WO2020070228A1 - Procédé et dispositif de mesure optique non invasive de propriétés d'un tissu vivant - Google Patents

Procédé et dispositif de mesure optique non invasive de propriétés d'un tissu vivant

Info

Publication number
WO2020070228A1
WO2020070228A1 PCT/EP2019/076776 EP2019076776W WO2020070228A1 WO 2020070228 A1 WO2020070228 A1 WO 2020070228A1 EP 2019076776 W EP2019076776 W EP 2019076776W WO 2020070228 A1 WO2020070228 A1 WO 2020070228A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
measuring device
intensity
measurement
contact pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/076776
Other languages
German (de)
English (en)
Inventor
Vera Herrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nirlus Engr AG
Original Assignee
Nirlus Engr AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nirlus Engr AG filed Critical Nirlus Engr AG
Publication of WO2020070228A1 publication Critical patent/WO2020070228A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6843—Monitoring or controlling sensor contact pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6844—Monitoring or controlling distance between sensor and tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/7405—Details of notification to user or communication with user or patient; User input means using sound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays

Definitions

  • the invention relates to a method for non-invasive optical measurement (or in vivo measurement) of properties of living tissue (including flowing blood) inside a (human) body, with a measuring device which has at least one light source and a detector, wherein the measuring device or at least part of the measuring device against the surface, e.g. B. the skin of the body is pressed, wherein the body is illuminated by means of the light source with light having at least one light wavelength and wherein the backscattered light from the body or the light passing through the body is detected with the detector and the detector signal for determining a property of the tissue or for determining several properties of the tissue is evaluated.
  • the body is therefore preferably a human body.
  • Non-invasive measurement means e.g. B.
  • the non-invasive measurement of the concentration of blood components in blood vessels e.g. B. the measurement of hemoglobin concentration, oxygen saturation, blood sugar or the like.
  • the invention also includes measurement in tissue outside a bloodstream, e.g. B. in the course of in vivo tissue classification.
  • Light e.g. B. one or more laser light sources are radiated into the body and by measuring and evaluating the backscattered scattered light, the parameters sought are determined in various ways.
  • electromagnetic radiation e.g. laser light radiation
  • electromagnetic radiation from the visible range and / or the infrared range is usually used, e.g. B. between about 550 nm and 2,000 nm
  • a method for the optical measurement of properties of flowing blood by means of ultrasound localization is e.g. B. known from EP 1 601 285 B1.
  • the ultrasound radiation is focused on the interior of a central blood vessel and a light source and an adjacent detection unit for detecting the backscattered light on the skin surface are positioned above the blood vessel in such a way that the distance between the light source and the majority of the light receptors of the detection unit with the Depth of the examining blood tissue corresponds.
  • the target tissue is illuminated with at least two discrete light wavelengths and the backscattered light is measured.
  • the interaction with blood and tissue causes changes in the optical properties, in particular the reflectivity and scattering power, of the ultrasonic wave field. This leads to a modulation of the backscattered light with the frequency of the ultrasound radiation, so that the modulated portion can be extracted in the course of the evaluation.
  • DE 10 2006 036 920 B3 describes a method for the spectrometric determination of the blood glucose concentration in the pulsating flowing blood. Implementation of this method for the non-invasive in vivo determination of the glucose concentration additionally requires a non-invasive determination of the temperature of the blood.
  • Such a method for non-invasive, optical determination of the temperature of a medium within a body is, for. B. is known from DE 10 2008 006 245 A1. Even with this optical
  • Temperature measurement can be the location of the measurement inside a body, e.g. B. a bloodstream, are marked by means of pulsed ultrasound radiation.
  • the body is irradiated with ultrasound radiation to mark a blood vessel with ultrasound radiation, the body being illuminated by the blood vessel with light having at least one light wavelength and the backscattered light being detected by a detector, the part of the light reflected from the body outside the blood vessel also being included a frequency is modulated which corresponds to the ultrasound frequency.
  • the backscattered portion of light inside the blood vessel is modulated due to the Doppler effect in the flowing blood with a frequency shifted by the Doppler shift relative to the frequency of the ultrasound radiation.
  • the signal component modulated with the shifted frequency can be extracted from the detector signal measured at the detector.
