WO2020078022A1 - Analyseur d'immunité en chimioluminescence entièrement automatique - Google Patents

Analyseur d'immunité en chimioluminescence entièrement automatique Download PDF

Info

Publication number
WO2020078022A1
WO2020078022A1 PCT/CN2019/091427 CN2019091427W WO2020078022A1 WO 2020078022 A1 WO2020078022 A1 WO 2020078022A1 CN 2019091427 W CN2019091427 W CN 2019091427W WO 2020078022 A1 WO2020078022 A1 WO 2020078022A1
Authority
WO
WIPO (PCT)
Prior art keywords
reaction
drive
assembly
reaction cup
arm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2019/091427
Other languages
English (en)
Chinese (zh)
Inventor
彭建康
李祥
李佳凤
饶友亮
常平海
宰云峰
许德晨
景宏维
孙家振
张国秀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Getein Biotech Inc
Original Assignee
Getein Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Getein Biotech Inc filed Critical Getein Biotech Inc
Publication of WO2020078022A1 publication Critical patent/WO2020078022A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels

Definitions

  • the present application relates to the field of automatic chemical reflective immunoassay detection systems or instruments, in particular, to a fully automatic chemiluminescence immunoassay analyzer.
  • the structure of the automatic chemiluminescence immunoassay analyzer common in the prior art is not optimized enough, resulting in a low detection speed, which affects the accuracy of the detection and cannot meet the current high-throughput and high-speed detection requirements.
  • the purpose of this application is to provide a fully automatic chemiluminescence immunoassay analyzer with fast detection speed.
  • An automatic chemiluminescence immunoanalyzer includes: a sample delivery device, a reaction cup delivery device, a reagent delivery device, a reaction device, and an optical detection device; the reaction device is used to place the reaction cup delivered by the reaction cup delivery device and receive the sample The sample transported by the transport device and the reagent transported by the reagent transport device into the reaction cup; the reaction device includes a reaction tray, an incubation assembly, and a shaker mechanism; the reaction tray is provided with at least two circles of reaction cup rails, each of which has the same rail A reaction cup accommodating cavity is provided at the position; the incubation components are arranged along the circumference of the reaction tray; the shaker mechanism is fixedly connected to the reaction cup accommodating cavity at any position. After the reaction cup rotates to the reaction cup accommodating cavity, The shaker mechanism shakes the reaction cup; the optical detection device is used to receive and detect the test solution after the reaction device has reacted.
  • a rotating mechanism is provided at the bottom of the reaction tray, and the rotating mechanism is drive-connected to the reaction tray to drive at least two turns of the reaction cup track to rotate simultaneously.
  • the shaker mechanism includes a shaker drive part, a rotating shaft, and a reaction cup sleeve
  • the shaker drive part is drive-connected to the rotation shaft
  • the reaction cup sleeve is connected to the rotation shaft
  • the reaction cup sleeve is provided with Spiral chute
  • the rotating shaft can rotate in the spiral chute, driving the reaction cup sleeve up and down; when the reaction cup rotates to the position of the shaker mechanism, the reaction cup is connected to the reaction cup sleeve, and the shaker mechanism shakes the reaction cup uniform.
  • the reagent delivery device includes a reagent cartridge storage structure and a reagent needle delivery arm, and the reagent needle delivery arm is disposed between the reagent cartridge storage structure and the reaction tray;
  • the reagent cartridge storage structure includes a first storage portion and The second storage portion;
  • the first storage portion includes a first ring bracket and a first drive portion;
  • the first drive portion is connected to the first ring bracket, the first drive portion is configured to drive the first ring bracket to rotate;
  • a plurality of first accommodating portions for accommodating the first reagent cartridge are provided on the first annular bracket;
  • a plurality of first accommodating portions are provided along the circumferential direction of the first annular bracket;
  • the second storage portion includes a second The ring bracket and the second drive part;
  • the second drive part is connected to the second ring bracket, the second drive part is configured to drive the second ring bracket to rotate;
  • the second ring bracket is provided with a plurality of The second accommodating part for accommodating the second reagent box; the plurality
  • each first accommodating portion includes a first baffle plate and a second baffle plate disposed oppositely; a first limiting portion is provided on the first baffle plate; and a second baffle plate A second limiting portion is provided; the first limiting portion and the second limiting portion are arranged oppositely; each second accommodating portion includes a third baffle and a fourth baffle arranged oppositely; the third baffle is provided There is a third limit portion; a fourth limit portion is provided on the fourth baffle; the third limit portion and the fourth limit portion are oppositely arranged.
  • the shapes of the first limiting portion and the second limiting portion are both generally cylindrical; the shapes of the third limiting portion and the fourth limiting portion are both generally rectangular parallelepiped shapes.
