WO2019201092A1 - Appareil d'aspiration de sang sous vide - Google Patents

Appareil d'aspiration de sang sous vide Download PDF

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Publication number
WO2019201092A1
WO2019201092A1 PCT/CN2019/081274 CN2019081274W WO2019201092A1 WO 2019201092 A1 WO2019201092 A1 WO 2019201092A1 CN 2019081274 W CN2019081274 W CN 2019081274W WO 2019201092 A1 WO2019201092 A1 WO 2019201092A1
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WIPO (PCT)
Prior art keywords
blood
supply needle
tube
blood supply
blood collection
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/CN2019/081274
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English (en)
Chinese (zh)
Inventor
董东生
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Beijing Yangsheng Hengtai Technology Co Ltd
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Beijing Yangsheng Hengtai Technology Co Ltd
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Publication of WO2019201092A1 publication Critical patent/WO2019201092A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means

Definitions

  • the invention relates to a vacuum blood collection device, belonging to the technical field of medical instruments.
  • Venous blood collection is the most commonly used technique in clinical departments.
  • the most commonly used blood collection needle includes a blood collection needle for piercing the skin and vein wall, a blood collection needle holder for fixing the blood collection needle tube, and a blood supply needle tube.
  • the lumen of the blood supply needle tube is directly connected to the inner cavity of the blood collection needle tube through the lumen of the delivery hose; a plastic sleeve is arranged outside the blood supply needle tube, and the rubber sleeve separates the blood supply needle tube from the external fluid; when the blood collection needle tube enters After the vein, the blood supply needle needs to pierce the rubber plug that closes the opening of the top end of the vacuum blood collection tube body, and the blood jet flows into the inner cavity of the vacuum blood collection tube.
  • the blood supply needle tube When the blood volume is sufficient, the blood supply needle tube is pulled out, and the rubber sleeve is elastically restored and the blood supply needle tube is covered again. The tip prevents blood from flowing out and can then continue to puncture another vacuum blood collection tube to continue the blood collection process.
  • the outer diameter of the blood supply needle tube is usually less than 1mm, the inner diameter is about 0.5mm, the side wall thickness of the rubber sleeve is about 0.7mm, the blind end wall thickness is about 2mm, and the tip of the blood supply needle is about 4mm from the inner surface of the blind end of the rubber sleeve.
  • the tip of the blood-sucking needle pierces the rubber plug at the top of the vacuum blood collection tube to make the rubber sleeve compress and stack outside the rubber plug, and the blood flows rapidly from the edge of the pinhole of the sharp and rough blood supply needle of the rigid surface under the microscopic size.
  • the distance between the tip of the blood supply needle tube and the inner surface of the blind end of the rubber sleeve must be about 4 mm.
  • the sealing effect on the tip of the blood supply needle tube depends on the blind end portion with a thickness of about 2 mm, and when the penetration angle is not perpendicular, the above-mentioned spacing of about 4 mm easily causes the heavy blind end portion to be offset and the blood supply needle tube is deflected.
  • the tip is pierced from the side wall having a thickness of about 0.7 mm, and it is not easy to recover actively and the blood is easily leaked.
  • the blood is rapidly turbulently sprayed from the sharp surface of the rigid surface under the microscopic size and the rough needle hole of the blood supply needle, which easily leads to the destruction of a large number of blood cells, especially red blood cells.
  • the turbulent jet of blood directly hits the hard tube wall of the vacuum blood collection tube, which easily leads to the destruction of a large number of blood cells, especially red blood cells.
  • the traditional rubber sleeve active restoration structure relies on the distance between the tip of the blood supply needle and the tip of the rubber sleeve and the thickness of the side wall. When the penetration is heavy, the blind end portion is easily offset and the tip of the blood supply needle is The side wall is pierced, and the rubber sleeve is not easy to recover actively and the blood is easily leaked when pulled out.
  • the present invention provides a vacuum blood collection device.
