WO2020046543A3 - Complexes tétrapyrrole solubles dans l'eau contenant des ligands de biladiène utiles en thérapie photodynamique - Google Patents

Complexes tétrapyrrole solubles dans l'eau contenant des ligands de biladiène utiles en thérapie photodynamique Download PDF

Info

Publication number
WO2020046543A3
WO2020046543A3 PCT/US2019/045250 US2019045250W WO2020046543A3 WO 2020046543 A3 WO2020046543 A3 WO 2020046543A3 US 2019045250 W US2019045250 W US 2019045250W WO 2020046543 A3 WO2020046543 A3 WO 2020046543A3
Authority
WO
WIPO (PCT)
Prior art keywords
water soluble
photodynamic therapy
tetrapyrrole
biladiene
complexes containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2019/045250
Other languages
English (en)
Other versions
WO2020046543A2 (fr
Inventor
Joel Rosenthal
Andrea POTOCNY
Maxwell I. MARTIN
Anthony RICE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2020046543A2 publication Critical patent/WO2020046543A2/fr
Publication of WO2020046543A3 publication Critical patent/WO2020046543A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Les complexes de tétrapyrrole de métaux solubles dans l'eau sont utiles en thérapie photodynamique, les complexes étant capables de fonctionner en tant que photosensibilisateurs qui, activés par la lumière, conduisent à la génération d'oxygène singulet. L'oxygène singulet ainsi produit est toxique pour les cellules cancéreuses. Les ligands de tétrapyrrole présents dans ces complexes sont caractérisés par la présence d'au moins un segment de solubilisation dans l'eau (qui peut être présenté, par exemple, sous la forme d'un poly (oxyalkylène) contenant un substituant), ce qui aide à favoriser la biocompatibilité du complexe.
PCT/US2019/045250 2018-08-06 2019-08-06 Complexes tétrapyrrole solubles dans l'eau contenant des ligands de biladiène utiles en thérapie photodynamique Ceased WO2020046543A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862714856P 2018-08-06 2018-08-06
US62/714,856 2018-08-06

Publications (2)

Publication Number Publication Date
WO2020046543A2 WO2020046543A2 (fr) 2020-03-05
WO2020046543A3 true WO2020046543A3 (fr) 2020-05-14

Family

ID=69643971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/045250 Ceased WO2020046543A2 (fr) 2018-08-06 2019-08-06 Complexes tétrapyrrole solubles dans l'eau contenant des ligands de biladiène utiles en thérapie photodynamique

Country Status (1)

Country Link
WO (1) WO2020046543A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186285A1 (en) * 2003-03-21 2004-09-23 Ceramoptec Industries, Inc. Water-soluble mono-PEGylated tetrapyrrole derivatives for photodynamic therapy and method of production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186285A1 (en) * 2003-03-21 2004-09-23 Ceramoptec Industries, Inc. Water-soluble mono-PEGylated tetrapyrrole derivatives for photodynamic therapy and method of production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KIM ET AL.: "Water-Soluble Porphyrin-Polyethylene Glycol Conjugates with Enhanced Cellular Uptake for Photodynamic Therapy", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 9, 2009, pages 7130 - 7135 *
LUCIANO, MICHAEL ET AL.: "Modifications of Porphyrins and Hydroporphyrins for Their Solubilization in Aqueous Media", MOLECULES, vol. 22, no. 6, 2017, pages 1 - 47, XP055708111, DOI: 10.3390/molecules22060980 *
POTOCNY, ANDREA M. ET AL.: "Electrochemical, Spectroscopic, and 102 Sensitization Characteristics of Synthetically Accessible Linear Tetrapyrrole Complexes of Palladium and Platinum", INORG CHEM., vol. 56, no. 21, 6 November 2017 (2017-11-06), pages 12703 - 12711, XP055708116, DOI: 10.1021/acs.inorgchem.7b00796 *

Also Published As

Publication number Publication date
WO2020046543A2 (fr) 2020-03-05

Similar Documents

Publication Publication Date Title
Imberti et al. New designs for phototherapeutic transition metal complexes
Hempel et al. Crosstalk between calcium and reactive oxygen species signaling in cancer
Wu et al. Recent advances in noble metal complex based photodynamic therapy
Hynek et al. Porous framework materials for singlet oxygen generation
Dąbrowski et al. Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers
Shaili Platinum anticancer drugs and photochemotherapeutic agents: recent advances and future developments
Stacey et al. New avenues in the design and potential application of metal complexes for photodynamic therapy
Lazarides et al. Photocatalytic hydrogen production from a noble metal free system based on a water soluble porphyrin derivative and a cobaloxime catalyst
Therrien Transporting and Shielding Photosensitisers by Using Water‐Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy
Yu et al. Chemical modification of temoporfin–a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation
Guan et al. Phosphorescent iridium (III) complexes for anticancer applications
Tovmasyan et al. Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology
T de Oliveira et al. Chlorins: natural sources, synthetic developments and main applications
Mehanna et al. Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru (ii) polypyridyl complex
GB2433070A (en) Porphyrin derivatives and their use in photon activation therapy
Chen et al. Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru (II) arene complex with dual activities of photobinding and photocleavage toward DNA
MX2014013632A (es) Compuestos de pirimidina para el tratamiento de cancer.
PH12012500789A1 (en) Prolyl hydroxylase inhibitors
Cole et al. Ru (II) phenanthroline-based oligothienyl complexes as phototherapy agents
TW200730532A (en) Camptothecin derivatives as chemoradiosensitizing agents
Zhou et al. A novel azopyridine-based Ru (ii) complex with GSH-responsive DNA photobinding ability
Banerjee et al. Dual-action platinum (II) Schiff base complexes: photocytotoxicity and cellular imaging
Sweigert et al. Nickel, copper, and zinc centered ruthenium-substituted porphyrins: effect of transition metals on photoinduced DNA cleavage and photoinduced melanoma cell toxicity
WO2006126177A3 (fr) Derives de 2-indolyl imidazo[4,5-d]phenanthroline et utilisation dans le traitement du cancer
Toupin et al. Unlocking the Potential of Ru (II) Dual‐action Compounds with the Power of the Heavy‐atom Effect

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19854266

Country of ref document: EP

Kind code of ref document: A2