WO2019190010A1 - Composition d'extraction éthanolique de citri unshius pericarpium, magnolia officinalis, corydalis remota et acacia catechu, ayant des effets d'amélioration des rides cutanées, d'hydratation, d'antioxydation ou de réduction d'inflammation - Google Patents

Composition d'extraction éthanolique de citri unshius pericarpium, magnolia officinalis, corydalis remota et acacia catechu, ayant des effets d'amélioration des rides cutanées, d'hydratation, d'antioxydation ou de réduction d'inflammation Download PDF

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Publication number
WO2019190010A1
WO2019190010A1 PCT/KR2018/011337 KR2018011337W WO2019190010A1 WO 2019190010 A1 WO2019190010 A1 WO 2019190010A1 KR 2018011337 W KR2018011337 W KR 2018011337W WO 2019190010 A1 WO2019190010 A1 WO 2019190010A1
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Prior art keywords
skin
cosmetic
composition
ethanol
present
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English (en)
Korean (ko)
Inventor
백남현
최민수
정청일
김석중
권세미
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Dong Wha Pharm Co Ltd
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Dong Wha Pharm Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof

Definitions

  • the present invention relates to a skin composition for improving skin wrinkles, moisturizing, antioxidant or anti-inflammatory, and a method for preparing the same, comprising ethanol extracts of dermis, scabbard, calendula, and sun medicaments as active ingredients.
  • Skin plays a role in maintaining homeostasis in response to environmental changes such as sensory function against external changes, temperature control function, and protection of human body from external foreign matters.
  • the skin acts as an epidermis and dermis. It is composed.
  • the epidermal layer is mostly composed of keratinocytes, melanocytes, Langerhans cells, atypical cells, and Merkel cells, and protects the body from foreign foreign bodies and plays an immune role.
  • the dermis is divided into papillary dermis and reticulated dermis, and consists of matrix proteins such as collagen fibers and elastic fibers to maintain the structure and elasticity of the skin, and when lacked or damaged, skin elasticity is lost and wrinkles are formed to make it look like old skin. .
  • the present inventors have made diligent efforts to develop novel functional cosmetic compositions.
  • the composition comprising ethanol extract of dermis, groin, sageum and sunscreen as an active ingredient has excellent skin wrinkle improvement, skin moisturizing, antioxidant and anti-inflammatory effects.
  • the present invention was completed by confirming.
  • One object of the present invention is to provide a cosmetic composition for improving skin wrinkles, skin moisturizing, antioxidant or anti-inflammatory, comprising ethanol extracts of dermis, thick skin, Hyunho color and sunscreen as an active ingredient.
  • Another object of the present invention is to provide a method for preparing a cosmetic composition for skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory, comprising the step of extracting dermis, thick skin, corydalis and sun medicament with ethanol.
  • composition comprising the ethanol extract of the dermis, hunchus, Hyunho color of the present invention and the sun medicament as an active ingredient is very excellent in skin wrinkle improvement, skin moisturizing, antioxidant and anti-inflammatory effect, it can be usefully used as a functional cosmetic composition.
  • Figure 1 shows the manufacturing process of the ethanol extract of Example 1 and the cosmetic mixture of Example 2.
  • Figure 2 shows the cell viability of HDFa in a medium in which 0.5% to 50% of each of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 of the present invention is mixed.
  • Figure 3 shows the collagen expression of HDFa in a medium in which each of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 of the present invention is mixed with 0.1% to 1% (AD: Adenoisine 0.01%).
  • Figure 4 shows the HAS-2 expression of HDFa in a medium in which each of the cosmetic mixture prepared in Example 2 and Comparative Example 2 of 0.1% to 1% mixed (HA: Hyaluronic Acid 0.01%).
  • FIG. 5 shows the filaggrin expression of HaCaT in a medium in which 0.5% to 1% of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 of the present invention were mixed (HA: Hyaluronic Acid 0.01%).