  • a vacuum blood collection device comprises: a tube body, a rubber plug and a tube cover; the top end of the tube body is open, the bottom end is a closed blind end, and the elastic rubber plug closes the top end opening of the tube body to make the tube body cavity with vacuum degree and the outside world
  • the fluid is isolated, the tube cover is sleeved on the rubber plug, and the tube cover opening is arranged at the center of the top end of the tube cover; and the capsular bag-shaped accommodating cavity is included, and the accommodating cavity is downward from the inner surface of the top end of the tube cover and the upper surface of the top end of the rubber plug
  • the plastic plug recesses jointly form a large pocket-like cavity with a small cavity; the opening of the cap is the external opening of the receiving cavity, and the opening area of the cap is smaller than the opening area of the plug.
  • the opening of the tube cover is circular or approximately circular, and the diameter or area of the upper edge loop of the opening of the tube cover is larger than the diameter or area of the lower edge loop line; the upper edge loop line and the lower edge loop line are both A ring line or an approximately circular ring line.
  • the diameter of the upper edge ring line is larger; when it is an ellipse or other approximate circle, the area of the upper edge ring line is larger.
  • the accommodating cavity formed by the structure can completely accommodate the compression stack of the rubber sleeve when the blood supply needle tube penetrates into the vacuum blood collection tube lumen, and the lower edge loop line of the tube cover opening is blocked by the moving edge of the moving rubber sleeve when the tube is pulled out.
  • the passive sleeve is not dependent on the recovery of its own elasticity, and the tip of the blood supply needle is coated again; because the elasticity of the side wall of the sleeve is not relied on, the side wall is greatly thinned, thereby increasing the diameter of the lumen of the blood supply needle, and then Increase the cross-sectional area of the blood outlet, reduce the blood flow rate, reduce hemolysis; and make the distance between the tip of the blood-sucking needle tip and the inner end of the blind end of the rubber sleeve less than 2mm, even shrink to 0, the thick blind end of the rubber sleeve It will not be deflected because of the poor puncture angle.
  • the risk of blood leakage caused by the tip of the blood supply needle penetrating from the side wall of the rubber sleeve is greatly reduced due to the blind end deflection.
  • the inner surface of the bottom end of the rubber stopper is extended downward to form a rubber plug extension portion, and the inner cavity of the rubber stopper extension portion can accommodate the rubber stopper.
  • Receiving part of the blood supply needle tube; the rubber plug extension portion can serve as a support and seal, and the flexible inner surface can receive the blood ejected from the blood supply needle tube, and the rubber plug receiving portion refers to the rubber plug depression located at the top end of the rubber stopper The portion between the bottom end surface and the lower surface of the bottom end of the rubber plug that can be punctured by the blood receiving needle and can be resealed after the blood supply needle is dispensed.
  • the bottom surface of the bottom end of the rubber stopper extends to a skirt-like portion downwardly to the thin wall of the circumference, and the skirt inner cavity with the inner surface of the skirt portion of the rubber plug can accommodate the blood supply needle tube passing through the receiving portion of the rubber stopper The free end of the skirt portion faces the bottom end of the tubular body.
  • the lower surface of the bottom end of the rubber stopper extends to a skirt-like portion downwardly to the thin wall of the circumference, and the skirt inner cavity with the inner surface of the skirt portion of the rubber plug can accommodate the blood supply needle tube passing through the receiving portion of the rubber stopper;
  • a gap is left between the outer surface of the rim portion and the inner surface of the tube, which is an outer gap of the skirt; the outer gap of the skirt can cause the skirt portion to be outwardly deformed and buffered when the inner surface of the skirt portion is subjected to blood flow.
  • the free end of the skirt portion of the rubber plug is provided with a wavy or serrated gap.
  • the free end of the skirt portion of the rubber plug is provided with a wavy or serrated slit; and a shallow groove extending upward along a portion of the slit away from the free end is further provided.
  • the vacuum blood collection device further comprises a blood collection needle for piercing the skin and the vein wall, a blood collection needle holder for fixing the blood collection needle tube, and a blood supply needle tube;
  • the blood supply needle tube lumen is directly or through the delivery hose lumen and The inner part of the blood collection needle tube is connected;
  • the outer part of the blood supply needle tube is sleeved with a rubber sleeve, and the rubber sleeve separates the blood supply needle tube from the external fluid;
  • the blood injection hose is also arranged, and a part of the blood ejection hose is located in the inner cavity of the blood supply needle tube.
