WO2018192285A1 - 复合性材料 - Google Patents

复合性材料 Download PDF

Info

Publication number
WO2018192285A1
WO2018192285A1 PCT/CN2018/074042 CN2018074042W WO2018192285A1 WO 2018192285 A1 WO2018192285 A1 WO 2018192285A1 CN 2018074042 W CN2018074042 W CN 2018074042W WO 2018192285 A1 WO2018192285 A1 WO 2018192285A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophilic
composite material
compound
hydrophilic polymer
wound healing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2018/074042
Other languages
English (en)
French (fr)
Inventor
王宛婷
朱业修
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to KR1020197031607A priority Critical patent/KR102377115B1/ko
Priority to US16/605,498 priority patent/US11235083B2/en
Priority to JP2019556222A priority patent/JP2020516667A/ja
Priority to EP18788094.3A priority patent/EP3613444A4/en
Publication of WO2018192285A1 publication Critical patent/WO2018192285A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/48—Surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • C08F220/585—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine and containing other heteroatoms, e.g. 2-acrylamido-2-methylpropane sulfonic acid [AMPS]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/36—Amides or imides
    • C08F222/38—Amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Definitions

  • the present invention relates to a composite material which is a solid hydrophilic polymer having a high strength three-dimensional network structure of a compound which promotes wound healing.
  • the hydrocolloid dressing has a water content of ⁇ 10%, and the wound uses a hydrocolloid dressing when the exudate is low, which tends to make the wound dry and painful, and can not maintain the wound moist; further, the hydrocolloid dressing is carboxymethyl cellulose. Mainly, bacteria that are susceptible to infected wounds break down and produce odor; therefore, hydrocolloids are not available in infectious wounds.
  • Another water-swellable hydrogel has insufficient mechanical strength, for example, Taiwan Patent Publication No. M419555, I267387, I429462, and I504420; Chinese Patent Publication No. CN204863670 and US Patent Publication No.
  • the patent of 2013/0072843 discloses that the structure is strengthened by a hydrogel combined with a non-woven fabric or a fiber as a support layer; however, the structure of the hydrogel after absorbing the aqueous solution is still fragile, resulting in the removal of the residual glue which is difficult to remove when the dressing is removed.
  • U.S. Patent Nos. 5,489,304 and 5,716,411 disclose the application of collagen-glycosaminoglycan to the wound surface and coating a layer of cultured animal or human epidermal cells to promote skin. regeneration.
  • U.S. Patent No. 5,977,088 discloses a pharmaceutical composition comprising a medicament for treating or promoting skin irritation and hyaluronic acid, which utilizes hyaluronic acid to promote or cause delivery of a medicament to the skin of a wounded person. The drug can be accumulated and extended to stay in the area.
  • Taiwan Patent Publication No. I264306 discloses a collagen-hyaluronic acid mixture coated gauze dressing, it is a composite material of dry gauze which is unfavorable for wound healing.
  • the present invention provides a hydrophilic dressing having suitable mechanical strength, comprising a composite material and a film, most particularly the composite material consisting of a hydrophilic polymer and a wound healing promoting Composition of compounds.
  • the hydrophilic polymer is a polymer having a combination of high strength and hydrophilicity; therefore, the hydrophilic polymer not only maintains wound wetting, but also accelerates the movement and proliferation of epidermal cells due to the hydrophilic polymerization.
  • the material is a solid hydrophilic polymer having a high-strength three-dimensional network structure, so that the hydrogel is swelled and fragrant after absorbing the aqueous solution.
  • the hydrophilic polymer utilizes an adsorbing hydrophilic group to adsorb a compound which promotes wound healing such as water-soluble collagen or hyaluronic acid, and adsorbs to a three-dimensional network structure inside the hydrophilic polymer, in the wound Slow release promotes wound healing factors during treatment and accelerates wound healing.
  • the wounded person needs to apply the wound healing compound first, and then cover the dressing, so a two-step care process is needed, but the hydrophilic dressing of the present invention can achieve the above-mentioned treatment purpose in one step, and the wound can be healed. Time can be shortened more effectively.
  • the present invention provides a composite material comprising a hydrophilic substrate and a compound for promoting wound healing, wherein the hydrophilic substrate is a reaction product of a hydrophilic polymer, wherein The hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent, and an inorganic silicon oxide compound, wherein the compound for promoting wound healing is distributed in the hydrophilic substrate.
  • the "hydrophilic monomer” herein contains a reactive monomer having a hydrophilic group.
  • a hydrophilic monomer useful in the preparation of the hydrophilic polymer of the present invention having at least one polymerizable double bond and at least one hydrophilic functional group.
  • a functional group having a polymerizable double bond and examples thereof include: acrylic acid, methacrylic acid, acrylamide group, methacrylamide group, fumaric acid, maleic acid, styryl group, isopropenylphenyl group, O - a double bond of ethylene carbonate, O-vinyl urethane, allyl, O-vinyl acetyl, N-vinyl lactam, and N-vinyl amide.
  • Types of hydrophilic monomers suitable for the present invention comprise monomers containing acrylic or vinyl groups.
  • DMA N,N-dimethylacrylamide
  • HEMA 2-hydroxyethyl methacrylate
  • glyceryl methacrylate 2-hydroxyethylmethacrylamide
  • Polyethylene glycol monomethacrylate methacrylic acid, mixtures thereof and the like.
  • Vinyl containing monomers including, but not limited to, monomers such as N-vinyl amide, N-vinyl lactam (eg NVP), N-vinyl-N-methylacetamide, N-vinyl-N-ethyl B Amide, N-vinyl-N-ethylformamide, N-vinylformamide.
  • hydrophilic monomers useful in the present invention include, but are not limited to, polyoxyethylene polyols having one or more terminal hydroxyl groups substituted with a functional group containing a polymerizable double bond.
  • examples include polyethylene glycol, ethoxylated alkyl glucosides and ethoxylated bisphenol A, which react with one or more molar equivalent end-capping groups, such as methacrylic acid Isocyanoethyl ester (IEM), methacrylic anhydride, methacryloyl chloride, vinyl benzoyl chloride or the like to produce a polyethyl alcohol having one or more terminally polymerizable alkenyl groups, and the one Or a plurality of terminally polymerizable alkenyl groups are bonded to the polyethylene glycol via a linking moiety, such as a urethane ester group.
  • IEM methacrylic acid Isocyanoethyl ester
  • methacrylic anhydride
  • the hydrophilic monomer of the present invention may be any hydrophilic monomer known to be useful in the manufacture of hydrogels.
  • the hydrophilic monomer comprises an acrylic acid having a double bond or a derivative thereof, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof a class, a polyethylene glycol or a derivative thereof or a combination thereof.
  • the hydrophilic monomer comprises from 8 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the hydrophilic monomer comprises from 10 to 50% by weight of the hydrophilic polymer.
  • crosslinker includes, but is not limited to, compounds having at least two ethylenically unsaturated groups.
  • the crosslinking agent comprises an N,N'-methylenebisacrylamide, a monoethylene glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol.
  • Methacrylate triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, monomethacrylate, monoethylene diamine Methylacrylamide, glyceryl monomethacrylate, diethylene glycol dimethacrylate, monovinylbenzene or a combination thereof.
  • the crosslinking agent comprises from 0.1 to 20% by weight of the hydrophilic polymer. In a preferred embodiment, the crosslinking agent comprises from 0.2 to 10% by weight of the hydrophilic polymer. In a more preferred embodiment, the crosslinking agent comprises from 0.5 to 5% by weight of the hydrophilic polymer.
  • the present invention increases the strength of the reaction product of the hydrophilic polymer by adding an inorganic silicon oxy compound to the hydrophilic polymer, that is, the hydrophilic substrate, so that the hydrophilic substrate has high strength three-dimensional
  • the network structure overcomes the situation that the structure of the hydrogel has been swelled and fragrant after absorbing the aqueous solution.
  • the inorganic silicone compound is a compound having a silicon oxide chain as a main chain.
  • the basic structural unit of the siloxane chain is a silicon-oxygen bond structure having a reactive group capable of chemically bonding with an inorganic material and capable of chemically bonding with an organic material.
  • the structure of the inorganic silicon oxide has both "organic group” binding ability and “inorganic structure”, and the special composition and reactive group structure, when reacted with the organic polymerizable monomer, its special physical and chemical properties
  • the coupling reaction is effective to improve the mechanical strength, water resistance, cold resistance and adhesion of the polymeric material.
  • the inorganic silicon oxy compound of the present invention comprises an inorganic silicate.
  • the inorganic silicate refers to a compound (SixOy) composed of silicon and oxygen, which can be represented by a salt produced by silica or silicic acid.
  • the inorganic silicone compound is a silica or a metal silicate.
  • the term "metal silicate” is a generic term for compounds composed of silicon, oxygen and metal elements.
  • the metal silicate means that the silicon-oxygen bond of the silica is replaced by a metal salt, and the metal silicate produced has a small particle size and a large specific surface area, and the original single particle is 0.02 ⁇ m, and the aggregated particle is 5 ⁇ m.