  • FIG. 6 shows SOD-2 expression of HaCaT in a medium in which each of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 was mixed at 1% (BHT: 10 ⁇ M of Butylated hydroxytoluence).
  • FIG. 7 shows TNF- ⁇ expression of damaged HaCaT by UV in a medium in which each of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 of the present invention was mixed at 0.1% to 1% (HC: Hydroquinone 10 ⁇ M) .
  • One aspect of the present invention for achieving the above object is a dermal wrinkle, skin thickening, corolla and ethanol extract of sundae as an active ingredient, skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory cosmetic composition.
  • the term "dermis ( Citrus Unshiu Peel)” refers to citrus ushiu Markvich or mature pericarp of co- releasing plants.
  • the main components of the dermis are composed of essential oils, hesperidin, narizine, and rutin.
  • the essential oil component of the dermis has been reported pharmacological action, such as digestive stimulation, digestion promotion, expectoration, fermenting secretion, antibacterial action.
  • Magnolia Bark means dried stem or root bark of Magnolia officinalis which is a magnolia and plant. It has been reported to have neuroprotective and neurotrophic effects.
  • Corydalis (Corydalis) is mainly used for tubers with a medicinal Papaveraceae perennial plants. Corydalis Root Extract has been reported to have analgesic, calming, coughing, peripheral vasodilation and antibacterial activity.
  • the term "catechu (Gambir)” is used and widely native to the East Indies of the plant belonging to Rubiaceae, hemostatic, has a diuretic, cheongyeol, drug or the like decrypts and bloody stool, Donguibogam include the treatment that the tendons and bones pour sick It is said to heal both fresh and old.
  • the skin wrinkle improvement, moisturizing, antioxidant or anti-inflammatory effect of the composition containing all of the above medicines has not been reported to date.
  • the hot water extraction method used for the extraction of the active ingredient is disadvantageous in that it is difficult to express a higher effect due to insufficient extraction amount of the fat-soluble component which is an essential oil component and problems such as decomposition and modification of the active ingredient due to hot water.
  • the present inventors confirmed that the ethanol extracts of dermis, hunchus, hyacinth and sun medicinal extracts have significantly superior skin wrinkle improvement, skin moisturizing, antioxidant and anti-inflammatory effects as compared to hydrothermal extracts having a corresponding composition.
  • the term "extract” refers to all those obtained by extracting from dermis, thick pepper, corydalis and subsun.
  • the extract of the present invention is characterized in that obtained by using ethanol as a solvent, which has an excellent effect compared to the hydrothermal extract.
  • Ethanol used in the extraction process in the present invention may be, for example, 50% to 95% by weight ethanol, specifically 70% by weight ethanol, but is not limited thereto.
  • the extract in the present invention may include an extract, a dry powder thereof or any form formulated using the same, for example, the extract may be prepared in the form of a soft extract, but is not limited thereto.
  • the term "soft-core X" means that the extract obtained by putting a suitable solvent in the herbal medicines extracted for a certain time to make the same roughness as starch syrup.
  • the extraction method in the present invention is not particularly limited and may be extracted at room temperature or warmed under conditions in which the active ingredient of the herbal medicine is not destroyed or minimized.
  • the ethanol extract may further comprise filtering the extract to remove suspended solid particles. Particles may be filtered using cotton, nylon, diatomaceous earth, or the like, or ultrafiltration, freezing, centrifugation, or the like may be used, but is not limited thereto.
  • Concentration of the extract may be used, such as concentrated under reduced pressure, reverse osmosis concentration.
  • the drying step after the concentration includes, but is not limited to, lyophilization, vacuum drying, hot air drying, spray drying, reduced pressure drying, foam drying, high frequency drying, or infrared drying.
  • the method may further include a step of pulverizing the final dried extract or by omitting the drying step to sterilize the concentrate to prepare a soft extract form.
