WO2020175681A1 - Corps stratifié destiné à adhérer à la peau et son procédé de production - Google Patents

Corps stratifié destiné à adhérer à la peau et son procédé de production Download PDF

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Publication number
WO2020175681A1
WO2020175681A1 PCT/JP2020/008363 JP2020008363W WO2020175681A1 WO 2020175681 A1 WO2020175681 A1 WO 2020175681A1 JP 2020008363 W JP2020008363 W JP 2020008363W WO 2020175681 A1 WO2020175681 A1 WO 2020175681A1
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WIPO (PCT)
Prior art keywords
layer
laminate
skin
support
silicone
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Ceased
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PCT/JP2020/008363
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English (en)
Japanese (ja)
Inventor
米山　聡
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Fujifilm Corp
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Fujifilm Corp
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Publication of WO2020175681A1 publication Critical patent/WO2020175681A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B25/00—Layered products comprising a layer of natural or synthetic rubber
    • B32B25/20—Layered products comprising a layer of natural or synthetic rubber comprising silicone rubber

Definitions

  • Laminate for skin application and method for producing the same
  • the present disclosure relates to a laminate for skin application and a method for producing the same.
  • Examples of the skin-adhesive laminate include wound dressings and transdermal preparations, which have various uses.
  • a pressure-sensitive adhesive layer containing a carboxylic acid ester for sticking to a living body and one of the pressure-sensitive adhesive layers in the thickness direction is used.
  • Absolute value of A laminated body for sticking to a living body is disclosed.
  • Japanese Patent Laid-Open No. 2106-10 2 2 2 23 there is described a film base material, a first adhesive layer on the bottom surface of the film base material, and a second adhesive layer on the upper surface of the film base material. And a first release liner and a second release liner attached to each of the first adhesive layer and the second adhesive layer of the protective film member.
  • the following medical protective film material is disclosed.
  • Some of the laminates for skin application are desired to be applied to the skin for a long time.
  • Such a skin patch laminate has excellent permeability of water vapor released from the skin, and has less discomfort due to the weight and feeling of foreign matter when it is applied, and follows the movement of the skin. Is also desired.
  • an object of an embodiment of the present disclosure is to apply a skin that is applied without feeling uncomfortable, follows the movement of the skin, and has excellent permeability of water vapor released from the skin. ⁇ 0 2020/175681 2 (:171? 2020/008363
  • An object of the present invention is to provide a laminated body for use and a manufacturing method thereof.
  • Laminate for skin application Laminate for skin application.
  • the surface of the first support on the first layer side and the surface of the second support on the second layer side at least _ have a silicone layer or are surface-treated with silicone.
  • Step 8 a coating liquid containing a silicone polymer having a crosslinkable group, a crosslinking agent, and a solvent is applied and dried on the first support to form a first layer.
  • Step 8 a coating liquid containing a silicone polymer having a crosslinkable group, a crosslinking agent, silica particles, and a silicone solvent is applied and dried on the first support to form a first layer.
  • step S is a step of forming the second layer on the first layer.
  • Laminate for skin application according to any one of [9] to [12], in which the first support is continuously conveyed and the process and process are performed by the mouth-to-roll method. Body manufacturing method.
  • Step 1 of attaching a protective film to the surface of the first layer formed in step 8 between step 8 and step _, and the laminated protective film from the surface of the first layer The method for producing a skin patch laminate according to any one of [9] to [13], further comprising a peeling step 82.
  • the surface of the first layer hydrophilically treated in step 83 has a contact angle with 1 ⁇ 1-methyl-2-pyrrolidone of 60° or less, and the skin according to [1 5] Method for manufacturing laminated body for sticking.
  • a skin-adhesive laminate which is affixed without any discomfort, follows the movement of the skin, and has excellent permeability of water vapor released from the skin, and a method for producing the same. be able to.
  • the numerical range indicated by “to” indicates the range including the numerical values before and after “to” as the minimum value and the maximum value, respectively.
