WO2017142265A1 - Composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité de la peau - Google Patents

Composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité de la peau Download PDF

Info

Publication number
WO2017142265A1
WO2017142265A1 PCT/KR2017/001528 KR2017001528W WO2017142265A1 WO 2017142265 A1 WO2017142265 A1 WO 2017142265A1 KR 2017001528 W KR2017001528 W KR 2017001528W WO 2017142265 A1 WO2017142265 A1 WO 2017142265A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
composition
adipic acid
elasticity
lotion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2017/001528
Other languages
English (en)
Korean (ko)
Inventor
박태선
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Yonsei University
Original Assignee
Industry Academic Cooperation Foundation of Yonsei University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Yonsei University filed Critical Industry Academic Cooperation Foundation of Yonsei University
Publication of WO2017142265A1 publication Critical patent/WO2017142265A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a composition for improving skin wrinkles and elasticity containing adipic acid as an active ingredient, and more particularly, to a cosmetic composition for improving wrinkles or enhancing elasticity containing adipic acid as an active ingredient, an external preparation for skin, food
  • the present invention relates to a method for improving skin wrinkles or enhancing skin elasticity using a composition and a composition comprising a pharmaceutical composition and adipic acid as an active ingredient.
  • the skin is composed of three layers: epidermis, dermis and hypodermis.
  • the epidermis especially the stratum corneum, which is the outermost layer of the epidermis, acts as a skin barrier, preventing the loss of moisture and electrolyte from the skin.
  • the dermal layer plays a role in maintaining the elasticity of the skin and supporting the structure through collagen and elastin synthesis.
  • collagen and elastin are major proteins produced in fibroblasts and are involved in skin mechanical firmness, tissue binding strength and elasticity.
  • Collagen forms various isoforms according to the form and structural features, and there are 28 kinds of collagen isotypes in human tissues. Among them, collagen is present in types 1, 3. 4. 6. 7. 13, 14, 17 and the like are known. Collagen types 1 and 3 make up the interstitial components of the dermal layer, and collagen type 7 is the major component of the dermal and epidermal junctions.
  • Type 1 collagen is the largest amount of extracellular matrix protein in skin connective tissue, and other proteins such as elastin, fibronectin, integrin, fibrin, and proteoglycan are present.
  • the newly synthesized procollagen is hydroxylated at the proline and lysine amino acid residues and is secreted into the extracellular space in the form of three strands of twisted helix.
  • procollagen is cut off at both ends by procollagen proteinase to form collagen protein, and the latter form microfibrils of triple helix configuration, and microfibrils are leucine-rich small proteoglycans.
  • the fibrils thus formed form collagen fibers that provide skin binding and elasticity.
  • Skin aging is known to decrease collagen content, a protein that accounts for most of the collagen of skin dermis. Collagen decreases the skin's tension and strength. have. Skin aging is largely divided into endogenous aging due to physiological aging and photoaging caused by continuous ultraviolet radiation (UV) exposure. Repeated ultraviolet exposure results in increased collagen degrading enzymes and causing denaturation and destruction of collagen fibers, reducing the elasticity of the skin and promoting the production of wrinkles.
  • UV continuous ultraviolet radiation
  • the present inventors also conducted research to develop a food or cosmetic material that is effective in improving wrinkles by inhibiting the action of collagen degrading enzymes in natural products with few side effects and promoting collagen synthesis.
  • adipic acid which has been used only for the use of acidity regulators until now, has the effect of enhancing skin elasticity and alleviating skin wrinkles, and completed the present invention.
  • the present inventors have completed the present invention by developing a cosmetic composition, skin external preparation, food and pharmaceutical compositions for improving wrinkles or skin elasticity containing adipic acid as an active ingredient.
  • an object of the present invention is to provide a cosmetic composition, skin external composition, food composition and pharmaceutical composition for improving wrinkles or enhancing skin elasticity containing adipic acid as an active ingredient.
  • Still another object of the present invention is to provide a method for improving skin wrinkles or improving skin elasticity using a composition containing adipic acid as an active ingredient.
  • the present invention provides a cosmetic composition for improving wrinkles containing adipic acid as an active ingredient.
  • adipic acid may be included in 0.0001 to 20% by weight based on the total weight of the cosmetic.
  • the composition of the present invention has at least one effect selected from the group consisting of increased procollagen secretion, promoting collagen biosynthesis, reducing the expression of the MMP-1 gene and inhibiting the formation of skin stratum corneum. It may be to have.
  • the cosmetic of the present invention skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream , Essence, Pack, Mask Pack, Mask Sheet, Soap, Shampoo, Cleansing Foam, Cleansing Lotion, Cleansing Cream, Body Lotion, Body Cleanser, Latex, Press Powder, Loose Powder and Eye Shadow have.
  • composition of the present invention may further comprise a cosmetically acceptable carrier.
  • the composition of the present invention may further comprise a skin wrinkle improvement component or skin elasticity enhancing component.
  • the skin wrinkle improvement component or skin elasticity enhancing component may be specifically selected from the group consisting of vitamin C, retinoic acid, TGF, protein from animal placenta, betulinic acid and chlorella extract.
  • the present invention also provides a skin external composition for improving wrinkles containing adipic acid as an active ingredient.
  • the present invention also provides a food composition for improving wrinkles containing adipic acid as an active ingredient.
  • the food of the present invention may be prepared in any one formulation selected from the group consisting of tablets, granules, powders, capsules, liquid solutions and rings.
  • the present invention also provides a pharmaceutical composition for improving wrinkles containing adipic acid as an active ingredient.
  • the present invention also provides a cosmetic composition for enhancing skin elasticity, a skin external preparation, a food composition and a pharmaceutical composition containing adipic acid as an active ingredient.
  • the present invention also provides a method for improving skin wrinkles or improving skin elasticity using a composition containing adipic acid as an active ingredient.
  • adipic acid may be included in 0.0001 to 20% by weight based on the total weight of the composition.
  • the composition of the present invention has at least one effect selected from the group consisting of increased procollagen secretion, promoting collagen biosynthesis, reducing the expression of the MMP-1 gene and inhibiting the formation of skin stratum corneum. It may be to have.
