WO2017194903A3 - Particule virale pour le transfert d'arns, notamment dans les cellules impliquées dans la réponse immune - Google Patents

Particule virale pour le transfert d'arns, notamment dans les cellules impliquées dans la réponse immune Download PDF

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Publication number
WO2017194903A3
WO2017194903A3 PCT/FR2017/051165 FR2017051165W WO2017194903A3 WO 2017194903 A3 WO2017194903 A3 WO 2017194903A3 FR 2017051165 W FR2017051165 W FR 2017051165W WO 2017194903 A3 WO2017194903 A3 WO 2017194903A3
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WIPO (PCT)
Prior art keywords
viral particle
cells involved
rna transfer
viral rnas
integrase
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Ceased
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PCT/FR2017/051165
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English (en)
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WO2017194903A8 (fr
WO2017194903A2 (fr
Inventor
Pascale BOUILLE
Christine DUTHOIT
Lucille LAMOUROUX
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VECTALYS
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VECTALYS
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Priority claimed from FR1654333A external-priority patent/FR3051197B1/fr
Priority to JP2018559309A priority Critical patent/JP6916209B2/ja
Priority to EP17730842.6A priority patent/EP3454889A2/fr
Priority to IL262944A priority patent/IL262944B2/en
Priority to US16/301,354 priority patent/US11371059B2/en
Priority to AU2017263138A priority patent/AU2017263138B2/en
Application filed by VECTALYS filed Critical VECTALYS
Priority to SG11201810014UA priority patent/SG11201810014UA/en
Priority to CA3023788A priority patent/CA3023788A1/fr
Priority to CN201780043718.0A priority patent/CN109562150A/zh
Publication of WO2017194903A2 publication Critical patent/WO2017194903A2/fr
Publication of WO2017194903A3 publication Critical patent/WO2017194903A3/fr
Anticipated expiration legal-status Critical
Publication of WO2017194903A8 publication Critical patent/WO2017194903A8/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4245—Tyrosinase or tyrosinase related proteinases [TRP-1 or TRP-2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A61K40/4273—Glycoprotein 100 [Gp100]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/161—HIV-1 ; HIV-2 gag-pol, e.g. p55, p24/25, p17/18, p7, p6, p66/68, p51/52, p31/34, p32, p40
    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/85—Fusion polypeptide containing an RNA binding domain
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2795/00—Bacteriophages
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    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
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    • C12N2800/50—Vectors for producing vectors
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
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  • AIDS & HIV (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention se rapporte à une particule rétrovirale comportant une protéine issue de la polyprotéine Gag, une protéine d'enveloppe, optionnellement une intégrase et au moins deux ARN non viraux encapsidés, les ARN non viraux encapsidés comportant chacun une séquence d'ARN d'intérêt liée à une séquence d'encapsidation, chaque séquence d'encapsidation étant reconnue par un domaine de liaison introduit dans la protéine issue de la polyprotéine Gag et/ou dans l'intégrase, et l'une au moins dédites séquences d'intérêt des ARN non viraux encapsidés comporte une partie codant pour au moins un épitope et/ou au moins une structure moléculaire reconnaissant spécifiquement un épitope.
PCT/FR2017/051165 2016-05-13 2017-05-12 Particule virale pour le transfert d'arns, notamment dans les cellules impliquées dans la réponse immune Ceased WO2017194903A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201780043718.0A CN109562150A (zh) 2016-05-13 2017-05-12 用于将rna转移到尤其参与免疫应答的细胞中的病毒颗粒
CA3023788A CA3023788A1 (fr) 2016-05-13 2017-05-12 Particule virale pour le transfert d'arns, notamment dans les cellules impliquees dans la reponse immune
IL262944A IL262944B2 (en) 2016-05-13 2017-05-12 Viral particle for rna transfer, especially into cells involved in immune response
US16/301,354 US11371059B2 (en) 2016-05-13 2017-05-12 Viral particle for the transfer of RNAs, especially into cells involved in immune response
AU2017263138A AU2017263138B2 (en) 2016-05-13 2017-05-12 Viral particle for RNA transfer, especially into cells involved in immune response
JP2018559309A JP6916209B2 (ja) 2016-05-13 2017-05-12 特に免疫応答に関与する細胞への、ｒｎａの転移のためのウイルス粒子
SG11201810014UA SG11201810014UA (en) 2016-05-13 2017-05-12 Viral particle for rna transfer, especially into cells involved in immune response
EP17730842.6A EP3454889A2 (fr) 2016-05-13 2017-05-12 Particule virale pour le transfert d'arns, notamment dans les cellules impliquées dans la réponse immune

