WO2020171691A1 - Dispositif automatisé pour la détection du cancer du col de l'utérus - Google Patents

Dispositif automatisé pour la détection du cancer du col de l'utérus Download PDF

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Publication number
WO2020171691A1
WO2020171691A1 PCT/MX2019/000070 MX2019000070W WO2020171691A1 WO 2020171691 A1 WO2020171691 A1 WO 2020171691A1 MX 2019000070 W MX2019000070 W MX 2019000070W WO 2020171691 A1 WO2020171691 A1 WO 2020171691A1
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WO
WIPO (PCT)
Prior art keywords
cervical cancer
motor
support
slot
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MX2019/000070
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English (en)
Spanish (es)
Inventor
Nicole Stephanie MUÑOZ FILIPPETTI
Jesús Raúl BELTRÁN RAMÍREZ
Jovan Ricardo ZEPEDA GÓMEZ
Javier ESPINOZA JR.
Rosa Elizabeth GONZÁLEZ ESPINOZA
Víctor Hugo SANDOVAL RUBIO
Benajmín VILLANUEVA ÁVALOS
Carlos Augusto GONZÁLEZ SANDOVAL
Jonathan De Jesús MARTÍNEZ MENDOZA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consorcio De Investigacion E Innovacion Abierta SAPI De CV
Original Assignee
Consorcio De Investigacion E Innovacion Abierta SAPI De CV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Consorcio De Investigacion E Innovacion Abierta SAPI De CV filed Critical Consorcio De Investigacion E Innovacion Abierta SAPI De CV
Publication of WO2020171691A1 publication Critical patent/WO2020171691A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Definitions