  • the composition may be the cosmetic composition, the skin external composition, the food composition or the pharmaceutical composition.
  • the present invention provides a cosmetic composition, skin external composition, food composition and pharmaceutical composition for improving wrinkles or improving elasticity containing adipic acid as an active ingredient.
  • the composition containing adipic acid has an effect of increasing the amount of procollagen secretion, promoting collagen biosynthesis, decreasing the expression of the MMP-1 gene and inhibiting skin thickening of the skin epidermis, which is effective in improving skin wrinkles or enhancing skin elasticity.
  • 1 is a graph measuring procollagen secretion in human dermal fibroblasts (-UVB: control group not treated with UVB, + UVB: control group treated with UVB, AA: experimental group treated with adipic acid after irradiation with UVB, VitC: control group treated with vitamin C after UVB irradiation, AA + VitC: experimental group treated with adipic acid and vitamin C after UVB irradiation).
  • Figure 2 is an electrophoresis picture and a graph measuring the amount of procollagen and MMP-1 gene expression in human fibroblasts.
  • Figure 3 is a graph showing the weight gain (A and B) and the dietary intake (C and D) of mice fed the experimental diet.
  • Figure 4 is a graph measuring the water content (A), water evaporation (B), elasticity (C) and erythema index (D) of the mouse skin tissue ingested experimental diet.
  • 5 is a photograph of the back skin tissue of a mouse fed an experimental diet.
  • Figure 6 is a photograph (A) and a graph (B) showing the degree of wrinkle formation of skin tissues, such as mice fed the experimental diet.
  • Figure 7 is a graph (A) and a picture (B) showing the skin thickness of the mouse fed the experimental diet.
  • FIG. 8 is an electrophoretic photograph and graph showing changes in collagen and MMPs gene expression in adipic acid-treated mouse back tissues.
  • FIG. 9 is a graph measuring the elastin gene expression of mouse skin tissues fed an experimental diet containing adipic acid.
  • composition containing adipic acid provided by the present invention has an effect of increasing the amount of procollagen secretion, promoting collagen biosynthesis, decreasing the expression of MMP-1 gene and inhibiting skin thickening of the skin epidermis, thereby improving skin wrinkles or enhancing skin elasticity. .
  • the present invention provides a cosmetic composition for improving wrinkles or enhancing elasticity containing adipic acid as an active ingredient.
  • Adipic acid is a carboxyl compound contained in sugar beet, gambir, and the like; adipic acid, adipic acid, 1,4-butanedicarboxylic acid; 1,6-hexanedioic acid; acifloctin; acinetten; adipinic acid; hexanedioic acid; Also called octafluorohexanedioic acid.
  • Adipic acid of the present invention can be obtained by extraction, separation and purification from various plants including adipic acid.
  • Cas No. 124-04-9 and the adipic acid is a structural formula is C 6 H 10 O 4, and the molecular weight of 146.1 g / mol.
  • the specific structure is shown in the following formula (1).
  • Adipic acid is a combustible material and can be electrostatically charged in dry places by vortexing, air transport, injection and the like. Decomposes to heat to produce corrosive chemical gases and toxic substances containing valeric acid and other substances.
  • Adipic acid is registered as a food additive with the use of "acid regulator" in the Korean Food Code, and is registered as a pH regulator in the Food and Color Additive Database of the US FDA.
  • Adipic acid is added as a yeast acidifier to baking powder and as an acidifier to fruit flavored juices and concentrated powders of bottled drinks. It can also be used to improve the melting properties and texture of processed cheese and cheese spreads.
  • Adipic acid can be added to foam well into products containing egg whites and can be used as a gel generator in jams and jellies.
  • Adipic acid has been added to foods as a buffer and neutralizer, used as a raw material for pharmaceuticals and as a perfume fixative.
  • adipic acid has been reported to be anti-chitogenic and antihypertensive.
  • Adipic acid has been reported to improve ketosis caused by long-chain and short-chain monocarboxylic acids in rats.
  • amlodipine adipate was ingested for eight weeks, resulting in improved blood pressure.
  • adipic acid there is no known effect of adipic acid on improving skin elasticity and reducing skin wrinkles.
  • LD 50 obtained by administration of adipic acid by the method of inhalation, intravenous injection, oral administration, intraperitoneal injection in various kinds of experimental animals is shown in [Table 1] and the weight of 11,000 mg / kg when orally administered to mice Reported as.
  • Adipic Acid Toxicity Report End point Animal species Route of administration Volume Toxic effect Reference TDL0 Rat oral- 140 g / kg / 5 weeks (intermittent) Overexercise, diarrhea, weight loss or weight loss FAO Nutrition Meetings Report Series, 40,1 (1967) LD50 Rat Abdominal cavity 275 mg / kg Drowsiness (overall suppressed activity), other changes, bleeding H.J. Horn et al., Agric. Food Chem, 5: 759-762, 1957. LD50 mouse oral- 1,900 mg / kg Gastrointestinal changes H.J. Horn et al., Agric. Food Chem, 5: 759-762, 1957.
  • adipic acid (2, 20, 200 ⁇ g / ml) and a positive control and negative control compound, there was no obvious abnormality of the chromosome.
  • adipic acid was administered at 3.75, 37.5, and 375 mg / kg / day for 5 consecutive days to evaluate myeloid cell chromosome abnormalities.
  • adipic acid is only partially metabolized after ingestion in the human body and the remainder is excreted in the urine without change. For example, it has been reported that rats receive 0.75 g of adipic acid per day for four weeks and no residues of adipic acid have been detected in tissues sacrificed three days after stopping ingestion. Adipic acid has been reported to be metabolized to succinic acid and acetic acid through beta oxidation, and then to other normal intermediate metabolites. Metabolites detected in urine after ingestion of radioactive adipic acid in fasting rats , Glutamic acid, lactic acid, beta ketoadipic acid and citric acid.
  • adipic acid at low concentrations in particular from 0.001 to 3000 mg / kg, more preferably from 0.001 to 1500 mg / kg, is not very toxic or cosmetic compositions, skin preparations, food compositions or pharmaceutical compositions.
  • adipic acid at low concentrations in particular from 0.001 to 3000 mg / kg, more preferably from 0.001 to 1500 mg / kg, is not very toxic or cosmetic compositions, skin preparations, food compositions or pharmaceutical compositions.
  • the term "improve skin wrinkles or enhance elasticity” means to maintain or enhance the ability to relate to wrinkles and elasticity of the skin.
  • Collagen (collagen) and elastic fiber elastin (collagen) in the dermal layer of the skin is the main protein that plays a role in the skin elasticity, collagen biosynthesis is affected by the internal and external skin.
  • the skin cells are reduced in cell activity due to natural aging, the collagen fibers are reduced, or the active oxygen produced by excessive irradiation of ultraviolet rays or stress as an external factor, the thiol group of the protein (thiol: -SH)
  • the enzyme activity or by increasing the expression of degradation enzymes, such as collagen, elastin, increase the wrinkles of the skin and decrease the elasticity, the skin aging progresses.
