WO2020043548A1 - Procédé de fonctionnement d'un dispositif de mesure par résonance magnétique nucléaire pour mesurer une grandeur caractéristique d'un fluide qui s'écoule à travers un corps - Google Patents

Procédé de fonctionnement d'un dispositif de mesure par résonance magnétique nucléaire pour mesurer une grandeur caractéristique d'un fluide qui s'écoule à travers un corps Download PDF

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Publication number
WO2020043548A1
WO2020043548A1 PCT/EP2019/072227 EP2019072227W WO2020043548A1 WO 2020043548 A1 WO2020043548 A1 WO 2020043548A1 EP 2019072227 W EP2019072227 W EP 2019072227W WO 2020043548 A1 WO2020043548 A1 WO 2020043548A1
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WIPO (PCT)
Prior art keywords
measuring device
fluid
polarization
nmr
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/072227
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German (de)
English (en)
Inventor
Seda Tacer
Irene Dahl
Michael Stumber
Ralf Stein
Sanghmitra Gupta
Stephan Rittler
Tom Collins
Alan Halil
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Robert Bosch GmbH
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Robert Bosch GmbH
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Filing date
Publication date
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Publication of WO2020043548A1 publication Critical patent/WO2020043548A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56308—Characterization of motion or flow; Dynamic imaging

Definitions

  • Nuclear magnetic resonance measuring device in which at least one parameter of a fluid flowing through a body is measured at least in one method step, wherein in at least one method step, a magnetic field for at least partial polarization of the fluid by means of a magnetic device of the NMR measuring device is known.
  • the invention is based on a method for operating a, in particular hand-held, magnetic resonance measuring device (NMR measuring device), in which at least one parameter of a fluid flowing through a body is measured in at least one method step, in at least one
  • NMR measuring device magnetic resonance measuring device
  • Method step using a magnetic device of the NMR measuring device generates at least one magnetic field for at least partial polarization of the fluid.
  • a measurement signal for measuring the at least one parameter of the fluid on the at least partially polarized fluid is recorded in an active depolarization area of the NMR measurement device.
  • the NMR measuring device preferably comprises at least one
  • Magnet device for generating a static magnetic field and / or an alternating magnetic field, in particular in the radio frequency range.
  • a static magnetic field is preferably generated in at least one method step by means of the magnetic device.
  • a “static magnetic field” is to be understood here to mean in particular a magnetic field that is present in at least one
  • the magnetic device preferably comprises, in particular for generating a static one
  • the magnet unit preferably comprises at least one permanent magnet element and / or at least one
  • the magnetic device preferably comprises at least one, in particular for generating an alternating magnetic field
  • the NMR measuring device for generating an alternating magnetic field has a radio frequency horn, a current-carrying conductor section with an adapted geometry and / or another antenna element which seems useful to the person skilled in the art for generating, in particular emitting, an alternating magnetic field.
  • a magnetic one is preferably used in at least one method step
  • the NMR measuring device preferably has at least one measuring unit for recording and / or evaluating a measuring signal.
  • the measuring unit preferably comprises at least one
  • Receiver unit for acquiring a measurement signal, in particular for acquiring an electromagnetic wave, in particular an electromagnetic wave emanating from the fluid.
  • the magnetic coil unit is preferably formed in one piece with the receiving unit.
  • the NMR measuring device has at least one
  • Antenna unit which can be used both as a magnetic coil unit and as a receiving unit, in particular with a time delay and / or simultaneously.
  • a measurement signal recorded by means of the measurement unit is preferably evaluated with regard to the characteristic variable.
  • the parameter preferably describes a composition of the fluid, in particular an absolute and / or relative proportion of an individual component, for example alcohol content, glucose content, proportion of organic acids, heavy metal proportion or the like.
  • the NMR measuring device preferably comprises an examination area in which the static magnetic field and / or the alternating magnetic field are generated.
  • the examination area is preferably designed to receive the body with the fluid.
  • a body to be examined, through which a fluid flows, preferably has channel elements in which the fluid flows, for example pipes, hoses, friction lines, arteries or the like. However, it is also conceivable that the body is porous and / or is otherwise fluid permeable.
  • the NMR measuring device in particular within the Examination area, at least one polarization area.
  • Polarization area generated to at least partially polarize the body located in the polarization area and / or the fluid This means that “an element is at least partially polarized should in particular be understood to mean that the element has a magnetization which has at least more than 25%, preferably more than 50%, particularly preferably more than 75%, of a maximum, in particular temperature-dependent, magnetizability of the Elements corresponds.
  • a partial polarization of the body and / or the fluid is preferably carried out in at least one method step by adjusting the activation time of the static
  • Magnetic field in particular by adjusting the residence time of the body and / or the fluid within the static magnetic field.
  • the NMR measuring device in particular within the
  • Examination area at least one active depolarization area.
  • the active depolarization region is preferably in at least one
  • Method step provided to at least substantially completely shut off the body and / or the fluid within the active depolarization region
  • Magnetization having at least less than 25%, preferably less than 10%, particularly preferably less than 5%, a maximum, in particular
  • the “depolarization area is active” should in particular be understood to mean that the NMR measuring device uses energy to depolarize the body and / or the fluid in the active depolarization area.