  • the sample transport device includes a sample tray and a sample transport joint arm; the sample transport joint arm is disposed between the sample tray and the reaction tray; the sample transport joint arm includes a frame, a rotating shaft assembly, and a first rotation The arm, the second rotating arm and the driving mechanism; the rotating shaft assembly is connected to the frame; one end of the first rotating arm is fixedly connected to the rotating shaft assembly; the second rotating arm is rotationally connected to the other end of the first rotating arm; the second rotating arm is free The end is used to connect the sampling needle assembly; the drive mechanism includes a first drive mechanism, a second drive mechanism, and a third drive mechanism, the drive mechanism is connected to the frame; the first drive mechanism is connected to the rotating shaft assembly, and the first drive mechanism is configured For driving the rotating shaft assembly to move up and down relative to the frame; the second driving mechanism is connected to the rotating shaft assembly, and the second driving mechanism is configured to drive the rotating shaft assembly to drive the first rotating arm to rotate; the third driving mechanism is connected to the second For the rotating arm, the
  • the cuvette transport device includes a cuvette storage compartment and a cuvette gripping arm;
  • the cuvette gripping arm includes a guide rail and a gripper body;
  • the guide rail is disposed above the cuvette storage compartment and extends to the reaction On the plate, the grip body is slidingly connected to the guide rail.
  • the reaction device further includes a cleaning arm disposed near the reaction tray;
  • the cleaning arm includes a bracket assembly, a transmission assembly, a needle assembly, and a drive assembly;
  • the transmission assembly includes at least one linear guide; at least one The linear guide is connected to the bracket assembly;
  • the needle assembly includes a liquid injection needle and a suction needle;
  • the needle assembly is fixedly connected to the transmission assembly;
  • the drive assembly is connected to the transmission assembly;
  • the drive assembly is configured to drive the transmission assembly to drive the liquid injection and suction The liquid needle moves along at least one linear guide.
  • the drive assembly includes a motor and a synchronous pulley assembly; the motor transmission is connected to the synchronous pulley assembly; the synchronous pulley assembly is disposed along at least one linear guide; the transmission assembly further includes a slider and a transmission Shaft; the drive shaft is connected to the slider; the needle assembly is fixedly connected to the drive shaft; the drive shaft extends above the bracket assembly, the needle assembly is located above the bracket assembly; the slider is slidingly connected to at least one linear guide, and the synchronous pulley assembly is connected to Slider.
  • An automatic chemiluminescence immunoassay analyzer provided by the present application includes: a sample delivery device, a reaction cup delivery device, a reagent delivery device, a reaction device, and an optical detection device.
  • the reaction device is used for placing the reaction cup conveyed by the reaction cup conveying device, and receiving the sample conveyed by the sample conveying device and the reagent conveyed by the reagent conveying device into the reaction cup.
  • the reaction device includes a reaction disk, an incubation assembly, and a shaker mechanism.
  • the reaction tray is provided with at least two circles of reaction cup rails, and each reaction cup rail is provided with a reaction cup accommodating cavity at the same position; the incubation components are arranged along the circumferential direction of the reaction tray; At the cup accommodating cavity, after the reaction cup rotates to the cuvette accommodating cavity, the shaker mechanism shakes the reaction cup.
  • the optical detection device is used to receive and detect the test solution after the reaction device has completed the reaction.
  • the reaction plate of the analyzer is provided with at least two circles of reaction cup tracks, which increases the number of the reaction cups accommodated, and satisfies the detection requirements of large flux and high speed measurement in the prior art.
  • the analyzer sample conveying device, reaction cup conveying device, reagent conveying device, reaction device and optical detection device cooperate with each other to optimize the structure of the entire analyzer and increase the detection speed.
  • FIG. 1 is a schematic structural diagram of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application
  • FIG. 2 is a schematic structural view of a reaction device of a fully automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application from a first perspective;
  • FIG. 3 is a schematic structural view of a reaction device of a fully automatic chemiluminescence immunoassay analyzer according to an embodiment of the present application from a second perspective;
  • FIG. 4 is a schematic structural view from a third perspective of the reaction device of the automatic chemiluminescence immunoassay analyzer provided by the embodiment of the present application;