  • the cosmetic composition of the present invention may include 0.1 wt% to 10 wt% of ethanol extracts of dermis, thick, hyacinth, and sundae, but the content is determined by those skilled in the art according to the purpose, frequency of application, usage, usage, formulation, and the like. It may be appropriately altered by the amount, and may be included in an appropriate amount to exhibit skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory effect.
  • the cosmetic mixture is a solvent, excipients, etc. Mixing may be used at a concentration of 0.1 to 10% (v / v), but is not limited thereto.
  • the cosmetic composition according to the present invention in addition to the ethanol extract of the dermis, thick skin, Hyunho color and sunscreen as described above, various components generally used in the external preparation for skin within the range that does not deteriorate the effect of the present invention as necessary, for example, water-soluble. It can be comprised by mix
  • the formulation of the cosmetic composition according to the present invention can be selected arbitrarily, with water, physiological saline, glycerol, oils, surfactants, humectants, thickeners, chelating agents, pigments, together with the active ingredients dermis, thick pepper, corolla and ethanol extracts of sunscreens.
  • Known cosmetic excipients such as preservatives and fragrances, can be mixed into solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, waxes
  • Cosmetic compositions in the form of a foundation or spray may be formed.
  • the cosmetic composition may be used to prepare basic cosmetics such as flexible lotion, milk lotion, nourishing cream, massage cream, essence, cleansing foam, cleansing water, pack or body oil, and color cosmetics such as foundation, lipstick, mascara or makeup base. It may also prepare face washes and baths.
  • basic cosmetics such as flexible lotion, milk lotion, nourishing cream, massage cream, essence, cleansing foam, cleansing water, pack or body oil
  • color cosmetics such as foundation, lipstick, mascara or makeup base. It may also prepare face washes and baths.
  • the ethanol extract soft extract of dermis, thick, hyacinth, and sundae was prepared, and it was prepared as a 1% by weight cosmetic mixture with butylene glycol and purified water (Example 2).
  • the expression of SOD-2 was confirmed to confirm the antioxidant efficacy of the cosmetic composition of the present invention. As a result, it was confirmed that the expression of SOD-2 increased compared to the cosmetic mixture prepared in Comparative Example 2, it was confirmed that the cosmetic composition of the present invention has an excellent antioxidant effect (Fig. 6).
  • the expression of TNF- ⁇ was confirmed in order to confirm the anti-inflammatory effect of the cosmetic composition of the present invention.
  • the expression of TNF- ⁇ which is a representative inflammation-inducing factor, was reduced compared to the cosmetic mixture prepared in Comparative Example 2, and it was confirmed that there was an effect on the inflammatory response (FIG. 7).
  • the cosmetic composition of the present invention has an excellent effect on skin wrinkle improvement, skin moisturizing, antioxidant and anti-inflammatory by participating in the expression of various genes. Therefore, the present invention can be applied to a variety of products by using as a functional cosmetic raw material with improved skin wrinkles, skin moisturizing, antioxidant and anti-inflammatory effect.
  • Another aspect of the present invention is a method for preparing a cosmetic composition for skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory, comprising extracting the dermis, thick pepper, corydalis and sun medicament with ethanol.
  • the cosmetic composition comprising the dermis, thick skin, corydalis and sun ethanol extract, skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory use of the composition and the method of preparing the composition are as described above.
  • the production method of the present invention may further comprise a filtration, concentration and sterilization process.
  • the cosmetic composition of the present invention is a step 1 of immersing the cut and dried dermis, thick, hyacinth, sub Sun medicine in a stirring tank containing ethanol for 3 days; Separating the dipping solution and filtering with a filter and diatomaceous earth of 1 ⁇ m to 5 ⁇ m; Concentration under reduced pressure of less than 60 °C concentrated to less than 38% drying step 3; And it may be prepared in four stages of sterilization for 40 minutes at 85 °C two times, but is not limited thereto.
