WO2017143356A1 - Module à haute température pour système de dépôt d'imprimante biologique 3d - Google Patents

Module à haute température pour système de dépôt d'imprimante biologique 3d Download PDF

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Publication number
WO2017143356A1
WO2017143356A1 PCT/US2017/021270 US2017021270W WO2017143356A1 WO 2017143356 A1 WO2017143356 A1 WO 2017143356A1 US 2017021270 W US2017021270 W US 2017021270W WO 2017143356 A1 WO2017143356 A1 WO 2017143356A1
Authority
WO
WIPO (PCT)
Prior art keywords
filament
bioactive
extruded bioactive
extruded
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2017/021270
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English (en)
Inventor
Wei Sun
Qudus Hamid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunp Biotech LLC
Original Assignee
Sunp Biotech LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunp Biotech LLC filed Critical Sunp Biotech LLC
Publication of WO2017143356A1 publication Critical patent/WO2017143356A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B29C64/295—Heating elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y40/00—Auxiliary operations or equipment, e.g. for material handling

Definitions

  • 3D printing could print complex structures required to transport oxygen and nutrients and could print cells, extracellular matrix, and growth factors precisely to create samples that better mimic in vivo tissue.
  • the key of successfully building a functional tissue construct is having the right tool.
  • the material delivery system In order to assemble cells into a functional array, the material delivery system must sustain cell life and have full control of the fluid/bio-suspension being printed.
  • a printer's deposition system must have the capabilities to handle and/or utilize an expansive library of biologically compatible materials. This library will increase the printer's abilities to fabricate more complex physiologically relevant tissue constructs.
  • This temperature module will be primarily responsible for heating of the fabrication head. Heat can be used to maintain a cell friendly temperature or even heat polymers such that its viscosity changes, making it printable.
  • This article presents a high temperature module for a 3D biologies printer's deposition system.
  • This module is designed to be adaptive and integrative to current biological printer while providing the abilities to maintain a "hot” environment within the fabrication head.
  • a "hot” environment is defined as changing and maintain the temperature within the printer's fabrication system of at least one degrees Celsius (1°C) above ambient temperature.
  • Figure 1 depicts a round heating element with heating wires enclosed within the walls
  • Figure 2 depicts a rectangular heating element with a ceramic heating wire
  • Figure 3 depicts the configuration of the PID controller with the heating element
  • Figure 4 depicts the heating system with all its components
  • Figure 5 depicts the heating element mounted on a 3D Printer's fabrication heat
  • This high temperature module has two classification, namely; 1) heating and maintaining a "hot” environment up to forty degrees Celsius (40 °C), and 2) heating and maintaining a "hot” environment up to five hundred degrees Celsius (500 °C).
  • the first classification of heating and maintaining a "hot" environment up to forty degrees Celsius (40 °C) is and will be referred to in this article as the cell-friendly temperature.
  • Human cells prefer an environment where the temperature is 37 °C, however, some cells can survive an environment where is about 40 °C. Due to this, the first classification is referred to the cell-friendly temperature.
  • the second classification of heating and maintaining a "hot" environment up to five hundred degrees Celsius (500 °C) is and will be referred to the hot-melt temperature.
  • the hot-melt processes are primarily used to change the viscosity of the bio-polymer within the fabrication system, rendering it printable. Most bio-polymer are rigid at ambient temperature and cannot be printed on a biological printer. Some processes used to make these material printable are chemical synthesis. Most chemical process will change the material properties, or even worst, introduce hard toxins, making it useless for the use of cells.
  • Figure 1 and Figure 2 shows two designs of the heating elements.
  • Figure 1 is a round heating element with the heating wires enclosed within its walls. This design is best for fast heating, high heating, and limited space applications.
  • Figure 2 is designed with a ceramic heating wire that conducts heats thru the heating block. This design is for relatively low heating applications.
  • Figure 3 shows the system configuration and the closed-loop feedback PID controller.
  • This high temperature module for a 3D biological printer's deposition system has a proportional-integral-derivative (PID) temperature control unit,
  • thermocouple relay system, heating element, heating body, and mounting apparatus.
  • the PID temperature control unit is integrated with the biological printer such that all settings and processes can be controlled by the end-user and/or with the printer's control system.
  • the PID system provides a unique feedback control system that reduces error and over-shooting temperature settings. Over-shooting temperature can create an environment that is too hot, hence causing cell dead or burning the material in the fabrication system. Coupled with the PID system is the relay system. Together these two systems provides and maintain thermal equilibrium (set by the end user).
  • Figure 4 shows the heating elements and its system components.
  • the heating element is designed based on the operator's main objectives. If the desire is for hot-melt, a high wattage heating element will be used. If the desire if for cell- friendly temperature, a low wattage heating element will be used.
  • the heating element is a thermal electric system that generates heat from electricity. This heating element is place inside the heating body where it heats the heating body. The heating body will conduct and uniformly transfer and maintain the heat (energy) onto the fabrication system.
  • the heating body is fabrication from high conductive bio-compatible material.
  • Also on the heating body is a thermocouple. The thermocouple reports current conditions about the heating body back to the PID controller. The thermocouple provides real-time temperature monitoring. To maintain a tight fit on the fabrication system, a mounting apparatus is used.
  • Figure 5 shows an image of the heating element mounted onto the fabrication head of an existing 3D cell printer.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Optics & Photonics (AREA)

