WO2019022482A3 - 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물 - Google Patents

황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2019022482A3
WO2019022482A3 PCT/KR2018/008374 KR2018008374W WO2019022482A3 WO 2019022482 A3 WO2019022482 A3 WO 2019022482A3 KR 2018008374 W KR2018008374 W KR 2018008374W WO 2019022482 A3 WO2019022482 A3 WO 2019022482A3
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
dendropanax morbifera
composition
morbifera extract
fibrotic diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/008374
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English (en)
French (fr)
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WO2019022482A2 (ko
Inventor
최철희
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chosun University Industry Academic Cooperation Foundation
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Chosun University Industry Academic Cooperation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chosun University Industry Academic Cooperation Foundation filed Critical Chosun University Industry Academic Cooperation Foundation
Priority to CN201880049638.0A priority Critical patent/CN111356468B/zh
Publication of WO2019022482A2 publication Critical patent/WO2019022482A2/ko
Publication of WO2019022482A3 publication Critical patent/WO2019022482A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

본 발명은 황칠나무 추출물을 유효성분으로 포함하는 항섬유화 활성을 갖는 조성물에 관한 것으로, 구체적으로 본 발명의 황칠나무 추출물은 섬유화에 중요한 역할을 하는 TGF-β1의 신호전달 경로를 효과적으로 억제하는 활성이 있어 TGF-β1으로 유도되는 α-SMA, CTGF, FN-EDAM 및 콜라겐과 같은 세포외기질 인자들의 발현 및 활성을 억제할 수 있으며, 높은 항산화 활성이 있으므로 황칠나무 추출물을 유효성분으로 함유하는 본 발명의 조성물은 섬유화 질환의 치료제 및 건강기능성 식품의 제조에 유용하게 사용할 수 있는 효과가 있다.
PCT/KR2018/008374 2017-07-25 2018-07-24 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물 Ceased WO2019022482A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201880049638.0A CN111356468B (zh) 2017-07-25 2018-07-24 包含黄漆木提取物作为有效成分的用于预防或治疗纤维化疾病的组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0094083 2017-07-25
KR1020170094083A KR101956620B1 (ko) 2017-07-25 2017-07-25 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물

Publications (2)

Publication Number Publication Date
WO2019022482A2 WO2019022482A2 (ko) 2019-01-31
WO2019022482A3 true WO2019022482A3 (ko) 2019-03-21

Family

ID=65040262

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/008374 Ceased WO2019022482A2 (ko) 2017-07-25 2018-07-24 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물

Country Status (3)

Country Link
KR (1) KR101956620B1 (ko)
CN (1) CN111356468B (ko)
WO (1) WO2019022482A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210108748A (ko) * 2020-02-26 2021-09-03 농업회사법인 휴림황칠(주) 황칠 추출물을 포함하는 고요산혈증 개선용 조성물
KR20220001801A (ko) * 2020-06-30 2022-01-06 주식회사 고암바이오알앤디수 황칠나무 추출물 또는 이로부터 유래된 화합물을 포함하는 신장독성 및 신장섬유화 질환의 예방 및 치료용 약학적 조성물
KR102447045B1 (ko) * 2020-10-21 2022-09-22 성균관대학교산학협력단 황칠나무 추출물을 유효성분으로 함유하는 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030079205A (ko) * 2002-04-02 2003-10-10 주식회사 디피바이오텍 간세포 보호 효과를 갖는 황칠 추출물, 황칠 분획물 및이들을 함유한 약학 조성물
KR20110078527A (ko) * 2009-12-31 2011-07-07 주식회사 코리아나화장품 황칠나무 추출물을 유효성분으로 함유하는 화장료 조성물
KR101194947B1 (ko) * 2012-02-07 2012-10-25 박소현 황칠나무 추출물을 포함하는 간질환 치료용 약학 조성물
WO2013180336A1 (ko) * 2012-05-30 2013-12-05 조선대학교 산학협력단 15-히드록시프로타글란딘 디히드로게나제 및 ｐｇｅ2 활성을 조절하는 황칠나무 추출물의 용도

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102413705B1 (ko) * 2014-05-29 2022-06-27 주식회사유한양행 황칠 나무 추출물을 함유하는 간 기능 개선용 조성물
KR101731903B1 (ko) * 2014-09-19 2017-05-02 한국생명공학연구원 황칠나무 추출물 및 이의 분획물을 유효성분으로 함유하는 천식 예방 및 치료용 약학적 조성물
KR101739518B1 (ko) * 2015-08-20 2017-05-26 비알 컨설팅 인코포레이티드 황칠나무의 추출물을 포함하는 조성물
KR101734986B1 (ko) 2016-07-20 2017-05-12 부산대학교 산학협력단 아리스몰을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물

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KR20110078527A (ko) * 2009-12-31 2011-07-07 주식회사 코리아나화장품 황칠나무 추출물을 유효성분으로 함유하는 화장료 조성물
KR101194947B1 (ko) * 2012-02-07 2012-10-25 박소현 황칠나무 추출물을 포함하는 간질환 치료용 약학 조성물
WO2013180336A1 (ko) * 2012-05-30 2013-12-05 조선대학교 산학협력단 15-히드록시프로타글란딘 디히드로게나제 및 ｐｇｅ2 활성을 조절하는 황칠나무 추출물의 용도

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YANG HOON YOUNG ET AL.: "Dendropanax Morbifera Protective Agent against Thioacetamide-induced Liver Fibrosis", THE KOREAN SOCIETY OF ENVIRONMENTAL HEALTH AND TOXICOLOGY, 26 May 2017 (2017-05-26) *

Also Published As

Publication number Publication date
KR101956620B1 (ko) 2019-03-11
KR20190011482A (ko) 2019-02-07
WO2019022482A2 (ko) 2019-01-31
CN111356468B (zh) 2022-05-03
CN111356468A (zh) 2020-06-30

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