  • FIG. 5 is a schematic structural diagram of a first storage unit of a fully automated chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • FIG. 6 is a cross-sectional view of a first storage part of a fully automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • FIG. 7 is a schematic diagram of a first accommodating part of a first storage part of a fully automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • FIG. 8 is a schematic structural diagram of a second storage unit of a fully automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • FIG. 9 is a schematic structural diagram of a second kit with a magnetic bead container bracket provided by an embodiment of the present application.
  • FIG. 10 is a schematic structural diagram of a first kit with a magnetic bead container bracket provided by an embodiment of the present application;
  • FIG. 11 is a schematic structural diagram of a second kit provided by an embodiment of the present application.
  • FIG. 12 is a schematic structural diagram of a first kit provided by an embodiment of the present application.
  • FIG. 13 is a schematic structural diagram of a sample delivery articulated arm of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • FIG. 14 is a schematic structural diagram of a cleaning arm of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • 15 is a schematic structural view of a needle assembly of a cleaning arm of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application;
  • 16 is a schematic structural diagram of a driving assembly of a cleaning arm of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application.
  • FIG. 17 is a schematic structural diagram of a transmission assembly of a cleaning arm of an automatic chemiluminescence immunoassay analyzer provided by an embodiment of the present application.
  • Pictograms 10-Automatic Chemiluminescence Immunoanalyzer; 100-Sample Delivery Device; 110-Sample Tray; 120-Sample Delivery Joint Arm; 121-Frame; 122-Rotary Shaft Assembly; 123-First Rotating Arm; 124-No.
  • orientations or positional relationships indicated by the terms “upper” and “inner” are based on the orientations or positional relationships shown in the drawings, or are habitually swayed when the product of the application is used
  • the orientation or position relationship is only for the convenience of describing the application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limit.
  • this embodiment provides a fully automatic chemiluminescence immunoassay analyzer 10, which includes a sample delivery device 100, a cuvette delivery device 200, a reagent delivery device 300, a reaction device 400, and an optical detection device 500.
  • the reaction cup conveying device 200 conveys the reaction cup to the reaction device 400.
  • the reaction cup is placed on the reaction device 400.
  • the sample delivery device 100 delivers the sample to be detected into the reaction cup on the reaction device 400.
  • the reagent delivery device 300 adds the reagent to the reaction cup on the reaction device 400 to react with the sample.
  • the optical detection device 500 transfers and completes the test solution reacted on the reaction device 400 for detection.
  • the sample delivery device 100, the reaction cup delivery device 200, the reagent delivery device 300, the reaction device 400, and the optical detection device 500 of the automatic chemiluminescence immunoassay analyzer 10 cooperate with each other to optimize the structure of the entire analyzer and increase the detection speed .
  • reaction device 400 includes a reaction tray 410, an incubation assembly 420, and a shaking mechanism 430.
  • reaction cup rails 411 are provided on the reaction disk 410, and a reaction cup accommodating cavity 412 is provided at the same position of each reaction cup rail 411.
  • reaction cup rails 411 By providing at least two circles of reaction cup rails 411 on the reaction disk 410, the number of the reaction cups 600 accommodated is increased, which satisfies the detection requirements of large flux and high speed measurement in the prior art.
  • a rotating mechanism 440 is provided at the bottom of the reaction tray 410, and the rotation mechanism 440 is drivingly connected to the reaction tray 410 to drive the reaction cup track 411 to rotate at least two times at the same time.
  • the reaction cup track 411 is driven to rotate at least two times at the same time, thereby improving the stability of the operation of the entire reaction disk 410.
  • the reaction plate 410 effectively overcomes the defects, improves the compactness of the entire reaction plate 410, and makes the operation of the entire reaction plate 410 more efficient. Is stable and reliable.
  • the shape of the reaction disk 410 is circular.
  • the upper surface of the circular reaction disk 410 is provided with two circles of reaction cup rails 411, which are an inner ring rail 4112 and an outer ring rail 4113, respectively.
  • the outer ring rail 4113 is close to the edge of the reaction disk 410, and the inner ring rail 4112 is inside the outer ring rail 4113.
  • the number of reaction cup accommodating chambers 412 on the outer ring rail 4113 and the inner ring rail 4112 is equal.
  • the gap between the two adjacent reaction cup accommodating chambers 412 on the outer ring rail 4113 is slightly larger than the gap between the two adjacent reaction cup accommodating chambers 412 on the inner ring rail 4112, thereby ensuring the outer
  • the number of cuvette accommodating chambers 412 on the ring rail 4113 and the inner ring rail 4112 is equal, and it is ensured that a cuvette accommodating cavity 412 is provided at the same position of each cuvette rail 411. Further, labeling is performed at each position, so that each labeling position has two reaction cup accommodating chambers 412, which effectively increases the number of the reaction cups 600 to meet the requirements of large flux and high speed measurement.