  • the amount of each component contained in the composition means the total amount of the plurality of substances, unless otherwise specified, when the composition contains a plurality of substances corresponding to the respective components.
  • the upper limit value or the lower limit value described in a certain numerical range may be replaced with the upper limit value or the lower limit value of another stepwise described numerical range. .. Further, in the numerical ranges described in the present specification, the upper limit value or the lower limit value described in a certain numerical range may be replaced with the values shown in the examples.
  • (meth)acrylic means at least one of acrylic and methacrylic.
  • a skin patch laminate of the present disclosure (hereinafter, also referred to as “laminate of the present disclosure”) has a first layer containing a silicone elastomer, and a second layer that is in contact with the first layer and exhibits adhesiveness. ..
  • the laminate of the first layer and the second layer of the laminate of the present disclosure has a tensile stress at 40% elongation of ⁇ .
  • the total thickness is less than or equal to 101 01. ⁇ 02020/175681 5 ⁇ (: 171? 2020 /008363
  • the laminate of the present disclosure has a tensile stress of 40% elongation of the laminate of the first layer and the second layer. Below, and the total thickness is 1 It is presumed that the following will be applied with no discomfort and will have the effect of following the movement of the skin.
  • the first layer is a layer containing a silicone elastomer, it is presumed that the first layer has an effect of being excellent in permeability of water vapor released from the skin due to its material.
  • None of the laminates described in Japanese Patent Publication No. 3 has a layer containing a silicone elastomer as a layer adjacent to the adhesive layer. Further, in the laminates described in JP-A-2010-04395-O and JP-A-2016-022223, the tensile stress in the laminate of the adhesive layer and the adjacent layer is not examined at all.
  • the tensile stress at 40% elongation of the laminate of the first layer and the second layer is 0. It is the following.
  • the tensile stress at 40% elongation of the laminate is easy to follow the movement of the skin.
  • the following is preferred, and ⁇ .61 ⁇ /1 3 or less is more preferred, ⁇ .
  • the lower limit of tensile stress at 40% elongation of the laminate is, for example, 0.001 IV! 3 .
  • the tensile stress at 10% elongation of the laminated body of the first layer and the second layer is ⁇ . It is preferably not more than 0.21, more preferably not more than 0.13 and even more preferably not more than 0.1 IV! 3.
  • the lower limit of the tensile stress at 10% elongation of the laminate is, for example, 0.001 IV! 3 .
  • the tensile elongation at break of the laminate of the first layer and the second layer is preferably 100% or more, and 150% or more. Is more preferable and 200% or more is further preferable.
  • the upper limit of the tensile elongation at break of the laminate is, for example, 900%.
  • the method for adjusting the tensile stress and the tensile elongation at break of the first layer, the tensile stress and the tensile elongation at break of the second layer are adjusted. And a method of adjusting the film thickness ratio between the first layer and the second layer.
  • the tensile stress and tensile elongation at break of the laminate should be adjusted by adjusting the tensile stress and tensile elongation at break of the first layer in the laminate. It is preferable to control by a method.
  • the tensile stress at 40% elongation and the tensile elongation at break in the laminate are measured as follows.
  • the test piece shall be extended in an environment of 25 ⁇ 2 ° .
  • the tensile stress at 10% elongation is the tensile stress at 10% elongation except that the load (1 ⁇ ) when the test piece is expanded by 10% is added to the above formula (1). It is calculated in the same way as.
  • the total thickness of the laminate of the first layer and the second layer is 1101 or less.
  • Total thickness is 1 The following items make it less likely to feel weight and foreign matter when applied to the skin, so that the product can be applied comfortably.
  • the total thickness of the laminate is: 7 is preferable, 0.0 1 01 01 to ⁇ 0.5 01 01 is more preferable, and ⁇ . Is more preferable, and 0.02 ⁇ 1 111 to ⁇ 0.11 111 is particularly preferable.