  • Adipic acid contained in the cosmetic composition described in the present invention may be included in 0.0001 to 20% by weight relative to the total weight of the cosmetic. Less than 0.0001% by weight of adipic acid in the cosmetics may be a small amount of the effect of improving wrinkles, and more than 20% by weight of adipic acid may exhibit known toxicity.
  • composition of the present invention may have one or more effects selected from the group consisting of increased procollagen secretion, promotion of collagen biosynthesis, decreased expression of MMP-1 gene, and inhibition of stratum corneum formation.
  • the human skin fibroblasts were treated with UV irradiation with drugs to measure the amount of procollagen and procollagen type I C-peptide (PIP) secreted into the extracellular matrix.
  • procollagen secretion was significantly decreased in control cells (+ UVB) irradiated with ultraviolet rays, compared to normal cells (-UVB).
  • the amount of collagen was increased by 18% compared to + UVB).
  • the amount of collagen was significantly increased by 50% compared to the control cells (+ UVB), which was treated with vitamin C (+ 27%) or adipic acid (+ 18%) alone.
  • the values were higher than the amount of collagen observed in one cell (see Figure 1).
  • the expression of collagen type 1 ⁇ 1 and ⁇ 2, and collagen type 3 ⁇ 1 were significantly increased in the adipic acid-intake group compared to the + UVB control group, and MMP-1a and -1b, MMP-3, And MMP-9 gene expression was significantly reduced (see Figure 8), elastin expression was significantly increased (see Figure 9).
  • adipic acid increases collagen protein synthesis in the subcutaneous tissue and inhibits degradation of collagen fibers, thereby alleviating wrinkles caused by UV irradiation.
  • the procollagen and MMP-1 gene expression changes after treatment of the drug in human skin fibroblasts, as shown in Figure 2, adipic acid significantly reduced pro-UV While expression of collagen was significantly increased, MMP-1 gene expression significantly increased by ultraviolet light was significantly decreased.
  • Such gene expression control efficacy of adipic acid was shown to be similar to vitamin C (see Figure 2).
  • the term "cosmetic composition” is a composition comprising the compound, the formulation may be in any form.
  • formulations include cosmetics prepared using the composition, such as nutrition creams, eye creams, massage creams, creams such as cleansing creams, packs, lotions such as nutrient lotions, essences, soft cosmetics, and nutrient cosmetics.
  • powders, foundations, makeup bases, and the like and may be prepared and commercialized in any of these forms to achieve the object of the present invention, and are not limited to the above examples.
  • the cosmetic composition according to the present invention can be formulated by a conventional cosmetic preparation method.
  • the cosmetics of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, pack, mask pack, mask sheet It may be one having a formulation selected from the group consisting of, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder and eye shadow.
  • the cosmetic composition of the present invention may further include a cosmetically acceptable carrier, and it is possible to apply and formulate as needed the usual ingredients to be formulated in general skin cosmetics.
  • the cosmetic composition of the present invention may further include a transdermal penetration enhancer.
  • transdermal penetration enhancer is a composition that allows a desired component to penetrate into the blood vessel cells of the skin at a high absorption rate.
  • phospholipid components, liposome components and the like used in lecithin cosmetics are included, but are not limited to these.
  • oil which can be mainly used as an oil phase component
  • one or more selected from vegetable oil, mineral oil, silicone oil and synthetic oil can be used. More specifically, mineral oil, cyclomethicone, squalane, octyldodecyl myristate, olive oil, Vitis binifera seed oil, macadamia nut oil, glyceryl octanoate, castor oil, ethylhexyl isononanoate, dimethicone Chicon, cyclopentasiloxane, sunflower seed oil and the like can be used.
  • a surfactant may be added to reinforce the emulsifying ability.
  • surfactants may be used conventional surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, phospholipids, and the like, specifically, sorbitan sesquinolate, polysorbate 60 , Glyceryl stearate, lipophilic glyceryl stearate, sorbitan oleate, sorbitan stearate, die-cetyl phosphate, sorbitan stearate / sucrosecoate, glyceryl stearate / polyethylene glycol-100 Stearate, ceteareth-6 oleate, arachidyl alcohol / behenyl alcohol / arachidyl glucoside.
  • Polypropylene glycol-26-butes-26 / polyethylene glycol-40 hydrogenated castor oil and the like can be used.
  • alcohols having 12 to 20 carbon atoms such as cetyl alcohol, stearyl alcohol, octyldodecanol, isostearyl alcohol, etc. may be used alone or in combination of one or more thereof.
  • the aqueous phase component may further add 0.001 to 5% by weight of one or more thickeners such as carbomer, xanthan gum, bentonite, magnesium aluminum silicate, cellulose gum, dextrin palmitate and the like to adjust the viscosity or hardness of the aqueous phase.
  • thickeners such as carbomer, xanthan gum, bentonite, magnesium aluminum silicate, cellulose gum, dextrin palmitate and the like to adjust the viscosity or hardness of the aqueous phase.
  • the cosmetic composition of the present invention if necessary, active ingredients such as higher fatty acids, vitamins, sunscreens, antioxidants (butylhydroxyanisole, propyl gallic acid, elixolic acid, tocopheryl acetate, butylated hydroxy) Toluene), preservatives (methylparaben, butylparaben, propylparaben, phenoxyethanol, imidazolidinylurea, chlorphenesin, etc.), colorants, pH adjusters (triethanolamine, citric acid, citric acid, sodium citrate, malic acid, Sodium malic acid, fmaric acid, sodium pramate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, etc., moisturizers (glycerine, sorbitol, propylene glycol, butylene glycol, hexylene glycol, diglycerin , Betaine, glycerin-26, methylgluse-20 and the like), lubric acid,
  • the cosmetic composition of the present invention further comprises a substance capable of auxiliaryly providing essential nutrients to the skin, and may preferably contain auxiliary agents including, but not limited to, natural flavors, cosmetic flavors, or herbal medicines. have.
  • the cosmetic composition of the present invention may further comprise a skin wrinkle improvement component or skin elasticity enhancing component.
  • the specific skin wrinkle improving component or skin elasticity enhancing component may be any one or more selected from the group consisting of vitamin C, retinoic acid, TGF, protein from animal placenta, betulinic acid and chlorella extract, most preferably Vitamin C.
  • the present invention provides an external composition for improving wrinkles or enhancing elasticity containing adipic acid as an active ingredient.
  • the external preparation composition of the present invention is used for the purpose of improving the wrinkles of the skin, preventing the formation of wrinkles and delaying them, and is not particularly limited in the formulation thereof.
  • softening water, nourishing cosmetics, massage It may be a cosmetic composition having a formulation of a cream, a nourishing cream, a pack, a mask pack, a mask sheet, a gel or a skin adhesive cosmetic, and may also be a transdermal formulation such as a lotion, an ointment, a gel, a cream, a patch or a spray. have.
  • the present invention provides a food composition for improving wrinkles or enhancing elasticity containing adipic acid as an active ingredient.
