WO2020050568A1 - Dispositif de mesure et de stimulation de signal biologique comportant une bioélectrode - Google Patents

Dispositif de mesure et de stimulation de signal biologique comportant une bioélectrode Download PDF

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Publication number
WO2020050568A1
WO2020050568A1 PCT/KR2019/011261 KR2019011261W WO2020050568A1 WO 2020050568 A1 WO2020050568 A1 WO 2020050568A1 KR 2019011261 W KR2019011261 W KR 2019011261W WO 2020050568 A1 WO2020050568 A1 WO 2020050568A1
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WO
WIPO (PCT)
Prior art keywords
microelectrodes
measurement
bio
biosignal
bioelectrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2019/011261
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English (en)
Korean (ko)
Inventor
최헌진
채영철
성재석
나주관
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Yonsei University
Original Assignee
Industry Academic Cooperation Foundation of Yonsei University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190094932A external-priority patent/KR20200027417A/ko
Application filed by Industry Academic Cooperation Foundation of Yonsei University filed Critical Industry Academic Cooperation Foundation of Yonsei University
Priority to US17/272,754 priority Critical patent/US20210204855A1/en
Publication of WO2020050568A1 publication Critical patent/WO2020050568A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0024—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system for multiple sensor units attached to the patient, e.g. using a body or personal area network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225—Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation

Definitions

  • the present invention relates to a bio-signal measurement and stimulation device. Specifically, it relates to a bio-signal measurement and stimulation device equipped with a bio-electrode.
  • the present invention relates to a technique for measuring a neural biosignal and analyzing the signal, and then providing an appropriate stimulus.
  • the biosignal is precisely measured to identify the biological structure / function of a living body, an animal, or a plant.
  • Bio-signal measurement and stimulation structure for measurement and analysis.
  • the biosignal measurement and stimulation apparatus equipped with the bioelectrode according to the present invention has the following problems.
  • the present invention is a bio-signal measuring device in which a signal measuring unit provided with a plurality of microelectrodes is disposed on a substrate, wherein at least one of a signal measuring unit, a measuring signal processing unit and a driving power unit or a wireless communication unit is disposed on the substrate. It is a biosignal measurement and stimulation device equipped with a bioelectrode, which is arranged in the longitudinal or transverse direction and measures or stimulates a biosignal from the microelectrodes formed in an array pattern.
  • the microelectrode according to the present invention may be provided as a solder bump.
  • the solder bump according to the present invention may be in a round shape or a tapered cone shape in upper and lower light.
  • the power unit for driving according to the present invention is any one of a coin type battery, a film type thin film battery, a piezoelectric battery, a friction electric battery, a solar power wireless power transmitter, an RF wireless power transmitter, a bio fuel cell, and a super capacity. It is preferred.
  • the wireless communication unit according to the present invention may use any one of Bluetooth communication elements, Wi-Fi communication elements and BCC communication elements.
  • the microelectrodes formed in the array pattern are set of one microelectrode as a reference electrode and other microelectrodes located at the same distance from the reference electrode, and corresponding electrode groups are set for each corresponding electrode group. It is possible to average the measured values of the biosignal with each of the fine electrodes of the and corresponding electrode groups.
  • an average of measured values excluding at least one of an upper limit value or a lower limit value among measured values for each corresponding electrode group can be obtained.
  • the plurality of microelectrodes according to the present invention are patterns arranged in the same number in the longitudinal and transverse directions, and the reference electrode is preferably any one of the multiple microelectrodes.
  • the plurality of microelectrodes according to the present invention are arranged in the same number of odd numbers in the longitudinal and transverse directions, and the reference electrode may be set as a microelectrode located at the center.
  • the plurality of microelectrodes according to the present invention are patterns arranged in different numbers in the longitudinal and transverse directions, and the reference electrode is preferably any one of the multiple microelectrodes.
  • a plurality of microelectrodes according to the present invention are disposed on a circle center of a plurality of concentric circles and a circumference of each concentric circle, a reference electrode is a microelectrode disposed at the center of the circle, and a corresponding electrode group is a microelectrode disposed on the circumference of each concentric circle It is preferred to be electrodes.
  • the biosignal measurement and stimulation apparatus equipped with the bioelectrode according to the present invention has the following effects.
  • the signal measuring unit, the measuring signal processing unit, the driving power unit and the wireless communication unit are arranged in the longitudinal or transverse direction, thereby miniaturizing the biosignal measuring device.
  • a wireless communication device such as a Bluetooth communication device, a WiFi communication device, a BCC communication device, there is an effect of easily transmitting the measured value wirelessly.
  • FIGS. 1A to 1C are various embodiments of structural schematic diagrams of a bio-signal measuring apparatus according to the present invention.
  • FIGS. 2A to 2C show schematic diagrams of overall shapes and vertical cross-sections of a biosignal measuring apparatus according to the present invention.
  • 3A and 3B show an embodiment of a solder bump according to the present invention.
  • Figure 4 shows an embodiment in which the configuration of the bio-signal measuring apparatus according to the present invention is arranged in the lateral direction.
  • 5 to 7 show various embodiments of the microelectrode array pattern according to the present invention.
  • the present invention is a bio-signal measuring device in which a signal measuring unit provided with a plurality of microelectrodes is disposed on a substrate, wherein at least one of a signal measuring unit, a measuring signal processing unit and a driving power unit or a wireless communication unit is disposed on the substrate. It is a biosignal measurement and stimulation device equipped with a bioelectrode, which is arranged in the longitudinal or transverse direction and measures or stimulates a biosignal from the microelectrodes formed in an array pattern.
  • the meaning of “comprising” embodies certain properties, regions, integers, steps, actions, elements and / or components, and other specific properties, regions, integers, steps, actions, elements, components and / or It does not exclude the presence or addition of the military.
  • the present invention is a bio-signal measuring device in which the signal measuring unit 200 provided with a plurality of micro-electrodes 210 is disposed on the substrate 100, on the substrate 100, the signal measuring unit 200 At least one of the measurement signal processing unit 300 and the driving power unit 400 or the wireless communication unit 500 is disposed in the longitudinal or transverse direction, and measures or stimulates a biosignal from the microelectrodes formed in an array pattern. It is characterized by.
  • the present invention relates to a basic device and a structure of a device for measuring / analyzing a high-precision and high-resolution device required for characterization of a biostructure and function as a device for measuring a biosignal and giving stimulation when necessary.
  • a 'signal measuring unit' for measuring a biosignal and a 'measurement signal processing unit' for processing the measured massive signal are required.
  • a 'power unit for driving' for driving these elements is included, and a 'wireless communication unit' for transmitting the obtained signals to the outside may be included.
  • a 'signal measurement unit' as the most important structure for measuring a biosignal, and additionally, the entire module is formed with a structure including a 'measurement signal processing unit', a 'power unit for driving', and a 'wireless communication unit'.
  • the substrate according to the present invention may be applied to both a flexible PCB substrate or a rigid PCB substrate.
  • a flexible substrate in order to increase the contactability of the biosensor, it will be desirable to use a flexible substrate.
  • FIG. 1 is a view showing various embodiments of a structural schematic diagram of a bio-signal measuring apparatus according to the present invention, in which a configuration according to the present invention is arranged in a longitudinal direction.
  • the bio-signal measuring apparatus includes a substrate 100, a signal measuring unit 200 and a measuring signal processing unit 300, and a driving power unit 400 and a wireless communication unit 500 can be selectively provided. have.
  • FIGS. 1A to 1C are schematic structural diagrams of a biosignal measuring device according to the present invention. As described above, it is possible to read a biosignal and to provide a 'neural signal measuring unit' for giving stimulation, and to be connected to a 'measurement signal processing unit' for processing it.
  • the 'power unit for driving' is not external, but may be integrally disposed in the module to have a structure for supplying power, and the 'wireless communication unit for sending and receiving the measured signal as shown in FIG. 1B.
  • 'A may be integrally disposed in the module, and also, as shown in FIG. 1C, such a' power unit for driving 'and a' wireless communication unit 'may be configured to be integrated in the module.
  • FIG. 1A is an embodiment in which the driving power unit 400-the measurement signal processing unit 300-the substrate 100-the signal measurement unit 200 is provided in the longitudinal direction from below.