  • the present invention is related to the technical field of mechanics and electronics since it provides an automated device for the detection of cervical cancer.
  • Cervical cancer also known as cervical cancer, is a malignant tumor that begins in the cervix and is more common in women over 30 years of age.
  • Cervical cancer is the abnormal growth of cells found in the neck of the womb. Initially, the lesions are so small that they cannot be seen with the naked eye and thus last for several years.
  • the normal cervix has two main types of cells: squamous (or flat) cells, which protect the exterior of the cervix, and the glandular cells that are found primarily within the cervix, and produce the fluid and mucus commonly seen during ovulation.
  • Cervical cancer is caused by abnormal changes in any of these cell types in the cervix, and it is the only gynecological cancer that can be prevented with regular screening and preventive vaccination.
  • cervical cancer The development of cervical cancer is generally very slow and begins as a precancerous condition called dysplasia. This condition can be detected by Pap smear and is 100% curable. It can take years for dysplasia to develop into cervical cancer. Most women who are diagnosed with cervical cancer today have not had regular Pap tests or have not been followed up for abnormal Pap tests.
  • cancer When cancer is in an advanced stage, it can be seen with the naked eye on gynecological examination or cause other discomfort, including abnormal bleeding after intercourse, between menstrual periods, or after menopause, increased flow of bleeding Bad smelling genital tract, hip pain and weight loss.
  • treatment may be with surgery to remove the womb or with radiation therapy and chemotherapy in more advanced cases.
  • BIMANUAL GYNECOLOGICAL EXAMINATION There are a number of tests and procedures that can be used to screen for cervical cancer: BIMANUAL GYNECOLOGICAL EXAMINATION.
  • the doctor checks the woman's body for any unusual changes in the cervix, uterus, vagina, ovaries, and other nearby organs. To begin, the doctor determines if there are changes in the vulva outside the body and then, using an instrument called a speculum to separate the walls of the vagina, the doctor checks the inside of the woman's body. Some of the nearby organs are not visible during this exam, so the doctor then inserts 2 fingers from 1 hand into the patient's vagina while gently pressing on the lower abdomen with the other hand to palpate the uterus and the ovaries. This exam usually takes a few minutes and is done in the exam room of your doctor's office.
  • HPV TEST This test is done on a sample of cells taken from the woman's cervix, which is the same sample that is used for the Pap test. This sample is tested for the HPV strains that are most commonly associated with cervical cancer.
  • the HPV test can be done individually or in combination with a Pap test. This test can also be done on a sample of cells from a woman's vagina that she can collect herself.
  • the Pap test has been the most common test to detect premature changes in cells that can lead to cervical cancer. This test is also called a Pap smear. For the Pap test, You must obtain a sample of cells from the cervix. It is often done at the same time as a bimanual gynecological examination. A Pap test can be combined with an HPV test.
  • VIA VISUAL INSPECTION WITH ACETIC ACID
  • VIA is a screening test that can be done with a few tools and with the naked eye. During VIA, a dilution of white vinegar is applied to the cervix. The healthcare provider then looks for abnormalities on the cervix, which will turn white when it comes in contact with the vinegar. This screening test is very useful in places where access to medical care is limited.
  • the document described above is equipped with a staining technique, and filtering processes for cells through a membrane.
  • Said device is intended to process the samples and fix them for examination.
  • it does not show that the process is carried out in an automated manner, nor that it has a camera mounted on a microscope which is connected to a computer equipment for the analysis of the captured images; there is also no evidence that it has a control module that manages various electromechanical components that help the application of the staining reagent, thus achieving automate the staining process and also implement a system that performs the capture and analysis of images of the sample, with a mechanism that helps in the process.
  • patent number JP6231885 (B2), with publication date of November 15, 2017, entitled “MEDICAL INSTRUMENT TO EXAMINE THE CERVIX”, which mentions a medical instrument to examine the cervix that includes an optical examination system, a processor for controlling the medical instrument, and a memory containing machine-executable instructions.
  • Executing the instructions makes the processor: acquires a cervical image using the optical examination system; calculates a set of POI locations using a digital filter; calculates a filtered set of POI locations using the POI location set and a morphological filter; calculates a reduced set of POI locations using the filtered set of POI locations and a neighborhood-based filter; calculates a classified set of points of interest; calculates a set of scoring locations using the ranked set of POI locations and a second neighborhood-based filter; and calculates the regions of the score marks using the locations of the score points.
  • document JP6231885 (B2) aims to analyze a cervical image obtained by means of an optical examination system, which classifies the images and the locations of the specific points of these images.
  • an optical examination system which classifies the images and the locations of the specific points of these images.
  • the MEDICAL INSTRUMENT TO EXAMINE CERVIX uses images to perform a prediagnosis, it does not use a microscope connected to a camera, nor does it have a photomultiplier, which is used during the process of image capture and processing of is.
  • the document describes an input unit through which a cell sample is introduced whose objective is to analyze the nucleic acid level, and which is interpreted by a computational unit, but does not evidence the analysis of samples through a staining process, in which process an infusion pump is involved and a mechanism that helps to apply the reagent, nor does it describe that once the sample is processed it is analyzed by means of an image capture module, made up of a microscope with a camera connected to computer equipment.
  • object of the present invention to provide an automated device for the detection of cervical cancer, which solves the aforementioned problems.
  • Figure 1 shows a front perspective view of the automated device for cervical cancer detection.
  • Figure 2 shows a rear perspective view of an automated device for cervical cancer detection.
  • Figure 3 shows a left side view of the automated device for cervical cancer detection.
  • Figure 4 shows a rear view of the automated device for cervical cancer detection.
  • Figure 5 shows a front view of the automated device for cervical cancer detection.
  • Figure 6 shows a top view of the automated device for cervical cancer detection.
  • Figure 7 shows a right side view of the automated device for cervical cancer detection.
  • Figure 8 shows an exploded view of the automated device for cervical cancer detection.
  • Figure 9 shows a detailed view of the infusion pump of the automated device for the detection of cervical cancer.
  • Figure 10 shows a detailed view of the display mechanism of the automated device for cervical cancer detection.
  • Figure 11 shows a detailed view of the photomultiplier of the automated device for cervical cancer detection.
  • Figure 12 shows a detailed view of the arm support of the automated device for cervical cancer detection.