  • the NMR measuring device floods the active depolarization region in one method step to depolarization with electromagnetic radiation with at least one at least substantially resonant frequency of the fluid and / or the body, in particular a nuclear spin within the fluid and / or the body, and / or a frequency band that includes at least the resonant frequency.
  • the NMR measuring device heats the active depolarization region as a whole via heating elements and / or locally, for example by focusing a laser, in a method step for depolarization.
  • the NMR measuring device induces depolarization in one process step
  • a measurement signal in particular an electromagnetic wave emanating from the fluid, is preferably detected in the active depolarization area.
  • at least one known, in particular spectroscopic, NMR measurement sequence is preferably carried out by means of the magnetic device for generating the measurement signal in the active depolarization region.
  • An NMR measurement sequence for excitation of hydrogen, in particular a 1 H isotope, is preferably carried out in at least one process step.
  • “Handheld” is to be understood in particular to mean that the NMR measuring device without the aid of a transport machine and / or one
  • Holding device with the hands, in particular with one hand, transported and in particular can be operated to carry out a measurement.
  • the mass of the measuring device is less than 10 kg, preferably less than 5 kg and particularly preferably less than 1 kg. It is also conceivable that the NMR measuring device has a holding device for a temporary and / or permanent arrangement on a fluid guide device of a technical system, for example a production system and / or a fuel recycling system, in particular for monitoring and / or regulating the technical system .
  • Provided is to be understood to mean, in particular, specially programmed, designed and / or equipped.
  • the fact that an object is provided for a specific function should in particular be understood to mean that the object fulfills and / or executes this specific function in at least one application and / or operating state.
  • a measurement can advantageously be carried out selectively on the partially polarized fluid, which flows in particular through the body from the polarization region into the active depolarization region.
  • the parameter of the partially polarized fluid can have an advantageously low interference component due to an advantageously low residual polarization of the active depolarization region
  • located part of the body can be measured.
  • a magnetic pulse sequence should be essentially complete using the magnetic device
  • a “pulse sequence” is to be understood in particular as a defined sequence of electromagnetic pulses.
  • the sequence comprises at least one electromagnetic pulse.
  • At least one electromagnetic pulse is generated by means of the
  • Magnetic device as an alternating magnetic field, especially in
  • Radio frequency range realized with a specified time start point and a specified time end point.
  • the pulse sequence is preferably generated by means of the magnetic coil unit.
  • the pulse sequence is particularly preferably generated with the same magnetic coil unit with which, in particular in one
  • an NMR measurement sequence is generated.
  • the pulse sequence is generated by means of a further magnet coil unit of the magnet device.
  • An envelope, in particular a temporal amplitude profile, of the pulse realized as an alternating magnetic field is preferably at least essentially rectangular, triangular and / or trapezoidal.
  • Essentially rectangular is to be understood in particular to mean that an imaginary rectangle with the same area as an area enclosed by the envelope and the zero line from the starting point to the end point overlaps at least 75%, preferably more than 90%, with the enclosed area can be positioned.
  • “essentially triangular” and “essentially trapezoidal” should be understood analogously.
  • the envelope it is also possible for the envelope to have a smooth transition between a minimum value before the start point and / or after the end point and a maximum value during the pulse.
  • the smooth transition is sinusoidal or
  • a pulse in particular in addition to an at least substantially rectangular, triangular and / or trapezoidal basic shape, has an amplitude modulation.
  • the magnetic alternating field is frequency and / or phase modulated during a pulse.
  • the pulse sequence preferably comprises one and / or several, in particular identical, pulses.
  • the pulse sequence comprises at least two differently designed pulses. For example, pulses differ in particular in amplitude, frequency, phase, polarization, shape of the envelope, duration of the transmission and / or direction of transmission.
  • the pulse sequence preferably comprises more than five, particularly preferably more than ten 90 ° pulses, in particular in a rapid sequence.
  • “in a rapid sequence of pulses” should be understood to mean a sequence of pulses with a minimum time interval between two successive pulses of less than 500 ms, preferably less than 100 ms, particularly preferably less than 50 ms. It is but it is also conceivable that the pulse sequence consists of a single uninterrupted, in particular resonant, pulse.
  • an NMR measuring device operated with the method can advantageously be made compact.
  • Excitation pulse sequence for initiating the measurement is created in a controllable time window after depolarization.
  • An “excitation pulse sequence” is to be understood in particular as a pulse sequence in which the polarization of the magnetic alternating field used is at least substantially perpendicular to the polarization of the static magnetic field and in which the frequency of the magnetic alternating field used is preferably selected to be at least one known nuclear spin transition .
  • an excitation pulse sequence is provided to cause a phase-coherent nuclear spin transition of several nuclear spins of the fluid and / or the body.
  • substantially perpendicular is intended here to define in particular an orientation of a direction relative to a reference direction, the direction and the reference direction, viewed in particular in one plane, enclosing an angle of 90 ° and the angle a maximum deviation of in particular less than 8 °, advantageously less than 5 ° and particularly advantageously less than 2 °.