  • the food composition of the present invention may be prepared in any one formulation selected from the group consisting of tablets, granules, powders, capsules, liquid solutions and rings.
  • Food composition according to the present invention may be formulated in the form of powder, liquid, tablets, soft capsules, granules, tea bags, instant tea or drink by including adipic acid as an active ingredient.
  • the content of adipic acid as an active ingredient can be suitably determined depending on the purpose of use (prevention or improvement).
  • the amount of adipic acid included in the food composition may be added at 0.1 to 90% by weight of the total food weight. However, in the case of prolonged intake for health and hygiene purposes or health control purposes, the amount may be below the above range.
  • the food composition according to the present invention in addition to adipic acid, other ingredients that can give a synergistic effect to the main effect, preferably within the range of not impairing the main effect of the present invention, such as vitamin C.
  • Wrinkle improvement compounds or natural extracts such as green tea extract, mulberry extract, licorice extract, lettuce extract, betel nut extract, golden extract, wild ginseng extract.
  • the food composition formulated in such a form may be added to the food as it is, or used with other foods or food ingredients, and may be appropriately used according to conventional methods.
  • foods include drinks, meats, sausages, breads, biscuits, rice cakes, chocolate, candy, snacks, confectionery, pizza, ramen, dairy products including other noodles, gums, ice creams, various soups, beverages, alcoholic beverages and vitamin complexes. , Dairy products and dairy products, and all functional foods in the conventional sense.
  • the food composition of the present invention when the food composition of the present invention is a drink, it contains adipic acid as an essential ingredient in the ratio indicated, and there are no particular limitations on other ingredients used for the manufacture of other drinks, and various flavors such as ordinary drinks or Natural carbohydrates and the like may be included as additional components.
  • natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And conventional sugars such as polysaccharides such as dextrin, cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • a natural flavoring agent, a synthetic flavoring agent, etc. can be used as a flavoring agent other than the above-mentioned.
  • the proportion of such natural carbohydrates is generally about 1 to 20 g, preferably about 5 to 12 g per 100 ml of the composition of the present invention.
  • the food composition of the present invention is a variety of nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese, chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like.
  • the food composition of the present invention may contain a pulp for producing natural fruit juice and fruit juice beverage and vegetable beverage. These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected in the range of 0.1 to about 20 parts by weight per 100 parts by weight of adipic acid of the present invention.
  • the present invention provides a pharmaceutical composition for improving wrinkles or enhancing elasticity containing adipic acid as an active ingredient.
  • the compound of the present invention has a skin aging inhibitory effect by inhibiting the cellular aging and the generation of reactive oxygen species by UV, and by promoting the expression of extracellular matrix protein in the skin cells, it is effective in improving wrinkles of the skin, thereby inhibiting skin aging. Or it may be used as a pharmaceutical composition for improving skin wrinkles.
  • the throughput of the pharmaceutical composition for improving wrinkles or enhancing skin elasticity used in the present invention should be a pharmaceutically effective amount.
  • pharmaceutically effective amount refers to an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and an effective dose level may refer to an individual type and severity, age, sex, It can be determined according to the type of virus infected, the activity of the drug, the sensitivity to the drug, the time of administration, the route of administration and the rate of release, the duration of treatment, factors including the drug used concurrently and other factors well known in the medical arts. Effective amounts may vary depending on the route of treatment, the use of excipients, and the possibility of use with other agents, as will be appreciated by those skilled in the art.
  • compositions for improving wrinkles or enhancing skin elasticity of the present invention may be prepared in pharmaceutical formulations using methods well known in the art to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal. Can be.
  • the active ingredient is mixed or diluted with the carrier or enclosed in a carrier in the form of a container.
  • the pharmaceutical composition for improving wrinkles or enhancing skin elasticity of the present invention may be in the form of powder, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, oral formulations, external preparations and patches according to conventional methods. It may be formulated and used further and may further comprise suitable carriers, excipients or diluents commonly used in the manufacture of compositions.
  • carriers, excipients and diluents that may be included in the pharmaceutical composition of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium Phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.
  • diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used.
  • the pharmaceutical composition of the present invention may be added and used in the manufacture of quasi-drugs for the purpose of inhibiting skin aging or skin wrinkle improvement.
  • the pharmaceutical composition of the present invention is used as an quasi-drug additive, the compound may be added as it is or used with other quasi-drug or quasi-drug components, and may be appropriately used according to a conventional method.
  • the mixed amount of the active ingredient may be suitably determined depending on the purpose of use (prevention, health or therapeutic treatment).
  • the quasi-drug may be a disinfectant cleaner, shower foam, gagreen, wet tissue, detergent soap, hand wash, humidifier filler, mask, ointment, coating agent or filter filler.
  • the present invention also provides a method for improving skin wrinkles or improving skin elasticity using a composition containing adipic acid as an active ingredient.
  • Example One Human skin fibroblasts Wrinkle improvement effect of adipic acid
  • Normal human dermal fibroblasts (neonatal foreskin) were purchased from ATCC (Manassas, VA, USA) and used. The purchased cells were incubated in a 37%, 5% CO 2 incubator using a fibroblast growth medium (Promo Cell, Heidelberg) and used for the experiment.
  • human fibroblasts were dispensed in 12 well-plates at 1.0 ⁇ 10 6 cells / well, and adipic acid and vitamin C were added at a concentration of 100 ⁇ M and incubated in a CO 2 incubator for 24 hours. After removing the medium of each well, washed once with PBS, and again put 1 ml of PBS and irradiated with ultraviolet B (UVB) at 20 mJ / cm 2 conditions. PBS of each well was replaced with medium again and cultured for 24 hours, and then the amount of procollagen secreted into the medium was measured using a procollagen type I C-peptide EIA kit (Takara bio, Japan). The standard solution included in the collagen measurement kit was diluted by concentration, and the absorbance was measured at 450 nm to prepare a standard concentration curve and calculate the amount of collagen produced.