  • This method ensures that only those light components of the backscattered light that actually are backscattered from the blood flow into the evaluation, since only these are modulated with a different modulation frequency than the light components backscattered from the adjacent tissue due to the Doppler effect. This makes it possible to mark the bloodstream precisely, regardless of whether or not focused ultrasound radiation is used.
  • the ultrasound radiation is not used to find the blood vessel, but the use of the Doppler effect also flows directly into the evaluation of the optical measurement.
  • US 2012/0190944 A1 discloses a device and a method for the non-invasive optical measurement of physiological properties, the tissue to be examined being illuminated with light and the transmitted or reflected light being measured as a signal. In addition, the pressure is measured, which is applied to the measuring device by the user.
  • US Pat. No. 7,672,701 B2 discloses the non-invasive in vivo measurement for determining the blood sugar concentration by means of Raman spectroscopy. The pressure of a finger on the actuating surface of the device can be measured with the aid of a pressure sensor.
  • the object of the invention is to create a method which enables and prefers a reliable, non-invasive optical measurement of the properties of living tissue inside a body characterized by improved ease of use and / or increased insensitivity to incorrect operation.
  • the invention teaches in a generic method of the type described in the introduction that before, during and / or after the measurement of the optical properties, the contact pressure of the measuring device against the body is checked, preferably also with optical means, so that at increased functionality of the equipment effort is not increased or not significantly.
  • the invention is based first of all on the known finding that the known optical methods are fundamentally outstandingly suitable for the non-invasive optical measurement of properties of living tissue in the interior of a body, both on the basis of transmission measurements and on the basis of reflection measurements. It is always expedient to place a measuring device, which has at least one light source and a detector, directly on the body, e.g. B. to put on the skin, on the one hand to radiate the light properly into the body and on the other hand to detect the light components passing through the body and / or the light components scattered back from the body with a detector.
  • the invention has recognized that a varying contact pressure, which is exerted on the body to be examined and consequently on the tissue to be examined with the measuring device, can influence the measurement results. Should z.
  • the properties of flowing blood e.g. If, for example, the oxygen saturation or the blood sugar content are examined using optical methods, a varying contact pressure of the device can influence the conditions in the bloodstream and / or in the adjacent tissue and thus falsify the measurement.
  • the positions or orientations of the scattering particles within the bloodstream usually change in a pulsating manner and thus lead to pulsatingly varying absorption properties of the blood, specifically because of the pulsatingly changing ones
  • Density and the pulsating changing orientation are such.
  • B. influenced by a changed contact pressure of the measuring device and thus disturbed. It can e.g. B. can lead to a “pulse disappearance” due to the contact pressure.
  • an increased density of the scattering centers in the tissue can change the measurement due to the increased contact pressure.
  • a "traffic jam" of a certain "optical situation” can also occur, so that during the course of the measurement the determined values no longer correspond to the current values.
  • the invention has recognized that a check of the contact pressure is expedient, in particular to avoid an impermissibly high influence on the measurement by an excessively high or too low contact pressure.
  • a permissible pressing pressure interval with a lower limit value and an upper limit value can be defined in a control unit of the measuring device and z. B. be stored in the control unit. If the measurement shows that the pressing pressure is outside the permissible range, z. B. a (subsequent) measurement of the optical properties of the tissue or blood can be prevented. As an alternative or in addition, a warning signal can sound. This will be discussed in the following. In a particularly preferred embodiment, the determination or control of the pressing pressure itself is likewise carried out using optical means.
  • Intensity lies within or outside the permissible intensity interval.
  • the optical measurement for determining the tissue properties can be prevented if the intensity measured in the course of the pressure control lies outside the intensity interval, i. H. the "actual" measurement is only permitted if the intensity measured during pressure control lies within the intensity interval.
  • an optical and / or acoustic warning signal can also be generated.