  • the aggregate particles were 30 ⁇ m and the specific surface area was 20-800 m 2 /g.
  • the specific surface area of the metal silicate is more than 50 m 2 /g, the surface silanol groups cause interaction between the particles, and when used as a filler of a hydrophobic plastic polymer such as rubber or plastic, imparts an excellent reinforcing effect to the plastic.
  • the metal silicate is a magnesium aluminum silicate.
  • the specific surface area of a particle refers to the total surface area of a unit mass (or volume) of a particulate material, and can be used as one of important parameters for evaluating the performance of a catalyst, an adsorbent, and other porous materials. Therefore, the specific surface area of the particles is increased, and the adsorption area thereof can be increased, thereby increasing the adsorption capacity.
  • the inorganic silicon oxide particles have a specific surface area greater than 50 m 2 /g. In a preferred embodiment, the inorganic silicon oxide particles have a specific surface area greater than 100 m 2 /g. In a more preferred embodiment, the inorganic silicon oxide particles have a specific surface area greater than 150 m 2 /g.
  • the inorganic silicone compound comprises from 2 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the inorganic silicone compound comprises from 4 to 50% by weight of the hydrophilic polymer. In a more preferred embodiment, the inorganic silicone compound comprises from 6 to 40% by weight of the hydrophilic polymer.
  • the inorganic silicon oxy compound is an inorganic compound having a silicon oxytetrahedral structure or a polysiloxane tetrahedral structure. Therefore, the strength of the hydrophilic polymer can be improved by polymerizing the inorganic silicone compound into a three-dimensional network structure in the hydrophilic polymer.
  • the hydrophilic polymer further comprises one or more polymerization initiators.
  • the polymerization initiator is used in an effective amount in the hydrophilic polymer to initiate photopolymerization of the hydrophilic polymer.
  • the polymerization of the hydrophilic polymer can be initiated using heat, visible light, ultraviolet light or other suitable means depending on the polymerization initiator used. Alternatively, it can be initiated without a photoinitiator, for example using an electron beam (e-beam).
  • e-beam electron beam
  • polymerization initiator examples include, but are not limited to, lauryl peroxide, benzoyl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which will occur at moderately elevated temperatures.
  • Producing free radicals, as well as photoinitiator systems such as aromatic avatar hydroxy ketone, alkoxy benzoin, acetophenone, acylphosphine oxide, bisacylphosphine oxide and tertiary amine plus diketone, of the foregoing Mixtures with similar ones.
  • the UV photopolymerization initiator contained Irgacure 1173 and Irgacure 2959 (Ciba Specialty Chemicals).
  • the polymerization initiator can cause the other components of the hydrophilic polymer to undergo polymerization reaction with each other to obtain a reaction product of a hydrophilic polymer as the hydrophilic substrate.
  • the water-soluble promoting wound healing factor is adsorbed to the three-dimensional network structure inside the hydrophilic substrate by using the hydrophilic group having adsorptivity, thereby forming the composite material. Therefore, when the composite material is made into a hydrophilic dressing, when it is attached to the wound, the promoting wound healing factor is released from the composite material, which accelerates wound healing.
  • the hydrophilic substrate has a water content of > 40%. In a preferred embodiment, the hydrophilic substrate has a water content of > 50%. In a more preferred embodiment, the hydrophilic substrate has a water content of > 60%. Therefore, the hydrophilic substrate of the present invention has a high water content, and when the composite material is made into a hydrophilic dressing, it can maintain the wound moist when attached to the wound, and reduce the discomfort of the wounded person to the wound. sense.
  • the "wound” herein may be an open wound and a closed wound.
  • Open wounds can be divided into many types, including cuts (caused by clean, sharp objects such as knives or razors), cracks (rough irregular wounds caused by pressure or tear), and scratches (usually due to slipping over rough surfaces) The resulting surface damage, the uppermost skin is rubbed off) and the stab wound (caused by an object such as a nail or needle piercing the skin).
  • Closed wounds are classified much less, but are as dangerous as open wounds. They are contused or injured (injury to the underlying tissues caused by hard forces), hematoma (caused by blood vessel damage caused by blood vessel accumulation under the skin), and crush (due to long or large external forces) .
  • a compound that promotes wound healing includes, but is not limited to, a compound having an effect of promoting wound healing.
  • the compound that promotes wound healing comprises a water soluble compound that promotes wound healing.
  • the compound that promotes wound healing comprises a factor that promotes wound healing.
  • the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, a few Butanose or a combination thereof.
  • cytokine includes, but is not limited to, interleukins and interferons.
  • growth factor includes, but is not limited to, epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), connective tissue growth.
  • Connective tissue growth factor platelet-derived growth factor (PDGF), insulin-like growth factor, nerve growth factor, cell colony stimulating factor (colony) -stimulating factor), stem cell factor, keratinocyte growth factor, granulocyte colony-stimulating factor, granulocyte macrophage colony- Stimulating factor), glial-derived neurotropic factor, endothelial-monocyte activating polypeptide, epithelial neutrophil activation peptide (epithelial neutro) Phil activating peptide, erythropoietin, BRAK, and transforming growth factor beta.
  • the compound that promotes wound healing is from 0.01 to 20% of the total weight of the hydrophilic polymer. In a preferred embodiment, the compound that promotes wound healing is from 0.05 to 18% of the total weight of the hydrophilic polymer. In a more preferred embodiment, the compound that promotes wound healing is from 0.1 to 15% of the total weight of the hydrophilic polymer.
  • the composite material of the present invention is further bonded to a film to form a hydrophilic dressing.
  • the film has a two-sided structure, one of which is an adhesive surface that is bonded to the composite material.
  • the film is a film having the effect of being waterproof and breathable.
  • the film is a polyurethane (PU) film.
  • the surface area of the film is greater than the surface area of the composite material. Therefore, the adhesive surface of the film may have a bonding area outside the composite material to provide adhesion of the hydrophilic dressing to the skin. In another embodiment, the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to bond the composite material and the skin of one body.
  • the invention also provides a method for preparing a composite material, the steps comprising: (1) crosslinking and polymerizing a hydrophilic polymer to obtain a hydrophilic substrate, wherein the hydrophilic polymer comprises a hydrophilicity a monomer, a crosslinking agent, and an inorganic silicon oxy compound; and (2) adding a compound for promoting wound healing to the hydrophilic substrate to obtain the composite material, wherein the compound for promoting wound healing is The hydrophilic substrate is adsorbed and distributed in the hydrophilic substrate.
  • the hydrophilic monomer comprises an acrylic acid having a double bond or a derivative thereof, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof a class, a polyethylene glycol or a derivative thereof or a combination thereof.
  • the hydrophilic monomer comprises from 8 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the hydrophilic monomer comprises from 10 to 50% by weight of the hydrophilic polymer.
  • the crosslinking agent comprises an N,N'-methylenebisacrylamide, a monoethylene glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol.
  • the crosslinking agent comprises from 0.1 to 20% by weight of the hydrophilic polymer. In a preferred embodiment, the crosslinking agent comprises from 0.2 to 10% by weight of the hydrophilic polymer. In a more preferred embodiment, the crosslinking agent comprises from 0.5 to 5% by weight of the hydrophilic polymer.
  • the inorganic silicone compound comprises an inorganic silicate.
  • the inorganic silicone compound is a silica or a metal silicate.
  • the metal silicate is a magnesium aluminum silicate.
  • the inorganic silicon oxy compound is an inorganic compound having a silicon oxytetrahedral structure or a polysiloxane tetrahedral structure.
  • the inorganic silicon oxide particles have a specific surface area greater than 50 m 2 /g. In a preferred embodiment, the inorganic silicon oxide particles have a specific surface area greater than 100 m 2 /g. In a more preferred embodiment, the inorganic silicon oxide particles have a specific surface area greater than 150 m 2 /g.
  • the inorganic silicone compound comprises from 2 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the inorganic silicone compound comprises from 4 to 50% by weight of the hydrophilic polymer. In a more preferred embodiment, the inorganic silicone compound comprises from 6 to 40% by weight of the hydrophilic polymer.
  • the hydrophilic polymer of the step (1) in the production method of the present invention further contains a polymerization initiator.
  • the polymerization initiator is used in an effective amount in the hydrophilic polymer to initiate photopolymerization of the hydrophilic polymer.
  • examples of the polymerization initiator include, but are not limited to, lauryl peroxide, benzoyl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which will occur at moderately elevated temperatures.
  • the polymerization initiator is a UV photopolymerization initiator.