  • Another aspect of the present invention comprises administering to a subject in need thereof a cosmetic composition
  • a cosmetic composition comprising an ethanol extract of dermis, groin, corydalis and sundae as an active ingredient, skin wrinkle improvement, skin moisturizing, antioxidant or anti It is a method for inflammation.
  • Still another aspect of the present invention is the use of a composition comprising an ethanol extract of dermis, groin, calendula and sun medicament as an active ingredient for skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory cosmetic composition.
  • the cosmetic composition comprising the dermis, groin, corydalis and sun ethanol extract, and the skin wrinkle improvement, skin moisturizing, antioxidant or anti-inflammatory use of the composition are as described above.
  • An embodiment of the present invention consists of a process of mixing, immersing in room temperature, extracting / separating extracts, filtration, decompression concentration, and sterilization using 70 wt% ethanol, dermis, thick foil, corolla color and sunscreen (FIG. 1).
  • Step 1 Into a stirring tank containing 316 kg of water and 740 kg of ethanol (70% by weight of ethanol), 129.31 kg of shredded dermis, 25.86 kg of hull, 93.11 kg of calendula, and 51.73 kg of subwire were stirred.
  • Step 2 The skin of the first step dermis, thick, hydrangea and sundae were soaked for 3 days at room temperature so that the active ingredient can be extracted in 70% by weight of ethanol solvent.
  • Step 3 The extraction solution of the immersion mixture of the two steps was separated, and filtered with a 1 ⁇ m filtration filter and diatomaceous earth to separate the extract from the fine solids.
  • Step 4 The extract from which solids were separated in step 3 was concentrated under reduced pressure at 60 ° C. to be 38 wt% or less, and thus prepared as a soft extract.
  • Step 5 In order to sterilize the microorganisms that may occur during the process of step 1 to step 4, the pressure-sensitive concentrate of step 4 was sterilized for 40 minutes at 85 °C, this process was repeated twice to prepare an ethanol extract soft extract.
  • Step 1 100 kg of water was added to the agitator, and 129.31 kg of chopped dermis, 25.86 kg of thick skin, 93.11 kg of corydalis and 51.73 kg of subwire were added.
  • Step 2 The extract was heated at 100 ° C. for 1 hour in order to extract the active ingredients of the dermis, hulk, hyacinth color and sub-medicine of the first step.
  • the extract was prepared by hot water extraction soft extract through the separation / filtration, concentration, sterilization process.
  • the cytotoxicity test of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 was confirmed by performing MTT-ASSAY to determine the cell viability by measuring the mitochondrial activity of the living cells, the results are shown in FIG.
  • HDFa human dermal fibroblast
  • Example 2 of the present invention was confirmed that the cell viability in the range of 0.5% to 1% is superior to Comparative Example 2 of the same concentration (Fig. 2).
  • Collagen a major component of the extracellular matrix, is a major substrate protein produced by skin fibroblasts and is synthesized in the form of a precursor called procollagen. Collagen is an essential ingredient for supporting and maintaining the entire body, such as skin and muscles, and is an important component of the dermal layer in the skin that causes wrinkles.
  • HDFa human dermal fibroblast
  • HDFa human dermal fibroblast
  • the cosmetic mixtures prepared in Example 2 and Comparative Example 2 were mixed at concentrations of 0.1% to 1%, respectively, and fresh media were added and incubated for 48 hours.
  • RNA was extracted from the cultured cells, followed by RT-PCR for collagen gene (COL1A1; Collagen type 1 alpha 1 chain), and the amplified gene was subjected to gel documentation system. And analyzed.
  • the primer sequence for the COL1A1 gene is as follows.
  • COL1A1 forward primer 5'-GGC CCA GAA GAA CTG GTA CA-3 '(SEQ ID NO: 1)
  • COL1A1 reverse primer 5'-CGC TGT TCT TGC AGT GGT AG-3 '(SEQ ID NO: 2)
  • the cosmetic mixture prepared in Example 2 of the present invention was confirmed to increase the expression of collagen more than the cosmetic mixture prepared in the non-treated group (0%) and Comparative Example 2 of the same concentration (Fig. 3). Therefore, the cosmetic composition of the present invention has an excellent effect on skin moisturizing.