  • the invention has recognized that the intensity of the transmitted light and / or the intensity of the backscattered light are outstandingly suitable as control parameters for the contact pressure or contact pressure in such measurements. Because the contact pressure has a sensitive influence on the spreading capacity of the fabric. With increased contact pressure, the proportion of liquid in the tissue volume decreases significantly and the concentration of the scattering centers increases in this tissue volume and this results in an increased scattering coefficient.
  • light is irradiated, which is preferably in the infrared and / or visible wavelength range.
  • B. has a wavelength of 500 nm to 2,000 nm.
  • Light of a so-called isosbestic wavelength is particularly preferably used for this pressure control, e.g. B. light with a wavelength of about 800 to 810 nm, e.g. B. 805 to 808 nm. At this wavelength, the absorption and backscatter are independent of the state of loading with oxygen, since the
  • the length range is a measure of the scattering center concentration, whereby the relationship is not linear, but negative logarithmic.
  • the intensity of the light in the transmission direction is reduced and the proportion of the reflected light is increased.
  • the measurement of the intensity of the light - either in transmission or in reflection - enables the control of the pressing pressure, in particular when using an isosbestic wavelength, e.g. B. at 805 to 808 nm.
  • an optimal posture of the measuring device or the sensor is determined in the course of a calibration of the measuring system and z. B. deposited an appropriate intensity interval.
  • the optical pressing pressure control described is inventively used in connection with an optical measurement of the properties of living tissue, e.g. B. of blood or the like used. It can be based on the fundamentally known findings on the non-invasive optical measurement of properties of living tissue, for. B. blood.
  • the baling pressure control can e.g. B. used in the determination of blood oxygen saturation. It can also be used to study blood glucose levels.
  • the methods described in EP 1 601 285 B1, EP 2 046 190 B1, EP 3 170 446 A1 and WO 2015/177156 A1 can be used.
  • the optical measurements for determining the respective properties of the blood or tissue can be carried out with the wavelengths described in these publications.
  • Light sources with different wavelengths or at least one light source are used that generates several different light wavelengths. If necessary, one and the same detector can be used, provided that it has sufficient sensitivity for the different light wavelengths.
  • the optical measurement on the one hand and the baling pressure control on the other hand can be realized with one and the same light wavelength and consequently also with one and the same light source and the same detector.
  • z. B the possibility of measuring the glucose concentration in flowing blood also (among other things) a light wavelength in the range between 790 nm and 850 nm, e.g. B. to use about 805 nm to 808 nm, in which the two absorption curves of oxihemoglobin and deoxyhemoglobin intersect, so that at this wavelength the absorption and thus the proportion of the backscattered light is independent of the state of loading with oxygen.
  • EP 3 170 446 A1 can be used, according to which such a wavelength can be used as an indicator of the glucose concentration. It is interesting that a pressure control can be carried out with the same wavelength, since the intensity limits already mentioned lie far outside the values that occur in connection with the optical (physiological) measurement.
  • the invention also relates to a measuring device for the non-invasive optical measurement of properties of living tissue inside a body by a method of the type described.
  • the measuring device has at least one light source, a detector and a control unit, the measuring device or at least part of the measuring device is pressed against the surface of the body.
  • the control unit is for implementation
  • the control unit is now set up or programmed in such a way that the measuring device only permits an optical measurement of the properties of the tissue if the determined contact pressure or the corresponding optical intensities, which represent the contact pressure, lie within the stored range.
  • the measuring device can have a visual display and / or an acoustic display with which, for. B. a warning signal can be generated if the determined pressing pressure or the measured variable representing the pressing pressure is outside the predefined, permissible interval.
  • the measuring device can, moreover, not only one light source, but also several light sources, e.g. B. have multiple laser diodes.
  • Coherent laser light is preferably used. However, it is also within the scope of the invention to use non-coherent light, in particular for the light source used for the pressure control. It can e.g. B. continuous laser radiation with a continuous power in the order of 0.1 to 10 mW, preferably 0.5 to 2 mW, z. B. about 1 mW can be used.
  • the detector is adapted to the corresponding wavelength range. A detector is preferably used which is suitable both for the wavelength for the optical measurement and for the wavelength for the baling pressure control, so that a single sensor may be used. It can be z. B. is a Si PIN diode. Such a diode is used in particular when the light sources light in