  • the rotating mechanism 440 includes a motor 443 and a gear assembly.
  • the gear assembly includes a driving gear 441 and a driven gear 442.
  • the driving gear 441 is drivingly connected to the motor 443.
  • the driven gear 442 is installed at the bottom of the reaction disk 410 and meshes with the driving gear 441.
  • the rotating mechanism 440 further includes at least three sets of limit components 444, each set of limit components 444 includes a first limit member 4441 and a second limit member 4442, the top of the driven gear 442 and the reaction plate 410 A guide rail is formed between the first stopper 4441 and the second stopper 4442 is connected to the inside of the driven gear 442.
  • first limiter 4441 and the second limiter 4442 each include a bearing 4443 and a bearing support 4444.
  • the bearing support 4444 is connected to the bearing 4443, and the bearing 4443 is rotatably connected to the aforementioned guide rail or The inside of the driven gear 442.
  • the bearing support 4444 is connected to the base plate 401.
  • the substrate 401 and the reaction plate 410 can also be optionally provided with support columns 402 to further provide support stability.
  • the reaction plate 410 is provided with three sets of limit components 444, and each set of limit components 444 includes a first limit component 4441 and a second limit component 4442. Due to the stability of the triangular structure, the rotation of the reaction disk 410 can be further ensured to be reliable and stable.
  • the incubation assembly 420 is arranged along the circumferential direction of the reaction tray 410.
  • the incubation assembly 420 includes a heating member 421, a heat insulating member 422, and a heat insulating layer 423.
  • the heat-retaining member 422 covers the outside of the heating member 421.
  • the heat insulating layer 423 is provided between the heating member 421 and the heat insulating member 422. Therefore, it is possible to effectively prevent the heat from dissipating too fast and the temperature from changing too much, and further ensure the reliability of the operation of the entire reaction disk 410.
  • At least one shaker mechanism 430 is fixedly connected to the reaction cup accommodating cavity 412 at any position. After the reaction cup 600 rotates to the reaction cup accommodating cavity 412, the shaker mechanism 430 shakes the reaction cup 600 .
  • the shaker mechanism 430 includes a shaker drive part 431, a rotating shaft 432 and a reaction cup sleeve 433, the shaker drive part 431 is connected to the rotation shaft 432 by transmission, and the reaction cup sleeve 433 is connected to the rotation shaft 432 and the reaction cup sleeve 433 A spiral chute is provided, and the rotating shaft 432 can rotate in the spiral chute to drive the reaction cup sleeve 433 up and down.
  • the reaction cup rotates to the position of the shaking mechanism 430, the reaction cup is connected to the reaction cup sleeve 433, and the shaking mechanism 430 shakes the reaction cup.
  • the reaction cup cover 433 is lowered by the shaking driving portion 431 and the rotating shaft 432, thereby ensuring the normal rotation of the reaction disk 410.
  • the reaction cup sleeve 433 rises again, cooperates with the reaction cup, and performs the shaking operation.
  • the shake driving unit 431 selects the motor.
  • the cleaning arm 450 is disposed near the reaction tray 410, and is used to cooperate with cleaning during the reaction.
  • the cleaning arm 450 includes a bracket assembly 451, a transmission assembly 452, a needle assembly 453, and a drive assembly 454.
  • the transmission assembly 452 includes at least one linear guide 4521; at least one linear guide 4521 is connected to the bracket assembly 451; the needle assembly 453 includes a liquid injection needle 4531 and a suction needle 4532;
  • the drive assembly 452 is configured to drive the drive assembly 452 to drive the liquid injection needle 4531 and the liquid suction needle 4532 to move along at least one linear guide 4521.
  • the driving assembly 454 includes a motor 4541 and a timing pulley assembly 4542.
  • the motor 4541 is drivingly connected to the synchronous pulley assembly 4542; the synchronous pulley assembly 4542 is disposed along at least one linear guide 4521.
  • the transmission assembly 452 further includes a slider 4523 and a transmission shaft 4522; the transmission shaft 4522 is connected to the slider 4523; the needle assembly 453 is fixedly connected to the transmission shaft 4522; the transmission shaft 4522 extends above the bracket assembly 451, and the needle assembly 453 is located on the bracket assembly 451 Above; the slider 4523 is slidingly connected to at least one linear guide 4521, and the timing pulley assembly 4542 is connected to the slider 4523.
  • the liquid injection needle 4531 and the liquid suction needle 4532 can move simultaneously.
  • the liquid suction and liquid pump are vertically moved by two motion mechanisms, and the structure of the liquid suction and liquid pump movements are independent of each other.
  • the cleaning arm 450 greatly reduces the volume of the entire device and shortens the liquid suction and liquid pump.
  • the execution time of the liquid action greatly improves the detection speed of the entire instrument.
  • the number of cleaning arms 450 is selected and set according to actual needs. In this embodiment, optionally, two cleaning arms 450 are selected.