  • the UV photopolymerization initiator is irradiated with UV light to initiate a polymerization reaction.
  • the UV photopolymerization initiator is Irgacure 1173 or Irgacure 2959.
  • the method of cross-linking the hydrophilic polymer comprises causing the hydrophilic polymer to produce a cross-linking polymerization using heat, visible light or ultraviolet light.
  • the compound that promotes wound healing comprises a water soluble compound that promotes wound healing.
  • the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, a few Butanose or a combination thereof.
  • the compound that promotes wound healing is from 0.01 to 20% of the total weight of the hydrophilic polymer. In a preferred embodiment, the compound that promotes wound healing is from 0.05 to 18% of the total weight of the hydrophilic polymer. In a more preferred embodiment, the compound that promotes wound healing is from 0.1 to 15% of the total weight of the hydrophilic polymer.
  • the hydrophilic substrate itself has a hydrophilic group, it can adsorb a compound that promotes wound healing; and the hydrophilic substrate is a solid hydrophilic polymer having a three-dimensional network structure, so the three-dimensional network structure can be slowed down.
  • a compound that promotes wound healing is enhanced to enhance the wound healing effect of the composite material.
  • the composite material prepared by the present invention can be further bonded to a film to obtain a hydrophilic dressing for wound healing.
  • the film of the present invention can have both waterproof, transparent and breathable properties; thereby, not only water or bacteria can be prevented from entering the hydrophilic dressing, but also good gas permeability can be maintained.
  • the film is a film having the effect of being waterproof and breathable.
  • the gas permeable membrane layer can be made of polyurethane (PU).
  • the film of the present invention is a film having a single-sided adhesive which, in addition to bonding to the composite material, also provides adhesion to the skin of one body. Therefore, in a specific embodiment, the film has a two-sided structure, one of which is an adhesive surface, and the adhesive surface is bonded to the composite material.
  • the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to bond the composite material and the skin of one body. In another embodiment, the surface area of the film is greater than the surface area of the composite material.
  • the adhesive surface of the film may have a bonding area other than the composite material to provide adhesion between the hydrophilic dressing and the skin of the body; and the skin bonding area is a seal for oxygen supply and moisture exchange. Environment, insulting microorganisms and contaminants into the wound to promote the wound to be wet without excessive infiltration or drying.
  • the individual is an animal, preferably a mammal, and more preferably a human.
  • the present invention further provides a hydrogel structure comprising a hydrophilic substrate layer and a plurality of molecular particles, wherein the hydrophilic substrate layer is composed of a hydrophilic polymer, wherein the hydrophilic polymerization
  • the material comprises a hydrophilic monomer, a crosslinking agent and an inorganic silicon oxide compound, wherein the plurality of molecular particles are distributed in the hydrophilic substrate layer, wherein each of the plurality of molecular particles is a compound for promoting wound healing .
  • the hydrophilic substrate layer has a three-dimensional network structure, and the plurality of molecular particles adhere to the three-dimensional network structure.
  • the plurality of molecular particles are in the shape of a sphere.
  • the hydrophilic monomer comprises an acrylic acid having a double bond or a derivative thereof, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof a class, a polyethylene glycol or a derivative thereof or a combination thereof.
  • the crosslinking agent comprises an N,N'-methylenebisacrylamide, monoethylene glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol. Dimethacrylate, triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, monomethacrylate, monoethylenediamine Dimethyl acrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, monovinyl benzene or a combination thereof.
  • the inorganic silicon oxy compound is an inorganic compound having a silicon oxytetrahedral structure or a polysiloxane tetrahedral structure.
  • the hydrophilic polymer further comprises a polymerization initiator.
  • the polymerization initiator is an Irgacure 2959.
  • the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, and a chitosan. Sugar or a combination thereof.
  • the hydrogel structure further adheres to a film layer disposed over the hydrogel structure and having a surface area greater than a surface area of the hydrogel structure.
  • the film layer has a two-sided structure, one of which is an adhesive surface that is bonded to the hydrogel structure.
  • the film layer is made of a polyurethane (PU).
  • the hydrophilic polymer has a hydrophilic group, so it has hygroscopic and anti-hydrolysis properties, can absorb wound exudate and maintain wound moistion; and a three-dimensional network solid structure of appropriate strength covers the wound, thereby not only isolating the external environment to protect the wound, It can accelerate the proliferation and movement of wound epidermal cells and accelerate wound healing.
  • Another object of the present invention is to provide a solid hydrophilic polymer of suitable strength, which does not require non-woven fabric or fiber as a support layer for strengthening its structure, and utilizes a hydrophilic group thereof to adsorb and promote a wound healing factor, and The three-dimensional network structure in the hydrophilic polymer is used to achieve the effect of sustained release promoting wound healing factor and accelerate wound healing.
  • Figure 1 is a schematic view showing the structure of a composite material of the present invention
  • Figure 2 is a side view showing the structure of the hydrophilic dressing of the present invention.
  • 100, 220 composite material; 110: hydrophilic substrate; 120: wound healing effective factor; 200: hydrophilic dressing; 210: film.
  • the present invention is a hydrophilic monomer having a hydrophilic group-containing reactive monomer, a crosslinking agent and a silicon tetrahedral structure, and is cured and polymerized to form a high-strength solid hydrophilic polymer which is insoluble in water, and then hydrophilically polymerized.
  • the adsorption property of the hydrophilic group of the substrate itself, the wound healing effective factor, is adsorbed in the hydrophilic polymer of the solid three-dimensional network structure.
  • an initiator Irgacure 2959 (added in an amount of 2% by weight based on the total weight of the hydrophilic polymer) was added to the solution and stirred well.
  • the solution is transferred to a reaction mold, and under the irradiation of ultraviolet light, the solution in the reaction mold starts to undergo cross-linking polymerization, and the liquid oligomer in the solution gradually forms a hydrophilic polymerization of a solid three-dimensional network structure insoluble in water.
  • a hydrophilic substrate As a hydrophilic substrate.
  • FIG. 1 it is a schematic structural view of a composite material 100 of the present invention.
  • the composite material 100 comprises a hydrophilic substrate 110 and a wound healing effective factor 120.
  • the hydrophilic substrate 110 is a reaction product of a hydrophilic polymer having a solid structure of a three-dimensional network structure, wherein the hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent and an inorganic silicon. Oxygen compound.
  • the wound healing effective factor 120 is distributed in the three-dimensional network structure of the hydrophilic substrate 110; the wound healing effective factor 120 can be in the composite material 100 when the composite material 100 is used to treat a wound. Released to accelerate wound healing.
  • a specific embodiment of the wound healing effective factor 120 is collagen.
  • the invention only adjusts the addition amount of the silica portion in the hydrophilic polymer or replaces the silica with other components, that is, the original 3 g acrylamide and 7 g 2-propene.
  • the composition and the added amount of amido-2-methylpropanesulfonic acid and N,N'-methylenebisacrylamide (the amount of which is 1% of the total weight of the hydrophilic polymer) are not changed to prepare Samples of four different composite materials were produced.
  • sample 1 silica was added in an amount of 2 g
  • sample 2 silica was added in an amount of 6 g
  • sample 3 silica was replaced with magnesium aluminum silicate, and the addition thereof was carried out.
  • the amount was 2 g
  • the sample 4 silica was replaced with magnesium aluminum silicate, and the amount thereof was 6 g.
  • a film of a single-sided adhesive (for example, a commercially available "supplement coating" having a waterproof and breathable function) is bonded to the composite material described above, that is, the side having the adhesive on the film is attached to the composite material.
  • a hydrophilic dressing is obtained.
  • the hydrophilic dressing 200 includes a film 210 and a composite material 220.
  • the film 210 is disposed above the composite material 220. .
  • the film 210 has a two-sided structure, one of which is an adhesive surface (not shown), the adhesive surface has an adhesive, and the adhesive surface is bonded to the composite material 220 to make the film 210 and the composite material. 220 constitutes the hydrophilic dressing 200.
  • the surface area of the film 210 is greater than the surface area of the composite material 220. Therefore, the bonding surface of the film 210 may have an adhesive area bonded to the composite material 220 to provide the hydrophilic dressing 200 and a body.
  • the skin adheres, and the skin adhesion area is a sealed environment for oxygen and moisture exchange, which insulates microorganisms and contaminants into the wound to promote the wound to be wet without excessive infiltration or drying.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

