WO2019021065A3 - Nouveau système et nouveau procédé de collecte, d'enrichissement et d'isolement de cellules trophoblastiques à partir d'un canal endocervical - Google Patents

Nouveau système et nouveau procédé de collecte, d'enrichissement et d'isolement de cellules trophoblastiques à partir d'un canal endocervical Download PDF

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Publication number
WO2019021065A3
WO2019021065A3 PCT/IB2018/001078 IB2018001078W WO2019021065A3 WO 2019021065 A3 WO2019021065 A3 WO 2019021065A3 IB 2018001078 W IB2018001078 W IB 2018001078W WO 2019021065 A3 WO2019021065 A3 WO 2019021065A3
Authority
WO
WIPO (PCT)
Prior art keywords
endocervical
collecting
collection device
trophoblasts
enriching
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/001078
Other languages
English (en)
Other versions
WO2019021065A2 (fr
Inventor
Zitao LIU
Lian Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trophodiagnostics LLC
Original Assignee
Trophodiagnostics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophodiagnostics LLC filed Critical Trophodiagnostics LLC
Priority claimed from US15/894,949 external-priority patent/US20190247030A1/en
Publication of WO2019021065A2 publication Critical patent/WO2019021065A2/fr
Publication of WO2019021065A3 publication Critical patent/WO2019021065A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des systèmes et des procédés améliorés pour collecter, isoler et analyser des trophoblastes à partir du canal endocervical pour un test génétique prénatal. La présente invention concerne, plus précisément, un dispositif de collecte d'échantillon endocervical, le dispositif de collecte étant amélioré avec des nanostructures/microstructures de surface et fonctionnalisé avec des anticorps spécifiques aux trophoblastes pour permettre au dispositif de collecte d'adhérer de préférence à des trophoblastes fœtaux et de prélever les trophoblastes fœtaux au lieu de cellules maternelles et/ou de matériaux non cellulaires tels que le mucus endocervical. L'invention concerne en outre une préparation mucolytique non caustique pour traiter un échantillon endocervical afin d'éliminer le mucus tout en conservant les cellules trophoblastiques intactes et viables pour une culture et un traitement en aval.
PCT/IB2018/001078 2017-02-13 2018-02-13 Nouveau système et nouveau procédé de collecte, d'enrichissement et d'isolement de cellules trophoblastiques à partir d'un canal endocervical Ceased WO2019021065A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762458375P 2017-02-13 2017-02-13
US62/458,375 2017-02-13
US15/894,949 2018-02-13
US15/894,949 US20190247030A1 (en) 2018-02-13 2018-02-13 System and Method for Collecting, Enriching and Isolating Trophoblast Cells From Endocervical Canal

Publications (2)

Publication Number Publication Date
WO2019021065A2 WO2019021065A2 (fr) 2019-01-31
WO2019021065A3 true WO2019021065A3 (fr) 2019-04-11

Family

ID=65041081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/001078 Ceased WO2019021065A2 (fr) 2017-02-13 2018-02-13 Nouveau système et nouveau procédé de collecte, d'enrichissement et d'isolement de cellules trophoblastiques à partir d'un canal endocervical

Country Status (1)

Country Link
WO (1) WO2019021065A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN223601478U (zh) * 2024-01-16 2025-11-28 创健医疗(香港)有限公司 细胞取样单元及细胞取样工具
CN120732476B (zh) * 2025-07-31 2026-03-17 首都医科大学附属北京同仁医院 鼻咽腺样体采集器

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070282222A1 (en) * 2006-06-01 2007-12-06 Daniel Larkin Sexually transmitted infection sampling device
US20080262384A1 (en) * 2004-11-05 2008-10-23 Southwest Research Institute Method and Devices for Screening Cervical Cancer
US20100049083A1 (en) * 2005-02-02 2010-02-25 Commissariat A L'energie Atomique Device for contact molecular sampling
US20110301442A1 (en) * 2008-09-23 2011-12-08 Gilupi Gmbh Diagnostic analyte collection device based on flexible polymers with biological surface modification and microfluidic functionality
US8152739B1 (en) * 2007-09-19 2012-04-10 Christine A. McCully Adjustable dual-brush cervical cytology collection device
US20140073989A1 (en) * 2009-01-27 2014-03-13 Genetic Technologies, Ltd. Biological sampling device
US20150267240A1 (en) * 2012-10-19 2015-09-24 Michael P DIAMOND Identification and analysis of fetal trophoblast cells in cervical mucus for prenatal diagnosis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262384A1 (en) * 2004-11-05 2008-10-23 Southwest Research Institute Method and Devices for Screening Cervical Cancer
US20100049083A1 (en) * 2005-02-02 2010-02-25 Commissariat A L'energie Atomique Device for contact molecular sampling
US20070282222A1 (en) * 2006-06-01 2007-12-06 Daniel Larkin Sexually transmitted infection sampling device
US8152739B1 (en) * 2007-09-19 2012-04-10 Christine A. McCully Adjustable dual-brush cervical cytology collection device
US20110301442A1 (en) * 2008-09-23 2011-12-08 Gilupi Gmbh Diagnostic analyte collection device based on flexible polymers with biological surface modification and microfluidic functionality
US20140073989A1 (en) * 2009-01-27 2014-03-13 Genetic Technologies, Ltd. Biological sampling device
US20150267240A1 (en) * 2012-10-19 2015-09-24 Michael P DIAMOND Identification and analysis of fetal trophoblast cells in cervical mucus for prenatal diagnosis

Also Published As

Publication number Publication date
WO2019021065A2 (fr) 2019-01-31

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