  • Excitation pulse sequence a measurement phase for recording the measurement signal.
  • the time window in which the excitation pulse sequence for initiating the measurement is generated can preferably be controlled, in particular by means of a control or regulating unit of the NMR measuring device.
  • a start time of the time window can be controlled.
  • an end time of the time window can be controlled.
  • the start time and / or the end time are / are selected in at least one method step depending on a speed parameter of the fluid.
  • a “speed parameter of the fluid” is to be understood in particular as a size and / or characteristic number which describes and / or characterizes a change in position of the fluid relative to the body.
  • the speed parameter is, for example, as a volume flow, mass flow, as a duration, in particular in closed systems as a frequency and / or period, as an average
  • Method step the start time depending on a minimum distance of the active depolarization area, in particular a start of the active one Depolarization range, selected from the polarization range, in particular from a center point of the polarization range.
  • the start time is preferably dependent on a minimum distance between the active depolarization region, in particular an end of the active one
  • Depolarization range selected from the polarization range, in particular from a center point of the polarization range.
  • the end time is preferably determined on the basis of an expected repolarization time of the body located in the active depolarization region.
  • An expected repolarization time is, for example, stored in the table in the factory in a memory unit of the NMR measuring device for different materials and / or measuring situations, in particular a temperature of the body, a suitable value being selected by means of a user input and / or a sensor unit during operation of the NMR measuring device becomes.
  • the configuration according to the invention can advantageously ensure that a measurement takes place while the at least partially polarized fluid is located in the at least substantially depolarized partial area of the body.
  • a time for the measurement can be selected such that an advantageously large proportion of the fluid located in the active depolarization region is at least partially polarized.
  • a speed parameter of the fluid be determined in at least one method step using an NMR calibration measurement.
  • a measurement parameter of the NMR measurement device is preferably adapted to a measurement object in the course of the NMR calibration measurement.
  • the speed parameter of the fluid is preferably recorded in the course of the NMR calibration measurement.
  • a material and / or a temperature of the body are / is recorded during the NMR calibration measurement, in particular to determine an expected repolarization time.
  • At least two NMR measurement sequences with different measurement parameters are preferably carried out during the NMR calibration measurement. In particular, at least two NMR measurement sequences are carried out with a varying time window.
  • a setting for the measurement parameter is preferably selected on the basis of a maximum contrast of the measurement signal. The one resulting from the measurement parameter is preferably used
  • Speed detection unit for performing magnetic resonance velocimetry (MRV) and / or for magnetic-inductive flow measurement (MID).
  • the speed detection unit is preferably formed at least partially in one piece with the magnetic device.
  • the speed parameter of the fluid can be recorded.
  • a measurement can advantageously be tailored precisely to varying fluid velocities.
  • An NMR measuring device operated with the method can advantageously be used universally and flexibly.
  • At least one warning can be issued that a
  • Range of values of the measurement parameters of the NMR measuring device is.
  • the polarization of a partial area of the body located in the active depolarizing area generated by the magnetic device is canceled again.
  • the polarization of the body located in the polarization region is canceled again.
  • Partial region of the body depolarized in the active depolarization region It is also conceivable that in at least one initialization step, in particular before polarization, a further depolarization of the body and / or the fluid is carried out.
  • the configuration according to the invention can ensure that a residual polarization of one in the active
  • Depolarizing area located portion of the body is advantageously small.
  • the invention is based on an NMR measuring device, in particular a hand-held NMR measuring device, with a measuring unit for measuring at least one parameter of a fluid flowing through a body, with a magnetic device for generating at least one magnetic field for at least partially polarizing the Fluids in a polarization range and with a control or regulating unit, in particular for carrying out a
  • the NMR measuring device have an active depolarization region comprising the measuring unit having.
  • the NMR measuring device preferably comprises at least one
  • Magnet device for generating a static magnetic field and / or an alternating magnetic field, in particular in the radio frequency range.
  • the magnetic device preferably comprises, in particular for generating a static one
  • the magnet unit preferably comprises at least one permanent magnet element and / or at least one
  • the magnetic device preferably comprises at least one, in particular for generating an alternating magnetic field
  • the NMR measuring device for generating an alternating magnetic field has a radio frequency horn, a current-carrying conductor section with an adapted geometry and / or another antenna element which seems useful to the person skilled in the art for generating, in particular emitting, an alternating magnetic field.
  • the magnetic coil unit is preferably provided to send out a pulse sequence for depolarization and / or for carrying out an NMR measurement sequence. But it is also conceivable that the magnetic device for the
  • the NMR measuring device preferably has at least one measuring unit for recording and / or evaluating a measuring signal.
  • the measuring unit preferably comprises at least one receiving unit for acquiring a measurement signal, in particular for acquiring an electromagnetic wave, in particular an electromagnetic wave emanating from excited atomic nuclei contained in the fluid.
  • the magnetic coil unit is preferably formed in one piece with the receiving unit.
  • the NMR measuring device has at least one
  • the NMR measuring device preferably comprises an examination area in which the static magnetic field and / or the alternating magnetic field are generated.