一种具有适当力学强度的亲水性敷料（200），包含一复合性材料（100、220）以及一薄膜（210）。复合性材料（100、220）包含一亲水性基材（110）以及一促进伤口愈合的化合物（120），其中亲水性基材（110）为一亲水性聚合物的反应产物，其中亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中促进伤口愈合的化合物（120）分布于亲水性基材（110）中。

Description

复合性材料 技术领域
本发明是关于一复合性材料，该复合性材料为一含有促进伤口愈合的化合物的高强度三维网络结构的固态亲水性聚合物。
背景技术
以往保持伤口干燥为主要护理原则，因此会使用干式的纱布敷料来保护伤口。但是，常发生伤口与纱布沾黏的情况，导致除去敷料时，沾黏到刚愈合的伤口而造成伤口二次伤害与疼痛。近年来，相关研究证明保持伤口湿润有助在表皮细胞的移动与增生，能加速伤口愈合，在是产生各种湿式敷料，如水胶体(Hydrocolloids)与水凝胶(Hydrogels)敷料。
然而，水胶体敷料的含水量＜10％，伤口在渗液少的时候使用水胶体敷料，容易使伤口偏干燥与疼痛感，无法维持伤口湿润；再者水胶体敷料系以羧甲基纤维素为主，易遭感染伤口之细菌分解并产生异味；因此，水胶体不可用在感染性伤口。
另一具有吸水膨润的水凝胶，现有产品的力学强度不足，例如，台湾专利公告号第M419555、I267387、I429462、I504420号专利；中国专利公告号第CN204863670号专利及美国专利公开号第2013/0072843号专利系揭示以水凝胶结合不织布或纤维做支持层强化其结构；但水凝胶吸收水性溶液膨润后结构仍旧易碎，导致除去敷料时，碎裂残胶不易清除。
一般为了加速慢性伤口的愈合，除了保持伤口湿润与阻隔外在伤害的敷料，亦需促进伤口愈合因子。例如，美国专利公告号第5,489,304及5,716,411号专利是将胶原蛋白-葡萄糖胺聚醣(glycosaminoglycan)混合后覆盖在伤口表面，再涂覆一层经培养的动物或人类的表皮细胞层，以促使皮肤再生。美国专利专利号第5,977,088号专利揭示一种含有治疗或促进缓解皮肤疾病的药剂及透明质酸的医药组合物，该医药组合物是利用透明质酸促进或引起药剂输送至 伤员的皮肤内，其并可累积及延长药剂停留在该部位。
但上述加速伤口愈合的有效因子或湿式敷料，皆需先涂敷有效因子后，再覆盖敷料保护的二步骤，故照护流程烦琐；再者，促进伤口愈合因子若涂敷过量，不仅浪费又易使敷料固定不佳。虽有台湾专利公告号第I264306号专利揭露一胶原蛋白-透明质酸混合物涂布纱布敷料，却属不利伤口愈合的干式纱布的复合性材料。
因此，目前如何将有加速伤口愈合的有效因子与湿式敷料有效的结合，加强伤口护理和愈合，是目前业界解决的问题。
发明内容
有鉴于此，本发明提供一种具有适当力学强度的亲水性敷料，其包含一复合性材料以及一薄膜，最特别的是该复合性材料由一亲水性聚合物以及一促进伤口愈合的化合物所组成。该亲水性聚合物为具有高强度与亲水性有利的特性组合的聚合物；因此，该亲水性聚合物除了维持伤口湿润，加速表皮细胞的移动与增生外，因该亲水性聚合物为具有高强度三维网络结构的固态亲水聚合物，故克服以往水凝胶因吸收水性溶液而膨润后易碎的情况。此外，该亲水性聚合物利用其具有吸附性的亲水基团，将水溶性的胶原蛋白或透明质酸液等促进伤口愈合的化合物，吸附至亲水性聚合物内部的三维网络结构，在伤口治疗时能缓释促进伤口愈合因子，能加速伤口愈合。此外，目前伤口处理，伤员需先涂敷伤口愈合化合物，再覆盖敷料，故需要二步骤的照护流程，但本发明的亲水性敷料可一步骤就达到上述的疗程目的，可使伤口愈合的时间能更有效地缩短。
为达上述的目的，本发明提供一种复合性材料，其包含一亲水性基材以及一促进伤口愈合的化合物，其中该亲水性基材为一亲水性聚合物的反应产物，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该促进伤口愈合的化合物分布在该亲水性基材中。
本文中的用语「一」或「一种」是用以叙述本发明的组件及成分。此术语仅为了叙述方便及给予本发明的基本观念。此叙述应被理解为包括一种或至少一种，且除非明显地另有所指，表示单数时也包括复数。在在申请专利范围中 和”包含”一词一起使用时，该用语「一」可意谓一个或超过一个。
本文中的用语「或」其意同「及/或」。
本文中的「亲水性单体」包含一具有亲水性基团的反应性单体。可用在制备本发明的亲水性聚合物的亲水性单体，其具有至少一个可聚合的双键与至少一个亲水性的官能性基团。具有可聚合双键的官能性基团，其实例包括：丙烯酸、甲基丙烯酸、丙烯酰胺基、甲基丙烯酰胺基、富马酸、马来酸、苯乙烯基、异丙烯基苯基、O-乙烯碳酸酯、O-乙烯胺基甲酸酯、烯丙基、O-乙烯乙酰基、与N-乙烯内酰胺、与N-乙烯酰胺基的双键。
合适本发明的亲水性单体的类型包含含丙烯酸或乙烯基的单体。用语「丙烯酸」或「含丙烯酸」的单体为含有下列丙烯酸基团的单体：(CH2＝CRCOX)，其中R为H或CH3，且X为O或N，其也已知为可迅速进行聚合反应的单体，例如N，N-二甲基丙烯酰胺(DMA)、甲基丙烯酸2-羟乙基酯(HEMA)、甲基丙烯酸甘油酯、2-羟乙基甲基丙烯基酰胺、聚乙二醇单甲基丙烯酸酯、甲基丙烯酸、其混合物与类似者。用语「乙烯基」或「含乙烯基」的单体是指含乙烯基基团(-CH＝CH2)且能够进行聚合反应的单体。含乙烯基单体，包括但不限于单体如N-乙烯酰胺、N-乙烯内酰胺(例如NVP)、N-乙烯基-N-甲基乙酰胺、N-乙烯基-N-乙基乙酰胺、N-乙烯基-N-乙基甲酰胺、N-乙烯基甲酰胺。
其他可用于本发明的亲水性单体包括但不限于聚氧乙烯多元醇，其具有一或多个经一含可聚合双键的官能基置换的末端羟基基团。实例包括聚乙二醇、乙氧基化烷基葡苷与乙氧基化双酚A，其与一或多个莫耳当量的封端基团(end-capping group)反应，例如甲基丙烯酸异氰基乙酯(IEM)、甲基丙烯酸酐、甲基丙烯酰氯、乙烯基苯甲酰氯或类似者，以产生具有一或多个末端可聚合烯基团的聚乙多元醇，并且该一或多个末端可聚合烯基团透过联结部分(linking moiety)，如胺基甲酸酯或酯基团键结至该聚乙多元醇。
本发明所述的亲水性单体可为任何已知可用于制造水凝胶的亲水性单体。在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其 衍生物或它们的组合。
在另一具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为8至80％。在一较佳具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为10至50％。
本发明的交联剂无特别限制，只要其能与该亲水性聚合物的官能基反应以引发交联作用即可。本文中「交联剂」包含但不限于具有至少两个烯系不饱和基团的化合物。在一具体实施例中，该交联剂包含一N，N’-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯中或它们的组合。
在另一具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.1至20％。在一较佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.2至10％。在一更佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.5至5％。
本发明通过在该亲水性聚合物中加入无机硅氧化合物，以提高该亲水性聚合物的反应产物的强度，即该亲水性基材，使该亲水性基材具有高强度三维网络结构，故克服以往水凝胶的结构因吸收水性溶液而膨润后易碎的情况。在一具体实施例中，该无机硅氧化合物为一以硅氧链为主链的化合物。硅氧链的基本结构单元是由硅-氧键结构成，具有能与无机材料进行化学性结合，也能够与有机材料进行化学性结合的反应基团。故无机硅氧化合物的结构中既具有″有机基团″结合能力，又含有″无机结构″，这种特殊组成与反应基团的结构，当与有机聚合单体进行反应时，其特殊物化性能起偶联反应，有效提高聚合材料的机械强度，耐水性，耐寒性，黏结度等。
本发明的该无机硅氧化合物包含一无机硅酸盐。无机硅酸盐是指由硅和氧组成的化合物(SixOy)，可用由二氧化硅或硅酸产生的盐表示。在一具体实施例中，该无机硅氧化合物为一二氧化硅或一金属硅酸盐。本文中「金属硅酸盐」 一词是由硅元素、氧元素和金属元素组成的化合物的总称。该金属硅酸盐是指二氧化硅的硅氧键改以金属盐替换，其所产生的的金属硅酸盐的粒径小，比表面积大，原始单个粒子为0.02μm，聚集态粒子为5μm，集合体粒子为30μm，比表面积为20-800m 2/g。当金属硅酸盐的比表面积大于50m 2/g时，表面的硅醇基使粒子之间产生相互作用，在作为橡胶或塑料等疏水塑料聚合物的填料时，赋予塑料优良的补强作用。在一较佳具体实施例中，该金属硅酸盐为一硅酸镁铝。