  • the reagent delivery device 300 includes a reagent cartridge storage structure and a reagent needle delivery arm 330, and the reagent needle delivery arm 330 is disposed between the reagent cartridge storage structure and the reaction tray 410. It is convenient to transfer the reagent to the reaction tray 410.
  • the reagent cartridge storage structure includes a first storage section 310, a second storage section 320, and a shaker section 340.
  • first storage unit 310 and the second storage unit 320 By providing the first storage unit 310 and the second storage unit 320, reagent cartridges of different specifications can be accommodated. Compared with the prior art, only a single kit can be accommodated, and the storage structure of the kit has a large number of reagents and many types of reagents.
  • the reagent needle sucking assembly can suck the reagent from the first storage part 310 and the second storage part 320 at the same time, thereby effectively shortening the reagent suction time, which is beneficial to increase the detection speed.
  • the first storage part 310 includes a first ring carrier 311 and a first drive part 312; the first drive part 312 is connected to the first ring carrier 311, and the first drive part 312 is configured to drive the first ring carrier 311 Rotation; a plurality of first accommodating portions 314 for accommodating the first reagent cartridge 313 are provided on the first annular bracket 311; a plurality of first accommodating portions 314 are provided along the circumferential direction of the first annular bracket 311.
  • Each first accommodating portion 314 includes a first baffle 315 and a second baffle 316 disposed oppositely; the first baffle 315 is provided with a first limiting portion 3151; the second baffle 316 is provided with a second The limiting portion 3161; the first limiting portion 3151 and the second limiting portion 3161 are oppositely arranged.
  • the shapes of the first limiting portion 3151 and the second limiting portion 3161 are both substantially cylindrical. Therefore, it can be matched with the corresponding reagent kit, and then it is firmly defined in the first accommodating portion 314.
  • first accommodating portions 314 share a first baffle 315 or a second baffle 316.
  • the first limiting portion 3151 and the second limiting portion 3161 are used to partition the first accommodating portion 314 into a first part and a second part, so as to adapt to the shape of the first reagent box 313.
  • the specific structure of the first kit 313 in this embodiment is a two-component reagent integrated kit.
  • the connecting portion of the first reagent box 313 is arc-shaped, and can adapt to the shapes of the first limiting portion 3151 and the second limiting portion 3161, so as to be well accommodated in the first accommodating portion 314.
  • the first part is close to the inside of the first ring bracket 311, and the second part is close to the edge of the first ring bracket 311; the first part has a first end wall body and an opposite second end wall body.
  • the first end wall body is close to the inside of the first ring bracket 311.
  • the height of the first end wall body is lower than the height of the second end wall body. Therefore, the first type reagent kit 317 with a magnetic bead container holder can be accommodated.
  • the first driving part 312 includes a first driving wheel 3121, a first rotating shaft 3122, and a turntable 3123.
  • the first driving wheel 3121 is connected to the first rotating shaft 3122.
  • the first rotating shaft 3122 is connected to the turntable 3123.
  • the first ring brackets 311 are all mounted on the outer edge of the turntable 3123 along the circumferential direction of the turntable 3123.
  • the shaker portion 340 includes a shaker gear 341 and a gear drive portion 342; the gear drive portion 342 is connected to the shaker gear 341; the shaker gear 341 is located inside the first ring bracket 311, and the shaker gear 341 is configured to To engage with the magnetic bead container placed in the first accommodating portion 314. The magnetic bead container is driven to rotate to realize the mixing of the magnetic beads.
  • the second storage portion 320 includes a second ring-shaped bracket 321 and a second drive portion 322; the second drive portion 322 is connected to the second ring-shaped bracket 321, and the second drive portion 322 is configured to drive the second ring-shaped
  • the bracket 321 rotates; the second annular bracket 321 is provided with a plurality of second accommodating portions 324 for accommodating the second reagent cartridge 323; the plurality of second accommodating portions 324 are along the circumference of the second annular bracket 321 To set.
  • the specific structure of the second driving part 322 is completely the same as the specific structure of the first driving part 312.
  • the specific structure of the second ring bracket 321 is basically the same as the specific structure of the first ring bracket 311, the difference is that the specific structure of the second accommodating portion 324 provided on the second ring bracket 321 Since they are different, the specifications and models of the second reagent cartridge 323 that can be accommodated in the second accommodating portion 324 are also different.
  • each second accommodating portion 324 includes a third baffle and a fourth baffle disposed oppositely; a third limit portion is provided on the third baffle; a fourth limit is provided on the fourth baffle The third limiting part and the fourth limiting part are relatively arranged.