  • UVB ultraviolet B
  • UV / VIS spectrophotometer (Beckman coulter, DU730) was used to measure the concentration of RNA samples extracted at 260 nm and 280 nm wavelength, and agarose gel electrophoresis was performed to determine the integrity of the RNA samples (integrity) Confirmed.
  • RNA samples extracted from human skin fibroblasts were synthesized by oligonucleotide dT primers and superscript reverse transcriptase (GIBCO BRL, Gaithersburg, MD, USA) to perform global death.
  • PCR was performed using the 5D and 3 'flanking sequences of the gene cDNA to be amplified as a template and the cDNA obtained through reverse transcription.
  • the primer sequences used are shown in [Table 2]. As shown. 1 ⁇ l of the amplified PCR product was electrophoresed on a 1% agarose gel to confirm DNA bands.
  • Primer sequences used for RT-PCR gene primer Sequence (5 ' ⁇ 3') Annealing Temperature (°C) PCR product (bp) SEQ ID NO: Procollagen F TCTTCAAGCCATCCTGTGTG 60 168 One R GCGAGTCTGTGTTTTTGCAG 2 Metalloproteinase 1 (MMP-1) F ATGACATGAGTCCGGAGCAA 60 122 3 R TCATCTCCTGGGTCCCTTTC 4 Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) F GTGATGGCATGGACTGTGGT 55 203 5 R GGAGCCAAAAGGGTCATCAT 6
  • Collagen the main protein constituting the skin, is synthesized in the form of procollagen from fibroblasts present in the dermis and then secreted into the extracellular matrix.
  • Procollagen secreted into the extracellular matrix is cleaved at the C-terminus by the procollagen peptidase present on the cell surface and formed into active collagen, so the activated collagen content can be determined by measuring the C-peptide content.
  • PIP procollagen type I C-peptide
  • Collagen content was 18 compared to control cells (+ UVB) irradiated with UV only in cells treated with adipic acid with UV irradiation. % Increased significantly.
  • the amount of collagen was increased by 50% compared to the control cells (+ UVB), which was treated with vitamin C (+ 27%) or adipic acid (+ 18%) alone. It is higher than the amount of collagen observed in one cell (see Figure 1). Therefore, adipic acid increases the amount of collagen in human skin fibroblasts, and it can be seen that this collagen increase effect is more effective when used with vitamin C.
  • adipic acid significantly increased the expression of procollagen which was significantly reduced by UV light.
  • MMP-1 gene expression significantly increased by UV light decreased significantly.
  • Such gene expression control efficacy of adipic acid was shown to be similar to vitamin C (see Figure 2). Therefore, adipic acid may not only increase procollagen synthesis in UV-irradiated human skin fibroblasts, but also inhibit MMP-1 expression and ultimately contribute to the increase in collagen content closely related to skin wrinkles.
  • mice Five-week-old female albino hairless mice (SKH-1) used in this experiment were purchased from Orient Bio (Gyeonggi-do, Korea) and subjected to a one-week adaptation period with solid feed. Experimental animals were divided into 4 groups and 4 animals were used for each group. All experimental groups were divided into the normal control group (-UVB), the ultraviolet irradiation group (+ UVB), and the intake of adipic acid (AA) or vitamin C (VitC) together with ultraviolet irradiation. Feed and water were freely ingested during the breeding period, and the temperature was maintained at 22 ⁇ 1 ° C and humidity at 60 ⁇ 5%, and the photoperiod and dark cycle were adjusted to 12 hours daily.
  • -UVB normal control group
  • AA adipic acid
  • VitC vitamin C
  • the -UVB and + UVB groups consumed a tablet diet prepared according to the AIN-93 rat diet (Reeves, PG et al., J Nutr, 123: 1939-1951, 1993).
  • the composition of the detailed experimental diet is shown in [Table 3]. The diet was fed with water between 10 am and 11 am daily, and dietary intake was measured daily.
  • UVB Ultraviolet B
  • the UV irradiation dose was 73 mJ / cm 2 for the first week, 146 mJ / cm 2 for the second week, and 219 from 3 to 13 weeks It was investigated at mJ / cm 2 .
  • body weight and skin thickness were measured and back skin photographs were taken every week. Skin thickness was measured by the hip portion of hairless mice using a digital micro caliper (Marathon Watch Company Ltd, Ontario, Canada). The caliper used in the measurement was able to measure up to 0.01 mm, and it was able to measure the thickness of the skin under the same force with the adjustment function to apply a constant force to the thickness.
  • the animals were anesthetized and blood was collected and used for hematological analysis. Some of the dorsal skin tissues were cut and stored in the freezer, and some were used for molecular biological tests. Fixed to and used for immunohistochemical staining.
  • the skin of the hairless mice irradiated with ultraviolet rays for 13 weeks was made with silicone rubber to measure the extent of wrinkle formation.
  • Fabrication temperature of the replica plate was carried out in a constant temperature and humidity condition of 20 ⁇ 23 °C, humidity 45 ⁇ 50%, was used a silicon plate rubber impression material (Epigem, Seoul, Korea) for the production.
  • Analysis of the simulated platen was performed using a computer image analyzer (Visioline VL650, CK electronic GmbH, Germany) for total wrinkle area, maximum wrinkle depth, mean depth and mean wrinkles.
  • Four wrinkle indicator items such as mean length were analyzed.
  • mice The back skin tissue of hairless mice was extracted, fixed in 10% formalin, and stained with hematoxylin and eosin (H & E). Observations were made using a fluorescence microscope (ECLIPSE E600, Nikon, Japan), and photographs were taken using a digital camera (DXM 1200F, Nickon, Japan).
  • the tissue was pulverized by adding 1 ml of Trizol solution per 0.1 g of back skin tissue, and then centrifuged at 4 ° C. and 12,000 ⁇ g for 10 minutes. The supernatant was transferred to a new tube and 200 ⁇ l of chloroform was added and vortexed. This process was repeated twice, after which the supernatant was transferred to a new tube, and isopropanol and supernatant were added in a 1: 1 ratio.
  • UV / VIS spectrophotometer (Beckman coulter, DU730) was used to measure the concentration of RNA samples extracted at 260 nm and 280 nm wavelength, and agarose gel electrophoresis was performed to confirm the integrity of the RNA samples (integrity) It was.
  • CDNA was synthesized by performing reverse transcription using oligo dT primer and superscript reverse transcriptase (GIBCO BRL, Gaithersburg, MD, USA). PCR was performed using the cDNA obtained through reverse transcription as a template and 5 'and 3' flanking sequences of the gene cDNA to be amplified as primers, and the primer sequences used were shown in [Table 4]. As shown. 1 ⁇ l of the amplified PCR product was electrophoresed on a 1% agarose gel to confirm DNA bands.
  • UV irradiation, adipic acid and vitamin C intake did not have a significant effect on the weight and dietary intake of hairless mice mice (see Figure 3).
  • AA adipic acid-ingested group
  • the skin of the back skin of the hairless mice irradiated with UV light for 13 weeks was prepared by using a silicone rubber to measure the extent of wrinkle formation.
  • the + UVB control group was thicker and deeper than the normal group (-UVB). It was observed that the fine wrinkles were formed, and the adipic acid intake group showed a significant improvement in the thickness and depth of the wrinkles, although the deep wrinkles were almost disappeared compared to the + UVB control group despite the UV irradiation of the same intensity. (See Figure 6).