粒子的比表面积是指单位质量(或体积)颗粒状物质的总表面积，可作为用以评价催化剂、吸附剂及其他多孔性物质性能的重要参数之一。因此，粒子的比表面积增大，可增大其吸附面积，从而增加其吸附能力。在一具体实施例中，该无机硅氧化合物的粒子的比表面积大于50m 2/g。在一较佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于100m 2/g。在一更佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于150m 2/g。
在另一具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为2至80％。在一较佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为4至50％。在一更佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为6至40％。
在一具体实施例中，该无机硅氧化合物为一具有硅氧四面体结构或一聚硅氧四面体结构的无机化合物。因此，透过该无机硅氧化合物在该亲水性聚合物中聚合成三维网络结构，可提高该亲水性聚合物的强度。
该亲水性聚合物进一步包含一或多种聚合引发剂。该聚合引发剂以有效量在该亲水性聚合物中使用，以引发该亲水性聚合物的光聚合。该亲水性聚合物的聚合可使用加热、可见光、紫外光或其他方式的适当选择引发，取决于所使用的聚合引发剂。或者，可在没有光引发剂下引发，例如使用电子束(e-beam)。
该聚合引发剂的实例包括但不限于月桂基过氧化物、苯甲酰基过氧化物、过氧碳酸异丙酯、偶氮双异丁腈与类似者，其在中度升高的温度下会产生自由基，以及光引发剂系统如芳族阿伐羟基酮、烷氧基氧基安息香、苯乙酮、酰基 膦氧化物、双酰基膦氧化物与三级胺加上二酮、前述物质的混合物与类似者。UV光聚合引发剂包含Irgacure 1173与Irgacure 2959(Ciba Specialty Chemicals)。
因此，该聚合引发剂可促使该亲水性聚合物的其他成份彼此产生聚合反应，反应后以得一亲水性聚合物的反应产物，以作为该亲水性基材。
待上述亲水性基材固化后，利用其具有吸附性的亲水基团，将水溶性促进伤口愈合因子，吸附至该亲水性基材内部的三维网络结构，形成该复合性材料。因此，该复合性材料制成亲水性敷料后，将其贴附于伤口上时，该促进伤口愈合因子从该复合性材料释放出，可加速伤口愈合。
另外，在一具体实施例中，该亲水性基材的含水量＞40％。在一较佳具体实施例中，该亲水性基材的含水量＞50％。在一更佳具体实施例中，该亲水性基材的含水量＞60％。因此，本发明的该亲水性基材的含水量高，使该复合性材料制成亲水性敷料后，将其贴附于伤口上时，可维持伤口湿润，减少伤者对伤口的不适感。
本文中的「伤口」可以是开放伤口和闭合伤口。开放伤口可以分为许多类型，包括割伤(由干净的锋利的物体如刀或剃刀引起)、裂口(由压力或撕扯引起的粗糙不规则的伤口)、擦伤(通常是由于滑过粗糙表面所引起的很表面的伤，其最上层的皮肤被擦掉)和刺伤(被一个物体例如钉或针刺破皮肤引起)。闭合伤口的分类少得多，但是同开放伤口一样危险。它们是挫伤或打伤(由硬力引起的皮肤下组织的伤害)、血肿(由血管受损使得血液在皮肤下聚集引起)以及压伤(由于长期施加的很大或极大的外力引起)。
本文中的「促进伤口愈合的化合物」包含但不限于具有促进伤口愈合的功效的化合物。在一具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合的水溶性化合物。在一较佳具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合因子。在一更佳具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。本文中「细胞因子」包含但不限于白 细胞介素及干扰素。本文中「生长因子」包含但不限于上皮生长因子(epidermal growth factor；EGF)、纤维母细胞生长因子(fibroblast growth factor；FGF)、血管内皮生长因子(vascular endothelial growth factor；VEGF)、结缔组织生长因子(connective tissue growth factor)、血小板衍生性生长因子(platelet-derived growth factor；PDGF)、类胰岛素生长因子(insulin-like growth factor)、神经生长因子(nerve growth factor)、细胞聚落刺激因子(colony-stimulating factor)、干细胞因子(stem call factor)、角质细胞生长因子(keratinocyte growth factor)、颗粒球细胞聚落刺激因子(granulocyte colony-stimulating factor)、颗粒球巨噬细胞聚落刺激因子(granulocyte macrophage colony-stimulating factor)、胶质衍生神经营养因子(glial-derived neurotropic factor)、内皮单核细胞活化多胜肽(endothelial-monocyte activating polypeptide)、上皮中性粒细胞活化胜肽(epithelial neutrophil activating peptide)、红血球生成素(erythropoietin)、BRAK及转化生长因子-β(transforming growth factor beta)。
在另一具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。在一较佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.05至18％。在一更佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.1至15％。
本发明的复合性材料进一步黏合一薄膜，以形成一亲水性敷料。在一具体实施例中，该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合。在另一具体实施例中，该薄膜为一具有防水透气的功效的薄膜。在一较佳具体实施例中，该薄膜为一聚氨酯(Polyurethane；PU)薄膜。
在一具体实施例中，该薄膜的表面积大于该复合性材料的表面积。因此该薄膜的该黏合面会有多出黏合该复合性材料外的黏合区域，用以提供该亲水性敷料与肌肤黏合。在另一具体实施例中，该黏合面为一压克力胶黏合面。该压克力胶黏合面以用以黏合该复合性料以及一个体的皮肤。
本发明还提供一复合性材料的制备方法，其步骤包含：(1)交联聚合一亲 水性聚合物，以得一亲水性基材，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物；以及(2)加入一促进伤口愈合的化合物于该亲水性基材中，以得该复合性材料，其中该促进伤口愈合的化合物被该亲水性基材所吸附且分布在该亲水性基材中。
在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
在另一具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为8至80％。在一较佳具体实施例中，该亲水性单体占该亲水性聚合物的重量百分比为10至50％。
在一具体实施例中，该交联剂包含一N，N’-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯中或它们的组合。
在另一具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.1至20％。在一较佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.2至10％。在一更佳具体实施例中，该交联剂占该亲水性聚合物的重量百分比为0.5至5％。
在一具体实施例中，该无机硅氧化合物包含一无机硅酸盐。在一较佳具体实施例中，该无机硅氧化合物为一二氧化硅或一金属硅酸盐。在一更佳具体实施例中，该金属硅酸盐为一硅酸镁铝。
在另一具体实施例中，该无机硅氧化合物为一具硅氧四面体结构或一聚硅氧四面体结构的无机化合物。在另一具体实施例中，该无机硅氧化合物的粒子的比表面积大于50m 2/g。在一较佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于100m 2/g。在一更佳具体实施例中，该无机硅氧化合物的粒子的比表面积大于150m 2/g。
在一具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为2至80％。在一较佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为4至50％。在一更佳具体实施例中，该无机硅氧化合物占该亲水性聚合物的重量百分比为6至40％。