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR1654333 2016-05-13
FR1654333A FR3051197B1 (fr) 2016-05-13 2016-05-13 Particule virale pour le transfert d'arns dans les cellules impliquees dans la reponse immune
FR1752819 2017-03-31
FR1752819 2017-03-31

Publications (3)

Publication Number Publication Date
WO2017194903A2 WO2017194903A2 (fr) 2017-11-16
WO2017194903A3 true WO2017194903A3 (fr) 2018-01-25
WO2017194903A8 WO2017194903A8 (fr) 2018-12-27

Family

ID=59070996

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PCT/FR2017/051165 Ceased WO2017194903A2 (fr) 2016-05-13 2017-05-12 Particule virale pour le transfert d'arns, notamment dans les cellules impliquées dans la réponse immune

Country Status (9)

Country Link
US (1) US11371059B2 (fr)
EP (1) EP3454889A2 (fr)
JP (1) JP6916209B2 (fr)
CN (1) CN109562150A (fr)
AU (1) AU2017263138B2 (fr)
CA (1) CA3023788A1 (fr)
IL (1) IL262944B2 (fr)
SG (1) SG11201810014UA (fr)
WO (1) WO2017194903A2 (fr)

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US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
EP3294756B1 (fr) * 2015-05-15 2020-12-02 Flash Therapeutics Particule rétrovirale comportant au moins deux arn non viraux encapsidés différents
CN110662556A (zh) 2017-03-09 2020-01-07 哈佛大学的校长及成员们 癌症疫苗
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
WO2020154500A1 (fr) 2019-01-23 2020-07-30 The Broad Institute, Inc. Protéines chargées supernégativement et utilisations associées
EP3696189A1 (fr) * 2019-02-14 2020-08-19 European Molecular Biology Laboratory Moyens et procédés de préparation de protéines cibles modifiées par dilatation de code génétique dans une protéine cible de manière sélective
GB2601618B (en) 2019-03-19 2024-11-06 Broad Inst Inc Methods and compositions for editing nucleotide sequences
WO2020214842A1 (fr) 2019-04-17 2020-10-22 The Broad Institute, Inc. Éditeurs de base d'adénine présentant des effets hors cible réduits
WO2020252455A1 (fr) 2019-06-13 2020-12-17 The General Hospital Corporation Pseudo-particules virales endogènes humaines génétiquement modifiées et leurs méthodes d'utilisation en vue d'une administration à des cellules
US20210129135A1 (en) * 2019-11-01 2021-05-06 Nicholas Crabtree Hourglass shaped blood fractionation tube and system
AU2021310950A1 (en) 2020-07-24 2023-02-16 President And Fellows Of Harvard College Enhanced virus-like particles and methods of use thereof for delivery to cells

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KATHERINE H. CARRUTHERS ET AL: "Fat Grafting as a Vehicle for the Delivery of Recombinant Adenoassociated Viral Vectors to Achieve Gene Modification of Muscle Flaps", ANNALS OF PLASTIC SURGERY., vol. 70, no. 6, 1 June 2013 (2013-06-01), US, pages 726 - 731, XP055353454, ISSN: 0148-7043, DOI: 10.1097/SAP.0b013e3182414add *
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Also Published As

Publication number Publication date
US11371059B2 (en) 2022-06-28
WO2017194903A8 (fr) 2018-12-27
AU2017263138B2 (en) 2022-08-25
EP3454889A2 (fr) 2019-03-20
AU2017263138A1 (en) 2019-01-03
JP6916209B2 (ja) 2021-08-11
IL262944A (en) 2018-12-31
JP2019514413A (ja) 2019-06-06
IL262944B1 (en) 2025-07-01
WO2017194903A2 (fr) 2017-11-16
CN109562150A (zh) 2019-04-02
US20190203228A1 (en) 2019-07-04
CA3023788A1 (fr) 2017-11-16
SG11201810014UA (en) 2018-12-28
IL262944B2 (en) 2025-11-01

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