  • Hyaluronic acid is a carbohydrate-like component that binds to moisture in the dermis and plays an important role in creating an environment in which cells can function normally.
  • the synthesis of HA was carried out by hyaluronan synthase (HAS), and three types of HAS genes were reported: HAS-1, HAS-2, and HAS-3, of which HAS-2 was crucial for the synthesis of HA in fibroblasts. It turns out to play a role.
  • HAS hyaluronan synthase
  • HAS-2 in human fibroblasts was confirmed by treating each of the cosmetic mixtures prepared in Example 2 and Comparative Example 2 to HDFa (human dermal fibroblast), and the results are shown in FIG. 4.
  • HDFa human dermal fibroblast
  • HDFa human dermal fibroblast
  • the cosmetic mixtures prepared in Example 2 and Comparative Example 2 were mixed at a concentration of 0.1% to 1%, fresh medium was added and incubated for 48 hours.
  • RNA was extracted from the cultured cells and subjected to RT-PCR for the HAS-2 gene, and the amplified gene was analyzed using a gel documentation system.
  • the primer sequence for the HAS-2 gene is as follows.
  • HAS-2 forward primer 5'-GCT ACC AGT TTA TCC AAA CG-3 '(SEQ ID NO: 3)
  • HAS-2 reverse primer 5'-GTG ACT CAT CTG TCT CAC CG-3 '(SEQ ID NO: 4)
  • the cosmetic composition of the present invention has an excellent effect on skin moisturizing.
  • Filaggrin Core proteins that make up the skin barrier are known as Filaggrin, Loricrin and Involucrin.
  • Filagrin is a protein produced by the degradation of profilaggrin, which constitutes KG (keratohyaline granule) in the epidermal granule cells, and plays an important role in the skin barrier by aggregation of keratin filaments in keratinocytes. do.
  • filaggrin is finally decomposed into free amino acid by various enzymes and functions as a natural moisturizing factor, thus participating in epidermal moisture retention.
  • First HaCaT human keratinocyte
  • an incubator containing 37 °C, 5% CO 2
  • the cosmetic mixtures prepared in Example 2 and Comparative Example 2 were mixed at concentrations of 0.5% to 1%, respectively, and fresh media were added and incubated for 48 hours.
  • RNA was extracted from the cultured cells, followed by RT-PCR for the filaggrin gene, and the amplified gene was analyzed using a gel documentation system.
  • Primer sequences for the Filaggrin gene are as follows.
  • Filaggrin Forward Primer 5'-AGT GCA CTC AGG GGG CTC ACA-3 '(SEQ ID NO: 5)
  • Filaggrin Reverse Primer 5'-CCG GCT TGG CCG TAA TGT GT-3 '(SEQ ID NO: 6)
  • the cosmetic mixture prepared in Example 2 of the present invention was confirmed to increase the expression of filaggrin than the cosmetic mixture prepared in the non-treated group (0%) and Comparative Example 2 of the same concentration (Fig. 5). Therefore, the cosmetic composition of the present invention has excellent effects as skin barrier formation and natural moisturizing factor.
  • antioxidant enzymes such as SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) act as antioxidants by inactivating or removing them.
  • HDFa human dermal fibroblast
  • the cosmetic mixtures prepared in Example 2 and Comparative Example 2 were each mixed at a concentration of 1%, fresh medium was added, and cultured for 48 hours.
  • RNA was extracted from the cultured cells, followed by RT-PCR for the SOD-2 gene, and the amplified gene was analyzed using a gel documentation system.
  • the primer sequence for the SOD-2 gene is as follows.