  • Figure 13 shows a detailed view of the screw of the automated device for the detection of cervical cancer.
  • Figure 14 shows a detailed view of the base of the automated device for cervical cancer detection.
  • Figure 15 shows a detailed view of the cylindrical structure of the automated device for cervical cancer detection.
  • Figure 16 shows a detailed view of the structure of the automated device for the detection of cervical cancer.
  • the automated device for cervical cancer detection is made up of a base (1) with a prismatic shape, preferably rectangular, which has a cavity (2) on its surface configured to house an electronic system (not illustrated) that has a microcontroller that allows controlling the electromechanical parts of the device of the present invention.
  • a support (3) is placed perpendicularly at one of the ends of the base (1), said support supports a hollow prismatic structure (4) that has a slot (5) in its upper wall, said structure (4) it is preferably cubic.
  • both the support (3) and the structure (4) have a hole (6) through which the shaft of a first motor (7) passes that is fixed on the support ( 3) from the base (1).
  • a cylindrical structure (8) made up of two parallel wheels (9) joined together by means of at least four slides (10) placed on the internal circumference of each wheel (9); said cylindrical structure (8) is placed inside the structure (4) mounted on the shaft of the first motor (7) by means of a hub (22) and spokes (23) that are inside one of the wheels (9), this configuration allows that when the first motor (7) is activated by means of the electrical system (not illustrated), the cylindrical structure (8) rotates inside of the structure (4) on its own axis, allowing to align each of the slides (10) with the slot (5), for a time determined by the electrical system.
  • cylindrical structure (8) is removable, to be able to remove the samples and enter new ones with another cylindrical structure (8), as well as to give maintenance and be changed in case if necessary in a faster and easier way.
  • An arm support (11) is placed on the base (1) at the opposite end where the support (3) is located, said arm support (11) is configured to be placed inside the structure (4), at the center of the cylindrical structure (8) and aligned to the slot (5); the end of the arm support (11) placed inside the structure (4) has a clamping mechanism (12) that supports a photomultiplier (13) which can be contracted and retracted so that the structure can be removed in this way cylindrical (8) with the samples;
  • the photomultiplier (13) is in charge of radiating the samples when the slide (10) is placed under said photomultiplier, this in order that the sample can be visible to a display mechanism (15), which is made up of a microscope (16) and a camera (17); said display mechanism may have a lighting element (not illustrated), for example a lamp.
  • the automated device for the detection of cervical cancer has an infusion pump (14) on the structure (4), which is connected to a hose (not illustrated) that extends into the structure (4) remaining in a point over which the slides (10) pass, to dose drops of luminol on the sample to generate a reaction that with the radiation of the photomultiplier (13) can help improve the visibility and analysis of said sample.
  • At least two bearings (18) are placed on the structure (4) near the slot (5) of the upper wall of said structure, in the bearings an endless screw (19) is installed which is connected to a second motor (20) which is preferably stepped, and gives movement to the worm (19) on which the display mechanism (15) is mounted in such a way that the camera (17), the microscope (16) and the lighting element are suspended inside the structure (4) through the slot (5);
  • This configuration allows that when the second motor (20) is activated, the endless screw (19) begins to rotate allowing the display mechanism (15) to move along the slot (5) allowing a sample scan , to capture images and test for cervical cancer.
  • a third motor (21) is placed on the display mechanism (15) giving it movement in the axis of the "y” so that said mechanism can go down or up and the microscope (16) and the camera (17) manage to take the best image of each sample for analysis; Once each sample is imaged, the information is sent via a wireless interface (not illustrated) to a computer and / or a smart device, to determine if samples show cervical cancer.
  • the smart device can be a computer, phone, or tablet.
  • a series of sensors send the information to the microcontroller of the electronic system (not illustrated) to send the instruction to the motors (7, 20 and 21) of the moment in which each one should start working or stop;
  • the microcontroller also sends the instruction to the display mechanism (15) so that it starts with the taking of images of each one of the samples.
  • a power source (not shown) supplies power to the components of the automated cervical cancer detection device for operation.
  • the structure (4) is configured for the protection and isolation of the samples, and a removable cover (24) is placed to protect the components that are on the structure (4).
  • Example 1 Operation of the automated device for the detection of cervical cancer.
  • Some containers with the samples to be analyzed are placed on the slides (10) of the cylindrical structure (8), to later introduce it into the structure (4) aligning the hub (22) of one of the wheels (9) of the cylindrical structure (8), so that later one of the sensors detects the position of the slides (10) and if it is not under the hose (not illustrated ) of the infusion pump (14), send the signal to the microcontroller (not illustrated) so that the first motor (7) begins to work making the cylindrical structure (8) rotate until the microscope slide (10) is under the hose and that by means of the infusion pump (14) doses drops of luminol on the sample to generate a reaction in it; Once the first sample was dosed with luminol, the first motor (7) is activated again so that the cylindrical structure (8) rotates again until the slide (10) is positioned below the photomultiplier (13), at that time The first motor (7) stops working so that the photomultiplier (13) can radiate the samples dosed with luminol, while this happens, the second slide (10) is under the
  • the second motor (20) and the third motor (21) begin to work, so that the microscope (16) and the camera (17) begin to make a scan to the ideal height, so that the display mechanism (15) can obtain the image of the sample and this is sent through a wireless interface (not shown) to a computer and / or a smart device, to determine if the images sample have cervical cancer.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne un dispositif automatisé pour la détection du cancer du col de l'utérus qui comprend une chambre montée sur un microscope qui est reliée à un dispositif informatique pour l'analyse des images capturées, ainsi qu'une série de mécanismes utilisés pour réaliser la coloration de l'échantillon, lequel est prélevé sur l'utilisatrice, sans être évasif pendant le processus, à la différence du dispositif du document concerné, comprend également un photomultiplicateur qui est utilisé pendant le processus de capture d'image et de traitement de celle-ci. Le dispositif automatisé pour la détection du cancer du col de l'utérus selon la présente invention est portable et peut par conséquent être utilisé dans des régions qui se situent à une grande distance de la ville où ce type d'analyse pourrait être fait.
PCT/MX2019/000070 2019-02-21 2019-06-06 Dispositif automatisé pour la détection du cancer du col de l'utérus Ceased WO2020171691A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2019002090A MX386825B (es) 2019-02-21 2019-02-21 Dispositivo automatizado para la detección de cáncer cervicouterino.
MXMX/A/2019/002090 2019-02-21