  • FIG. 1 schematically simplified a device according to the invention and FIG. 2 a simplified flow diagram for the operation of the device according to FIG. 1.
  • the measuring device according to the invention is used for the non-invasive optical measurement of properties of living tissue inside a body, e.g. B. the determination of oxygen saturation or for determining the glucose concentration of the blood or for determining properties of the tissue (z. B. for tissue classification).
  • the measuring device 2 shown in a highly simplified manner in FIG. 1 has at least one light source 3 and at least one detector 4 or 4 '. This measuring device 2 or at least part of the measuring device can be pressed against the surface of the indicated body 1. 1 shows the possibility of a reflection measurement on the one hand, i. H. the detector 4 is indicated in the reflection direction on the same side of the body 1 as the light source 3. In a simplified broken line, an arrangement of the detector 4 'for a transmission measurement is optionally shown.
  • This control of the contact pressure takes place optically with the aid of the light source 3 shown in FIG. 1 and the detector 4 and a control unit, not shown. It is e.g. B. with the light source 3 light (z. B. laser light) with a wavelength of about 805 nm into the body and measured with the help of the detector 4 the backscattered light.
  • the intensity l r of the backscattered light depends on the contact pressure, ie the measured intensity represents the contact pressure. This is due to the fact that the contact pressure influences the scattering capacity of the fabric 1.
  • a lower limit value I min and an upper limit value I ma x are stored in the control unit of the measuring device, so that the control unit can determine whether the measured intensity lt or l r is within or outside the permissible intensity interval. This procedure is illustrated in FIG. 2.
  • the light source 3 is switched on (a) and with the aid of the detector 4 the backscattered light component l r (or alternatively the transmitted light component l t) is measured with the detector 4 '(b).
  • the control unit checks whether the determined intensity value lt or I r lies within the stored intensity interval [I min , Lax] (c). If this is the case, the optical measurement (d) of the desired properties of the fabric, e.g. B. the measurement of oxygen saturation or the measurement of blood glucose concentration. If the intensity value representing the pressing pressure lies outside the defined intensity interval, a warning signal (e) is issued and this optical measurement is not permitted (f). It is then possible for the user to position the measuring device on the body in a different position and to repeat the measurement.
  • the algorithm shown in Fig. 2 can e.g. B. be stored in the control unit.
  • Fig. 1 shows only the components that are required for the pressure control.
  • the components required in this way and the components additionally required for the optical examination of the tissue are preferably integrated in a uniform housing, so that the pressure control is part of the measuring device is used in a generally known manner for determining the properties of the tissue / blood.
  • such a device can contain one or more light sources for generating different light wavelengths in order to enable the respective measurements.
  • the components shown in FIG. 1, in particular the light source 3 and the detector 4 can, if appropriate, also be used both for the pressure control and for the optically physiological measurement.
  • the invention can also be combined with measurement methods based on the marking of the tissue with ultrasound radiation.
  • the necessary components for such an ultrasonic localization can consequently also be integrated into the measuring device 2.
  • the state of the art for. B. EP 1 601 285 B1, EP 3 170 446 A1 or WO 2015/177156 A1.
  • the components required in practice for a device which is only shown schematically in simplified form in FIG. 1 (e.g. power supply and lines, control lines etc.) are not shown in FIG. 1.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé de mesure optique non invasive de propriétés d'un tissu vivant à l'intérieur d'un corps (1), comprenant un dispositif de mesure (2) qui présente au moins une source de lumière (3) et un détecteur (4), le dispositif de mesure ou au moins une partie de ce dernier étant pressé(e) contre la surface, par exemple la peau, du corps (1), le corps (1) étant éclairé au moyen de la source de lumière (3) avec une lumière présentant au moins une longueur d'onde lumineuse, la lumière rétrodiffusée par le corps (1) ou traversant le corps (1) étant détectée au moyen du détecteur (4) et le signal de détection étant évalué pour déterminer une propriété du tissu. Le procédé est caractérisé en ce que la pression d'appui du dispositif de mesure (2) contre le corps (1) est contrôlée avant, pendant et/ou après la mesure de la propriété optique.
PCT/EP2019/076776 2018-10-04 2019-10-02 Procédé et dispositif de mesure optique non invasive de propriétés d'un tissu vivant Ceased WO2020070228A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018124531.9 2018-10-04
DE102018124531.9A DE102018124531A1 (de) 2018-10-04 2018-10-04 Verfahren und Vorrichtung zur nichtinvasiven optischen Messung von Eigenschaften von lebendem Gewebe

