WO2017176077A1 - Micro-aiguille mettant en œuvre un métal biodégradable - Google Patents

Micro-aiguille mettant en œuvre un métal biodégradable Download PDF

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Publication number
WO2017176077A1
WO2017176077A1 PCT/KR2017/003792 KR2017003792W WO2017176077A1 WO 2017176077 A1 WO2017176077 A1 WO 2017176077A1 KR 2017003792 W KR2017003792 W KR 2017003792W WO 2017176077 A1 WO2017176077 A1 WO 2017176077A1
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WO
WIPO (PCT)
Prior art keywords
microneedle
skin
metal
drug
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2017/003792
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English (en)
Korean (ko)
Inventor
조성윤
김종택
추현욱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labnpeople Co Ltd
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Labnpeople Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020160162337A external-priority patent/KR20170115429A/ko
Priority to PL17779377.5T priority Critical patent/PL3444003T3/pl
Priority to EP17779377.5A priority patent/EP3444003B1/fr
Priority to JP2019503883A priority patent/JP6794528B2/ja
Priority to CN201780021995.1A priority patent/CN109069814A/zh
Priority to MX2018012236A priority patent/MX2018012236A/es
Application filed by Labnpeople Co Ltd filed Critical Labnpeople Co Ltd
Priority to ES17779377T priority patent/ES2913153T3/es
Priority to US16/091,718 priority patent/US11135415B2/en
Priority to BR112018070666A priority patent/BR112018070666A2/pt
Publication of WO2017176077A1 publication Critical patent/WO2017176077A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to an apparatus for delivering a drug to the body, and more particularly to a microneedle using a biodegradable metal and a microneedle patch comprising the same.
  • the microneedles When the microneedles are inserted into the skin, the microneedles must maintain a sufficiently high physical strength so that the microneedles can be inserted without being bent or broken.
  • stainless steel was used as the material of the microneedle, but inflammation occurred when small particles remained in the body, and polymers (PLA, PGA, and biodegradable copolymer) were used. There was a problem of not being penetration.
  • Korean Laid-Open Patent No. 2016-0058261 uses polyglycolide (PGA), polylactide-glycolide copolymer (PLGA), hyaluronic acid, alginic acid, pectin and the like.
  • PGA polyglycolide
  • PLGA polylactide-glycolide copolymer
  • hyaluronic acid alginic acid
  • pectin pectin and the like.
  • One water-soluble microneedle and a method of manufacturing the same have been disclosed
  • Korean Patent No. 1622388 discloses a silicon microneedle stamp and a method of manufacturing the same.
  • Korean Patent Application Publication No. 2015-0121053 discloses silicon, silicon dioxide, ceramics, and metals (stainless steel).
  • Titanium, nickel, molybdenum, chromium, cobalt and the like) and synthetic or natural resins have been disclosed.
  • the present inventors have made efforts to solve the above problems, as a result of using a microdegradable metal such as magnesium, calcium, zinc as the material of the microneedle, not only skin invasion is possible but also its own mineral components and hydrogen gas when left under the skin. It was confirmed that the supply can improve the skin by improving the wrinkle response and inflammatory response to complete the present invention.
  • a microdegradable metal such as magnesium, calcium, zinc
  • An object of the present invention is to solve the disadvantages of the existing drug delivery device, the pain causing and infection concerns, and medical waste, metal that can be used as a mineral for skin improvement while having physical properties that can penetrate the skin
  • the present invention provides a microneedle including a material and a microneedle patch including the same.
  • the present invention is represented by the formula (1), inserted into the subcutaneous or epithelium, absorbed and decomposed to release the magnesium or zinc metal ions and decomposition products in the body using a micro-degradable metal Serve the needle.
  • X is at least one selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce and P
  • the biodegradable metal is characterized in that pure Mg or pure Zn containing inevitable impurities.
  • the biodegradable metal is characterized in that the decomposition rate is accelerated by creating a galvanic circuit of two or more metal phases.
  • the microneedle is characterized in that it comprises an Mg 2 Ca phase.
  • the microneedle is characterized in that it comprises an MgZn phase.
