intensity, which ensures uniform illumination of the upper and lower sides of the light treatment bag by the ultraviolet lamp.
  • the ultraviolet lamp and the box are connected by a distance adjusting arm, and the adjusting arm can adjust the distance between the ultraviolet lamp and the light bag processing tray to meet the requirements of different blood products. The need for different parameters (UV intensity).
  • the blood inlet tube of the light treatment bag of the present invention is disposed at the top of the light treatment bag and connected to the light treatment bag.
  • the connecting member of the light processing bag of the present invention is selected from one or a combination of two or more of a hard plate, a fixing hole, and a snap.
  • the connecting member is disposed at four corners of the top edge and the bottom edge of the light processing bag. More preferably, the connecting member is a hard plate and a fixing hole, and the fixing hole is disposed on the hard plate.
  • the light processing bag tray of the present invention comprises a horizontally disposed frame.
  • the light processing bag tray further comprises a quartz plate, the quartz plate being embedded in the frame.
  • the illumination processing bag tray does not shield the ultraviolet lamps from the upper and lower directions.
  • the light treatment bag fixing member according to the present invention is preferably one or a combination of two or more of a clip, a hook and a snap.
  • the light treatment bag fixing member provided on the frame is a clip
  • the hard plate of the top edge and the bottom edge of the light treatment bag can be clamped, so that the blood bag is kept horizontally fixed.
  • the blood bag can be horizontally fixed by connecting the fixing holes of the top edge and the bottom edge of the light treatment bag.
  • the light treatment bag fixing member disposed on the frame is a snap button
  • the snap connection of the top edge and the bottom edge of the bag can be processed by the light treatment, so that the blood bag is kept horizontally fixed.
  • the light treatment bag fixing members are disposed at the four corners of the light processing bag tray or the frame.
  • a telescopic device is arranged between the box and the tray, and the tray can be expanded and retracted into and out of the equipment box.
  • the multi-directional rocking device is connected to the tray, and the slight horizontal vibration and the swing of the tray can be realized to uniformly irradiate the blood products in the light processing bag.
  • the multi-directional rocking device is connected to the swing motor.
  • the blood treatment bag of the present invention is further provided with a needle at the top of the blood inlet tube for piercing the original plasma, platelets or whole blood bags.
  • the riboflavin additive of the blood bag of the present invention is disposed at the top of the light treatment bag and connected to the light treatment bag.
  • the riboflavin additive is connected to the light treatment bag through the easy folding part, when the blood passes through the blood. After the inlet tube enters the light treatment bag, the easy-folding member is broken, and the riboflavin is mixed into the blood of the light treatment bag.
  • the riboflavin additive of the blood bag is placed on the blood vessel, and when the blood product flows in from the blood vessel, the riboflavin is added to the blood product to carry out the light virus inactivation.
  • the riboflavin addition member is a thick and short tubular tube having a capacity of 1-4 mL and is prepared from a hard material.
  • the riboflavin additive is a translucent member or the riboflavin additive is provided with a light-proof outer casing to protect the riboflavin from photolysis and on the other hand to observe the inflow of plasma. Or whether the riboflavin after platelet is completely dissolved.
  • the riboflavin in the riboflavin additive of the present invention is a liquid or a powder.
  • the blood bag of the present invention further includes a finished bag, and the finished bag is connected to the bottom end of the light treatment bag through a communication tube, and the communication tube is provided with a stop clip.
  • the finished bag may be a common plasma bag or a platelet bag.
  • the finished bag is a normal 200 mL plasma bag. Used to contain plasma or platelets or whole blood after treatment.
  • the finished bag may be 1-3.
  • the blood inlet tube and/or the communication tube of the blood bag of the present invention is provided with a flow stop clip for sealing the nozzle after plasma or platelet/or whole blood flows in, preventing backflow.
  • the light treatment bag of the present invention is preferably made of ultra-thin, high-transmission ultraviolet light material, including but not limited to ethylene-vinyl acetate copolymer (EVA) material, which ensures ultraviolet light irradiation efficiency and makes ultraviolet light effective during illumination treatment. Inactivate all types of pathogens.
  • EVA ethylene-vinyl acetate copolymer
  • the blood bag of the present invention is preferably sterilized.
  • the blood bag sterilization process can adopt the method of canning after the whole sterilization, when the core is
  • the flavin supplement is powdered riboflavin
  • the blood bag sterilization treatment can adopt an integral sterilization treatment method.
  • the blood product processing box of the present invention is further provided with a finished bag placing part for placing the finished bag.
  • a finished bag placement component may be a hook, a tray, a support net, or the like.
  • the riboflavin-based photochemical blood product processing system of the present invention further includes a thermostatic component.