  • a part is protruded from the pinhole of the tip of the blood supply needle, and a vertical opening is arranged at the end of the protruding portion of the ejection hose; the same penetration resistance can be used to increase the inside and outside diameter of the blood supply needle.
  • a part of the ejection hose is located in the lumen of the blood supply needle, a part of which is protruded from the needle hole at the tip of the blood supply needle, and a vertical opening is provided at the end of the protruding portion of the ejection hose and At least one side opening.
  • an ejection hose is also included, a part of the ejection hose is located in the lumen of the blood supply needle, and a part is protruded from the needle hole at the tip of the blood supply needle, and the blood is injected.
  • the end of the hose probing portion is a blind end, and the end of the ejection hose is provided with at least one lateral opening.
  • One way is to include a blood collection needle for piercing the skin and the vein wall, a blood collection needle holder for fixing the blood collection needle tube, and a blood supply needle tube;
  • the blood supply needle lumen is directly or through the delivery hose lumen It is connected with the inner cavity of the blood collection needle tube;
  • a plastic sleeve is arranged outside the blood supply needle tube, and the rubber sleeve separates the blood supply needle tube from the external fluid;
  • the tip of the blood supply needle tube is a blind end, and the needle hole for blood flow is a lateral pinhole
  • the lateral pinhole is at least one.
  • the tip of the blood supply needle is a blind end, the needle hole for blood flowing out is a lateral pinhole, and the lateral pinhole is at least one; the ejection hose is located in the lumen of the blood supply needle tube, and the ejection hose is provided with the side a lateral opening corresponding to the pinhole; the corresponding means that the positions of the two are in close proximity and the center overlaps, and the blood flows out from the lateral opening of the ejection hose directly into the blood collection tube from the lateral needle hole of the blood supply needle tube
  • the inside of the cavity without touching the edge of the lateral pinhole, avoids damage to the blood cells by the rough edges of the lateral pinhole.
  • the tip of the blood supply needle is a blind end
  • the needle hole for the blood flowing out is a lateral pinhole
  • the lateral pinhole is at least one
  • the ejection hose is located in the lumen of the blood supply needle tube, and the ejection hose is provided with
  • the lateral pinhole corresponds to a lateral opening; the area of the lateral opening of the ejection hose is smaller than the area of the lateral pinhole.
  • the tip of the blood supply needle is a blind end
  • the needle hole for blood flow is a lateral pinhole
  • the lateral pinhole is at least one; between the lower end surface of the annular boss of the blood supply needle seat and the lateral pinhole of the farthest side The distance is less than the distance between the outer surface of the top end of the tube of the vacuum blood collection device and the lower edge of the extended portion of the rubber plug; to ensure that the blood ejected from the lateral pinhole splashes on the flexible inner surface of the extended portion of the rubber plug, reducing the hemolysis rate.
  • the tip of the blood supply needle is a blind end, the needle hole for the blood flowing out is a lateral pinhole, and the lateral pinhole is at least one; the lower end surface of the annular boss of the blood donor needle seat and the lateral pinhole at the farthest side
  • the distance between the outer surface of the cap of the vacuum blood collection device and the free end of the skirt portion of the rubber plug is ensured to ensure that the blood ejected from the lateral pinhole splashes on the flexible inner surface of the rubber plug extension portion, thereby reducing Hemolysis rate.
  • the straight line tip of the blood supply needle tip and the apex of the blind end of the rubber sleeve are less than 2 mm.
  • the blood flows into the vacuum blood collection tube lumen from the needle hole of the larger blood supply needle tube at a lower speed, thereby minimizing the damage of blood cells, especially red blood cells.
  • the blood flow ejected from the pinhole of the blood supply needle directly hits the extension of the flexible rubber plug of the vacuum blood collection tube or the thin-walled skirt-like portion, thereby minimizing the damage of blood cells, especially red blood cells.
  • the traditional rubber sleeve active restoration structure is replaced by a passive restoration structure.