  • the microneedle is characterized in that it comprises a Ca 2 Mg 6 Zn 3 phase.
  • the microneedle is characterized in that a second kind of metal is coated on the metal surface to form a galvanic circuit.
  • the second metal is composed of sodium, magnesium, potassium, iron, nickel, zinc, gallium, selenium, strontium, zirconium, molybdenum, niobium, tantalum, titanium, silicon, silver, gold, manganese and calcium It is characterized in that the at least one metal selected from the group.
  • the microneedle is characterized in that the drug is coated or supported.
  • the microneedle is characterized in that the thin plate-like.
  • the invention also provides a microneedle patch comprising the microneedle.
  • microneedle or microneedle patch to which the biodegradable metal of the present invention is applied can realize sufficient strength to penetrate the skin due to the metal's unique mechanical properties, and when inserted into the subcutaneous body to deliver the drug, By providing the generated decomposition products and gases to the skin, there is an effect that can swell the skin to improve wrinkles.
  • 1 to 3 is a state diagram according to the content of magnesium, zinc and calcium (circular number means an embodiment).
  • FIG. 4 is an exploded view of microneedles in which microneedles for penetrating skin and supporting drugs are formed on sheets composed of biodegradable metals.
  • 5 is a microneedle bent to machine the microneedle through the skin; It is a schematic diagram of the needle formed grooves on the outside of the needle and the grooves formed on the outside and inside to improve the drug carrying capacity.
  • FIG. 6 is a schematic diagram of a microneedle and microneedle holder in the form of a tip.
  • FIG. 7 is a prototype (A) of the microneedle manufactured according to an embodiment of the present invention (A) and a photograph (B) showing the stretching characteristics thereof.
  • FIG 8 is a photograph of a microneedle patch prepared according to one embodiment of the present invention (A: before use, B: after use).
  • FIG. 9 is a photograph of the microneedle prepared according to an embodiment of the present invention applied to the skin.
  • FIG. 10 is a schematic diagram of an apparatus (Eudiometer) for measuring the hydrogen generation amount according to the immersion time of the microneedle manufactured in accordance with an embodiment of the present invention.
  • FIG. 11 is a graph showing the hydrogen generation amount according to the immersion time of the microneedle prepared in accordance with an embodiment of the present invention.
  • FIG. 12 is a graph showing the results of a clinical experiment on the dermal density of the microneedle prepared in accordance with an embodiment of the present invention.
  • Figure 13 is a graph showing the results of clinical experiments on the skin thickness of the microneedle prepared in accordance with an embodiment of the present invention.
  • Figure 14 is a graph showing the results of clinical trials on the eye wrinkles of the microneedle prepared in accordance with an embodiment of the present invention.
  • Figure 15 is a photograph showing the results of clinical experiments on the eye wrinkles of the microneedle prepared in accordance with an embodiment of the present invention.
  • 16 is a photograph evaluating the polymer penetration capability of the microneedle patch prepared according to an embodiment of the present invention.
  • 17 is a photograph evaluating the drug penetration ability of the microneedle patch prepared according to an embodiment of the present invention.
  • the microneedle is made of at least one metal selected from the group consisting of Mg, Zn, Ca, Fe, Mn, Si, Na, Zr, Ce and P, not only skin invasion is possible but also subcutaneous. In addition, it did not cause inflammation, but rather to supply its own minerals to check that it can improve the skin.
  • a microneedle made of magnesium or zinc alone and a microneedle made of a biodegradable metal obtained by mixing another metal such as calcium with the metal, and invasiveness and skin improvement of the manufactured microneedle Ability was measured.
  • the microneedles made of magnesium, calcium or zinc as the sole material and the microneedles made of an alloy in which a different type of metal is mixed in the metal in a specific range have excellent invasiveness and skin improvement ability.
  • the present invention in one aspect, represented by the formula (1), is inserted into the subcutaneous or epithelium, absorbed and decomposed to release the magnesium or zinc metal ions and decomposition products in the body microneedle using a biodegradable metal It is about.
  • X is at least one selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce and P
  • microneedles are used for the purpose of delivering drugs to the skin, but unlike the conventional microneedles, the microneedles are inserted into the subcutaneous or epithelium for drug injection, and then absorbed and decomposed to form metal ions and powders. It is characterized in that seafood is released into the body.