  • the lower limit of the total thickness of the laminated body is, for example, from the viewpoint of manufacturing suitability, 0.00 0.001 01.
  • the total thickness of the laminate of the first layer and the second layer is measured as follows.
  • the thickness of the first support and the second support was calculated from the total thickness of this stack.
  • the total thickness of the first and second layers is obtained by subtracting the thickness. Therefore, the thickness of each of the first support and the second support should be measured beforehand with the above-mentioned constant pressure thickness gauge.
  • test pieces of the laminate used for the measurement have the same shape as the test pieces used for the measurement of the tensile stress and the tensile elongation at break, and three pieces are prepared. ⁇ 0 2020/175681 8 ⁇ (: 171? 2020 /008363
  • the center of the test piece is measured 3 times with the above-mentioned constant pressure thickness gauge, and the average value of 3 times is taken as the thickness of the test piece.
  • the same measurement is performed on three test pieces, and the average value of the thickness of the three test pieces is taken as the total thickness of the laminate of the first layer and the second layer.
  • the first support/first layer is used for the measurement.
  • a laminate composed of one layer/protective film may be applied.
  • the thickness of the first layer can be determined by subtracting the thickness of the first support and the protective film from the total thickness of this laminate. Therefore, in addition to the first support, measure the thickness of the protective film alone with the above-mentioned constant pressure thickness measuring device.
  • the laminate composed of the first support/first layer/protective film is, for example, the first support/first layer/protection obtained through step 1 in the method for producing a skin patch laminate described later.
  • a laminate composed of a film may be mentioned.
  • the thickness of the second layer can also be calculated by subtracting the thickness of only the first layer from the total thickness of the first layer and the second layer obtained by the above method.
  • the laminate of the present disclosure has a first layer that includes a silicone elastomer.
  • the first layer may contain silica particles in addition to the silicone elastomer.
  • the first layer may have a single-layer structure or a multi-layer structure. When the first layer has a multi-layer structure, at least one of the layers may contain a silicone elastomer.
  • the respective layers may have different cross-linking densities of the silicone elastomer.
  • the presence or absence of addition of silica particles may be changed in each layer, or the content of silica particles may be different.
  • the silicone elastomer refers to a crosslinked product of a silicone polymer, and is preferably a three-dimensional crosslinked product of a silicone polymer. ⁇ 02020/175681
  • the three-dimensional crosslinked product of the silicone polymer is more preferably a reaction product of a silicone polymer having a crosslinkable group and a crosslinking agent.
  • silicone polymer having a crosslinkable group examples include polydimethylsiloxane, polymethylphenylsiloxane, polymethyldiphenylsiloxane, and the like, which have two or more crosslinkable groups in the molecule. From the viewpoint of actual use and the ease of obtaining a three-dimensional crosslinked product, polydimethylsiloxane having two or more crosslinkable groups in the molecule is preferable, and polydimethylsiloxane having crosslinkable groups at both main chain terminals is particularly preferable. Is preferred.
  • the crosslinkable group contained in the silicone polymer may be a functional group used in reactions such as hydrosilylation, reaction with organic peroxide, deacetic acid, dehydration, dealcoholization, etc., which is known as a crosslinking reaction of silicone polymers. Good. Among them, as the crosslinking reaction of the silicone polymer, hydrosilylation that does not generate a reaction by-product is preferable, and as the crosslinking group, a vinyl group is particularly preferable.
  • silicone polymer having a crosslinkable group polydimethylsiloxane having vinyl groups at both main chain terminals is particularly preferable.
  • the weight average molecular weight of the silicone polymer having a crosslinkable group is not particularly limited, but examples thereof include 800 to 50,000, and preferably 10,000 to 300,000.
  • the silicone polymer having a crosslinkable group may be used alone or in combination of two or more.