  • 1B is an embodiment in which the wireless communication unit 500-the measurement signal processing unit 300-the substrate 100-the signal measurement unit 200 is provided in the longitudinal direction from below.
  • 1C is an embodiment in which the wireless communication unit 500-the driving power unit 400-the measurement signal processing unit 300-the substrate 100-the signal measurement unit 200 is provided in the longitudinal direction from below.
  • each technical configuration is arranged in the longitudinal direction, it is also possible an embodiment that is arranged in the horizontal direction on the horizontal surface as shown in FIG.
  • FIGS. 2A to 2C show schematic diagrams of overall shapes and vertical cross-sections of a biosignal measuring apparatus according to the present invention.
  • the electrode of the 'neural signal measurement unit' not only serves to measure the biosignal, but also can act as a stimulus that applies a constant current to the nerve.
  • the microelectrode 210 of the signal measuring unit 200 may be provided as a solder bump SB, and the solder bump SB is preferably provided in a round shape or a tapered cone shape toward the top. (See FIGS. 3 and 4).
  • solder bump on the electrode portion on the substrate 100, the solder bump itself is a 3D microelectrode. It can also be implemented as a structure.
  • Typical solder bumps are used for circuit-to-circuit connections, and round ball shapes are common.
  • the size of the spherical shape is about 100 to 200um, and in the case of micro bumps, the size is about 15 to 30um.
  • a micro micro bump in the form of a cone has also emerged.
  • the diameter of the cone bump is at least 2.5um, and this cone bump is also used for connection between circuits as it is soldered.
  • the micro bump itself in the form of a ball (round shape) or cone (tapered shape) is used as a fine 3D electrode. That is, for example, a cone-shaped bump is surface-mounted (SMT) on an electrode of a PCB substrate, and the surface-mounted bump itself is used as a bioelectrode without a separate additional soldering process.
  • SMT surface-mounted
  • the electrode forming process becomes very simple and has an advantage of improving contactability.
  • the bioelectrode is implemented in the form of an array electrode.
  • the microelectrodes formed in the array pattern are set of one microelectrode as a reference electrode and other microelectrodes located at the same distance from the reference electrode, and corresponding electrode groups are set for each corresponding electrode group. It is possible to average the measured values of the biosignal with each of the fine electrodes of the and corresponding electrode groups.
  • the bio-signal means a signal measured in vivo (invasive) or non-invasive (non invasive) of the human body phenomena.
  • bio signals such as electrocardiogram, electroencephalogram, and electromyography, and can be measured in various forms such as capacitance and impedance.
  • 5 to 7 show various embodiments of the microelectrode array pattern according to the present invention.
  • FIG. 5 is a schematic diagram illustrating a new method for measuring an array-type electrode presented in the present invention.
  • the present invention it is possible to dramatically improve precision and reliability by using a large number of array-type electrodes, measuring various bio signals between a large number of surrounding electrodes, and observing the amount of change.
  • an average of measured values can be obtained for each corresponding electrode group.
  • the array pattern structure of the microelectrode according to the present invention can be implemented in various embodiments.
  • the plurality of microelectrodes 210 are patterns arranged in the same number in the longitudinal and transverse directions, and the reference electrode may be any one of a plurality of microelectrodes.
  • the plurality of microelectrodes 210 are arranged in the same number of odd numbers in the longitudinal and transverse directions (see FIGS. 5 and 6), and it is preferable that the reference electrode is set as a centrally located microelectrode. However, it does not mean that a plurality of microelectrodes 210 are arranged in the same number in the longitudinal and transverse directions from the right range.
  • the plurality of microelectrodes 210 are patterns arranged in different numbers in the longitudinal and transverse directions (not shown), and the reference electrode may be any one of the plurality of microelectrodes.
  • the 'longitudinal direction' and 'transverse direction' used in the present specification are not limited to the vertical direction and the horizontal direction, and include concepts arranged in a diagonal direction.
  • the microelectrodes may be freely arranged in a vertical direction, a horizontal direction, a diagonal direction, and a random direction.
  • a feature is that a pattern is formed so that a plurality of other electrodes corresponding to the same distance as the reference electrode are provided.
  • FIG. 5 shows a pattern structure in which 25 microelectrodes are configured in an array form.
  • the center electrode P13 is set as a reference electrode, four microelectrodes (P8, P12, P18, and P14) having the same distance closest to the P13 electrode are described.
  • microelectrodes located at the same distance from the reference electrode are referred to as corresponding electrode groups.
  • Four microelectrodes of the closest equal distance are referred to as the first corresponding electrode group.
  • the first corresponding electrode group exists as four fine electrodes P8, P12, P18, and P14 on lines a1-a2 and a3-a4 in FIG. 5, and four measurement values with the reference electrode exist. .
  • the four microelectrodes P7, P9, P17, and P19 located at the same distance from the reference electrode become the second corresponding electrode group.
  • the four microelectrodes, and four measurement values with the reference electrode exist.
  • microelectrodes P3, P11, P15, and P23 of the same close distance after the second corresponding electrode group become the third corresponding electrode group.
  • microelectrodes P6, P20, P2, P24, P4, P22, P10, and P16 of the same distance close to the third corresponding electrode group become the fourth corresponding electrode group.
  • microelectrodes P6, P20, P2, P24, P4, P22, P10, and P16 of the same distance close to the fourth corresponding electrode group become the fifth corresponding electrode group.
  • FIG. 6 shows an example in which, for example, another electrode position P1 is set as a reference electrode.
  • a total of 24 measurement values can be obtained by setting a corresponding electrode group having the same distance from the closest equivalent electrode group to the farthest distance and measuring between electrodes with a reference electrode.
  • the number of measured values that come out in one measurement is n (n-1) / 2, and in the case of 100 electrodes, 4,950 measured values appear at a time.
  • FIG. 7 shows an embodiment in which the microelectrode array has a concentric circle pattern structure.
  • a plurality of microelectrodes 200 are disposed on a circle center of a plurality of concentric circles and a circumference of each concentric circle
  • a reference electrode is a microelectrode disposed at the center of the circle
  • a corresponding electrode group is a concentric circle It is possible to be fine electrodes disposed on the circumference of the.
  • the present invention can display a distribution of measurement values with numerous measurement values, and enables remarkably precise measurement.
  • the driving power unit 400 is any of a coin type battery, a film type thin film battery, a piezoelectric charging battery, a friction electric charging battery, a solar power wireless power transmission unit, an RF wireless power transmission unit and a bio fuel cell. It is possible to be one.
  • an ultra-compact coin type battery may be used, or a film type thin film battery battery may be used.
  • a supercapacitor type capacitor instead of a normal battery for instantaneous high energy storage.
  • the wireless communication unit 500 can use any one of the Bluetooth communication device, a Wi-Fi communication device and a BCC communication device.
  • It can be composed of RF communication elements such as Bluetooth or Wifi for wireless communication.
  • the wireless communication module When the wireless communication module is implanted into a living body, a problem that RF performance is reduced in the living body may occur. Accordingly, in order to prevent such attenuation, it is also possible to configure a device for BCC (Body Channel Communication) communication using a body, thereby giving or receiving a signal through BCC communication. In addition to this, wireless communication using various types of wireless communication elements is also possible.
  • BCC Body Channel Communication