本发明的制备方法中步骤(1)的该亲水性聚合物进一步包含一聚合引发剂。该聚合引发剂系以有效量在该亲水性聚合物中使用，以引发该亲水性聚合物的光聚合。该聚合引发剂的实例包括但不限于月桂基过氧化物、苯甲酰基过氧化物、过氧碳酸异丙酯、偶氮双异丁腈与类似者，其在中度升高的温度下会产生自由基，以及光引发剂系统如芳族阿伐羟基酮、烷氧基氧基安息香、苯乙酮、酰基膦氧化物、双酰基膦氧化物与三级胺加上二酮、前述物质的混合物与类似者。在一具体实施例中，该聚合引发剂为一UV光聚合引发剂。该UV光聚合引发剂是用UV光照射以引发聚合反应。在一较佳具体实施例中，该UV光聚合引发剂为Irgacure 1173或Irgacure 2959。
在一具体实施例中，交联聚合该亲水性聚合物的方法包含使用加热、可见光或紫外光的方式，使该亲水性聚合物产生交联聚合反应。
在另一具体实施例中，该促进伤口愈合的化合物包含一促进伤口愈合的水溶性化合物。在一较佳具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。
在一具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。在一较佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.05至18％。在一更佳具体实施例中，该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.1至15％。
因该亲水性基材本身具有亲水基团，故能吸附促进伤口愈合的化合物；且该亲水性基材为具有三维网络结构的固态亲水性聚合物，故该三维网络结构能缓释促进伤口愈合的化合物，加强该复合性材料的伤口愈合效果。
本发明所制备出的该复合性材料可进一步与一薄膜黏合，以得一亲水性敷 料，用于伤口愈合。
本发明的薄膜可兼具有防水、透明与透气等特性；藉此，不仅可避免水或细菌进入该亲水性敷料内，同时也可保持良好透气性。在一具有体实施例中，该薄膜为一具有有防水透气的功效的薄膜。在一较佳具有体实施例中，该透气膜层可由聚氨酯(Polyurethane；PU)所制成。
此外，本发明的薄膜为一具有单面黏合剂的薄膜，除了与该复合性材料黏合外，也提供与一个体的肌肤黏合的作用。故在一具体实施例中，该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合。在一较佳具体实施例中，该黏合面为一压克力胶黏合面。该压克力胶黏合面以用以黏合该复合性料以及一个体的皮肤。在另一具体实施例中，该薄膜的表面积大于该复合性材料的表面积。因此，该薄膜的该黏合面会有多出黏合该复合性材料以外的黏合区域，用以提供该亲水性敷料与一个体的肌肤黏合；而肌肤黏合区域为一供氧和湿气交换的密封环境，隔绝微生物与污染物进入伤口，以促进伤口处于潮湿而不过度浸润或干燥现象。
在一具体实施例中，该个体为动物，较佳为哺乳类，更佳为人类。
本发明进一步提供一种水凝胶结构，其包含一亲水性基材层以及复数个分子颗粒，其中该亲水性基材层由一亲水性聚合物所组成，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该复数个分子颗粒分布在该亲水性基材层中，其中各该复数个分子颗粒为促进伤口愈合的化合物。
在一具体实施例中，该亲水性基材层具有一三维网络结构，该复数个分子颗粒黏附在该三维网络结构上。
在另一具体实施例中，该复数个分子颗粒的形状为圆球状。
在一具体实施例中，该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
在另一具体实施例中，该交联剂包含一N，N’-亚甲基双丙烯酰胺、一乙二醇 二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯或它们的组合。
在一具体实施例中，该无机硅氧化合物为一具有硅氧四面体结构或一聚硅氧四面体结构的无机化合物。
在另一具体实施例中，该亲水性聚合物进一步包含一聚合引发剂。在一较佳具体实施例中，该聚合引发剂为一Irgacure 2959。
在一具体实施例中，该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一藻酸盐、一银离子、一几丁聚糖或它们的组合。
在另一具体实施例中，该水凝胶结构进一步黏合一薄膜层，其设在该水凝胶结构上方，且该薄膜层的表面积大于该水凝胶结构的表面积。在一较佳具体实施例中，该薄膜层具有两面结构，其中一面为一黏合面，该黏合面与该水凝胶结构黏合。在一更佳具体实施例中，该薄膜层的材质为一聚氨酯(PU)。
是以，本发明的主要目的在于，提供一种具有适当强度、弹性与三维网络结构的固态亲水性聚合物。该亲水性聚合物具有亲水基团，故具有吸湿及抗水解特性，可吸收伤口渗出液并维持伤口湿润；而适当强度的三维网络固态结构覆盖伤口，不仅隔绝外在环境防护伤口，更能加速伤口表皮细胞增生与移动，加速伤口愈合。
本发明的另一目的在于，此适当强度的固态亲水性聚合物，不需不织布或纤维作为强化其结构的支持层，又利用其具有的亲水基团，可吸附促进伤口愈合因子，并利用该亲水聚合物中的三维网络结构达到缓释促进伤口愈合因子的效果，加速伤口愈合。
附图说明
图1为本发明的复合性材料的结构示意图；
图2为本发明的亲水性敷料的侧面结构示意图；
其中，100、220：复合性材料；110：亲水性基材；120：伤口愈合有效因子；200：亲水性敷料；210：薄膜。
具体实施方式
下述范例具非局限性，且仅代表本发明的数个方面及特性。
本发明是以具亲水基团的反应性单体、交联剂及硅氧四面体结构的化合物，固化聚合形成不溶在水的高强度固态的亲水性聚合物，再利用亲水性聚合物基材本身的亲水基团的吸附特性，将伤口愈合有效因子，吸附于固态三维网络结构的亲水性聚合物中。
实施例1
亲水性聚合物的制备
将3克丙烯酰胺(亲水性单体)、7克2-丙烯酰胺基-2-甲基丙磺酸(亲水性单体)、2克二氧化硅、N，N’-亚甲基双丙烯酰胺(添加量为亲水性聚合物的总重量的1％)(交联剂)与水混合至100克，并搅拌均匀。
将上述溶液除氧气后，再向溶液中加入引发剂(initiator)Irgacure 2959(添加量为亲水性聚合物的总重量的2％)并搅拌均匀。将溶液移至反应模具中，在紫外光照射的情况下，使反应模具中的溶液开始发生交联聚合，溶液中液态低聚物逐渐形成不溶于水的固态的三维网络结构的亲水性聚合物，以作为一亲水性基材。
实施例2
复合性材料的制备
添加10克的10％胶原蛋白溶液，其为伤口愈合有效因子，在上述固态的亲 水性聚合物中。待固态的亲水性聚合物将胶原蛋白溶液完全吸附后，即可获得一复合性材料。
如图1所示，其为本发明的复合性材料100的结构示意图，该复合性材料100包含一亲水性基材110以及一伤口愈合有效因子120。该亲水性基材110为一亲水性聚合物的反应产物，其具有三维网络结构的固态物，其中该亲水性聚合物包含一亲水性单体、一交联剂及一无机硅氧化合物。而该伤口愈合有效因子120则分布在该亲水性基材110的三维网络结构中；在将该复合性材料100用于治疗伤口时，该伤口愈合有效因子120可在该复合性材料100中所释放，可加速伤口愈合。该伤口愈合有效因子120的一具体实施例为胶原蛋白。
实施例3
复合性材料的功效测试
本发明依据上述复合性材料的制备方法，仅调整亲水性聚合物中二氧化硅的部分的添加量或将二氧化硅改以其他成份替代，即原先3克丙烯酰胺、7克2-丙烯酰胺基-2-甲基丙磺酸、和N，N’-亚甲基双丙烯酰胺(其添加量为亲水性聚合物的总重量的1％)的成份及添加量不变动，以制备出四种不同的复合性材料的样本。各个样本的制备方法差别如下：样本1：二氧化硅的添加量为2克；样本2：二氧化硅的添加量为6克；样本3：二氧化硅以硅酸镁铝替代，且其添加量为2克；以及样本4：二氧化硅以硅酸镁铝替代，且其添加量为6克。
将上述四种配比不同的复合性材料样本与市面上贩卖的水凝胶敷料(作为对比组)进行比较，分别量测其浸生理食盐水前与浸渍完全膨润后的力学性质，其测试结果如表1所示。
表1、本发明的四种复合性材料样本与对比组的比较测试结果
Figure PCTCN2018074042-appb-000001
Figure PCTCN2018074042-appb-000002
实施例4
亲水性敷料的制备
将一单面黏合剂的薄膜(例如市售的”舒敷贴”，其具有防水透气的功能)与上述的复合性材料黏合，即将该薄膜上具有黏合剂的那一面贴合该复合性材料，就可得一亲水性敷料。
如图2所示，其为本发明的亲水性敷料200的侧面结构示意图，该亲水性敷料200包含一薄膜210以及一复合性材料220，其中该薄膜210设在该复合性材料220上方。该薄膜210具有两面结构，其中一面为一黏合面(黏合面未绘示)，该黏合面上具有黏合剂，该黏合面会与该复合性材料220黏合，以使该薄膜210以及该复合性材料220组成该亲水性敷料200。此外，该薄膜210的表面积大于该复合性材料220的表面积，因此该薄膜210的该黏合面会有多出黏合该复合性材料220外的黏合面积，用以提供该亲水性敷料200与一个体的肌肤黏合，而肌肤黏合区域为一供氧和湿气交换的密封环境，隔绝微生物与污染物进入伤口，以促进伤口处于潮湿而不过度浸润或干燥现象。
上述实施例仅为例示性说明本发明的功效，并阐述本发明的技术特征，而非用于限制本发明的保护范畴。任何熟悉本技术者在不违背本发明的技术原理及精神下，可轻易完成的改变或安排，均属本发明所主张的范围。因此，本发明的权利保护范围系如后附申请专利范围所列。