  • the thermostatic component comprises a heating device (such as a heater), a cooling device (such as a refrigerating gas fan), and a thermometer.
  • the thermostatic unit can control the temperature inside the box, and the temperature of the plasma after entering the device and the temperature of the treated plasma are ensured to ensure that the plasma is always controlled in the range of about 4 ⁇ 2°C from the entry to the outflow temperature, and the platelet is always controlled from the inflow to the outflow temperature. In the range of about 22 ⁇ 2 ° C.
  • the riboflavin-based photochemical blood product processing system of the present invention further includes a control panel, and the control panel is communicatively coupled to the telescopic device and the multi-directional rocking device.
  • the control panel comprises a liquid crystal display screen and an operation button, and the liquid crystal display screen displays a processing state, a temperature inside the box, a processing time, and the like, and the operation buttons include a power button, an input button, a setting button, and the like. It can realize the entry and exit of the tray and the processing time of the control.
  • the riboflavin photochemical blood product processing system of the present invention further comprises a bar code printing device, a scanning code device and a weighing device.
  • the bar code printing device, the scanning code device and the weighing device are preferably a bar code printer, a scanning code gun and a scale, and the management of the illuminated blood products is facilitated by weighing, printing the bar code, pasting the bar code and scanning the bar code.
  • the blood product processing chamber is provided with 2-10 light processing bag trays, more preferably 6-8 light processing bag trays.
  • the blood product processing system device comprises 1-10 blood product processing cabinets, for example 4-6.
  • the boxes processed by the blood products may be arranged vertically or horizontally.
  • the blood product processing box communication connection is used for recording the running status of the device and related information of all blood products processed by the device (such as blood product number, weight, processor, processing time), and according to requirements
  • the record information is linked to the record of the blood product in the LIS system.
  • the blood product processing system may be provided with 4-8 light processing bag trays or the blood product processing system comprising 2-5 layers of blood product processing boxes.
  • the body, wherein each light processing bag tray can be operated separately, respectively controls the entry and exit, does not affect the operation of other layers, realizes continuous operation all the time without interruption, and maximizes the utilization efficiency.
  • Still another aspect of the present invention provides a blood product processing apparatus including at least one blood product processing box, wherein the inside of the box is provided with an ultraviolet lamp and a light processing bag tray, and the ultraviolet lamp is located on the upper and lower sides of the box body.
  • the light processing bag tray is disposed in a middle portion of the box body, and the light processing bag tray includes a horizontally disposed frame.
  • the horizontally disposed bezel of the present invention is provided with a light treatment bag fixing member.
  • the light treatment bag fixing member is selected from one of a clip, a hook, a snap, or a combination of two or more.
  • the light processing bag tray of the present invention further includes a quartz plate, the quartz plate being embedded in the frame.
  • the telescopic device is arranged between the box body and the tray according to the present invention; the tray is provided with a multi-directional rocking device.
  • the ultraviolet lamp and the box body of the present invention are connected by a distance adjusting arm.
  • the package body of the present invention is further provided with a finished bag placement component.
  • the blood product processing box of the present invention is further provided with a thermostatic member.
  • the blood product processing apparatus of the present invention further includes a control panel, and the control panel is communicatively coupled to the telescopic device and the multi-directional rocking device.
  • the blood product processing apparatus of the present invention further includes a bar code printing device, a scanning code device, and a weighing device.
  • the blood product processing apparatus of the present invention comprises one, two, three, four, five or six tanks, and the casing is provided with 2-10 light processing bag trays.
  • Blood products of the invention include whole blood, plasma, platelets or other blood products.
  • the blood product processing system of the invention can effectively inactivate various pathogens (such as bacteria, viruses, protozoa, etc.) and lymphocytes, does not need to remove additives after inactivation treatment, and has no toxicity and side effects, and is simple in operation and safety.
  • pathogens such as bacteria, viruses, protozoa, etc.
  • lymphocytes does not need to remove additives after inactivation treatment, and has no toxicity and side effects, and is simple in operation and safety.
  • Higher, at the same time increase the constant temperature maintenance system, control the blood products in the most suitable temperature range, and operate the inactivation process through the automated system, which can more easily and effectively observe and control the processing status of blood products, realize automation and intelligence. Operational process
  • FIG. 1 is a schematic view showing the structure of a riboflavin photochemical blood product processing system of the present invention.
  • FIG. 2 is a schematic view showing the structure of a blood product processing system having three boxes placed in a horizontal row according to the present invention.
  • FIG. 3 is a schematic view showing the structure of a blood product processing system having four light processing bag trays placed vertically in the present invention.