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Publication Number Publication Date
WO2020070228A1 true WO2020070228A1 (fr) 2020-04-09

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WO (1) WO2020070228A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020134911A1 (de) 2020-12-23 2022-06-23 Nirlus Engineering Ag Verfahren und Vorrichtung zur nicht-invasiven optischen In-vivo-Bestimmung der Glukosekonzentration

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EP1601285A1 (fr) 2003-03-13 2005-12-07 Universität zu Lübeck Optode destinee au sang
DE102006036920B3 (de) 2006-08-04 2007-11-29 Nirlus Engineering Ag Verfahren zur Messung der Glukosekonzentration in pulsierendem Blut
DE102008006245A1 (de) 2008-01-25 2009-07-30 Nirlus Engineering Ag Verfahren zur nichtinvasiven, optischen Bestimmung der Temperatur eines Mediums
US7672701B2 (en) 2005-03-09 2010-03-02 Bury Sp.Z.O.O. Telephone hands-free system for a mobile telephone
US20120190944A1 (en) 2011-01-20 2012-07-26 Nitto Denko Corporation Devices and methods for non-invasive optical physiological measurements
GB2519075A (en) * 2013-10-08 2015-04-15 Telefield Ltd Apparatus and method for measuring pulse rate
WO2015177156A1 (fr) 2014-05-22 2015-11-26 Nirlus Engineering Ag Procédé de mesure optique non invasive de propriétés de sang en circulation
US20170055840A1 (en) * 2015-09-02 2017-03-02 Olympus Corporation Measurement probe and optical measurement system
EP3170446A1 (fr) 2015-11-20 2017-05-24 NIRLUS Engineering AG Procédé et dispositif de détermination optique in vivo non invasive de la concentration de glucose dans le sang en circulation
WO2018017251A1 (fr) * 2016-07-22 2018-01-25 Northwestern University Procédé et système pour détecter un contact entre une sonde optique et un tissu et pour automatiser la mesure du tissu
US20180125381A1 (en) * 2015-05-21 2018-05-10 Rohm Co., Ltd. Living Body Information Sensor

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Publication number Priority date Publication date Assignee Title
US7672702B2 (en) * 2007-03-13 2010-03-02 Samsung Electronics Co., Ltd. Noninvasive in vivo measuring system and noninvasive in vivo measuring method by correcting influence of Hemoglobin

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1601285A1 (fr) 2003-03-13 2005-12-07 Universität zu Lübeck Optode destinee au sang
US7672701B2 (en) 2005-03-09 2010-03-02 Bury Sp.Z.O.O. Telephone hands-free system for a mobile telephone
DE102006036920B3 (de) 2006-08-04 2007-11-29 Nirlus Engineering Ag Verfahren zur Messung der Glukosekonzentration in pulsierendem Blut
EP2046190A1 (fr) 2006-08-04 2009-04-15 Nirlus Engineering AG Procede de mesure de la concentration en glucose dans le sang pulsatile
DE102008006245A1 (de) 2008-01-25 2009-07-30 Nirlus Engineering Ag Verfahren zur nichtinvasiven, optischen Bestimmung der Temperatur eines Mediums
US20120190944A1 (en) 2011-01-20 2012-07-26 Nitto Denko Corporation Devices and methods for non-invasive optical physiological measurements
GB2519075A (en) * 2013-10-08 2015-04-15 Telefield Ltd Apparatus and method for measuring pulse rate
WO2015177156A1 (fr) 2014-05-22 2015-11-26 Nirlus Engineering Ag Procédé de mesure optique non invasive de propriétés de sang en circulation
US20180125381A1 (en) * 2015-05-21 2018-05-10 Rohm Co., Ltd. Living Body Information Sensor
US20170055840A1 (en) * 2015-09-02 2017-03-02 Olympus Corporation Measurement probe and optical measurement system
EP3170446A1 (fr) 2015-11-20 2017-05-24 NIRLUS Engineering AG Procédé et dispositif de détermination optique in vivo non invasive de la concentration de glucose dans le sang en circulation
WO2018017251A1 (fr) * 2016-07-22 2018-01-25 Northwestern University Procédé et système pour détecter un contact entre une sonde optique et un tissu et pour automatiser la mesure du tissu

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