  • the AA group had a total wrinkle area of 38%, a maximum wrinkle depth of 45%, an average wrinkle depth of 18%, and an average wrinkle in comparison with the + UVB group.
  • the length was significantly decreased by 37%, and the wrinkle improvement effect of adipic acid was similar to the wrinkle improvement effect observed in vitamin C (see FIG. 7B). Therefore, it can be seen that the intake of adipic acid significantly inhibits wrinkle formation by ultraviolet irradiation.
  • the adipic acid-ingested group was found to have a significant 24% reduction in skin thickness compared to the + UVB control group.
  • the + UVB control group showed thickening of the skin epidermal layer compared to the normal group (-UVB) that was not irradiated with ultraviolet rays. It was confirmed that the thickness of the thickened epidermal layer was significantly reduced compared to the control (see Fig. 7B).
  • Collagen types 1 and 3 are proteins that constitute the cytoplasmic components of the dermal layer, and in particular, type 1 collagen is present in the largest amount of extracellular matrix proteins present in skin connective tissue.
  • MMPs that catalyze collagen breakdown in mammals
  • MMP types known to increase by ultraviolet rays are known as Nos. 1, 3, and 9.
  • MMPs enzymes that degrade collagen types 1 and 3.
  • MMP-1 cuts the middle of collagen fibers
  • MMP-3 and MMP-9 are known to play a role in subdividing and cutting the cut collagen fibers.
  • the expression of collagen types 1 ⁇ 1 and ⁇ 2 and collagen type 3 ⁇ 1 in the skin tissues was significantly reduced compared to the normal group (-UVB), which was not irradiated with UV rays, and MMP-1a and -1b, MMP-3, and MMP-9 gene expression was significantly increased.
  • the expression of collagen type 1 ⁇ 1 and ⁇ 2 and collagen type 3 ⁇ 1 were significantly increased compared to the + UVB control group, and the expression of MMP-1a and -1b, MMP-3, and MMP-9 genes was significantly increased. Decreased (see Figure 8). Therefore, adipic acid is thought to mitigate wrinkle formation by UV irradiation by increasing collagen protein synthesis in the subcutaneous tissue and inhibiting collagen fiber degradation.
  • composition of the nutrition cream containing adipic acid was prepared as shown in Table 5 below. At this time, the unit of component content is weight%.
  • components 1 to 8 are first dissolved by heating at a temperature of 70 ° C, and then components 9 to 13 are dissolved and dispersed in component 14 and emulsified in heating to 70 ° C. . Thereafter, the emulsified product was cooled to a temperature of 56 ° C., and then component 15 dissolved in the fractionated component 9 was added thereto, stirred, and cooled to room temperature to prepare.
  • the comparative example for the formulation example, except for the component 15, adipic acid, except for the component composition or the manufacturing method was set to proceed in the same manner.
  • the nutrition cream (test group) of the formulation example was applied to 20 women over 20 years of age.
  • the nutritional cream of the comparative formulation was continuously used once a day for 12 weeks.
  • the anti-wrinkle effect of the nutritional cream of the formulation example was relatively evaluated based on the nutritional cream of the comparative formulation. This phenomenon was evaluated. The evaluation was performed based on the five-point method of very good (5 points), excellent (4 points), moderate (3 points), bad (2 points), very bad (1 point), and the results are shown in Table 6 below. Indicated. In Table 6, the skin irritation indicates the degree of no skin irritation.
  • the skin stimulation evaluation score for the cosmetic composition of the formulation example according to the present invention was evaluated very good as 4.40, confirming that the skin stimulation degree is low, as in Comparative Formula 4, the skin safety is excellent.
  • Table 6 the skin stimulation evaluation score for the cosmetic composition of the formulation example according to the present invention was evaluated very good as 4.40, confirming that the skin stimulation degree is low, as in Comparative Formula 4, the skin safety is excellent.
  • the relative skin wrinkle improvement effect of the cosmetic composition of the formulation example compared to the formulation comparative example was found to be very excellent in the degree of improvement to an evaluation score of 4.55.
  • the dermis is composed of collagen (collagen) and elastin (elastic fiber), of which collagen fibers form skin tension and structural integration, and elastin fibers are involved in skin elasticity. This means that the extracellular matrix is contracted due to the decrease in number and the amount of collagen and elastin.
  • the present inventors confirmed the degree of elastin gene expression in mouse skin tissues according to the method described in Example 2.
  • the primer set for elastin gene amplification the sequence of the following [Table 7] was used.
  • the present invention provides a cosmetic composition containing adipic acid as an active ingredient.
  • the cosmetic composition according to the present invention has no skin side effects, and is very useful for improving wrinkles of the skin because of its excellent anti-wrinkle effect, collagen synthesis effect, and collagenase expression inhibiting effect. It is believed that the composition containing adipic acid of the present invention may be used as a material for functional cosmetics or health functional foods in the future.
  • a flexible lotion containing adipic acid as an active ingredient was prepared according to a conventional method.
  • Adipic Acid 0.1 Glycerine 3.0, Butylene Glycol 2.0, Propylene Glycol 2.0, Carboxyvinyl Polymer 0.1, Ethanol 10.0, Triethanolamine 0.1, Preservative, Trace Color, Tracer, and Trace Residue
  • a nutritious cream containing adipic acid as an active ingredient was prepared according to a conventional method. Component content is described in weight percent.
  • Adipic acid 0.1 beeswax 10.0, polysorbate 60 1.5, sorbitan sesquioleate 0.5, liquid paraffin 10.0, squalane 5.0, caprylic / capric triglyceride 5.0, glycerin 5.0, butylene glycol 3.0, propylene glycol 3.0, Triethanolamine 0.2, preservatives, trace pigments, trace fragrances and trace purified water
  • a mask pack composition containing adipic acid as an active ingredient was prepared according to a conventional method. Component content is described in weight percent.
  • a mask pack product was prepared by impregnating the prepared mask pack composition into a nonwoven fabric (width x length, 10 ⁇ 10 cm).
  • tablets were prepared by tableting according to a conventional method for producing tablets.
  • the capsule was prepared by filling in gelatin capsules according to the conventional method for producing a capsule.
  • Adipic acid 150 mg of the present invention is Adipic acid 150 mg of the present invention
  • the functional food composition containing adipic acid was prepared by the conventional liquid preparation method with the same composition as the respective preparation examples.
  • the final volume is 100 ml in each liquid.
  • This formulation example can be prepared by a conventional production method as well as liquid tablets, powders, granules and the like.
  • Adipic Acid 100 mg, Honey 1500 mg, Vitamin C 50 mg, Vitamin B6 10 mg, Nicotinamide 10 mg, Royal Jelly 80 mg, Preservatives, Fragrance, Microbalance Residue 100 mg