  • the distance between the apex of the tip of the blood supply needle and the apex of the blind end of the rubber sleeve is significantly shortened, and the thickness of the side wall of the rubber sleeve is significantly reduced.
  • the blood supply needle tube has a significantly increased inner and outer diameter, and the leakage of blood due to the offset of the heavy blind end portion at the time of penetration is eliminated to the utmost extent.
  • FIG. 1A is a partial cross-sectional structural view of a conventional clinical vacuum blood collection device
  • FIG. 1B is a schematic exploded perspective view of a conventional vacuum blood collection tube used in clinical practice
  • Embodiment 1 of the present invention is a schematic overall structural view of Embodiment 1 of the present invention.
  • FIG. 3A is a perspective view showing a perspective cutaway structure of Embodiment 1 of the present invention.
  • FIG. 3B is a partial cross-sectional view showing the structure of the first embodiment of the present invention, the tip of the blood-sucking needle piercing the rubber plug;
  • Figure 3C is a partial cross-sectional view showing the first embodiment of the present invention, the tip of the blood-sucking needle is separated from the rubber stopper;
  • Figure 4 is a partial cross-sectional structural view showing a second embodiment of the present invention.
  • FIG. 5A is a partial cross-sectional structural view showing a third embodiment of the present invention.
  • FIG. 5B is a perspective view showing a perspective cutaway structure of Embodiment 3 of the present invention.
  • FIG. 5C is a schematic diagram showing the state of use of Embodiment 3 of the present invention.
  • Embodiment 4 of the present invention is a partially enlarged perspective structural view of Embodiment 4 of the present invention.
  • FIG. 7A is a partial cross-sectional structural view showing a fifth embodiment of the present invention, in which a tip of a blood feeding needle pierces a rubber stopper;
  • 7B is a partial cross-sectional view showing the fifth embodiment of the present invention, in which the tip of the blood-sucking needle pierces the rubber stopper;
  • Figure 8 is a schematic partial cross-sectional view showing a modification of Embodiment 5 of the present invention.
  • Figure 9 is a schematic view showing another alternative partial sectional structure of Embodiment 5 of the present invention.
  • Figure 10 is a schematic overall sectional view showing a sixth embodiment of the present invention.
  • Embodiment 7 of the present invention is a partially enlarged schematic structural view of Embodiment 7 of the present invention.
  • FIG. 11B is a partially enlarged schematic structural view of Embodiment 7 of the present invention.
  • FIG. 12 is a schematic partial cross-sectional structural view of a common embodiment of the present invention.
  • Figure 13A is a partially enlarged cross-sectional view showing a conventional blood supply needle tube for clinical use
  • FIG. 13B is a partially enlarged cross-sectional view showing a blood supply needle tube which is common to various embodiments of the present invention.
  • Figure 14 is a schematic overall sectional view showing the eighth embodiment of the present invention.
  • Figure 15 is a schematic cross-sectional view showing the entire structure of Embodiment 9 of the present invention.
  • rubber sleeve inner cavity 231. stacked rubber sleeve; 2311. tube cover opening at the rubber sleeve; 232. rubber sleeve blind end; 2321. The inner surface apex of the blind end; 233. the rubber sleeve sidewall; 24. the ejection hose; 241. the ejection hose probing portion; 2411. the vertical opening of the end of the ejection hose probing portion; 2412. a side opening of the hose detecting portion; 2413. a lateral opening corresponding to the lateral needle hole of the ejection hose; 242. an end of the ejection portion of the ejection hose; 31. a tube for vacuum blood collection tube; 310. Blood vessel lumen; 311.
  • skirt-like portion 350. skirt-like Partial inner cavity; 351. inner surface of the skirt portion; 352. outer surface of the skirt portion; 353. free end of the skirt portion; 3531. wavy or serrated gap; 3532. portion of the gap away from the free end; 3533. shallow groove; 36. skirt outer clearance; L1. blood supply needle seat annular boss lower end 2211 and the farthest lateral pinhole 213 lower end vertical distance L2. the vertical distance between the outer surface 333 of the top end of the cap and the lower edge 3232 of the extended portion of the rubber stopper; L3. the vertical distance between the outer surface 333 of the top end of the cap and the free end 353 of the skirt portion of the rubber plug; L4.