  • Magnesium (Mg), calcium (Ca), zinc (Zn) and the like used as the material of the microneedle of the present invention are alkali-based biodegradable metals, and a mechanism for releasing hydrogen gas by reacting with water as shown in the following formula.
  • the microneedle made of the metal material releases ions and decomposition products when absorbed and decomposed subcutaneously, and the hydrogen gas generated by the by-product can swell the subcutaneous effect and induce wrinkle improvement effect, and inflammation. It can reduce the erythema caused by skin and prevent skin damage caused by the sun (YOON, KS et al, Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice.
  • ZnO and MgCl may act as a drug delivery enhancer that enhances drug absorption even on the skin surface without penetrating subcutaneously. Therefore, the needle composed of the biodegradable metal can further enhance the drug delivery effect carried thereon.
  • the microneedles are made of magnesium (Mg), zinc (Zn) or the like as a single material, or two or more metals are used to accelerate the decomposition rate in the subcutaneous or epithelium, that is, to create a galvanic circuit. It can be manufactured as a material.
  • FIG. 1 to 3 is a state diagram according to the content of magnesium and zinc, calcium. As shown in Figures 1 to 3, magnesium, zinc and calcium may be present in various states depending on the content, Mg 2 Ca (C14_B) can create a galvanic circuit to increase the decomposition rate.
  • the microneedle is characterized in that a second kind of metal is coated on the surface of the biodegradable metal represented by Chemical Formula 1 to produce a galvanic circuit.
  • the second metal may include sodium, magnesium, potassium, iron, nickel, zinc, gallium, selenium, strontium, zirconium, molybdenum, niobium, tantalum, titanium, silicon, silver, gold, manganese, calcium, and the like. It is not limited. At this time, when manufacturing the microneedle using the iron (Fe) should not include stainless.
  • the microneedles may be manufactured by a method of manufacturing conventional soluble microneedles in the industry, such as laser cutting, sheet metal processing, casting, etching, and the like, and the manufacturing method is not particularly limited.
  • the microneedle may be manufactured by bending in a jig press.
  • the microneedle is characterized in that the drug is coated or supported.
  • Fig. 5 shows the microneedle 11, in which the processed microneedle is bent to penetrate the skin; It is a schematic diagram of the needle (12) formed grooves on the outside of the needle and the needle (13) formed on the outside and inside to improve the drug carrying capacity.
  • the drug may include a drug or a genetic material for disease prevention and treatment, and may be loaded with EGF (Epitermal Growth Factor) or hyaluronic acid (Hyaluronic acid) for skin care.
  • EGF Epidermal Growth Factor
  • Hyaluronic acid Hyaluronic acid
  • the microneedles with biodegradable metal applied for drug loading can be coated by dip coating, and a pocket for drug delivery inside the microneedles can be formed to deliver drugs inside the body. Can be.
  • the pocket method when the pocket method is applied, a part of the drug contained in the microneedle patch is released immediately after attachment by controlling the rate of decomposition of the biodegradable metal, and the other drug decomposes the rate of drug release as the pocket formed on the biodegradable metal needle is decomposed. You can also adjust.
  • the microneedle according to the present invention may be formed in one piece or may be composed of the microneedle 20 and the microneedle holder 21 as shown in FIG. 6.
  • the microneedle utilizing the form of the microneedle holder 21 may be artificially left in the subcutaneously by applying a twist after the needle is inserted into the subcutaneous skin rather than simply injecting a drug to the skin.
  • FIG. 7 is a prototype (A) of the microneedle manufactured according to an embodiment of the present invention (A) and a photograph (B) showing the stretching characteristics thereof.
  • the present invention also relates to a microneedle patch comprising the microneedle.
  • the microneedle patch is for fixing the microneedle to the skin, and is composed of a microneedle and a patch portion formed on an opposite side of the microneedle.
  • the size, shape and material of the patch can be used without particular limitation.
  • the microneedles used may be ionized and discolored subcutaneously.