  • the examination area is preferably designed to receive the body with the fluid.
  • the NMR measuring device in particular within the
  • the NMR measuring device in particular within the examination area, has at least one active depolarization area, in particular for an essentially complete depolarization of a partial area of the body and / or the fluid located in the active depolarization area.
  • the NMR measuring device on a control or regulating unit.
  • a “control or regulating unit” is to be understood in particular as a unit with at least one control electronics. Under “control electronics” in particular a unit with a processor unit and with a storage unit and with one in the
  • the NMR measuring device preferably comprises at least one housing, in particular for
  • the NMR measuring device preferably comprises at least one information interface, in particular one
  • the NMR measuring device preferably comprises a
  • Speed detection unit for determining a speed parameter of the fluid. Due to the configuration of the NMR measuring device according to the invention, a measurement can advantageously be carried out selectively on the partially polarized fluid, which flows in particular through the body from the polarization region into the active depolarization region.
  • the partially polarized fluid which flows in particular through the body from the polarization region into the active depolarization region.
  • Depolarizing area located part of the body can be measured.
  • the polarization region be formed at least partially without overlap from the active depolarization region. At least part of the body located in the polarization region and / or the fluid is preferably within the active one before depolarization
  • the active one is preferably located
  • Depolarization range at least partially within the polarization range.
  • the measuring unit is preferably arranged within the overlap region. It is particularly conceivable that the magnetic device in the active
  • Depolarization area has a further magnet unit for generating a further static magnetic field, so that the polarization area comprises at least two spatially spaced sub-areas.
  • the sub-area free of overlap with the active depolarization area is preferably provided primarily for polarizing the body and / or the fluid.
  • the area overlapping with the active depolarization area is preferably provided primarily for measurement by means of the measuring unit.
  • Design can advantageously be ensured that at least part of the partially polarized fluid remains at least partially polarized during depolarization.
  • the NMR measuring device be a
  • Guide unit for specifying a flow direction of the fluid with at least one inlet opening into the polarization region and one into the active one
  • Depolarizing area has an outlet.
  • a “guide unit” is to be understood in particular as a component which is provided for arranging the NMR measuring device on the body. Preferably centers the
  • the guide unit preferably comprises a receiving element, in particular tubular and / or ring-shaped, for receiving the body, which leads in and / or through a housing of the NMR measuring device.
  • a receiving element in particular tubular and / or ring-shaped, for receiving the body, which leads in and / or through a housing of the NMR measuring device.
  • Magnetic coil unit arranged around the receiving element.
  • the guide unit has a curved profile
  • the guide unit in particular in the case of a contactless measurement, comprises marking elements in order to identify the examination area.
  • the guide unit is preferably provided for a
  • the guide unit preferably has an entrance to an inlet of the fluid into the examination region, in particular into the polarization region.
  • the guide unit preferably has an outlet to an outlet of the fluid from the examination area, in particular from the active depolarization area.
  • Design can advantageously reliably reliable a spatial orientation of the NMR measuring device to the body and / or the fluid required for the measurement
  • the NMR measuring device have at least one
  • Alignment unit for adapting and / or fixing a spatial
  • the alignment unit is preferably provided for a minimum distance, in particular along the flow direction, between the polarization region, in particular a center point of the polarization region, and to adapt and / or fix the active depolarization area, in particular a start of the active depolarization area.
  • the NMR measuring device has a removable depolarization module and / or a removable polarization module, which are / are in particular freely movable against a housing of the NMR measuring device and, in particular wirelessly, communicate with the control or regulating unit arranged in the housing.
  • the NM R measuring device has a movably mounted depolarization module and / or a movably mounted polarization module, which / can be displaced in particular along an alignment unit designed as a guide rail.
  • the alignment unit is designed as an extendable telescopic rod, on which the magnet unit is mounted, in particular a
  • the magnetic coil unit has displaceable taps, in particular to adapt an active depolarization area.
  • a shift is preferably implemented automatically by means of a drive unit, for example an electric motor and / or an actuator.
  • a distance can be set by means of the control or regulating unit as a function of the determined velocity parameter of the fluid. Due to the configuration according to the invention, the
  • Examination area can be advantageously adapted to the speed parameter of the fluid.
  • An NMR measuring device operated with the method can advantageously be used universally and flexibly.
  • a blood measuring device for the non-invasive detection of a blood parameter, in particular blood sugar, with an NMR measuring device according to the invention and / or with an NMR measuring device with a control or regulating unit for carrying out a method according to the invention is proposed.
  • the blood parameter preferably describes a composition of blood in a human and / or animal body, in particular an absolute and / or relative proportion of an individual component, in particular a blood sugar concentration and / or a blood alcohol concentration.
  • the blood measuring device preferably comprises at least one user interface for outputting the blood parameter.
  • the user interface preferably comprises at least one display for outputting the blood parameter.
  • the user interface it is also conceivable for the user interface to be more visual
  • Output elements such as control lights, acoustic output elements, in particular loudspeakers, and / or haptic output elements, for example a vibration element.