  • the weight average molecular weight of the silicone polymer having a crosslinkable group can be measured by gel permeation chromatography (XX). Specifically, 1 ⁇ 11_ ⁇ 81 81 ⁇ ⁇ , 30-8020 (Tosoh Corporation) was used, and the column was D3 3 ⁇ 96 1, 3 Li 6 “1 ⁇ 11 ⁇ /1— 1 ⁇ 1 (Tosoh Corporation, 6.
  • sample concentration is 0.5 mass% and flow rate is 0.9.
  • the sample injection amount can be set to 10 (microliter), the measurement temperature can be set to 40 ° , and a differential refractometer ([3 ⁇ 4]) detector can be used.
  • ⁇ 02020/175681 10 ((171?2020/008363
  • the calibration curve is based on Tosoh Corporation “ ⁇ I ⁇ Standard sample knife 3
  • the cross-linking agent is not particularly limited as long as it has a functional group that reacts with the cross-linking group of the silicone polymer having a cross-linking group, but from the viewpoint of easy control of the cross-linking density, a siloxane compound is used. Preferably.
  • a siloxane compound having two or more hydrosilyl groups in the molecule is preferable.
  • polymethylhydrosiloxane a copolymer of methylhydrosiloxane and dimethylsiloxane, polymethylphenyl is preferable. Examples thereof include copolymers of siloxane or polymethyldiphenylsiloxane and polymethylhydrosiloxane.
  • cross-linking agent a copolymer of methylhydrosiloxane and dimethylsiloxane is particularly preferable.
  • the weight average molecular weight of the siloxane compound that is preferable as the crosslinking agent is not particularly limited, but examples thereof include 500 to 30,000, and preferably 10,000 to 25,000.
  • the weight average molecular weight of the siloxane compound is measured by the same method as the weight average molecular weight of the silicone polymer having a crosslinkable group.
  • the crosslinking agents may be used alone or in combination of two or more.
  • the amount ratio of the silicone polymer having a crosslinkable group and the crosslinking agent may be determined according to the tensile stress and the tensile elongation at break required for the first layer.
  • the silicone elastomer contained in the first layer is ⁇ 0 2020/175681 1 1 ⁇ (: 171? 2020 /008363
  • the presence of the crosslinked structure due to the hydrosilylation reaction can be estimated by confirming the presence or absence of a vinyl group and the presence or absence of a metal catalyst (preferably both) in the first layer.
  • a metal catalyst may be used in the hydrosilylation reaction as described later. Therefore, by confirming the presence or absence of the metal catalyst in the first layer, the existence of a crosslinked structure due to the hydrosilylation reaction in the silicone elastomer is estimated.
  • the presence or absence of the vinyl group can be confirmed by using the nuclear magnetic resonance spectroscopy or the like for the vinyl group remaining in the first layer.
  • Nuclear magnetic resonance spectroscopy can be performed, for example, by Bruker 888 1 ⁇ 100 III 600 is used.
  • the presence or absence of a metal catalyst can be confirmed by analyzing metal elements (platinum, titanium, etc.) by X-ray fluorescence analysis.
  • metal elements platinum, titanium, etc.
  • X-ray fluorescence analysis for example, “R011 type 311 manufactured by Rigaku Corporation” is used.
  • the content of the silicone elastomer (that is, a cross-linked product of the silicone polymer) is 70% by mass to 10% with respect to the total mass of the first layer. 0 mass% is preferable, 75 mass% to 100 mass% is more preferable, and 80 mass% to 100 mass% is further preferable.
  • the content of silicone elastomer _ (that is, a cross-linked product of silicone polymer) is 70% by mass to 93% by mass with respect to the total mass of the first layer. 75% by mass to 93% by mass is more preferable, and 80% by mass to 90% by mass is further preferable.
  • the first layer preferably contains silica particles. ⁇ 0 2020/175681 12 ⁇ (: 171? 2020 /008363
  • the inclusion of silica particles makes it easier to control the tensile stress and tensile fracture elongation of the first layer.