  • Clinically available blood transfusion The vertical distance between the tip apex 2111 of the needle tip and the apex 2321 of the inner end surface of the blind end of the rubber sleeve; L5.
  • FIG. 1A and FIG. 1B are schematic diagrams showing a partial cutaway structure of a conventional clinical vacuum blood collection device and a three-dimensional exploded structure diagram of a vacuum blood collection tube, and a vacuum blood collection device 1, comprising: a tube body 31, a rubber plug 32, and a tube.
  • the cover 33 has a top end opening 311, and the bottom end 312 is a closed blind end.
  • the elastic rubber plug 32 closes the top end opening 311 of the tube body 31 to isolate the inner body cavity 310 having a vacuum from the external fluid, and the tube cover 33 sets.
  • the rubber cap 32 is disposed at the center of the top end 331 of the tube cover, and the outer diameter of the blood supply needle tube 21 is usually less than 1 mm, the inner diameter is about 0.5 mm, and the side wall thickness of the rubber sleeve 23 is about 0.7 mm.
  • the wall thickness of the blind end of the rubber sleeve is about 2 mm, and the distance from the vertex 2111 of the tip of the blood supply needle is about 4 mm from the vertex 2321 of the inner surface of the blind end 232 of the rubber sleeve.
  • the tip end 211 of the blood supply needle penetrates the rubber plug 32 at the top of the vacuum blood collection tube.
  • the rubber sleeve 23 is compressed and stacked outside the rubber plug 32.
  • the tip end of the blood supply needle tip 2111 is away from the blind end of the rubber sleeve 232.
  • the spacing of the inner surface vertices 2321 must be about 4 mm; and the sealing effect on the blood supply needle tip 211 depends on the blind end 232 portion of the rubber sleeve having a thickness of about 2 mm, and when the penetration angle is not perpendicular, the above-mentioned spacing of about 4 mm is extremely easy to make.
  • the portion of the blind end 232 of the thick rubber sleeve is offset, so that the blood-sucking needle tip 211 is pierced from the side wall having a thickness of about 0.7 mm, which is not easy to be actively recovered and the blood is easily leaked.
  • the accommodating cavity 34 includes a capsular bag-shaped accommodating cavity 34.
  • the accommodating cavity 34 is formed by the inner surface 332 of the top end 331 of the cap 33 and the rubber plug 32.
  • the rubber plug recess 324 of the upper surface 321 of the top surface 321 is formed by a small cavity with a small cavity; the opening of the tube cover 330 is the external opening of the receiving cavity 34, and the area of the opening of the tube cover 330 is smaller than the opening of the rubber stopper 324. 3240 area.
  • the tube cover opening 330 is circular or approximately circular, and the diameter or area of the upper edge loop line 3311 of the tube cover opening 330 is larger than the diameter or area of the lower edge loop line 3312; the upper edge loop line 3311 and The lower edge loop line 3312 is a ring line or an approximately circular loop line.
  • the diameter of the upper edge loop line 3311 is large; when it is an ellipse or other approximate circle, the upper edge loop line 3311 has a large area.
  • the accommodating cavity 34 thus formed can completely accommodate the compression-stacked rubber sleeve 231 when the blood-sending needle tube 21 penetrates into the vacuum blood collection tube lumen 310, and when pulled out, as shown in FIG. 3B, the lower edge loop line of the tube cover opening 330 The portion of the portion of the cover 2311 of the cap opening 330 is squeezed to sequentially restore the stacked rubber sleeves 231. This recovery is different from the active restoration of the conventional rubber sleeves depending on their elasticity, but the rubber sleeve is passive. The self-resilient restoration does not rely on the blood-sucking needle tip 211 again, as shown in FIG.
  • the thick blind end 232 of the rubber sleeve is not deflected due to poor puncture angle, and the risk of blood leakage caused by the bleeding end 211 being deflected from the sleeve side wall 233 by the blind end 232 is greatly reduced.