  • the blood measuring device preferably has at least one actuating element for activating a measurement.
  • a blood parameter can advantageously be recorded in vivo in the embodiment of the blood measuring device.
  • a blood measuring device can be made available that can be operated hygienically and advantageously conveniently due to the non-invasive detection of the blood parameter.
  • the method according to the invention, the NMR measuring device according to the invention and / or the blood measuring device according to the invention should / should not be limited to the application and embodiment described above.
  • the method according to the invention, the NMR measuring device according to the invention and / or the blood measuring device according to the invention can have a number which differs from a number of individual elements, components and units as well as method steps mentioned in order to fulfill a function described herein.
  • those stated in this disclosure are intended to be
  • Fig. 1 is a schematic representation of an inventive
  • Fig. 2 is a schematic representation of an inventive
  • Nuclear magnetic resonance measuring device of the blood measuring device according to the invention
  • Fig. 4 is an illustration of a starting position of the invention
  • Fig. 5 is an illustration of a polarization phase of the invention
  • Process, 6 shows a further illustration of the polarization phase of the method according to the invention.
  • Fig. 12 is a schematic representation of another invention
  • FIG. 13 is a schematic representation of a longitudinal section of a further NMR measuring device according to the invention.
  • Fig. 14 is a schematic representation of a cross section of the other
  • FIG. 1 shows a blood measuring device 44a for the non-invasive detection of a blood parameter, in particular of blood sugar.
  • the blood measuring device 44a is preferably as
  • the blood measuring device 44a has a nuclear magnetic resonance measuring device (NMR measuring device) shown in more detail in FIG.
  • NMR measuring device nuclear magnetic resonance measuring device
  • the NMR measuring device 12a is preferably designed as a hand-held NMR measuring device 12a, in particular as a result of an arrangement of the N M R measuring device 12a on, preferably in, a device housing 46a of the blood measuring device 44a.
  • the blood measuring device 44a is preferably with the NMR measuring device 12a
  • the N M R measuring device 12a comprises a measuring unit 28a for a measurement 21a of at least one parameter of a fluid 14a (cf. FIGS. 4 to 10) which flows through a body 16a.
  • the NMR measuring device 12a comprises a magnetic device 18a for generating at least one magnetic field 20a.
  • the NMR measuring device 12a includes one Control or regulating unit 32a, in particular for carrying out a method 10a shown in FIGS. 3 to 10.
  • the NMR measuring device 12a has an active depolarization region 24a comprising the measuring unit 28a.
  • the blood measuring device 44a preferably has the device housing 46a. It is particularly conceivable that the device housing 46a can be designed to be disassembled and / or opened in a further embodiment for a simple arrangement of the body 16a in the polarization region 30a and / or the depolarization region 24a in at least two housing shells, in particular without tools. It is also conceivable for the device housing 46a to be configured in a simple manner on the body 16a from a flexible material, in particular as a sleeve.
  • the device housing 46a preferably has a holding area 47a for holding the blood measuring device 44a with one hand in a comfortable and slip-proof manner.
  • the blood measuring device 44a preferably has a user interface 48a, which is in particular embedded in the device housing 46a.
  • the user interface 48a is in particular embedded in the device housing 46a.
  • the NMR measuring device 12a preferably has a housing 50a, in particular for fixing a spatial arrangement of the magnetic device 18a and the measuring unit 28a and / or for protecting the control or regulating unit 32a.
  • the housing 50a is preferably in one piece with the device housing 46a
  • the NMR measuring device 12a is of modular design and in particular comprises an independent housing in order to remove the NMR measuring device 12a from the blood measuring device 44a and / or another device with a few hand movements and / or into the blood measuring device 44a and / or to install in another device in a few simple steps.
  • the N M R measuring device 12a comprises a guide unit 34a for specifying a flow direction 36a of the fluid 14a, in particular blood, with at least one inlet 38a opening into a polarization region 30a and with an outlet 40a opening into an active depolarization region 24a.
  • the guide unit 34a preferably extends through the housing 50a.
  • the polarization region 30a and / or the active depolarization region 24a are arranged within the housing 50a.
  • the guide unit 34a is provided for receiving the body 16a, for example a finger, and in particular in the
  • the guide unit 34a preferably has a straight longitudinal axis 52a, which extends from the inlet 38a to the outlet 40a.
  • the guide unit 34a is preferably rotationally symmetrical with respect to the longitudinal axis 52a,
  • the NMR measuring device 12a in particular the guide unit 34a, from which the fluid 14a flows essentially parallel to the longitudinal axis 52a from the input 38 through the polarization region 30a and through the active depolarization region 24a to the output 40a.
  • FIG. 2 shows the NMR measuring device 12a in a section along the longitudinal axis 52a.
  • the magnet device 18a preferably comprises at least one magnet unit 54a, in particular for generating a static magnetic field 20a.
  • the magnet unit 54a preferably comprises at least one permanent magnet element 56a, 58a.
  • the magnetic device 18a preferably comprises at least one magnetic coil unit 60a, in particular for generating an alternating magnetic field.