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Abstract

La présente invention concerne un dispositif de mesure de signal biologique dans lequel une unité de mesure de signal (200) comportant une bioélectrode constituée d'une pluralité de micro-électrodes (210) est disposée sur un substrat (100), le dispositif étant caractérisé en ce qu'au moins l'une parmi l'unité de mesure de signal (200), une unité de traitement de signal mesuré (300) et une unité de puissance d'entraînement (400) ou une unité de communication sans fil (500) est disposée sur le substrat (100) dans la direction longitudinale ou dans la direction transversale, et un signal biologique est mesuré ou stimulé grâce aux micro-électrodes agencées en forme de réseau.
PCT/KR2019/011261 2018-09-04 2019-09-02 Dispositif de mesure et de stimulation de signal biologique comportant une bioélectrode Ceased WO2020050568A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/272,754 US20210204855A1 (en) 2018-09-04 2019-09-02 Biosignal measuring and stimulating device having bioelectrode

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20180105113 2018-09-04
KR10-2018-0105113 2018-09-04
KR1020190094932A KR20200027417A (ko) 2018-09-04 2019-08-05 생체전극이 구비된 생체신호 측정 및 자극 장치
KR10-2019-0094932 2019-08-05

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101033907B1 (ko) * 2010-02-23 2011-05-11 한국과학기술연구원 미세전극 어레이 제조방법 및 이를 이용한 커넥터 연결방법
JP2016526972A (ja) * 2013-06-21 2016-09-08 ノースイースタン ユニバーシティ 電界脳波を含む脳の電気的活動測定用のセンサおよびプロセッサ
KR20170046593A (ko) * 2015-10-20 2017-05-02 샌 디에고 스테이트 유니버시티 리써치 파운데이션 삽입 가능한 양방향 무선 신경 기록 및 자극의 장치 및 방법
US20180153510A1 (en) * 2016-12-04 2018-06-07 Exo Imaging Inc. Low voltage, low power mems transducer with direct interconnect capability
US20180220912A1 (en) * 2017-02-03 2018-08-09 International Business Machines Corporation Flexible silicon nanowire electrode

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101716351B1 (ko) 2015-06-05 2017-03-14 주식회사 인프라웨어 의료용 진단 패치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101033907B1 (ko) * 2010-02-23 2011-05-11 한국과학기술연구원 미세전극 어레이 제조방법 및 이를 이용한 커넥터 연결방법
JP2016526972A (ja) * 2013-06-21 2016-09-08 ノースイースタン ユニバーシティ 電界脳波を含む脳の電気的活動測定用のセンサおよびプロセッサ
KR20170046593A (ko) * 2015-10-20 2017-05-02 샌 디에고 스테이트 유니버시티 리써치 파운데이션 삽입 가능한 양방향 무선 신경 기록 및 자극의 장치 및 방법
US20180153510A1 (en) * 2016-12-04 2018-06-07 Exo Imaging Inc. Low voltage, low power mems transducer with direct interconnect capability
US20180220912A1 (en) * 2017-02-03 2018-08-09 International Business Machines Corporation Flexible silicon nanowire electrode

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