  • the inner surface 313 of the end of the bottom end 322 of the rubber stopper 32 is extended downward to form a rubber plug extension portion 323.
  • the rubber plug extension portion 323 inner cavity 3230 can accommodate the blood supply needle tube 21 penetrating through the rubber stopper receiving portion 325; the rubber stopper extension portion 323 can serve as a support and seal, and the flexible inner surface 3231 can be ejected by the blood supply needle tube 21
  • the blood receiving portion 325 is located between the bottom end surface 3241 of the rubber plug recess 324 and the lower surface 3221 of the bottom end 322 of the rubber plug 32 at the top end 321 of the rubber plug. And the portion that can be resealed after the blood supply needle 21 is dispensed.
  • the lower surface 3221 of the bottom end 322 of the rubber stopper 32 extends downward into the thin wall of the circumference.
  • the skirt portion 35, the skirt inner cavity 350 having the inner surface 351 of the skirt portion 35 of the rubber plug 32 can accommodate the blood supply needle tube 21 penetrating the rubber stopper receiving portion 325; the skirt portion 35 free end 353 facing the tube The bottom end 312 of the body 31.
  • the bottom surface 3221 of the bottom end 322 of the rubber stopper 32 extends downward into a skirt-like portion 35, and the skirt inner cavity 350 of the inner surface 351 of the skirt portion 35 of the rubber plug 32 can accommodate the rubber plug.
  • the blood supply needle 21 of the receiving portion 325; a gap 36 between the outer surface 352 of the skirt portion 35 and the inner surface 313 of the tubular body 31 is a skirt outer gap 36; the skirt outer gap 36 allows the skirt portion 35
  • the skirt portion 35 can be deformed outwardly to be buffered.
  • the broken line indicates the blood flow path from the lateral pinhole of the blood supply needle, and the skirt portion 35 The right side region is deformed to the outside, and the skirt outer gap 36 is slightly reduced at this time.
  • the free end 353 of the skirt portion 35 of the rubber plug 32 is provided with a wavy or serrated gap 3531; further, The free end 353 of the skirt portion 35 of the rubber plug 32 is provided with a wavy or serrated gap 3531; and a shallow groove 3533 extending upward along a portion 3532 of the slit 3531 away from the free end 353.
  • the vacuum blood collection device further includes a blood collection needle tube 11 for piercing the skin and the vein wall, a blood collection needle holder 12 for fixing the blood collection needle tube 11 therein, and a blood supply needle tube 21;
  • the inner cavity 210 of the needle tube 21 is directly connected to the inner cavity 120 of the blood collection needle tube base 12 through the inner cavity 130 of the delivery hose 13;
  • a plastic sleeve 23 is appropriately disposed outside the blood supply needle tube 21, and the rubber sleeve 23 connects the blood supply needle tube 21 to the outside.
  • the fluid isolation tube further includes an ejection hose 24, a portion of the ejection hose 24 is located in the lumen 210 of the blood supply needle 21, a portion is protruded from the needle hole 212 of the tip end 211 of the blood supply needle 21, and the ejection hose 24 is partially protruded.
  • the distal end 242 of the 241 is provided with a vertical opening 2411; the use of the same puncture resistance allows the inner diameter and outer diameter of the blood supply needle tube 21 to increase.
  • the end 242 of the ejection portion 24 of the ejection hose 24 is provided with a vertical opening 2411 and at least one side opening 2412, two openings
  • the blood flow area is significantly increased, effectively reducing blood flow velocity and reducing hemolysis.
  • the end 242 of the ejection portion 24 of the ejection hose 24 is a blind end, and the ejection hose 24 is End 242 is provided with at least one lateral opening 2412.
  • one way is to further include a blood collection needle tube 11 for piercing the skin and the vein wall, a blood collection needle holder 12 for fixing the blood collection needle tube therein, a blood supply needle tube 21, and a blood supply needle tube 21;
  • the inner cavity 210 communicates with the inner cavity 120 of the blood collection needle tube 12 directly or through the inner cavity 130 of the delivery hose 13;
  • the outer sleeve of the blood supply needle tube 21 is sleeved with a rubber sleeve 23, and the rubber sleeve 23 isolates the blood supply needle tube 21 from the external fluid.