Abstract

La présente invention concerne un module à haute température pour système de dépôt d'imprimante biologique 3D. Ce module est conçu pour s'adapter et s'intégrer à des imprimantes biologiques actuelles, tout en étant capable de maintenir un environnement "chaud" dans la tête de fabrication. Un environnement "chaud" est défini comme étant la modification et le maintien de la température dans le système de fabrication de l'imprimante à au moins un degrés Celsius (1 °C) au-dessus de la température ambiante.
PCT/US2017/021270 2016-01-25 2017-03-08 Module à haute température pour système de dépôt d'imprimante biologique 3d Ceased WO2017143356A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662286508P 2016-01-25 2016-01-25
US62/286,508 2016-01-25

Publications (1)

Publication Number Publication Date
WO2017143356A1 true WO2017143356A1 (fr) 2017-08-24

Family

ID=59625472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2017/021270 Ceased WO2017143356A1 (fr) 2016-01-25 2017-03-08 Module à haute température pour système de dépôt d'imprimante biologique 3d

Country Status (1)

Country Link
WO (1) WO2017143356A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6372178B1 (en) * 1998-02-09 2002-04-16 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Method for freeform fabrication of a three-dimensional object
US20060195179A1 (en) * 2005-02-18 2006-08-31 Wei Sun Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US20120089238A1 (en) * 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
WO2013123049A1 (fr) * 2012-02-14 2013-08-22 Board Of Regents, The University Of Texas System Dispositif de génie tissulaire et construction de derme vascularisé
US20140328963A1 (en) * 2013-03-22 2014-11-06 Markforged, Inc. Apparatus for fiber reinforced additive manufacturing
US20150035206A1 (en) * 2013-08-01 2015-02-05 Sartorius Stedim Biotech Gmbh Single-use biological 3 dimensional printer
WO2015077262A1 (fr) * 2013-11-19 2015-05-28 Guill Tool & Engineering Entrées d'impression 3d coextrudées, multicouche et multicomposant
CN105012060A (zh) * 2015-07-08 2015-11-04 上海大学 制备三维多尺度血管化支架的方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US6372178B1 (en) * 1998-02-09 2002-04-16 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Method for freeform fabrication of a three-dimensional object
US20060195179A1 (en) * 2005-02-18 2006-08-31 Wei Sun Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US20120089238A1 (en) * 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
WO2013123049A1 (fr) * 2012-02-14 2013-08-22 Board Of Regents, The University Of Texas System Dispositif de génie tissulaire et construction de derme vascularisé
US20140328963A1 (en) * 2013-03-22 2014-11-06 Markforged, Inc. Apparatus for fiber reinforced additive manufacturing
US20150035206A1 (en) * 2013-08-01 2015-02-05 Sartorius Stedim Biotech Gmbh Single-use biological 3 dimensional printer
WO2015077262A1 (fr) * 2013-11-19 2015-05-28 Guill Tool & Engineering Entrées d'impression 3d coextrudées, multicouche et multicomposant
CN105012060A (zh) * 2015-07-08 2015-11-04 上海大学 制备三维多尺度血管化支架的方法

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