  • FIG. 4 is a schematic view showing the structure of a blood bag of the riboflavin photochemical blood product processing system of the present invention.
  • Figure 5 is a schematic view showing the structure of a blood bag of a riboflavin photochemical blood product processing system having a finished bag of the present invention (two-piece bag).
  • Fig. 6 is a schematic view showing the structure of a blood bag of a riboflavin photochemical blood product processing system having a finished bag according to the present invention (two-piece bag).
  • Figure 7 is a schematic view showing the structure of a blood bag of a riboflavin photochemical blood product processing system having three finished bags according to the present invention (four-piece bag).
  • 901-blood entry tube 902-light treatment bag, 903-riboflavin add-on, 904-needle, 905-stop clip, 906-finished product Bag, 907-connected tube, 911-hard board, 912-fixed hole.
  • a blood product processing system based on the riboflavin photochemical method of the present invention, comprising a virus inactivating box 100, an ultraviolet lamp 200, and an ultraviolet 200 lamp located on the upper and lower sides of the casing 100, and the casing 100 passing through the adjusting arm 201 connection, the distance between the UV lamp and the light bag can be adjusted, and the UV lamp 200 is arranged in the form of UVA combined with UVB.
  • the horizontally disposed bezel 301, the light processing bag fixing member 302 disposed at the four corners of the bezel 301, and the quartz plate 305 inlaid with the bezel 301 constitute a light processing bag tray.
  • a telescopic device 303 is disposed between the casing 100 and the tray, and the tray can be expanded and contracted into and out of the casing 100.
  • a multi-directional rocking device 304 is connected to the tray, and the tray is gently oscillated and oscillated after being opened, so that the blood products in the light processing bag 902 are uniformly irradiated.
  • a finished bag placement component 400 is also disposed within the cabinet 100 for receiving the finished bag 906 that is coupled to the light processing bag.
  • the cabinet 100 is also provided with a thermostatic component, including a thermostatic fan 502 and a thermometer 501 for controlling the temperature inside the cabinet.
  • FIG. 2 is a blood product processing system with three boxes placed in a horizontal row according to the present invention, comprising three boxes 100, each of which is provided with a box door 102, a display screen 601, and an operation button 602.
  • the display screen 601 and the operation button 602 constitute a control panel.
  • the control panel is communicably connected with the telescopic device 303 and the multi-directional rocking device 304 in the cabinet.
  • the operation button 602 is controlled to control the ingress and egress of the tray and the processing time.
  • each box 100 is connected with a barcode printer 701, a code scanner 702 and a scale 703.
  • the three boxes 100 are finally connected to the computer 800 for recording blood inactivation operation information.
  • the light processing bag tray 300 is provided with an ultraviolet lamp 200 on each of the light processing bag trays, and each of the light processing bag trays 300 is correspondingly provided with a box door 102 and a control panel 300, and each control panel 300 individually controls the ingress and egress of the tray.
  • the blood bag 901 is a blood bag of the riboflavin photochemical blood product processing system of the present invention, including a blood inlet tube 901, a light treatment bag 902, and a riboflavin addition member 903.
  • the blood inlet tube 901 is disposed at the top of the light treatment bag 902 and is irradiated with light.
  • the bag 902 is connected, and the riboflavin additive 903 is disposed at the top of the light treatment bag 902 and connected to the light treatment bag 902 via a frangible member, and the riboflavin additive 903 is filled with a riboflavin sodium phosphate liquid.
  • a needle 904 is disposed at the top of the blood inlet tube 901, and a stop clip 905 is sandwiched between the blood inlet tubes.
  • the four corners of the top edge and the bottom edge of the light processing bag 902 are provided with a connecting portion hard plate 911 and a fixing hole 912.
  • the blood When the blood product needs to be treated, the blood is transported into the light treatment bag 902 through the blood inlet tube 901, and the easy-folding member is broken, so that the riboflavin sodium liquid in the riboflavin additive 903 is mixed with the blood in the light treatment bag 902. .
  • the blood bag is placed in the tray, and the four corners of the light treatment bag 902 are fixed on the light treatment bag fixing member 302 to make the light processing bag 902
  • the parallel ultraviolet lamp 200 When the parallel ultraviolet lamp 200 is placed, the ultraviolet light line can be irradiated on both sides of the light treatment bag 902 without blocking, and the virus is killed.
  • FIG. 5 and 6 show a blood bag of a riboflavin photochemical blood product processing system having a finished bag of the present invention, usually a double bag for plasma or platelets.
  • the blood bag includes a blood inlet tube 901, a light treatment bag 902, and a riboflavin additive 903.
  • the top edge and the bottom edge of the light treatment bag 902 are provided with fixing holes 912 and/or a hard plate 911 at four corners.