  • the tip end 211 of the blood supply needle 21 is a blind end, the needle hole for blood flowing out is a lateral pin hole 213, and the lateral pin hole 213 is at least one; and the rubber plug 32 is provided with the aforementioned skirt portion 35, the direction of the arrow in the figure In the direction of blood flow, the blood flow directly hits the inner surface 351 of the soft skirt portion 35 in the shortest path, reducing hemolysis.
  • the tip end 211 of the blood supply needle tube 21 is a blind end
  • the needle hole for blood outflow is a lateral pinhole 213
  • the lateral pinhole 213 is at least one
  • the ejection hose 24 is located at the blood supply.
  • the ejection hose 24 is provided with a lateral opening 2413 corresponding to the lateral pinhole 213; the corresponding means that the positions of the two are immediately adjacent and the center overlaps, and the blood is ejected from the ejection hose.
  • the lateral opening 2413 of the 24 flows directly from the lateral pinhole 213 of the blood-supping needle 21 into the blood collection lumen 310 without contacting the edge of the lateral pinhole 213, avoiding damage to the blood cells by the rough edge of the lateral pinhole 213.
  • the tip end 211 of the blood supply needle tube 21 is a blind end, the needle hole for blood outflow is a lateral pinhole 213, and the lateral pinhole 213 is at least one; the ejection hose 24 is located in the blood supply needle tube 21.
  • the ejection hose 24 is provided with a lateral opening 2413 corresponding to the lateral pinhole 213; the lateral opening 2413 of the ejection hose 24 has an area smaller than the area of the lateral pinhole 213.
  • the needle hole for blood outflow is a lateral pinhole 213, and the lateral pinhole 213 is at least one;
  • the distance L1 between the lower end surface 2211 of the annular boss 221 and the lower end of the lateral pinhole 213 of the farthest side is smaller than the outer surface 333 of the top end 331 of the tube cover 33 of the vacuum blood collection device 1 and the lower edge 3232 of the extension portion 323 of the rubber plug 32.
  • the distance L2 is such that blood ejected from the lateral pinhole 213 is splashed on the flexible inner surface 3231 of the extended portion 323 of the rubber stopper 32, reducing the hemolysis rate.
  • the tip end 211 of the blood supply needle tube 21 is a blind end, the needle hole for blood flowing out is a lateral pinhole 213, and the lateral pinhole 213 is at least one; the lower end surface 2211 of the annular needle boss 221 of the blood supply needle holder 22 is the most
  • the distance L1 between the lower end points of the distal lateral pinholes 213 is smaller than the distance L3 between the outer surface 333 of the top end 331 of the cap 16 of the vacuum blood collection device 1 and the free end 353 of the skirt portion 35 of the rubber plug 32;
  • the blood ejected toward the pinhole 213 is splashed on the flexible inner surface 351 of the skirt portion 35 of the rubber stopper 32, reducing the hemolysis rate.
  • a precise general feature of the present invention is such that the tip end 211 of the blood supply needle 21 does not puncture the relatively weak rubber sheath side wall 233, the apex 2111 of the tip end 211 of the blood supply needle 21 and the inner surface of the blind end 232 of the rubber sleeve 23.
  • the vertex 2321 linear distance L5 is less than 2 mm, further preferably 1 mm or less; compared with the corresponding distance L4 of the conventional blood supply needle 21 and the rubber sleeve 23 of FIG. 13A, the value of about 4 mm is significantly reduced, and the blind end of the rubber sleeve blind 232 is deflected to cause blood supply.
  • the risk of blood leakage from the needle tip 211 penetrating from the sleeve side wall 233 is greatly reduced.
  • the accommodating cavity 34 is independently formed by the rubber plug recess 324 shown in FIG. 3A, and the rubber plug recess opening 3240 becomes small, and finally the capsule having a small cavity is formed.
  • the bag-shaped accommodating chamber 34 which is an opening for accommodating the cavity 34, has an effect similar to that of Embodiment 1.
