WO2020128020A3 - Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen - Google Patents

Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen Download PDF

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Publication number
WO2020128020A3
WO2020128020A3 PCT/EP2019/086760 EP2019086760W WO2020128020A3 WO 2020128020 A3 WO2020128020 A3 WO 2020128020A3 EP 2019086760 W EP2019086760 W EP 2019086760W WO 2020128020 A3 WO2020128020 A3 WO 2020128020A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyridines
alkoxy
methyl
amino
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/086760
Other languages
English (en)
French (fr)
Other versions
WO2020128020A2 (de
Inventor
Karsten VAN DEM BRUCH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saltigo GmbH
Original Assignee
Saltigo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saltigo GmbH filed Critical Saltigo GmbH
Priority to CN201980085079.3A priority Critical patent/CN113242853B/zh
Priority to US17/415,783 priority patent/US12168644B2/en
Priority to JP2021535144A priority patent/JP7292394B2/ja
Priority to EP19835407.8A priority patent/EP3898589A2/de
Publication of WO2020128020A2 publication Critical patent/WO2020128020A2/de
Publication of WO2020128020A3 publication Critical patent/WO2020128020A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 2-Alkoxy-4-amino-5-methyl-pyridinen der Formel (I) und/oder von 2-Alkoxy-4-alkylamino-5-methyl-pyridinen der Formel (II) aus den entsprechenden 2-Halogen-amino-pyridinen und den entsprechenden Alkoholen in Gegenwart von Base, sowie die daraus resultierenden Verbindungen.
PCT/EP2019/086760 2018-12-21 2019-12-20 Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen Ceased WO2020128020A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201980085079.3A CN113242853B (zh) 2018-12-21 2019-12-20 用于制备2-烷氧基-4-氨基-5-甲基-吡啶和/或2-烷氧基-4-烷基氨基-5-甲基-吡啶的方法
US17/415,783 US12168644B2 (en) 2018-12-21 2019-12-20 Process for preparing 2-alkoxy-4-amino-5-methyl-pyridines and/or 2-alkoxy-4-alkylamino-5-methyl-pyridines
JP2021535144A JP7292394B2 (ja) 2018-12-21 2019-12-20 ２－アルコキシ－４－アミノ－５－メチル－ピリジン及び／又は２－アルコキシ－４－アルキルアミノ－５－メチル－ピリジンを調製するためのプロセス
EP19835407.8A EP3898589A2 (de) 2018-12-21 2019-12-20 Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18215577.0 2018-12-21
EP18215577 2018-12-21

Publications (2)

Publication Number Publication Date
WO2020128020A2 WO2020128020A2 (de) 2020-06-25
WO2020128020A3 true WO2020128020A3 (de) 2020-10-01

Family

ID=64901418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2019/086760 Ceased WO2020128020A2 (de) 2018-12-21 2019-12-20 Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen

Country Status (5)

Country Link
US (1) US12168644B2 (de)
EP (1) EP3898589A2 (de)
JP (1) JP7292394B2 (de)
CN (1) CN113242853B (de)
WO (1) WO2020128020A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114656400A (zh) * 2022-04-26 2022-06-24 浙江科聚生物医药有限公司 一种非奈利酮关键中间体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130196993A1 (en) * 2010-09-29 2013-08-01 Michael Berger N-heteroaryl compounds
WO2017012647A1 (en) * 2015-07-20 2017-01-26 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US9561228B2 (en) * 2013-02-08 2017-02-07 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2679694A1 (en) * 2007-03-13 2008-09-18 Merck & Co., Inc. Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1
JP5670325B2 (ja) * 2008-06-19 2015-02-18 エックスカバリー ホールディング カンパニー エルエルシー キナーゼ阻害化合物としての置換されたピリダジンカルボキサミド化合物
WO2010016846A1 (en) * 2008-08-08 2010-02-11 Kalypsys, Inc. Heterocyclic modulators of tgr5 for treatment of disease
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
RU2560163C2 (ru) 2010-06-30 2015-08-20 Фуджифилм Корпорэйшн Новое производное никотинамида или его соль
EP2948442B1 (de) 2013-01-25 2016-10-26 Boehringer Ingelheim International GmbH Pyrrolidinderivate, pharmazeutische zusammensetzungen und verwendungen davon

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130196993A1 (en) * 2010-09-29 2013-08-01 Michael Berger N-heteroaryl compounds
US9561228B2 (en) * 2013-02-08 2017-02-07 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
WO2017012647A1 (en) * 2015-07-20 2017-01-26 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE PubChem Compound [online] 27 December 2013 (2013-12-27), XP002790884, Database accession no. 72213525 *
SARAVANAN GOWRISANKAR ET AL: "A General and Efficient Catalyst for Palladium-Catalyzed C-O Coupling Reactions of Aryl Halides with Primary Alcohols", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 33, 25 August 2010 (2010-08-25), pages 11592 - 11598, XP055583648, ISSN: 0002-7863, DOI: 10.1021/ja103248d *

Also Published As

Publication number Publication date
EP3898589A2 (de) 2021-10-27
US12168644B2 (en) 2024-12-17
JP7292394B2 (ja) 2023-06-16
CN113242853A (zh) 2021-08-10
CN113242853B (zh) 2025-06-24
WO2020128020A2 (de) 2020-06-25
US20220055992A1 (en) 2022-02-24
JP2022514033A (ja) 2022-02-09

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