WO2019147879A3 - Échafaudage enroulé pour culture cellulaire à grande échelle en monocouche - Google Patents

Échafaudage enroulé pour culture cellulaire à grande échelle en monocouche Download PDF

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Publication number
WO2019147879A3
WO2019147879A3 PCT/US2019/015063 US2019015063W WO2019147879A3 WO 2019147879 A3 WO2019147879 A3 WO 2019147879A3 US 2019015063 W US2019015063 W US 2019015063W WO 2019147879 A3 WO2019147879 A3 WO 2019147879A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell culture
rolled
monolayer
large scale
scale cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2019/015063
Other languages
English (en)
Other versions
WO2019147879A2 (fr
Inventor
Kidong Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana State University
Original Assignee
Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University filed Critical Louisiana State University
Priority to EP19743914.4A priority Critical patent/EP3743505A4/fr
Priority to US16/965,186 priority patent/US20240034976A1/en
Publication of WO2019147879A2 publication Critical patent/WO2019147879A2/fr
Publication of WO2019147879A3 publication Critical patent/WO2019147879A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B32B27/26—Layered products comprising a layer of synthetic resin characterised by the use of special additives using curing agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/28—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
    • B32B27/285—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42 comprising polyethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des dispositifs de type échafaudage enroulé et des systèmes de culture cellulaire qui peuvent fournir un rapport surface sur volume important pour la culture cellulaire étendue. Les échafaudages enroulés réduisent au maximum la contrainte de cisaillement sur des cellules cultivées et permettent d'obtenir des vitesses de transfert de masse suffisantes et uniformes de gaz et de nutriments. Les échafaudages enroulés peuvent être connectés à une source de milieu par l'intermédiaire de supports pour permettre une expansion et une maintenance à grande échelle de cultures cellulaires.
PCT/US2019/015063 2018-01-25 2019-01-25 Échafaudage enroulé pour culture cellulaire à grande échelle en monocouche Ceased WO2019147879A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19743914.4A EP3743505A4 (fr) 2018-01-25 2019-01-25 Échafaudage enroulé pour culture cellulaire à grande échelle en monocouche
US16/965,186 US20240034976A1 (en) 2018-01-25 2019-01-25 Rolled scaffold for large scale cell culture in monolayer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862621635P 2018-01-25 2018-01-25
US62/621,635 2018-01-25

Publications (2)

Publication Number Publication Date
WO2019147879A2 WO2019147879A2 (fr) 2019-08-01
WO2019147879A3 true WO2019147879A3 (fr) 2019-12-05

Family

ID=67395064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/015063 Ceased WO2019147879A2 (fr) 2018-01-25 2019-01-25 Échafaudage enroulé pour culture cellulaire à grande échelle en monocouche

Country Status (3)

Country Link
US (1) US20240034976A1 (fr)
EP (1) EP3743505A4 (fr)
WO (1) WO2019147879A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021084077A1 (fr) 2019-10-30 2021-05-06 Minaris Regenerative Medicine Gmbh Bioréacteur pour cellules adhérentes
EP4256024A1 (fr) * 2020-12-02 2023-10-11 Univercells Technologies S.A. Lit fixe monolithique structuré pour culture cellulaire, bioréacteur associé et procédés de fabrication
EP4347783A1 (fr) * 2021-06-03 2024-04-10 Univercells Technologies SA Système de bioréacteurs à capacités de collecte de cellules améliorées et procédés associés
WO2023118872A1 (fr) * 2021-12-22 2023-06-29 Cellular Agriculture Ltd Construction de culture cellulaire
EP4476321A1 (fr) * 2022-02-08 2024-12-18 Ivy Farm Technologies Limited Bioréacteur
GB202201818D0 (en) * 2022-02-11 2022-03-30 Ivy Farm Tech Limited Bioreactor
EP4497814A1 (fr) * 2023-07-28 2025-01-29 Green Elephant Biotech GmbH Dispositif de multiplication de cellules différenciées et indifférenciées et utilisation du dispositif pour la production de produits alimentaires cultivés

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853712A (en) * 1971-02-09 1974-12-10 Nat Res Dev Cell culture systems
US4689302A (en) * 1984-04-02 1987-08-25 Amerace Corporation Spiral designed reactor
US5079168A (en) * 1988-08-10 1992-01-07 Endotronics, Inc. Cell culture apparatus
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5869329A (en) * 1997-08-25 1999-02-09 Becton Dickinson And Company Blood culture vial or bottle having an agitation paddle
US20110196660A1 (en) * 2007-08-22 2011-08-11 3D Biotek, Llc Methods and Apparatus for Fabricating Porous 3-Dimensional Cell Culture Construct for Cell Culture and Other Biomedical Applications
US20130184724A1 (en) * 2010-09-20 2013-07-18 The University Of Manchester Medical device
US20140306371A1 (en) * 2011-11-23 2014-10-16 The Governing Council Of The University Of Toronto Devices and methods for producing planar polymeric materials using microfluidics
US20180116959A1 (en) * 2003-12-19 2018-05-03 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266476A (en) * 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
JP4112616B2 (ja) * 1995-10-06 2008-07-02 シード・キャピタル・インベストメンツ−２（エスシーアイ−２）・ビー・ブイ 細胞培養、特に肝細胞の培養に使用するための固相支持体、前記固相支持体を含む生物的リアクター、およびバイオ人工肝臓システムにおけるその使用

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853712A (en) * 1971-02-09 1974-12-10 Nat Res Dev Cell culture systems
US4689302A (en) * 1984-04-02 1987-08-25 Amerace Corporation Spiral designed reactor
US5079168A (en) * 1988-08-10 1992-01-07 Endotronics, Inc. Cell culture apparatus
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5869329A (en) * 1997-08-25 1999-02-09 Becton Dickinson And Company Blood culture vial or bottle having an agitation paddle
US20180116959A1 (en) * 2003-12-19 2018-05-03 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography
US20110196660A1 (en) * 2007-08-22 2011-08-11 3D Biotek, Llc Methods and Apparatus for Fabricating Porous 3-Dimensional Cell Culture Construct for Cell Culture and Other Biomedical Applications
US20130184724A1 (en) * 2010-09-20 2013-07-18 The University Of Manchester Medical device
US20140306371A1 (en) * 2011-11-23 2014-10-16 The Governing Council Of The University Of Toronto Devices and methods for producing planar polymeric materials using microfluidics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KOOY ET AL.: "A review of roll-to-roll nanoimprint lithography", NANOSCALE RESEARCH LETTERS, vol. 9, 320, 25 June 2014 (2014-06-25), XP055209284 *

Also Published As

Publication number Publication date
EP3743505A2 (fr) 2020-12-02
WO2019147879A2 (fr) 2019-08-01
EP3743505A4 (fr) 2021-10-20
US20240034976A1 (en) 2024-02-01

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