  • the structure of the second accommodating portion 324 is the same as that of the first accommodating portion 314 except that the shapes of the third limiting portion and the fourth limiting portion are both substantially rectangular parallelepiped shapes.
  • the sample delivery device 100 includes a sample tray 110 and a sample delivery joint arm 120; the sample delivery joint arm 120 is disposed between the sample tray 110 and the reaction tray 410, which facilitates the delivery of the sample to the reaction tray 410 and improves the detection speed.
  • the sample transport joint arm 120 includes a frame 121, a rotating shaft assembly 122, a first rotating arm 123, a second rotating arm 124, and a driving mechanism.
  • the rotating shaft assembly 122 is connected to the frame 121; one end of the first rotating arm 123 is fixedly connected to the rotating shaft assembly 122; the second rotating arm 124 is rotationally connected to the other end of the first rotating arm 123; the free end of the second rotating arm 124 is used to Connect the sampling needle assembly 126.
  • the driving mechanism includes a first driving mechanism 1251, a second driving mechanism 1252, and a third driving mechanism 1253.
  • the driving mechanisms are all connected to the frame 121; the first driving mechanism 1251 is drive-connected to the rotating shaft assembly 122, and the first driving mechanism 1251 is configured as Used to drive the rotating shaft assembly 122 to move up and down relative to the frame 121; the second driving mechanism 1252 is drivingly connected to the rotating shaft assembly 122, and the second driving mechanism 1252 is configured to drive the rotating shaft assembly 122 to drive the first rotating arm 123 to rotate; the third drive The mechanism 1253 is drivingly connected to the second rotating arm 124, and the third driving mechanism 1253 is configured to drive the second rotating arm 124 to rotate relative to the first rotating arm 123.
  • the sample delivery joint arm 120 does not only sample on a certain fixed radius circle, the sampling range is greatly increased, and the sampling area is more flexible.
  • the moments of inertia of the first turning arm 123 and the second turning arm 124 are reduced, which can be effectively avoided.
  • the first rotating arm 123 and the second rotating arm 124 are prone to out of step when rotating at high speed. Conducive to improving the detection speed of the entire instrument.
  • the above-mentioned sample tray 110 may select a carousel structure commonly used in the art to place samples.
  • the cuvette delivery device 200 includes a cuvette storage bin 210 and a cuvette gripping arm 220.
  • the reaction cup gripping arm 220 includes a guide rail 221 and a gripper body 222; the guide rail 221 is disposed above the reaction cup storage compartment 210 and extends to the reaction tray 410, and the gripper body 222 is slidingly connected to the guide rail 221.
  • the gripper body 222 may select a mechanical gripper common in the art.
  • the cuvette storage compartment 210 can select a cuvette storage structure common in the art.
  • the optical detection device 500 includes at least two detection chambers 510 and a test solution delivery joint arm 520.
  • the specific structure of the test solution transporting articulated arm 520 is completely the same as the structure of the sample transporting articulating arm 120, so that the test solution after the reaction can be sucked and transferred to the testing chamber 510, and the testing speed of the entire instrument can be improved.
  • the above two detection chambers 510 select optical detection structures that are common in the art and can be used for chemiluminescence immunoassay.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Robotics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne le domaine des systèmes ou instruments d'immunodétection en chimioluminescence entièrement automatiques, et spécifiquement un analyseur d'immunité en chimioluminescence entièrement automatique. L'analyseur comprend un dispositif de distribution d'échantillon, un dispositif de distribution de coupelle de réaction, un dispositif de distribution de réactif, un dispositif de réaction et un dispositif de détection optique. Le dispositif de réaction est utilisé pour placer des coupelles de réaction et recevoir des échantillons délivrés par le dispositif de distribution d'échantillon et des réactifs délivrés par le dispositif de distribution de réactif dans les coupelles de réaction. Au moins deux cercles de rails à coupelle de réaction sont disposés sur un disque de réaction, une cavité de maintien de coupelle de réaction étant disposée à la même position sur chaque rail à coupelle de réaction. Au moins deux cercles de rails à coupelle de réaction sont disposés sur un disque de réaction de l'analyseur, augmentant ainsi le nombre des coupelles de réaction maintenues et répondant aux exigences de détection d'un flux important et d'une vitesse de détection élevée dans l'état de la technique. Le dispositif de distribution d'échantillon, le dispositif de distribution de coupelle de réaction, le dispositif de distribution de réactif, le dispositif de réaction et le dispositif de détection optique de l'analyseur sont assortis les uns aux autres, et la structure de l'ensemble de l'analyseur est optimisée, ce qui permet d'augmenter la vitesse de détection.
PCT/CN2019/091427 2018-10-16 2019-06-14 Analyseur d'immunité en chimioluminescence entièrement automatique Ceased WO2020078022A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811204271.3A CN109358201B (zh) 2018-10-16 2018-10-16 全自动化学发光免疫分析仪
CN201811204271.3 2018-10-16

