WO2019070086A3 - Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication - Google Patents

Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication Download PDF

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Publication number
WO2019070086A3
WO2019070086A3 PCT/KP2018/000048 KP2018000048W WO2019070086A3 WO 2019070086 A3 WO2019070086 A3 WO 2019070086A3 KP 2018000048 W KP2018000048 W KP 2018000048W WO 2019070086 A3 WO2019070086 A3 WO 2019070086A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
haemoglobin
manufacturing
swine
oxygen carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KP2018/000048
Other languages
English (en)
Other versions
WO2019070086A2 (fr
Inventor
Won Nam Yun
Chol Hui HAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rim Chang Ho
Original Assignee
Rim Chang Ho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rim Chang Ho filed Critical Rim Chang Ho
Publication of WO2019070086A2 publication Critical patent/WO2019070086A2/fr
Publication of WO2019070086A3 publication Critical patent/WO2019070086A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc. La présente invention concerne un procédé de fabrication d'un substitut sanguin transportant de l'oxygène à partir de sang de porc. Ledit procédé comprend un processus d'élimination de la protéine plasmatique du sang de porc, un processus de séparation de l'hémoglobine, un processus de purification de l'hémoglobine avec une résine d'échange de cation fortement acide , un processus de polymérisation d'hémoglobine avec du glutaraldéhyde, un processus d'ultrafiltration de polymère d'hémoglobine, un processus d'inactivation de virus dans un polymère d'hémoglobine et un processus d'emballage.
PCT/KP2018/000048 2017-09-20 2018-11-20 Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication Ceased WO2019070086A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KP201720003509 2017-09-20
KP201720003509 2017-09-20

Publications (2)

Publication Number Publication Date
WO2019070086A2 WO2019070086A2 (fr) 2019-04-11
WO2019070086A3 true WO2019070086A3 (fr) 2019-06-13

Family

ID=65994508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KP2018/000048 Ceased WO2019070086A2 (fr) 2017-09-20 2018-11-20 Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication

Country Status (1)

Country Link
WO (1) WO2019070086A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113509488B (zh) * 2021-06-29 2022-05-20 西安交通大学 一种携氧仿生纳米解毒剂及其制备方法和应用
CN119367518A (zh) * 2024-10-28 2025-01-28 广州蕊特生物科技有限公司 一种人造血液及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301144A (en) * 1979-07-11 1981-11-17 Ajinomoto Company, Incorporated Blood substitute containing modified hemoglobin
WO2007136555A2 (fr) * 2006-05-09 2007-11-29 The United States Of America As Represented By The Secretary Of The Navy Substitut sanguin plurifonctionnel
EP2322207A2 (fr) * 2008-03-18 2011-05-18 Nauchno Proizvodstennaya Kompaniya "MEDBIOFARM" Substitut sanguin à fonction de transport d oxygène, composition pharmaceutique et variantes
CN107137699A (zh) * 2017-06-15 2017-09-08 中国医学科学院输血研究所 一种天然血红蛋白类血液代用品的脱氧方法和制备工艺

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301144A (en) * 1979-07-11 1981-11-17 Ajinomoto Company, Incorporated Blood substitute containing modified hemoglobin
WO2007136555A2 (fr) * 2006-05-09 2007-11-29 The United States Of America As Represented By The Secretary Of The Navy Substitut sanguin plurifonctionnel
EP2322207A2 (fr) * 2008-03-18 2011-05-18 Nauchno Proizvodstennaya Kompaniya "MEDBIOFARM" Substitut sanguin à fonction de transport d oxygène, composition pharmaceutique et variantes
CN107137699A (zh) * 2017-06-15 2017-09-08 中国医学科学院输血研究所 一种天然血红蛋白类血液代用品的脱氧方法和制备工艺

Also Published As

Publication number Publication date
WO2019070086A2 (fr) 2019-04-11

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