  • the bottom end of the processing bag 902 is connected to a finished bag 906 through a communication pipe 907, and a flow stop clip 905 may be disposed on the communication pipe 907.
  • the riboflavin additive 903 shown in FIG. 5 is disposed on the blood inlet tube 901.
  • the blood is transported into the light treatment bag 902 through the blood inlet tube 901, and the blood flow is performed.
  • the riboflavin additive 903 on the tube 901 the riboflavin sodium phosphate powder therein simultaneously flows into the light treatment bag 902 to be mixed with the blood.
  • the advantage of the design of Figure 5 is that the sterilization process is easier to handle during the production process because the powder is resistant to high temperatures.
  • the riboflavin additive 903 shown in FIG. 6 is disposed at the top of the light treatment bag 902, and is connected to the light treatment bag 902 through a fragile member.
  • the blood bag When the blood bag is used for pathogen or lymphocyte inactivation, the blood enters the tube 901. The blood is transferred into the light treatment bag 902, and the easy-folding member is broken, so that the riboflavin sodium liquid in the riboflavin additive 903 is mixed with the blood in the light treatment bag 902.
  • the advantage of the design of Figure 6 is that it is more suitable for liquid riboflavin, which can improve the problem of incomplete dissolution of powdered riboflavin.
  • Figure 7 is a blood bag of a riboflavin photochemical blood product processing system having three finished bags of the present invention, usually a quadruple bag for whole blood.
  • the blood bag includes a blood inlet tube 901, a light treatment bag 902, and a riboflavin additive 903.
  • a fixing hole 912 is provided at four corners of the top edge and the bottom edge of the light processing bag 902.
  • the bottom end of the light treatment bag 902 is connected to one or three finished bags 906 through a communication pipe 907, and a flow stop clip 905 is disposed on the communication pipe 907, respectively.
  • the blood When the blood bag is used for inactivation of the pathogen or lymphocytes, the blood is transported into the light treatment bag 902 through the blood inlet tube 901, and the easy-folding member is broken, so that the riboflavin sodium liquid in the riboflavin additive 903 is treated with light.
  • the bag 902 is mixed with blood.
  • the light treatment bag fixing member is passed through the fixing hole 22, and the finished bag 906 is placed at the finished bag placing member 400, so that the blood bag is horizontally fixed and subjected to ultraviolet light inactivation treatment.
  • the flow stop clip 905 on the communication tube 907 is released to allow blood to enter the finished bag 906.

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

L'invention concerne un système de traitement de produit sanguin sur la base d'un traitement photochimique à la Riboflavine, comprenant au moins une boîte de traitement de produit sanguin (100) et une poche de sang, une lampe à ultraviolets (200) et un plateau de poche à traiter par éclairement (300) étant agencés, respectivement, sur la partie supérieure et sur la partie inférieure à l'intérieur de la boîte (100) ; et la poche de sang comprend un tube d'entrée de sang (901), une poche à traiter par éclairement (902), un dispositif d'ajout de Riboflavine (903) et une poche de produit fini (906). Ce système de traitement de produit sanguin peut inactiver efficacement divers pathogènes et lymphocytes, sans l'enlèvement de l'additif après le traitement d'inactivation. Ce système très sûr et de fonctionnement simple ne présente pas d'effets toxiques ni secondaires, possède un système de température constante qui peut commander la température du produit sanguin afin que celle-ci se situe à l'intérieur d'une plage de températures optimales, et peut désactiver la procédure de traitement par l'intermédiaire de fonctionnements automatisés du système.
PCT/CN2017/071038 2016-02-02 2017-01-13 Système de traitement de produit sanguin sur la base d'un traitement photochimique à la riboflavine Ceased WO2017133422A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201610070102.XA CN105561359B (zh) 2016-02-02 2016-02-02 一种基于核黄素光化学法的血液制品处理系统
CN201620100929.6 2016-02-02
CN201620100930.9U CN205322836U (zh) 2016-02-02 2016-02-02 一种基于核黄素光化学法的血液制品处理设备
CN201620100929.6U CN205549056U (zh) 2016-02-02 2016-02-02 一种用于核黄素光化学法的血袋
CN201610070102.X 2016-02-02
CN201620100930.9 2016-02-02

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544296A (zh) * 2020-06-18 2020-08-18 四川省人民医院 一种血液制品光能保藏袋
CN112270389A (zh) * 2020-10-22 2021-01-26 贵州省生物技术研究所(贵州省生物技术重点实验室、贵州省马铃薯研究所、贵州省食品加工研究所) 一种基于大数据处理的食品安全检测设备及其使用方法

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