  • the accommodating cavity 34 is formed by the capsular bag-shaped accommodating cavity 34 formed by the extending portion 334 of the cap top 333 and the rubber plug recess 324. And similar effects.

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un appareil d'aspiration de sang sous vide comprenant un corps de tube (31), un bouchon en caoutchouc (32) et un capuchon de tube (33). L'extrémité supérieure du corps de tube (31) est une ouverture (311); l'extrémité inférieure (312) de celui-ci est une extrémité borgne fermée. Le bouchon en caoutchouc (32) souple ferme l'ouverture (311) au niveau de l'extrémité supérieure du corps de tube (31), permettant ainsi à une cavité de corps de tube (310) ayant un degré de vide d'être séparée d'un fluide externe. Le capuchon de tube (33) est emmanché sur le bouchon en caoutchouc (32). Une ouverture de capuchon de tube (330) est disposée au centre de l'extrémité supérieure du capuchon de tube (33). L'appareil d'aspiration de sang sous vide comprend également une cavité de réception en forme de sac (34). La cavité de réception (34) est une cavité en forme de sac ayant une petite ouverture et une grande cavité et constituée conjointement par la surface interne (332) de l'extrémité supérieure (331) du capuchon de tube (33) et un évidement de bouchon en caoutchouc (324) vers le bas de la surface supérieure (3211) de l'extrémité supérieure (321) du bouchon en caoutchouc (32). L'ouverture de capuchon de tube (330) est une ouverture tournée vers l'extérieur de la cavité de réception (34). La zone de l'ouverture de bouchon de tube (330) est plus petite que la zone d'une ouverture (3240) de l'évidement de bouchon en caoutchouc (342).
PCT/CN2019/081274 2018-04-16 2019-04-03 Appareil d'aspiration de sang sous vide Ceased WO2019201092A1 (fr)

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US11389801B2 (en) * 2020-02-03 2022-07-19 Unicocell Biomed Co., Ltd. Cell storage tube
EP4196011B1 (fr) * 2020-08-14 2026-04-15 Becton, Dickinson and Company Dispositif de prélèvement sanguin, et systèmes associés

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EP1077086A2 (fr) * 1999-08-18 2001-02-21 Becton Dickinson and Company Dispositif de fermeture comportant un bouchon et un capuchon protecteur
CN202161321U (zh) * 2011-04-25 2012-03-14 江阴市鸿萌橡塑制品有限公司 一种用于采血器管口的密封塞
CN204698571U (zh) * 2015-04-08 2015-10-14 杭州富阳新锐生物科技有限公司 一种医用采血管
CN106880364A (zh) * 2015-12-16 2017-06-23 江苏康捷医疗器械有限公司 改进结构的真空采血管
CN206275692U (zh) * 2016-08-24 2017-06-27 昆明医科大学 一种儿科采血针
CN208808492U (zh) * 2018-04-16 2019-05-03 北京仰生恒泰科技有限责任公司 一种真空采血装置

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CN202235402U (zh) * 2011-09-19 2012-05-30 杨馨艳 真空采血管
CN204072111U (zh) * 2014-04-04 2015-01-07 张树重 一种防止溶血的真空采血管
CN204016309U (zh) * 2014-07-24 2014-12-17 温州市高德医疗器械有限公司 新型真空采血管

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Publication number Priority date Publication date Assignee Title
EP1077086A2 (fr) * 1999-08-18 2001-02-21 Becton Dickinson and Company Dispositif de fermeture comportant un bouchon et un capuchon protecteur
CN202161321U (zh) * 2011-04-25 2012-03-14 江阴市鸿萌橡塑制品有限公司 一种用于采血器管口的密封塞
CN204698571U (zh) * 2015-04-08 2015-10-14 杭州富阳新锐生物科技有限公司 一种医用采血管
CN106880364A (zh) * 2015-12-16 2017-06-23 江苏康捷医疗器械有限公司 改进结构的真空采血管
CN206275692U (zh) * 2016-08-24 2017-06-27 昆明医科大学 一种儿科采血针
CN208808492U (zh) * 2018-04-16 2019-05-03 北京仰生恒泰科技有限责任公司 一种真空采血装置

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