Claims (10)

  1. 一种复合性材料，其包含一亲水性基材以及一促进伤口愈合的化合物，其中该亲水性基材为一亲水性聚合物的反应产物，其中该亲水性聚合物包含一亲水性单体、一交联剂以及一无机硅氧化合物，其中该促进伤口愈合的化合物分布在该亲水性基材中。
  2. 如权利要求1所述的复合性材料，其中该亲水性单体包含一具有双键的丙烯酸或其衍生物、一丙烯酰胺或其衍生物、一2-丙烯酰胺基-2-甲基丙磺酸或其盐类、一聚乙二醇或其衍生物或它们的组合。
  3. 如权利要求1所述的复合性材料，其中该亲水性单体占该亲水性聚合物的重量百分比为8至80％。
  4. 如权利要求1所述的复合性材料，其中该交联剂包含一N，N’-亚甲基双丙烯酰胺、一乙二醇二甲基丙烯酸酯、一聚乙二醇二丙烯酸酯、一四乙二醇二甲基丙烯酸酯、一三乙二醇二甲基丙烯酸酯、一聚乙二醇二甲基丙烯酸酯、一三甲基丙烷三甲基丙烯酸酯、一甲基丙烯酸乙烯酯、一乙二胺二甲基丙烯酰胺、一二甲基丙烯酸甘油酯、一二甲基丙烯酸二乙二醇酯、一二乙烯基苯或它们的组合。
  5. 如权利要求1所述的复合性材料，其中该交联剂占该亲水性聚合物的重量百分比为0.1至20％。
  6. 如权利要求1所述的复合性材料，其中该无机硅氧化合物为一具有硅氧四面体结构或一聚硅氧四面体结构的无机化合物。
  7. 如权利要求1所述的复合性材料，其中该无机硅氧化合物占该亲水性聚合物的重量百分比为2至80％。
  8. 如权利要求1所述的复合性材料，其中该促进伤口愈合的化合物包含一胶原蛋白、一透明质酸、一明胶、一生长因子、一细胞因子(cytokine)、一 藻酸盐、一银离子、一几丁聚糖或它们的组合。
  9. 如权利要求1所述的复合性材料，其中该促进伤口愈合的化合物为该亲水性聚合物的总重量的0.01至20％。
  10. 如权利要求1所述的复合性材料，其进一步黏合一薄膜，其中该薄膜具有两面结构，其中一面为一黏合面，该黏合面与该复合性材料黏合，且该薄膜的表面积大于该复合性材料的表面积。
PCT/CN2018/074042 2017-04-17 2018-01-24 复合性材料 Ceased WO2018192285A1 (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1020197031607A KR102377115B1 (ko) 2017-04-17 2018-01-24 복합 재료
US16/605,498 US11235083B2 (en) 2017-04-17 2018-01-24 Composite hydrogel and metal silicate wound healing material
JP2019556222A JP2020516667A (ja) 2017-04-17 2018-01-24 複合材料
EP18788094.3A EP3613444A4 (en) 2017-04-17 2018-01-24 COMPOSITE MATERIAL

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710248691.0A CN108721677B (zh) 2017-04-17 2017-04-17 复合性材料
CN201710248691.0 2017-04-17

Publications (1)

Publication Number Publication Date
WO2018192285A1 true WO2018192285A1 (zh) 2018-10-25

Family

ID=63856127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/074042 Ceased WO2018192285A1 (zh) 2017-04-17 2018-01-24 复合性材料

Country Status (6)

Country Link
US (1) US11235083B2 (zh)
EP (1) EP3613444A4 (zh)
JP (1) JP2020516667A (zh)
KR (1) KR102377115B1 (zh)
CN (1) CN108721677B (zh)
WO (1) WO2018192285A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021014450A (ja) * 2019-07-10 2021-02-12 美麗康生技股▲ふん▼有限公司Ｍｌｋ Ｂｉｏｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． タトゥーの色を維持し、強化する方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808376D0 (en) 2008-05-08 2008-06-18 Bristol Myers Squibb Co Wound dressing
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
GB201020236D0 (en) 2010-11-30 2011-01-12 Convatec Technologies Inc A composition for detecting biofilms on viable tissues
CN103347561B (zh) 2010-12-08 2016-09-07 康沃特克科技公司 用于评估伤口分泌液的集成系统
JP6151186B2 (ja) 2010-12-08 2017-06-21 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 創傷滲出液システム付属装置
JP5833134B2 (ja) 2010-12-08 2015-12-16 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 創傷部位から滲出液を除去するための方法およびシステム
GB201115182D0 (en) 2011-09-02 2011-10-19 Trio Healthcare Ltd Skin contact material
GB2497406A (en) 2011-11-29 2013-06-12 Webtec Converting Llc Dressing with a perforated binder layer
WO2014096843A2 (en) 2012-12-20 2014-06-26 Convatec Technologies Inc. Processing of chemically modified cellulosic fibres
GB2543544A (en) 2015-10-21 2017-04-26 Brightwake Ltd Wound dressing
SG11201808488XA (en) 2016-03-30 2018-10-30 Convatec Technologies Inc Detecting microbial infections in wounds
CA3019436A1 (en) 2016-03-30 2017-10-05 Qualizyme Diagnostics Gmbh & Co Kg Detecting microbial infection in wounds
GB201608099D0 (en) 2016-05-09 2016-06-22 Convatec Technologies Inc Negative pressure wound dressing
ES2912094T3 (es) 2016-07-08 2022-05-24 Convatec Technologies Inc Detección de flujo de fluidos
JP2019525799A (ja) 2016-07-08 2019-09-12 コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ 流体収集装置
EP3871645B1 (en) 2016-07-08 2022-05-04 ConvaTec Technologies Inc. Flexible negative pressure system
EP4360666A3 (en) 2017-11-16 2024-05-08 ConvaTec Limited Fluid collection apparatus
CN109331216B (zh) * 2018-11-28 2021-03-30 福建师范大学 一种快速止血水凝胶及其制备方法
SG11202112292QA (en) 2019-06-03 2021-12-30 Convatec Ltd Methods and devices to disrupt and contain pathogens
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
CN120959978B (zh) * 2025-10-22 2025-12-23 四川大学 一种超薄多功能水凝胶敷料及其制备方法、皮肤创面护理材料