  • the first layer contains silica particles as follows.
  • the presence or absence of silica particles can be directly confirmed by dissolving the first layer and observing the dissolved solution with a transmission electron microscope (Chomi! ⁇ /1).
  • a transmission electron microscope for example, is a JEOL Ltd.'s "1 ⁇ /1-1 2 0 0 ⁇ -Cho 1 ⁇ /1", and the acceleration voltage at the time of measurement is 1 2 0 1 ⁇
  • the solution for the first layer can be prepared by immersing the first layer in a mixed solution of methyl orthoformate, methanolic hydrochloric acid, and toluene, and stirring the solution.
  • the silica particles are not particularly limited, and may be any of fumed silica and colloidal silica, and may be crystalline or amorphous.
  • fumed silica is preferable from the viewpoints of dispersibility in a silicone solvent, dispersibility in a crosslinked product of a silicone polymer, and stability of coating solution viscosity.
  • the shape of silica particles is not particularly limited. However, a spherical shape, a plate shape, a needle shape, a bead shape, or a shape in which two or more kinds of these are combined is included.
  • the silica particles have an average primary particle size of 3 n from the viewpoint of dispersibility in the first layer.
  • the average primary particle size of the silica particles is measured by observing the first layer with a transmission electron microscope (Cho IV!). More specifically, the average primary particle diameter of the silica particles is, when the shape of the silica particles is spherical or substantially spherical with an elliptical cross section, the silica particles dispersed in the first layer are observed by a transmission electron microscope, From the obtained observation photograph, the projected area of 300 or more particles is measured, the equivalent circle diameter is determined from the projected area, and the obtained equivalent circle diameter is taken as the average primary particle diameter of silica particles. If the shape of silica particles is not spherical or nearly spherical, use another method. ⁇ 0 2020/175681 13 ⁇ (: 171? 2020 /008363
  • the average primary particle diameter of silica particles is determined.
  • the content of the silica particles is such that the bow I tensile stress and the tensile elongation at break of the first layer can be easily controlled with respect to the total mass of the first layer. , 7 mass% to 30 mass% is preferable, 7 mass% to 25 mass% is more preferable, and 10 mass% to 20 mass% is further preferable.
  • the first layer may contain other components in addition to the above-mentioned silicone elastomer (that is, a crosslinked product of silicone polymer) and silica particles.
  • Other components include a silicone elastomer (that is, a silicone polymer). (A crosslinked product of mer), and a reaction catalyst and the like used.
  • a coloring agent such as a pigment may be used.
  • the reaction catalyst used when obtaining the silicone elastomer may be any catalyst that contributes to the promotion of the reaction for obtaining the three-dimensional crosslinked product of the silicone polymer.
  • the reaction catalyst is preferably a catalyst for promoting the hydrosilylation reaction.
  • reaction catalyst examples include metal catalysts, and in particular, platinum, titanium, gold, silver and the like are mentioned from the viewpoint of low irritation to the skin.
  • titanium and platinum are preferable as the catalyst from the viewpoint of high reaction promoting efficiency and low skin irritation.
  • platinum catalyst a known platinum catalyst (preferably platinum complex) that contributes to reaction promotion for obtaining a three-dimensional crosslinked product of a silicone polymer can be applied.
  • the thickness of the first layer is from the viewpoint of suppressing a feeling of discomfort such as a feeling of weight during attachment, and ⁇ 0 2020/175681 14 ⁇ (: 171? 2020 /008363
  • the laminate of the present disclosure has a second layer that is in contact with the above-mentioned first layer and exhibits tackiness.
  • the second layer corresponds to the layer attached to the skin, it may be any layer that is adhesive to the skin.
  • adheresiveness refers to a property of stickiness, which is used for temporary adhesion and can be peeled off later.
  • the second layer is preferably a layer containing an adhesive.