  • the drug After injecting the drug into the microneedle sheet, the drug may be injected subcutaneously through a slit generated in the microneedle by attaching to the skin and applying pressure.
  • a microneedle was manufactured using a laser marking machine (JTY FIBER MA20, JT Y System) (FIG. 9). At this time, the tip angles of the microneedles were 15 °, 30 °, and 35 °, and the needle heights were 0.5 mm, 1.0 mm, and 1.5 mm.
  • Skin invasiveness evaluation was performed on the microneedle of Example 1 having the lowest physical properties (tensile strength: average 212.09 MPa, elongation: 11.32%, self-retained material evaluation results) in Examples 1 to 9, and as a result Is shown in Table 2.
  • the skin invasiveness evaluation was performed whether the microneedles can invade the eyes and pig skin of the human body, whether the invasion is maintained for 1 minute or more after the invasion on the rough skin of the back of the human body (see Fig. 9).
  • Example 2 From Table 2, it was confirmed that the microneedle of Example 1 having a tip angle of 15 to 35 ° and a needle height of 0.5 to 1.5 mm was excellent in skin invasive ability, and the tensile strength was increased by adding calcium and zinc. It could be deduced that the microneedles of Examples 2 to 9 also have excellent skin invasiveness.
  • the microneedles of Examples 2 to 5 in which the Mg 2 Ca phase was not produced showed hydrogen gas generation amount due to stable decomposition, but the microneedles of Examples 6 and 7 in which the Mg 2 Ca phase was produced were decomposed. It was confirmed that the speed was increased.
  • the microneedle patch was prepared by attaching a hydrocolloid patch coated with an adhesive to the opposite side where the needle of the microneedle prepared in Example 1 was produced.
  • the prepared microneedle patch was packaged and sterilized.
  • the average age of 30 subjects was 39.47 years old, consisting of 6 in 20s, 5 in 30s, 18 in 40s and 1 in 50s.
  • Subject preliminary survey The subject survey was conducted.
  • -Skin condition Skin disease, itching, stinging, erythema, cosmetic side effects, side effects of medicine, light sensitivity, atopy experience
  • the visual evaluation of the tester was based on the Frosch & Kligman, CTFA guideline, and the skin reactivity was calculated and calculated as the skin irritation index. The degree was divided.
  • the microneedle patch was patched for 24 hours, and the skin reaction after 1 hour and 24 hours after patch removal was visually evaluated by the tester to determine the skin irritation index and the degree of skin irritation.
  • the dermal density increased by 8.67%
  • the skin thickness increased by 5.31%
  • the wrinkles on the eyes were decreased by 2.11% after two weeks of use, compared to the microneedle patch.
  • methylene blue dye was supported on the microneedle patch instead of the drug, and then attached to the pig skin. After attachment, the dye penetration was accelerated by continuous pressure for 5 minutes, and after 30 minutes, the microneedle patch was removed, the cross section of the pig skin was incised, and the drug delivery ability was evaluated by the optical microscope.
  • microneedle or the microneedle patch of the present invention can be used for drug delivery for skin prevention and disease prevention through vaccine delivery in addition to drug delivery for treatment.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un appareil permettant d'administrer un médicament à un corps et, plus particulièrement, une micro-aiguille mettant en œuvre un métal biodégradable et un timbre à micro-aiguille comprenant cette dernière. La micro-aiguille est représentée par la formule chimique 1, et est absorbée et dégradée après l'insertion sous-cutanée ou épithéliale pour libérer des ions métalliques et des produits dégradés dans le corps. Dans la formule chimique 1, a, b et c représentent les pourcentages en poids des ingrédients respectifs ; a + b + c = 100 % en poids ; et a ou b a la valeur la plus élevée dans les plages de 0 ≤ a ≤ 100, 0 ≤ b ≤ 100, et 0 ≤ c ≤ 10 ; et X est au moins un élément choisi dans le groupe constitué par le Ca, le Fe, le Mn, le Si, le Na, le Zr, le Ce et le P. La micro-aiguille mettant en œuvre un métal biodégradable de la présente invention peut réaliser une résistance suffisante pour pénétrer dans la peau en raison des caractéristiques mécaniques uniques d'un métal. De plus, la micro-aiguille est insérée par voie sous-cutanée pour administrer un médicament, puis fournit à la peau des produits dégradés et des gaz générés au moment de la dégradation ainsi que des minéraux intrinsèques de ces derniers, permettant ainsi à la peau de gonfler pour réduire les rides. Par conséquent, la micro-aiguille peut être utilisée pour l'administration de médicament pour une thérapie, la prévention d'une maladie par l'administration de vaccin, l'administration de médicament pour un soin de la peau, et similaire.