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité et, plus particulièrement, une composition cosmétique, une préparation dermique pour une application externe, et une composition alimentaire, qui contiennent de l'acide adipique utilisé comme principe actif, pour l'atténuation des rides de la peau, et une composition cosmétique, une préparation dermique pour une application externe, et une composition alimentaire, qui contiennent de l'acide adipique utilisé comme principe actif, pour l'amélioration de l'élasticité.
PCT/KR2017/001528 2016-02-15 2017-02-13 Composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité de la peau Ceased WO2017142265A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2016-0017137 2016-02-15
KR1020160017137A KR101721022B1 (ko) 2016-02-15 2016-02-15 아디프산을 유효성분으로 함유하는 피부주름개선 및 피부탄력증진용 조성물

Publications (1)

Publication Number Publication Date
WO2017142265A1 true WO2017142265A1 (fr) 2017-08-24

Family

ID=58497912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/001528 Ceased WO2017142265A1 (fr) 2016-02-15 2017-02-13 Composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité de la peau

Country Status (2)

Country Link
KR (1) KR101721022B1 (fr)
WO (1) WO2017142265A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432284A (zh) * 2022-03-16 2022-05-06 中国农业大学 己二酸在制备抗皮肤光损伤产品中的用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102132817B1 (ko) * 2018-12-07 2020-07-10 조선대학교산학협력단 솔잎 유래의 말론산을 유효성분으로 포함하는 자외선에 대한 피부보호용 조성물
KR20230065584A (ko) 2021-11-05 2023-05-12 재단법인대구경북과학기술원 Ｒｇｄ 함유 엘라스틴 유사 폴리펩타이드 및 줄기세포를 포함하는 상처치유 재생 시 피부 탄력도 개선용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101101808B1 (ko) * 2011-06-01 2012-01-05 연세대학교 산학협력단 아디픽산의 신규한 용도
US20130116189A1 (en) * 2010-06-15 2013-05-09 Sunstar Inc. of Osaka, Japan Retinol-modified collagen, method for producing same, and external composition for skin containing same
KR101318084B1 (ko) * 2011-12-26 2013-10-14 한국콜마주식회사 폴리쿼터늄-51 및 아디프산/네오펜틸글리콜 크로스 폴리머 서스펜션 솔루션을 포함하는 수분산 화장료 조성물
US8568751B1 (en) * 2011-02-17 2013-10-29 Beachbody, LLC Anti-aging cosmeceutical composition
JP2014125432A (ja) * 2012-12-25 2014-07-07 Lion Corp 皮膚貼付剤組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104187702A (zh) * 2014-09-30 2014-12-10 青岛金佳慧食品有限公司 一种延缓皮肤衰老的保健食品