  • the pressure-sensitive adhesive is not particularly limited, and known pressure-sensitive adhesives can be used. Specific examples of the pressure sensitive adhesive include silicone pressure sensitive adhesive, acrylic pressure sensitive adhesive, rubber pressure sensitive adhesive and urethane pressure sensitive adhesive.
  • a silicone-based pressure-sensitive adhesive is preferable from the viewpoint of low irritation to the skin and from the viewpoint of adhesion to the first layer.
  • the silicone-based pressure-sensitive adhesive in the present disclosure means a pressure-sensitive adhesive that uses a silicone polymer as a base polymer (a main component among polymer components, that is, a component that accounts for 50% by mass or more of the entire polymer component).
  • the silicone adhesive is not particularly limited, and known silicone adhesives can be used.
  • silicone-based pressure-sensitive adhesive examples include an addition reaction-type silicone-based pressure-sensitive adhesive, a peroxide-curable silicone-based pressure-sensitive adhesive, and a condensation-type silicone-based pressure-sensitive adhesive. Above all, an addition reaction type silicone-based pressure-sensitive adhesive by hydrosilylation is preferable from the viewpoint that reaction by-products are not generated.
  • an addition reaction type silicone containing the same silicone polymer having a crosslinkable group and the crosslinking agent as the first layer ⁇ 0 2020/175681 15 ⁇ (: 171? 2020 /008363
  • the silicone-based pressure-sensitive adhesive preferably contains, for example, polydimethylsiloxane having vinyl groups at both ends of the main chain, and a copolymer of methylhydrosiloxane and dimethylsiloxan.
  • the silicone-based pressure-sensitive adhesive may contain a reaction catalyst.
  • silicone-based pressure-sensitive adhesive may optionally contain various additives contained in known silicone-based pressure-sensitive adhesives.
  • the acrylic pressure-sensitive adhesive in the present disclosure means a pressure-sensitive adhesive using an acrylic polymer as a base polymer.
  • the acrylic pressure-sensitive adhesive is not particularly limited, and known acrylic pressure-sensitive adhesives can be used.
  • acrylic polymer contained in the acrylic pressure-sensitive adhesive include a homopolymer of an acrylic acid ester compound or a copolymer of an acrylic acid ester compound and another monomer.
  • acrylic acid ester compounds include methyl (meth)acrylate, ethyl (meth)acrylate, butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, dimethyl.
  • Aminoethyl methacrylate, glycidyl methacrylate and the like can be mentioned.
  • examples of other monomers include vinyl acetate, (meth)acrylonitrile, (meth)acrylic amide, styrene, methacrylic acid, acrylic acid, itaconic acid, methylol acrylic amide, maleic anhydride and the like.
  • the acrylic polymer may have a crosslinked structure.
  • the acrylic pressure-sensitive adhesive may contain a tackifier in addition to the acrylic polymer from the viewpoint of enhancing the tackiness.
  • tackifiers include rosin-based tackifier resins, terpene-based tackifier resins, hydrocarbon-based tackifier resins, epoxy-based tackifier resins, and polyamides. ⁇ 0 2020/175681 16 ⁇ (: 171? 2020 /008363
  • tackifying resin examples include an elastomer-based tackifying resin, an elastomer-based tackifying resin, a phenol-based tackifying resin, and a ketone-based tackifying resin.
  • the acrylate-based pressure-sensitive adhesive may contain, in addition to the acrylate polymer and the tackifier, various additives contained in known acrylic-based pressure-sensitive adhesives, if necessary.
  • the rubber-based pressure-sensitive adhesive in the present disclosure means a pressure-sensitive adhesive having rubber as a base polymer.
  • the rubber is not particularly limited, and may be natural rubber (including modified natural rubber) or synthetic rubber.
  • a type or a type block copolymer is a thermoplastic block, and a type is a rubber block.
  • Styrene-isoprene styrene copolymer (3 1 3), styrene-butadiene Examples thereof include styrene copolymers (363) and the like.
  • the rubber may be a combination of natural rubber and synthetic rubber.