PCT/KR2017/003792 2016-04-07 2017-04-07 Micro-aiguille mettant en œuvre un métal biodégradable Ceased WO2017176077A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BR112018070666A BR112018070666A2 (pt) 2016-04-07 2017-04-07 microagulha que usa metal biodegradável
EP17779377.5A EP3444003B1 (fr) 2016-04-07 2017-04-07 Micro-aiguille mettant en oeuvre un métal biodégradable
JP2019503883A JP6794528B2 (ja) 2016-04-07 2017-04-07 生体分解性金属を用いたマイクロニードル
CN201780021995.1A CN109069814A (zh) 2016-04-07 2017-04-07 利用可生物降解金属的微针
MX2018012236A MX2018012236A (es) 2016-04-07 2017-04-07 Microaguja que utiliza metal biodegradable.
PL17779377.5T PL3444003T3 (pl) 2016-04-07 2017-04-07 Mikroigła z zastosowaniem biodegradowalnego metalu
ES17779377T ES2913153T3 (es) 2016-04-07 2017-04-07 Microaguja que utiliza metal biodegradable
US16/091,718 US11135415B2 (en) 2016-04-07 2017-04-07 Microneedle using biodegradable metal

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR20160042690 2016-04-07
KR10-2016-0042690 2016-04-07
KR10-2016-0162337 2016-11-30
KR1020160162337A KR20170115429A (ko) 2016-04-07 2016-11-30 생체분해성 금속을 이용한 마이크로 니들
KR10-2017-0044692 2017-04-06
KR1020170044692A KR102114472B1 (ko) 2016-04-07 2017-04-06 생체분해성 금속을 이용한 마이크로 니들

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111918691A (zh) * 2018-03-30 2020-11-10 实验室和人们 多功能型微针
CN112334126A (zh) * 2018-06-26 2021-02-05 实验室和人们有限公司 皮下插入用生物体吸收性药物传递胶囊
JP2021505267A (ja) * 2017-12-11 2021-02-18 ラブンピープル カンパニー リミテッドＬａｂｎｐｅｏｐｌｅ Ｃｏ．，Ｌｔｄ． 高密度マイクロニードル
CN112672698A (zh) * 2018-09-17 2021-04-16 实验室和人们有限公司 用于埋线疗法的线及包括其的用于埋线疗法的针具
JP2022500123A (ja) * 2018-09-17 2022-01-04 ラボエヌピープル カンパニー，リミテッド 埋線療法用ロープ及びこれを含む埋線療法用ニードル装置
CN115364042A (zh) * 2022-09-14 2022-11-22 上海交通大学医学院附属第九人民医院 负载氢化镁的微针及其在伤口愈合中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080030553A (ko) * 2005-04-25 2008-04-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 각질층 관통 장치를 사용한 좌창 치료 방법
JP2009521250A (ja) * 2005-12-14 2009-06-04 ゲーカーエスエス フオルシユングスツエントルーム ゲーエストハフト ゲーエムベーハー 生体適合マグネシウム材料
KR20110006539A (ko) * 2009-07-14 2011-01-20 한양대학교 산학협력단 터치스크린 내장형 전자영동 표시장치
US20140093417A1 (en) * 2012-08-24 2014-04-03 The Regents Of The University Of California Magnesium-zinc-strontium alloys for medical implants and devices
US20140097277A1 (en) * 2012-10-05 2014-04-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biodegradable iron-containing compositions, methods of preparing and applications therefor
CN104212998A (zh) * 2014-08-21 2014-12-17 北京大学 一种Zn-Mg系锌合金及其制备方法与应用