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WO2020171691A1 true WO2020171691A1 (fr) 2020-08-27

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1862535A1 (fr) * 2006-05-30 2007-12-05 Sysmex Corporation Procédé et appareil de traitement de cellules
WO2012178166A1 (fr) * 2011-06-24 2012-12-27 Arryx, Inc. Procédé et appareil de fractionnement de cellules et composants cellulaires génétiquement distincts
CN106754323A (zh) * 2016-12-23 2017-05-31 基努里(天津)生物科技有限公司 一种微生物基因检测分析仪
CN206420861U (zh) * 2017-02-09 2017-08-18 南昌源顺食品有限公司 一种食品检测台
CN206906116U (zh) * 2017-07-14 2018-01-19 南通市肺科医院（南通市第六人民医院） 一种便于操作的血细胞检测仪
AU2018101853A4 (en) * 2017-12-21 2019-01-17 Logic Systems Design Pty Limited Autosynchronous fluorescence microscopy system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1862535A1 (fr) * 2006-05-30 2007-12-05 Sysmex Corporation Procédé et appareil de traitement de cellules
WO2012178166A1 (fr) * 2011-06-24 2012-12-27 Arryx, Inc. Procédé et appareil de fractionnement de cellules et composants cellulaires génétiquement distincts
CN106754323A (zh) * 2016-12-23 2017-05-31 基努里(天津)生物科技有限公司 一种微生物基因检测分析仪
CN206420861U (zh) * 2017-02-09 2017-08-18 南昌源顺食品有限公司 一种食品检测台
CN206906116U (zh) * 2017-07-14 2018-01-19 南通市肺科医院（南通市第六人民医院） 一种便于操作的血细胞检测仪
AU2018101853A4 (en) * 2017-12-21 2019-01-17 Logic Systems Design Pty Limited Autosynchronous fluorescence microscopy system

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MX2019002090A (es) 2021-10-05
MX386825B (es) 2025-03-19

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