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130116189A1 (en) * 2010-06-15 2013-05-09 Sunstar Inc. of Osaka, Japan Retinol-modified collagen, method for producing same, and external composition for skin containing same
US8568751B1 (en) * 2011-02-17 2013-10-29 Beachbody, LLC Anti-aging cosmeceutical composition
KR101101808B1 (ko) * 2011-06-01 2012-01-05 연세대학교 산학협력단 아디픽산의 신규한 용도
KR101318084B1 (ko) * 2011-12-26 2013-10-14 한국콜마주식회사 폴리쿼터늄-51 및 아디프산/네오펜틸글리콜 크로스 폴리머 서스펜션 솔루션을 포함하는 수분산 화장료 조성물
JP2014125432A (ja) * 2012-12-25 2014-07-07 Lion Corp 皮膚貼付剤組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432284A (zh) * 2022-03-16 2022-05-06 中国农业大学 己二酸在制备抗皮肤光损伤产品中的用途

Also Published As

Publication number Publication date
KR101721022B1 (ko) 2017-03-29

Similar Documents

Publication Publication Date Title
WO2017146414A1 (fr) Composition pour l'hydratation de la peau et atténuation des rides cutanées, contenant du α-terpinéol en tant que substance active
WO2017222317A1 (fr) Composition ayant pour effet d'améliorer l'hydratation de la peau, d'éliminer la kératine cutanée, d'améliorer l'élasticité de la peau, d'inhiber l'érythème, d'atténuer les rides cutanées ou d'atténuer le photovieillissement cutané, contenant une ionone ou un sel de celle-ci comme ingrédient actif
WO2021261975A1 (fr) Extrait végétal comprenant du collagène végétal et de la mucine végétale, et son procédé de préparation
WO2024049120A1 (fr) Composition cosmétique contenant un extrait extrait au moyen d'un solvant eutectique naturel respectueux de l'environnement
WO2020071630A1 (fr) Composition pour améliorer la peau comprenant des extraits de produits naturels
WO2020246766A1 (fr) Composition pour prévenir ou atténuer le vieillissement cutané, contenant un extrait de rhodiola sachalinensis fermenté à l'aide de bovista plumbea
WO2024181725A1 (fr) Centella asiatica rouge fermenté avec monascus et son utilisation
WO2017142265A1 (fr) Composition contenant de l'acide adipique utilisé comme principe actif pour l'atténuation des rides de la peau et l'amélioration de l'élasticité de la peau
WO2018186640A1 (fr) Composition pour réduire les rides de la peau, hydrater la peau, améliorer son élasticité, l'exfolier, inhiber l'érythème ou réduire le photovieillissement cutané, contenant de l'ocimène ou un sel de celui-ci à titre de substance active
WO2017213346A1 (fr) Composition contenant de la diosmine ou son sel comme ingrédient actif et présentant un effet d'amélioration de l'hydratation de la peau, d'exfoliation de la peau, de renforcement de l'élasticité de la peau, d'inhibition de l'érythème, de réduction des rides de la peau, ou de retardement du photovieillissement de la peau
WO2022085858A1 (fr) Composition pour le blanchiment de la peau ou l'amélioration des rides comprenant un extrait de dendropanax morbiferus
WO2016117762A1 (fr) Composition contenant un extrait de groseille à maquereau ou du glutathion
WO2020218890A1 (fr) Composition consistant en un extrait d'actinidia polygama destiné à attenuer des lésions cutanées ou hydrater la peau
WO2018186641A1 (fr) Composition pour réduire les rides de la peau, hydrater la peau, améliorer son élasticité, l'exfolier, inhiber l'érythème ou réduire le photovieillissement de la peau, contenant du pipéronal ou l'un de ses sels à titre de principe actif
WO2018186644A1 (fr) Composition pour réduire les rides cutanées, hydrater la peau, améliorer l'élasticité de la peau, exfolier la peau, inhiber un érythème ou réduire le photovieillissement de la peau, contenant de la jasmone ou un sel de celle-ci en tant que substance active
WO2018186643A1 (fr) Composition pour réduire les rides de la peau, hydrater la peau, améliorer l'élasticité de la peau, exfolier la peau, inhiber l'érythème ou réduire le photo-vieillissement de la peau, contenant de la cinchonine ou un sel de celle-ci en tant que principe actif
WO2017014597A1 (fr) Composition cosmétique permettant d'améliorer le blanchissement de la peau contenant un extrait de graines de schisandra chinensis
WO2021040470A1 (fr) Composition contenant un extrait de lilium hansonii leichtlin ex baker
WO2018186639A1 (fr) Composition pour réduire les rides cutanées, hydrater la peau, améliorer l'élasticité de la peau, exfolier la peau, inhiber les érythèmes ou réduire le photovieillissement de la peau, contenant de l'ionol ou un sel de celui-ci en tant que principe actif
WO2024063587A1 (fr) Composition d'amélioration de la peau contenant, en tant que principe actif, un extrait de feuille d'eryobotrya japonica induisant une activité d'autophagie
WO2023219300A1 (fr) Nouvelle souche de chlorella vulgaris et son utilisation
WO2016003120A1 (fr) Composition de blanchiment comprenant un extrait de scutellaria alpina
KR102212343B1 (ko) 마리안 플럼 추출물을 유효성분으로 함유하는 피부 항노화 및 보습용 조성물
WO2021167269A1 (fr) Composition de blanchiment contenant un extrait de noyau de prune en tant que principe actif
WO2021002642A1 (fr) Composition pour prévenir ou traiter la polyarthrite rhumatoïde, comprenant du venin de serpent

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17753426

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17753426

Country of ref document: EP

Kind code of ref document: A1