WO2017149450A3 - Procédé d'évaluation de durée de vie de colonne chromatographique - Google Patents

Procédé d'évaluation de durée de vie de colonne chromatographique Download PDF

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Publication number
WO2017149450A3
WO2017149450A3 PCT/IB2017/051164 IB2017051164W WO2017149450A3 WO 2017149450 A3 WO2017149450 A3 WO 2017149450A3 IB 2017051164 W IB2017051164 W IB 2017051164W WO 2017149450 A3 WO2017149450 A3 WO 2017149450A3
Authority
WO
WIPO (PCT)
Prior art keywords
assess
chromatographic column
life time
column life
lifetime
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2017/051164
Other languages
English (en)
Other versions
WO2017149450A2 (fr
Inventor
Ketan SHARMA
Ritesh M DHUNDI
Shitanshu Srivastava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of WO2017149450A2 publication Critical patent/WO2017149450A2/fr
Publication of WO2017149450A3 publication Critical patent/WO2017149450A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/163—Pressure or speed conditioning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/889—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 monitoring the quality of the stationary phase; column performance

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

La présente invention concerne le domaine de la chromatographie préparative. L'invention concerne un procédé rapide pour évaluer la durée de vie de colonne chromatographique pendant une chromatographie à l'échelle préparative. Le procédé mesure de manière spécifique la différence des pressions de retour de colonne obtenues à deux débits différents, pendant l'étape de nettoyage d'un processus chromatographique, afin d'évaluer la capacité de réutilisation ou la durée de vie de la résine/matrice.
PCT/IB2017/051164 2016-03-01 2017-02-28 Procédé d'évaluation de durée de vie de colonne chromatographique Ceased WO2017149450A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201641007069 2016-03-01
IN201641007069 2016-03-01

Publications (2)

Publication Number Publication Date
WO2017149450A2 WO2017149450A2 (fr) 2017-09-08
WO2017149450A3 true WO2017149450A3 (fr) 2017-11-30

Family

ID=59742591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/051164 Ceased WO2017149450A2 (fr) 2016-03-01 2017-02-28 Procédé d'évaluation de durée de vie de colonne chromatographique

Country Status (1)

Country Link
WO (1) WO2017149450A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11493489B2 (en) 2018-02-27 2022-11-08 Cytiva Sweden Ab Apparatus, method, and computer program product for adapting a predefined liquid chromatography process

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250003932A1 (en) * 2021-08-02 2025-01-02 Roche Diagnostics Operations, Inc. Method for determining lifetime of at least one chromatography column
CN121117524A (zh) * 2025-11-17 2025-12-12 瑞莱谱(杭州)医疗科技有限公司 基于机器学习的液相色谱柱寿命预警方法及系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094203A2 (fr) * 2008-01-25 2009-07-30 Biogen Idec Ma Inc. Système automatisé et procédé pour surveiller la performance d'une colonne de chromatographie, et leurs applications

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094203A2 (fr) * 2008-01-25 2009-07-30 Biogen Idec Ma Inc. Système automatisé et procédé pour surveiller la performance d'une colonne de chromatographie, et leurs applications

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
J IANG, CANPING ET AL.: "A MECHANISTIC STUDY OF PROTEIN A CHROMATOGRAPHY RESIN LIFETIME", JOURNAL OF CHROMATOGRAPHY A, vol. 1216, no. 31, 2009, pages 5849 - 5855, XP026282083 *
JOSEPHINE HUI-CHUNG CHENG, PACKING AND QUALITY CONTROL OF A CHROMATOGRAPHY COLUMN, vol. 12, 2 October 2009 (2009-10-02), TAIWAN, pages 17 - 20, XP055444493 *
LARSON, TINA M. ET AL.: "USE OF PROCESS DATA TO ASSESS CHROMATOGRAPHIC PERFORMANCE IN PRODUCTIONSCALE PROTEIN PURIFICATION COLUMNS", BIOTECHNOLOGY PROGRESS, vol. 19, no. 2, 2003, pages 485 - 492, XP002554312 *
Q, S, DEAE: "CM CERAMIC HYPERD® F ION EXCHANGE SORBENTS", PALL LIFE SCIENCES, XP055444499 *
SHILLENN, JAMES K.: "VALIDATION PRACTICES FOR BIOTECHNOLOGY PRODUCTS.", ASTM, 1996, pages 81, XP055444487 *
STICKEL, JONATHAN J. ET AL.: "PRESSURE FLOW RELATIONSHIPS FOR PACKED BEDS OF COMPRESSIBLE CHROMATOGRAPHY MEDIA AT LABORATORY AND PRODUCTION SCALE", BIOTECHNOLOGY PROGRESS, vol. 17, no. 4, 2001, pages 744 - 751, XP055444496 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11493489B2 (en) 2018-02-27 2022-11-08 Cytiva Sweden Ab Apparatus, method, and computer program product for adapting a predefined liquid chromatography process
US12019058B2 (en) 2018-02-27 2024-06-25 Cytiva Sweden Ab Apparatus, method, and computer program product for adapting a predefined liquid chromatography process

Also Published As

Publication number Publication date
WO2017149450A2 (fr) 2017-09-08

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