Publications (1)

Publication Number Publication Date
WO2020078022A1 true WO2020078022A1 (fr) 2020-04-23

Family

ID=65349264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/091427 Ceased WO2020078022A1 (fr) 2018-10-16 2019-06-14 Analyseur d'immunité en chimioluminescence entièrement automatique

Country Status (2)

Country Link
CN (1) CN109358201B (fr)
WO (1) WO2020078022A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113433311A (zh) * 2021-06-29 2021-09-24 深圳市锦瑞生物科技有限公司 液体样本分析仪
CN115494249A (zh) * 2022-08-24 2022-12-20 安图实验仪器(郑州)有限公司 一种全自动化学发光免疫分析仪
CN116449045A (zh) * 2023-06-05 2023-07-18 安图实验仪器(郑州)有限公司 一种生化仪
US20230288295A1 (en) * 2020-07-22 2023-09-14 Shimadzu Corporation Automatic sample injection system and gas chromatography analysis system
CN116930534A (zh) * 2023-07-17 2023-10-24 科来思生物科技(重庆)有限公司 化学发光免疫分析仪排杯系统
CN118962163A (zh) * 2024-08-01 2024-11-15 鸿一盈创(北京)科技有限公司 一种高通量全自动化学发光免疫检测分析仪及分析方法
CN119246877A (zh) * 2024-12-05 2025-01-03 东软威特曼生物科技（沈阳）有限公司 一种免疫分析仪反应杯供给与卸载装置
CN119438566A (zh) * 2025-01-08 2025-02-14 东软威特曼生物科技（沈阳）有限公司 一种免疫分析仪变位装置
CN119574433A (zh) * 2024-11-08 2025-03-07 广州中景医学检验实验室有限公司 一种反应杯rv阵列
WO2025139746A1 (fr) * 2023-12-30 2025-07-03 杭州聚拓生物科技有限公司 Analyseur d'immunoessai à molécule unique entièrement automatisé

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109358201B (zh) * 2018-10-16 2024-11-19 基蛋生物科技股份有限公司 全自动化学发光免疫分析仪
CN110426527B (zh) * 2019-08-21 2023-05-02 东软威特曼生物科技（沈阳）有限公司 固体直热式反应盘驱动机构及全自动生化分析仪
CN114076757A (zh) * 2020-08-20 2022-02-22 科美诊断技术股份有限公司 用于化学发光检测的分析仪
CN112858709A (zh) * 2021-01-18 2021-05-28 桂林优利特医疗电子有限公司 一种化学发光免疫分析仪抓吸一体机构及使用方法
CN112730867A (zh) * 2021-01-21 2021-04-30 深圳唯公生物科技有限公司 一种流式分析仪的样本制备装置及制备方法
CN113376391A (zh) * 2021-07-09 2021-09-10 广州蓝勃生物科技有限公司 取液装置及全自动免疫分析仪
CN114660317B (zh) * 2022-02-10 2023-11-17 北京胡曼智造科技有限责任公司 一种流式荧光发光免疫分析仪
CN114965886B (zh) * 2022-05-18 2023-11-03 深圳无疆生命科学有限公司 加样盘装置以及样本分析仪
CN117129933A (zh) * 2023-08-28 2023-11-28 山东科立森生物股份有限公司 400速便携式生化分析仪

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2847270Y (zh) * 2005-12-06 2006-12-13 沈阳东软医疗系统有限公司 一种全自动生化分析仪比色杯的清洗装置
CN105388314A (zh) * 2015-12-17 2016-03-09 嘉兴凯实生物科技有限公司 一种全自动加样仪
CN106290942A (zh) * 2016-08-31 2017-01-04 成都恩普生医疗科技有限公司 一种全自动化学发光免疫分析仪
CN206960502U (zh) * 2017-07-13 2018-02-02 南京迪格诺斯生物技术有限公司 一种可精准控制的加样装置
CN108469529A (zh) * 2018-06-05 2018-08-31 深圳天辰医疗科技有限公司 Poct全自动化学发光免疫分析仪
CN207866831U (zh) * 2017-08-16 2018-09-14 北京普利生仪器有限公司 血液分析仪
CN109358201A (zh) * 2018-10-16 2019-02-19 基蛋生物科技股份有限公司 全自动化学发光免疫分析仪

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1041386B1 (fr) * 1999-03-25 2007-10-17 Tosoh Corporation Analyseur
CN101672842B (zh) * 2009-09-01 2013-01-02 郑州博赛生物技术股份有限公司 一种用于全自动免疫分析仪的检测试剂盒
CN102998473B (zh) * 2012-12-19 2014-06-11 北京利德曼生化股份有限公司 全自动化学发光免疫分析仪
CN203275173U (zh) * 2013-04-16 2013-11-06 深圳迈瑞生物医疗电子股份有限公司 反应液混匀装置及化学分析仪
CN103399161B (zh) * 2013-07-17 2014-11-05 深圳市新产业生物医学工程股份有限公司 一种便捷式全自动化学发光免疫分析系统及其分析方法
CN203825022U (zh) * 2013-12-16 2014-09-10 深圳市亚辉龙生物科技有限公司 一种全自动化学发光免疫分析仪
CN105510613A (zh) * 2015-12-21 2016-04-20 利多(香港)有限公司 试剂混匀传送装置和混匀方法
CN106199026B (zh) * 2016-03-09 2019-05-28 深圳雷杜生命科学股份有限公司 全自动化学发光免疫分析仪
CN108593949B (zh) * 2018-02-11 2024-01-26 金博特（北京）生物科技有限公司 一种化学发光免疫分析仪
CN208937504U (zh) * 2018-10-16 2019-06-04 基蛋生物科技股份有限公司 全自动化学发光免疫分析仪