  • the measuring unit 28a preferably comprises at least one receiving unit 62a for detecting a measurement signal, in particular for detecting an electromagnetic wave, in particular an electromagnetic wave emanating from the fluid 14a.
  • the magnetic coil unit 60a is preferably formed in one piece with the receiving unit 62a.
  • the measuring unit 28a preferably comprises an alternating field processing unit 68a for generating
  • the measuring unit 28a preferably comprises an evaluation unit 70a for determining the parameter of the fluid 14a from the, in particular by the
  • the N M R measuring device 12a preferably comprises an examination area 64a, in which the static magnetic field 20a and / or the alternating magnetic field are generated.
  • the examination area 64a is essentially congruent with an interior of the guide unit 34a for receiving the body 16a.
  • the examination area 64a preferably comprises the polarization area 30a, in particular to an at least partial polarization 19a of a fluid 14a located in the polarization area 30a.
  • the polarization area 30a preferably comprises the polarization area 30a, in particular to an at least partial polarization 19a of a fluid 14a located in the polarization area 30a.
  • the active depolarization area 24a in particular for an essentially complete depolarization 23a of a partial area 26a of the body 16a located in the active depolarization area 24a.
  • the polarization region 30a is formed at least partially without overlap from the active depolarization region 24a. In particular, a maximum extension of the active depolarization region 24a along the longitudinal axis 52a is im
  • the NMR measuring device 12a preferably comprises at least one information interface 66a, in particular for outputting the measurement signal and / or the parameter determined from the measurement signal and / or for inputting
  • the information interface 11 e 66a is preferably designed as a bus and in particular connected to the user interface 48a. In particular, it is also conceivable that the information interface 66a for
  • the NMR measuring device 12a has a separately designed one
  • FIG. 3 shows a flow diagram of the method 10a for operating the, in particular hand-held, NMR measuring device 12a, in which at least one
  • the method step measures at least one parameter of the fluid 14a flowing through the body 16a.
  • a single determination of the parameter of the fluid 14a consists of at least three phases, namely the partial polarization 19a of the fluid 14a, the essentially complete depolarization 23a of a partial area 26a of the body 16a, followed by the measurement 21a with an NMR known per se. Measurement sequence.
  • an NMR calibration measurement 25a can be carried out before the polarization 19a, in particular for a
  • a magnetic field 20a for at least partial polarization 19a of the fluid 14a is generated by means of a magnetic device 18a of the NMR measuring device 12a, cf. 4 to 6 in particular.
  • a measurement signal for a measurement 21a of the at least one parameter of the fluid 14a on the at least partially polarized fluid 22a is recorded in an active depolarization region 24a of the NMR measurement device 12a, see in particular FIG. 10.
  • the polarization of the partial region 26a generated by the magnetic device 18a becomes active
  • the magnetic device 18a generates a pulse sequence for an essentially complete depolarization 23a of the partial area 26a of the body 16a within the active depolarization area 24a, cf. 8 in particular.
  • a speed characteristic of the fluid 14a is determined in at least one method step using the NMR calibration measurement 25a.
  • At least one measurement parameter, in particular a timing of the polarization 19a, the depolarization 23a and / or the measurement 21a, is preferably adapted on the basis of the determined speed parameter.
  • FIGS. 4 to 10 show an illustration of the method 10a described in FIG. 3:
  • FIG. 4 shows the body 16a with the fluid 14a before the polarization 19a.
  • the fluid 14a preferably flows through the body 16a in the flow direction 36a.
  • the body 16a preferably has a channel element 71a, for example an artery or a fuel line, through which the fluid 14a flows within the body 16a.
  • the body 16a and the fluid 14a are preferably essentially completely depolarized, here represented by the arrows pointing in a random direction within the body 16a and / or the fluid 14a, or have a random polarization in some areas.
  • FIG. 5 shows a start of polarization 19a.
  • the start of polarization 19a Preferably in the
  • Polarization region 30a generates the static magnetic field 20a and / or the body 16a moves into the polarization region 30a with the already existing magnetic field 20a.
  • the body 16a is preferably at least substantially stationary during the polarization 19a, the depolarization 23a and the measurement 21a relative to the N M R measuring device 12a. It is particularly conceivable that the
  • Guide unit 34a has a fixing element, for example a clamp, for temporarily fixing the body 16a within the guide unit 34a.
  • the magnetic field 20a is preferably generated in a direction at least substantially perpendicular to the flow direction 36a and / or to the longitudinal axis 52a.
  • Figure 6 shows an effect of polarization 19a. After a polarization period, the fluid 14a and the body 16a are preferably within the
  • Polarization region 30a is at least partially polarized, here represented by the at least substantially parallel arrows.
  • the polarization period is shorter than a crossing period that a fixed volume of fluid requires to cross the polarization region 30a. It is special it is conceivable that during the NM R calibration measurement 25a the polarization duration is detected, for example, and by connecting or disconnecting others
  • Magnet units is adjustable along the longitudinal axis 52a.
  • a polarized fluid portion 72a has flowed out of the polarization region 30a within the polarization period.
  • a depolarized fluid portion 74a has flowed into the polarization region 30a within the polarization period.