  • SOD-2 forward primer 5'-CGT CAC CGA GGA GAA GTA CC-3 '(SEQ ID NO: 7)
  • SOD-2 reverse primer 5'-CTG ATT TGG ACA AGC AGC AA-3 '(SEQ ID NO: 8)
  • the cosmetic mixture prepared in Example 2 of the present invention increased the expression of SOD-2, an intracellular antioxidant, than the cosmetic mixture prepared in the untreated group (0%) and Comparative Example 2 (FIG. 6). Therefore, the cosmetic composition of the present invention has an excellent antioxidant effect.
  • Inflammation is caused by excessive production of inflammation-related cytokines such as IL-1 ⁇ , NF- ⁇ B and TNF- ⁇ by external stimuli such as UV, lipopolysaccharide (LPS).
  • IL-1 ⁇ inflammation-related cytokines
  • NF- ⁇ B inflammation-related cytokines
  • TNF- ⁇ inflammation-related cytokines
  • external stimuli such as UV, lipopolysaccharide (LPS).
  • LPS lipopolysaccharide
  • HaCaT human keratinocyte
  • First HaCaT human keratinocyte
  • an incubator containing 37 °C, 5% CO 2
  • the cosmetic mixtures prepared in Example 2 and Comparative Example 2 were mixed at a concentration of 0.1% to 1%, fresh medium was added and incubated for 48 hours.
  • the used medium was then removed and replaced with fresh medium, followed by irradiation of 20 mJ / cm 2 UV for 10 minutes to induce cell damage. Damaged cells were further cultured for 1 day after replacement with fresh medium, followed by RNA extraction from the cultured cells and RT-PCR for TNF- ⁇ gene.
  • Genes amplified via RT-PCR were analyzed using a gel documentation system.
  • the primer sequence for the TNF- ⁇ gene is as follows.
  • TNF- ⁇ forward primer 5'-CAT TCT GGG AGG GGT CTT CC-3 '(SEQ ID NO: 9)
  • TNF- ⁇ reverse primer 5'-GGT TGA GGG TGT CTG AAG GA-3 '(SEQ ID NO: 10)
  • the cosmetic composition of the present invention has an excellent effect of inhibiting the inflammatory response of the skin.
  • the ethanol extract including the dermis, hunchus, hyacinth and sunscreen of the present invention can be utilized as an active ingredient of functional cosmetics having an excellent effect on wrinkle improvement, moisturizing, antioxidant and inflammation reduction by participating in the expression of various genes. .

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Abstract

La présente invention concerne une composition cosmétique pour l'amélioration des rides cutanées, l'hydratation de la peau, l'action antioxydante ou l'action anti-inflammatoire et son procédé de préparation, la composition comprenant, en tant que substance active, un extrait éthanolique de Citri Unshius pericarpium, Magnolia officinalis, Corydalis remota et Acacia catechu. La composition présente d'excellents effets d'amélioration des rides cutanées, d'hydratation de la peau, antioxydants ou anti-inflammatoires et, par conséquent, ladite composition peut être utilisée en tant que composition cosmétique fonctionnelle.
PCT/KR2018/011337 2018-03-27 2018-09-21 Composition d'extraction éthanolique de citri unshius pericarpium, magnolia officinalis, corydalis remota et acacia catechu, ayant des effets d'amélioration des rides cutanées, d'hydratation, d'antioxydation ou de réduction d'inflammation Ceased WO2019190010A1 (fr)

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KR1020180035488A KR102283047B1 (ko) 2018-03-27 2018-03-27 피부 주름 개선, 보습, 항산화 및 염증 완화 효과가 증가된 진피, 후박, 현호색, 아선약의 에탄올 추출 조성물
KR10-2018-0035488 2018-03-27

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Cited By (1)

* Cited by examiner, † Cited by third party
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CN114209633A (zh) * 2021-07-21 2022-03-22 中科厚朴(广州)科技发展有限公司 一种抗炎舒敏修复组合物及其制备方法和应用

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