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2847270Y (zh) * 2005-12-06 2006-12-13 沈阳东软医疗系统有限公司 一种全自动生化分析仪比色杯的清洗装置
CN105388314A (zh) * 2015-12-17 2016-03-09 嘉兴凯实生物科技有限公司 一种全自动加样仪
CN106290942A (zh) * 2016-08-31 2017-01-04 成都恩普生医疗科技有限公司 一种全自动化学发光免疫分析仪
CN206960502U (zh) * 2017-07-13 2018-02-02 南京迪格诺斯生物技术有限公司 一种可精准控制的加样装置
CN207866831U (zh) * 2017-08-16 2018-09-14 北京普利生仪器有限公司 血液分析仪
CN108469529A (zh) * 2018-06-05 2018-08-31 深圳天辰医疗科技有限公司 Poct全自动化学发光免疫分析仪
CN109358201A (zh) * 2018-10-16 2019-02-19 基蛋生物科技股份有限公司 全自动化学发光免疫分析仪

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230288295A1 (en) * 2020-07-22 2023-09-14 Shimadzu Corporation Automatic sample injection system and gas chromatography analysis system
US12449437B2 (en) * 2020-07-22 2025-10-21 Shimadzu Corporation Automatic sample injection system and gas chromatography analysis system
CN113433311A (zh) * 2021-06-29 2021-09-24 深圳市锦瑞生物科技有限公司 液体样本分析仪
CN115494249A (zh) * 2022-08-24 2022-12-20 安图实验仪器(郑州)有限公司 一种全自动化学发光免疫分析仪
CN116449045A (zh) * 2023-06-05 2023-07-18 安图实验仪器(郑州)有限公司 一种生化仪
CN116930534A (zh) * 2023-07-17 2023-10-24 科来思生物科技(重庆)有限公司 化学发光免疫分析仪排杯系统
WO2025139746A1 (fr) * 2023-12-30 2025-07-03 杭州聚拓生物科技有限公司 Analyseur d'immunoessai à molécule unique entièrement automatisé
CN118962163A (zh) * 2024-08-01 2024-11-15 鸿一盈创(北京)科技有限公司 一种高通量全自动化学发光免疫检测分析仪及分析方法
CN119574433A (zh) * 2024-11-08 2025-03-07 广州中景医学检验实验室有限公司 一种反应杯rv阵列
CN119246877A (zh) * 2024-12-05 2025-01-03 东软威特曼生物科技（沈阳）有限公司 一种免疫分析仪反应杯供给与卸载装置
CN119438566A (zh) * 2025-01-08 2025-02-14 东软威特曼生物科技（沈阳）有限公司 一种免疫分析仪变位装置

Also Published As

Publication number Publication date
CN109358201A (zh) 2019-02-19
CN109358201B (zh) 2024-11-19

Similar Documents

Publication Publication Date Title
CN109358201B (zh) 全自动化学发光免疫分析仪
CN109917145B (zh) 全自动化学发光免疫分析仪
CN109142766B (zh) 化学发光检测仪
CN101162235B (zh) 分析仪
CN210090481U (zh) 一种化学发光免疫分析仪
CN101162236B (zh) 分析装置、试剂盛放器具及试剂吸移方法
JP4128449B2 (ja) 自動分析装置
CN110794154A (zh) 化学发光免疫分析仪及其检测方法
CN113504380A (zh) 一种全自动化学发光免疫分析仪
US4259289A (en) Apparatus for retrieving liquid samples from test tubes
JP6104843B2 (ja) 検体分析装置
CN104777321A (zh) 化学发光免疫分析装置
WO2020078021A1 (fr) Plaque de réaction et système
CN109975569B (zh) 化学发光检测仪的控制方法、系统及化学发光检测仪
CN215005420U (zh) 化学发光免疫分析仪
CN104111343A (zh) 一种样本试剂分注装置、免疫分析仪及其方法
CN105510613A (zh) 试剂混匀传送装置和混匀方法
CN110346586A (zh) 全自动检测装置
CN105388311B (zh) 全自动化学发光免疫分析仪
JP2008096223A (ja) 分析装置
CN208937504U (zh) 全自动化学发光免疫分析仪
CN111630394A (zh) 受试体测定装置、试剂容器及受试体测定方法
CN110333363A (zh) 一种全自动检测装置
CN222105480U (zh) 孵育装置及化学发光免疫分析仪
JP2017110961A (ja) 容器供給ユニット及び自動分析装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19874141

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19874141

Country of ref document: EP

Kind code of ref document: A1