  • FIG. 7 shows a state before depolarization 23a.
  • the active depolarization region 24a preferably lies at least partially within the
  • Polarization area 30a In particular, a partially polarized partial area 26a of the body 16a is located within the polarizing area 30a.
  • FIG. 8 essentially shows the feeding of a pulse sequence
  • FIG. 9 shows the result of the pulse sequence for the essentially complete one
  • Depolarization 23a of partial area 26a of body 16a is essentially completely depolarized within the active depolarization region 24a, repolarization of the partial region 26a in particular starting due to the magnetic field 20a.
  • the depolarization 23a generates a depolarized amount of fluid 92a of the fluid 14a.
  • FIG. 10 shows the start of measurement 21a.
  • the depolarized fluid quantity 92a located in the partial region 26a it has been replaced by at least partially polarized fluid 22a from the polarization region 30a.
  • a duration for replacement with the partially polarized fluid 22a within the active depolarization region 24a is shorter than one
  • the partially polarized fluid 14a within the active depolarization region 24a is preferably surrounded by the still substantially depolarized subregion 26a of the body 16a.
  • FIGS. 11 to 14 show two further exemplary embodiments of the invention. The following descriptions and the drawings are limited to
  • FIG. 11 shows an, in particular hand-held, N M R measuring device 12b.
  • the NMR measuring device 12b comprises a measuring unit 28b for measuring at least one parameter of a fluid flowing through a body.
  • the NMR measuring device 12b comprises a magnetic device 18b for generating at least one magnetic field.
  • the magnetic field is provided for at least partial polarization of the fluid in a polarization region 30b.
  • the NMR measuring device 12b comprises a control or regulating unit 32b, in particular for carrying out a method which is analogous to the method 10a shown in FIGS. 3 to 10.
  • the NMR measuring device 12b has an active depolarization region 24b comprising the measuring unit 28b.
  • the NMR measuring device 12b has at least one alignment unit 42b for adapting and / or fixing a spatial arrangement of the polarization region 30b and the active depolarization region 24b to one another.
  • the alignment unit 42b preferably comprises at least one guide rail 76b, 78b, which in particular is arranged at least substantially parallel to a longitudinal axis 52b.
  • the alignment unit 42b preferably comprises at least one guide rail 76b, 78b, which in particular is arranged at least substantially parallel to a longitudinal axis 52b.
  • Alignment unit 42b a guide carriage 80b for movement 82b along a guide unit 34b.
  • a magnetic coil unit 60b is preferably at least partially mounted on the guide carriage 80b, which is electrically and / or in particular via sliding contacts and / or induction elements 84b, 86b
  • Permanent magnet element 88b, 90b of the magnet unit 54b mounted to generate a, in particular local, static magnetic field.
  • the active depolarization region 24b can preferably be moved against the polarization region 30b, in particular for adaptation to the parameter of the fluid, in particular during an N M R calibration measurement.
  • FIG. 12 shows a blood measuring device 44c for the non-invasive detection of a
  • the blood measuring device 44c is preferred designed as a handheld blood measuring device 44c.
  • the blood measuring device 44c has a nuclear magnetic resonance measuring device (NMR measuring device) 12c shown in more detail in FIGS. 13 and 14.
  • the NMR measuring device 12c comprises a measuring unit 28c for measuring at least one parameter of a fluid flowing through a body.
  • the NMR measuring device 12c comprises a magnetic device 18c for generating at least one magnetic field.
  • the magnetic field is provided for at least partial polarization of the fluid in a polarization region 30b.
  • the NMR measuring device 12c comprises a control or regulating unit 32c, in particular for carrying out a method which is analogous to that in FIGS. 3 to 10
  • the NMR measuring device 12c has a
  • Measuring unit 28c comprising active depolarization region 24c.
  • An examination area 64c of the NMR measuring device 12c, in particular the polarization area 30b and / or the depolarization area 24c, is preferably arranged outside a device housing 46c of the blood measurement device 44c.
  • the NMR measuring device 12c preferably has a guide unit 34c for specifying a
  • the guide unit 34c is provided for application to the body.
  • the guide unit 34c is embedded in a housing 50c of the NMR device 12c and / or the device housing 46c and / or is formed in one piece with the housing 50c and / or the device housing 46c.
  • the guide unit 34c preferably comprises at least one marking element 94c for identifying the polarization region 30c.
  • the guide unit 34c preferably comprises at least one further marking element 96c
  • Marking element 94c and / or the further marking element 96c is designed as a colored marking.
  • the marking element 94c and / or the further marking element 96c is designed as a structural element, for example as a groove, rib, bulge or the like.
  • the marking element 94c and / or the further marking element 96c is designed as an anti-slip element and has a surface provided with knobs, lamellae or the like.
  • the blood measuring device 44c preferably comprises at least one fixing unit 98c, for a temporary fixing of the body in the
  • the fixing unit 98c preferably has at least one, in particular extendable and / or elastic, belt unit 100c, which in particular has a fastening element, not shown here, such as a Velcro fastener Has snap lock or the like.