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489304A (en) 1994-04-19 1996-02-06 Brigham & Women's Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
US5759570A (en) * 1992-11-23 1998-06-02 Johnson & Johnson Medical, Inc. Multi-layer wound dressing
US5977088A (en) 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
TW429462B (en) 1998-08-11 2001-04-11 Hitachi Ltd Manufacturing method and processing device for semiconductor device
TW504420B (en) 2002-02-27 2002-10-01 Advanced Semiconductor Eng Table saw device
TWI264306B (en) 2000-08-02 2006-10-21 Shin Era Technology Co Ltd Wound dressings and their preparation
TWI267387B (en) 2003-02-20 2006-12-01 Inst Nuclear Energy Res Aec The novel preparation of two-layer burn wound dressings
CN101041702A (zh) * 2006-03-24 2007-09-26 株式会社日本触媒 吸水性树脂及其制造方法
CN101125934A (zh) * 2007-09-30 2008-02-20 四川大学 含银离子的壳聚糖/尼龙复合抗菌膜的制备方法
CN101240052A (zh) * 2008-02-29 2008-08-13 厦门大学 一种丙烯酸系半互穿网络复合型高吸水性树脂的制备方法
CN101454027A (zh) * 2006-05-23 2009-06-10 3M创新有限公司 可固化的亲水组合物
TWM419555U (en) 2011-04-28 2012-01-01 Amed Co Ltd Wound dressing
US20130072843A1 (en) 2011-09-15 2013-03-21 Compose Element Limited Dressing
US20140341865A1 (en) * 2011-12-12 2014-11-20 Tego Science Inc. Dressing Material With Cell Components For Wound Healing
CN104740671A (zh) * 2008-03-05 2015-07-01 巴斯夫欧洲公司 制备超吸收剂的方法
CN204863670U (zh) 2015-08-20 2015-12-16 振朋生技股份有限公司 多层贴布结构
CN105169460A (zh) * 2015-10-26 2015-12-23 广东泰宝医疗科技股份有限公司 一种磁疗抗菌止血敷料及其制备方法
CN105683281A (zh) * 2013-12-13 2016-06-15 株式会社Lg化学 超吸收性聚合物组合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093673A (en) * 1974-11-14 1978-06-06 Ppg Industries, Inc. Coating compositions composed of hydroxyfunctional polymers or copolymers and alkoxysilanes
US4950699A (en) * 1988-01-11 1990-08-21 Genetic Laboratories, Inc. Wound dressing incorporating collagen in adhesive layer
CA2074235C (en) * 1991-07-18 2000-02-08 Hiroshi Itoh Hardenable composition, aqueous gel and applications thereof
US5725876A (en) * 1996-05-17 1998-03-10 Noven Pharmaceuticals Inc., Compositions and methods for using low-swell clays in nicotine containing dermal compositions
DE19854575A1 (de) * 1998-11-26 2000-05-31 Basf Ag Vernetzte quellfähige Polymere
RU2001135803A (ru) * 1999-05-26 2003-07-27 Альберта Ресерч Консил Инк. (Ca) Усиленный полимерно/глиняный сплавной состав с сетевой структурой
CA2310484A1 (en) * 1999-05-26 2000-11-26 Alberta Research Council Inc. Networked polymer/clay alloy
ES2331302T3 (es) * 2001-05-01 2009-12-29 A.V. Topchiev Institute Of Petrochemical Synthesis Composiciones de hidrogel.
CN1245450C (zh) * 2001-09-18 2006-03-15 积水化成品工业株式会社 聚合物水凝胶
AU2003266947A1 (en) * 2002-10-02 2004-04-23 Coloplast A/S A hydrogel
DE10331456A1 (de) * 2003-07-10 2005-02-24 Basf Ag (Meth)acrylsäureester alkoxilierter ungesättigter Polyolether und deren Herstellung
US7407709B2 (en) * 2003-12-22 2008-08-05 3M Innovative Properties Company Silicone pressure sensitive adhesive and articles
JP4567998B2 (ja) * 2004-03-22 2010-10-27 コスメディ製薬株式会社 親水性粘着剤を用いた親水性皮膚外用粘着剤組成物および親水性貼付剤
EP1791575B1 (en) * 2004-08-05 2014-10-08 Corium International, Inc. Adhesive composition
AU2006209239A1 (en) * 2005-01-27 2006-08-03 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrophilic biocompatible adhesive formulations and uses
JP2006321792A (ja) * 2005-04-18 2006-11-30 Showa Denko Kk 含水ゲル体及びその製造方法
CN101195664B (zh) * 2006-12-06 2012-01-04 新疆大学 有机无机复合型半互穿网络结构超强吸水剂的制备方法
CN101808730A (zh) * 2007-09-27 2010-08-18 Sca卫生用品公司 粘土连接的聚合物凝胶
CN101712785A (zh) * 2008-10-06 2010-05-26 常琛 新型高吸水树脂/无机纳米粒子复合材料及其制备方法和用途
US8222477B2 (en) * 2008-10-20 2012-07-17 Evonik Stockhausen, Llc Superabsorbent polymer containing clay, particulate, and method of making same
CN101735353B (zh) * 2010-01-07 2012-12-05 华南理工大学 N-乙烯基酰胺类聚合物和锂藻土复合水凝胶及制备方法
JP5688578B2 (ja) * 2010-11-17 2015-03-25 アルケア株式会社 粘着性ゲル
US9901660B2 (en) * 2013-07-04 2018-02-27 Yeda Research And Development Co. Ltd. Low friction hydrogels and hydrogel-containing composite materials
CN105980042B (zh) * 2014-02-24 2020-03-13 日产化学工业株式会社 凝胶的制造方法
EP3152250A4 (en) * 2014-06-04 2018-01-03 Klox Technologies Inc. Biophotonic hydrogels
KR20160004967A (ko) * 2014-07-04 2016-01-13 한화케미칼 주식회사 고흡수성 수지 및 이의 제조 방법
CN104262881B (zh) * 2014-10-10 2017-10-24 齐鲁工业大学 一种高强度双网络纳米二氧化硅复合水凝胶的制备方法
CN105561370B (zh) * 2015-04-28 2019-02-15 安徽省科晟生物科技有限公司 一种止血材料及其制备方法
WO2017058698A1 (en) * 2015-09-30 2017-04-06 3M Innovative Properties Company Hydrogel compositions bonded to polymeric substrates

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977088A (en) 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5759570A (en) * 1992-11-23 1998-06-02 Johnson & Johnson Medical, Inc. Multi-layer wound dressing
US5489304A (en) 1994-04-19 1996-02-06 Brigham & Women's Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
US5716411A (en) 1994-04-19 1998-02-10 Brigham & Womens Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
TW429462B (en) 1998-08-11 2001-04-11 Hitachi Ltd Manufacturing method and processing device for semiconductor device
TWI264306B (en) 2000-08-02 2006-10-21 Shin Era Technology Co Ltd Wound dressings and their preparation
TW504420B (en) 2002-02-27 2002-10-01 Advanced Semiconductor Eng Table saw device
TWI267387B (en) 2003-02-20 2006-12-01 Inst Nuclear Energy Res Aec The novel preparation of two-layer burn wound dressings
CN101041702A (zh) * 2006-03-24 2007-09-26 株式会社日本触媒 吸水性树脂及其制造方法
CN101454027A (zh) * 2006-05-23 2009-06-10 3M创新有限公司 可固化的亲水组合物
CN101125934A (zh) * 2007-09-30 2008-02-20 四川大学 含银离子的壳聚糖/尼龙复合抗菌膜的制备方法
CN101240052A (zh) * 2008-02-29 2008-08-13 厦门大学 一种丙烯酸系半互穿网络复合型高吸水性树脂的制备方法
CN104740671A (zh) * 2008-03-05 2015-07-01 巴斯夫欧洲公司 制备超吸收剂的方法
TWM419555U (en) 2011-04-28 2012-01-01 Amed Co Ltd Wound dressing
US20130072843A1 (en) 2011-09-15 2013-03-21 Compose Element Limited Dressing
US20140341865A1 (en) * 2011-12-12 2014-11-20 Tego Science Inc. Dressing Material With Cell Components For Wound Healing
CN105683281A (zh) * 2013-12-13 2016-06-15 株式会社Lg化学 超吸收性聚合物组合物
CN204863670U (zh) 2015-08-20 2015-12-16 振朋生技股份有限公司 多层贴布结构
CN105169460A (zh) * 2015-10-26 2015-12-23 广东泰宝医疗科技股份有限公司 一种磁疗抗菌止血敷料及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3613444A4

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021014450A (ja) * 2019-07-10 2021-02-12 美麗康生技股▲ふん▼有限公司Ｍｌｋ Ｂｉｏｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ． タトゥーの色を維持し、強化する方法

Also Published As

Publication number Publication date
US11235083B2 (en) 2022-02-01
US20200114039A1 (en) 2020-04-16
CN108721677A (zh) 2018-11-02
JP2020516667A (ja) 2020-06-11
KR20190131099A (ko) 2019-11-25
KR102377115B1 (ko) 2022-03-22
EP3613444A1 (en) 2020-02-26
EP3613444A4 (en) 2021-01-06
CN108721677B (zh) 2021-11-19

Similar Documents

Publication Publication Date Title
WO2018192285A1 (zh) 复合性材料
US8696975B2 (en) Methods of making shaped polymeric materials
CN105169465B (zh) 一种医用防粘水凝胶敷料及其制备方法
EP0601463B1 (en) Medical water-absorptive polymer and dressing for wound and medical bandage using the same
JP3532235B2 (ja) ヒドロゲルラミネート、絆創膏、複合体、およびそれらの製造法
US8263720B1 (en) Sacrificial adhesive coatings
WO2009073401A4 (en) Silicone hydrogels for tissue adhesives and tissue dressing applications
CN114920956A (zh) 一种具实时监测功能的止血抗菌促愈合水凝胶及制备方法
WO2009134414A2 (en) Devices for the treatment of wounds and methods and kits thereof
WO2005092403A1 (en) Hydrophilic materials from reactive oligomers having photoinitiator groups
CN105367712A (zh) 一种复合水凝胶及其制备方法
Zhang et al. A graphene hybrid supramolecular hydrogel with high stretchability, self-healable and photothermally responsive properties for wound healing
CN1826360B (zh) 用于治疗用途的热敏聚合物及其制备方法
JP2008528728A (ja) マイケル供与体側基を有するポリマーからの架橋性親水性材料
CN112999412B (zh) 用于伤口愈合的水凝胶敷料及其制备方法
WO2015042717A1 (en) Non-adherent hydrogel coating for wound dressings and methods for making the same
WO2005092402A1 (en) Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups
CN111548454A (zh) 可打印成型的高强度体温释放药物水凝胶的制备方法
US12485202B2 (en) Shape memory adhesive materials for diabetic wound healing
CN118059297B (zh) 具有温敏性的抗菌水凝胶材料及其制备方法、应用
US20030091851A1 (en) Method of preparing chitin films
TWI662072B (zh) 複合性材料
TWM559888U (zh) 水凝膠結構
CN119192484A (zh) 一种纳米凝胶增强防污抗菌水凝胶及其制备方法
CN118252963A (zh) 一种多层伤口敷料及其制备方法和应用

Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18788094

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2019556222

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 20197031607

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2018788094

Country of ref document: EP

Effective date: 20191118