KR20150050586A (ko) * 2012-08-31 2015-05-08 신세스 게엠바하 조정가능한 분해율을 갖는 초순수 마그네슘 합금
KR20160007923A (ko) * 2014-07-10 2016-01-21 연세대학교 산학협력단 경피전달용 미세돌기 구조체

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080030553A (ko) * 2005-04-25 2008-04-04 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 각질층 관통 장치를 사용한 좌창 치료 방법
JP2009521250A (ja) * 2005-12-14 2009-06-04 ゲーカーエスエス フオルシユングスツエントルーム ゲーエストハフト ゲーエムベーハー 生体適合マグネシウム材料
KR20110006539A (ko) * 2009-07-14 2011-01-20 한양대학교 산학협력단 터치스크린 내장형 전자영동 표시장치
US20140093417A1 (en) * 2012-08-24 2014-04-03 The Regents Of The University Of California Magnesium-zinc-strontium alloys for medical implants and devices
KR20150050586A (ko) * 2012-08-31 2015-05-08 신세스 게엠바하 조정가능한 분해율을 갖는 초순수 마그네슘 합금
US20140097277A1 (en) * 2012-10-05 2014-04-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biodegradable iron-containing compositions, methods of preparing and applications therefor
KR20160007923A (ko) * 2014-07-10 2016-01-21 연세대학교 산학협력단 경피전달용 미세돌기 구조체
CN104212998A (zh) * 2014-08-21 2014-12-17 北京大学 一种Zn-Mg系锌合金及其制备方法与应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3444003A4 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12083306B2 (en) 2017-12-11 2024-09-10 Labnpeople Co., Ltd. High-density microneedle
JP2021505267A (ja) * 2017-12-11 2021-02-18 ラブンピープル カンパニー リミテッドＬａｂｎｐｅｏｐｌｅ Ｃｏ．，Ｌｔｄ． 高密度マイクロニードル
EP3701997B1 (fr) * 2017-12-11 2024-03-13 Labnpeople Co.,Ltd. Micro-aiguille haute densité
JP7108031B2 (ja) 2017-12-11 2022-07-27 ラブンピープル カンパニー リミテッド 高密度マイクロニードル
CN111918691B (zh) * 2018-03-30 2022-07-15 实验室和人们 多功能型微针
CN111918691A (zh) * 2018-03-30 2020-11-10 实验室和人们 多功能型微针
JP2021529217A (ja) * 2018-06-26 2021-10-28 ラボエヌピープル カンパニー，リミテッド 皮下挿入用生体吸水性薬物伝達カプセル
EP3815676A4 (fr) * 2018-06-26 2022-04-06 LABnPEOPLE CO.,LTD. Capsule bioabsorbable pouvant être introduite par voie sous-cutanée pour administrer un médicament
JP7262143B2 (ja) 2018-06-26 2023-04-21 ラボエヌピープル カンパニー，リミテッド 皮下挿入用生体吸水性薬物送達カプセル
CN112334126A (zh) * 2018-06-26 2021-02-05 实验室和人们有限公司 皮下插入用生物体吸收性药物传递胶囊
JP2022500123A (ja) * 2018-09-17 2022-01-04 ラボエヌピープル カンパニー，リミテッド 埋線療法用ロープ及びこれを含む埋線療法用ニードル装置
JP2023106523A (ja) * 2018-09-17 2023-08-01 ラボエヌピープル カンパニー，リミテッド 埋線療法用ロープ及びこれを含む埋線療法用ニードル装置
JP7320301B2 (ja) 2018-09-17 2023-08-03 ラボエヌピープル カンパニー，リミテッド 埋線療法用ロープ及びこれを含む埋線療法用ニードル装置
CN112672698A (zh) * 2018-09-17 2021-04-16 实验室和人们有限公司 用于埋线疗法的线及包括其的用于埋线疗法的针具
CN112672698B (zh) * 2018-09-17 2024-07-02 实验室和人们有限公司 用于埋线疗法的线及包括其的用于埋线疗法的针具
CN115364042A (zh) * 2022-09-14 2022-11-22 上海交通大学医学院附属第九人民医院 负载氢化镁的微针及其在伤口愈合中的应用

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