  • the fixing unit 98c preferably comprises a deflection element 102, via which the belt unit 100c can be lashed down.
  • FIG. 13 shows a longitudinal section of the NMR measuring device 12c and FIG. 14 shows a cross section of the NMR measuring device 12c.
  • the polarization region 30c is preferably formed at a distance from a center of symmetry of a magnet unit 54c.
  • the magnet unit 54c generates at least during one operation of the NMR measuring device 12c in at least one method step in the
  • Polarization region 30c an inhomogeneous static magnetic field.
  • a gradient of the inhomogeneous static magnetic field is preferably at least substantially perpendicular to the predetermined flow direction 36c.
  • the gradient of the inhomogeneous static magnetic field is preferably at least substantially perpendicular to a wall of the housing 50c, in particular to a wall of the housing 50c, on which the guide unit 34c is arranged.
  • Axis of symmetry of the magnetic coil unit 60c at least substantially perpendicular to a wall of the housing 50c, in particular to the wall of the housing 50c, on which the guide unit 34c is arranged.
  • the axis of symmetry of the magnetic coil unit 60c is preferably at least substantially perpendicular to the predetermined flow direction 36c.
  • the axis of symmetry is preferably the
  • Magnetic coil unit 60c at least substantially parallel to the gradient of the static magnetic field.
  • a frequency is preferably one by means of a
  • Frequency is a minimal distance from a geometric center of the
  • Depolarization range in particular a measurement location of an NMR measurement sequence, can be set along the axis of symmetry of the magnetic coil unit 60c.
  • Depolarization range in particular a measurement location of an NMR measurement sequence, can be set along the axis of symmetry of the magnetic coil unit 60c.

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Abstract

L'invention concerne un procédé permettant de faire fonctionner un dispositif de mesure par résonance magnétique nucléaire (dispositif de mesure RMN), en particulier à main, selon lequel au moins une grandeur caractéristique d'un fluide (14a) qui s'écoule à travers un corps (16a) est mesurée dans au moins une étape du procédé, et au moins un champ magnétique (20a) est généré dans au moins une étape du procédé au moyen d'un dispositif magnétique (18a; 18b; 18c) du dispositif de mesure RMN pour polariser (19a) au moins en partie le fluide (14a). Selon l'invention, dans au moins une étape du procédé, un signal de mesure est détecté pour une mesure (21a) de la ou des grandeurs caractéristiques du fluide (14a) sur le fluide (22a) au moins partiellement polarisé dans une zone de dépolarisation active (24a) du dispositif de mesure RMN.
PCT/EP2019/072227 2018-08-27 2019-08-20 Procédé de fonctionnement d'un dispositif de mesure par résonance magnétique nucléaire pour mesurer une grandeur caractéristique d'un fluide qui s'écoule à travers un corps Ceased WO2020043548A1 (fr)

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DE102018214457.5A DE102018214457B3 (de) 2018-08-27 2018-08-27 Verfahren zum Betrieb einer Kernspinresonanz-Messvorrichtung
DE102018214457.5 2018-08-27

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DE102021134237A1 (de) 2021-12-22 2023-06-22 Endress+Hauser Flowtec Ag Vorrichtung zur Analyse von Verunreinigungen oder Fremdkörpern
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070035296A1 (en) * 2005-05-03 2007-02-15 Samsung Electronics Co., Ltd. Method for measuring nuclear magnetic resonance longitudinal axis relaxation time of blood and apparatus using the same
GB2432003A (en) * 2003-09-05 2007-05-09 Schlumberger Holdings Determining properties of flowing fluids by NMR
US20150018638A1 (en) * 2012-02-08 2015-01-15 Anatech Advanced Nmr Alorithms Technologies Ltd. Apparatus and method for non-invasive measurement of blood parameters
DE102014010324B3 (de) * 2014-05-23 2015-02-05 Krohne Ag Kernmagnetisches Durchflussmessgerät und Verfahren zum Betreiben eines kernmagnetischen Durchflussmessgeräts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629987A (en) 1983-09-08 1986-12-16 Southwest Research Institute Method and apparatus for nuclear magnetic resonant measurement of flow velocity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2432003A (en) * 2003-09-05 2007-05-09 Schlumberger Holdings Determining properties of flowing fluids by NMR
US20070035296A1 (en) * 2005-05-03 2007-02-15 Samsung Electronics Co., Ltd. Method for measuring nuclear magnetic resonance longitudinal axis relaxation time of blood and apparatus using the same
US7295006B2 (en) 2005-05-03 2007-11-13 Samsung Electronics Co., Ltd. Method for measuring nuclear magnetic resonance longitudinal axis relaxation time of blood and apparatus using the same
US20150018638A1 (en) * 2012-02-08 2015-01-15 Anatech Advanced Nmr Alorithms Technologies Ltd. Apparatus and method for non-invasive measurement of blood parameters
DE102014010324B3 (de) * 2014-05-23 2015-02-05 Krohne Ag Kernmagnetisches Durchflussmessgerät und Verfahren zum Betreiben eines kernmagnetischen Durchflussmessgeräts

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