  • the rubber-based pressure-sensitive adhesive may contain a tackifier in addition to the rubber from the viewpoint of enhancing the tackiness.
  • tackifier examples include various tackifier resins used for acrylate-based tackifiers.
  • the rubber-based pressure-sensitive adhesive may contain, in addition to the rubber and the tackifier, various additives contained in known rubber-based pressure-sensitive adhesives, if necessary.
  • the second layer may contain other components in addition to the adhesive. Other components may be appropriately determined depending on the use of the skin patch laminate.
  • the second layer preferably contains a drug and an additive for retaining and releasing the drug.
  • the drug a known drug applicable to transdermal preparations is used.
  • an additive for holding and releasing the drug from the viewpoint of actual use, for example, lactic acid, glycolic acid, stearic acid, oleic acid, isopropyl myristate,! _ _Menthol, ethanol, propylene glycol, etc.
  • the thickness of the second layer is 5 to 3 from the viewpoint of exhibiting adhesion to the skin.
  • the laminate of the present disclosure includes a first support member that contacts the surface of the first layer opposite to the surface that contacts the second layer, and a first support member that contacts the surface of the second layer opposite to the surface that contacts the first layer. Two supports may be included.
  • the first support and the second support are temporary supports that are peeled off when attached to the skin.
  • the first support and the second support are not particularly limited, and a resin film is preferably used.
  • first support and the second support may be the same or different.
  • the resin film examples include resin films such as polyester (for example, polyethylene terephthalate (polyester), polyethylene naphthalate, polypropylene terephthalate, etc.), polyurethane, silicone, polyolefin (for example, polyethylene, polypropylene, etc.), polystyrene, etc.
  • resin films such as polyester (for example, polyethylene terephthalate (polyester), polyethylene naphthalate, polypropylene terephthalate, etc.), polyurethane, silicone, polyolefin (for example, polyethylene, polypropylene, etc.), polystyrene, etc.
  • polyester for example, polyethylene terephthalate (polyester), polyethylene naphthalate, polypropylene terephthalate, etc.
  • polyurethane silicone
  • polyolefin for example, polyethylene, polypropylene, etc.
  • polystyrene etc.
  • polyethylene terephthalate (Mending) is preferable
  • the thickness of the first support and the second support is not particularly limited, but from the viewpoint of excellent handleability when applied to the mouth-to-roll method and the ease of peeling, 100 ! ⁇ 100 is preferred, 2011 ⁇ 100 is more preferred ⁇ 0 2020/175681 18 ⁇ (: 171? 2020 /008363
  • the first support and the second support are peeled off at the time of application to the skin, and therefore, between the first support and the first layer, and between the second support and the second layer. It is preferable to have a peeling property between them.
  • At least one of the first support side of the first support and the second support side of the second support has a silicone layer or is surface-treated with silicone, if necessary. ..
  • the silicone layer may be a layer containing a silicone polymer, and is preferably a layer containing a fluorosilicone polymer having a substituent containing a fluorine atom or a fluorine atom in the molecule (hereinafter, also referred to as a fluorosilicone layer). ..
  • a fluorosilicone layer By adjusting the amount of fluorine atoms in the fluorosilicone polymer, the peelability from the first layer and the second layer can be controlled.
  • the surface treatment with silicone includes, for example, surface treatment using liquid phase film formation using a solution coating/drying method.
  • surface treatment with a fluorine-containing compound may be used, for example.
  • surface treatment using vapor phase film formation such as sputtering or vapor deposition is applied.
  • first support and the second support commercially available products may be used.
  • commercially available products include a release film (for example, a fluorosilicone release film, etc.) having a silicone layer manufactured by Fujiko Co., Ltd. on one side or both sides.
  • the skin patch laminate of the present disclosure is preferably produced by the following method (that is, the method for producing the skin patch laminate of the present disclosure).
  • the method for producing a skin patch laminate of the present disclosure includes a step 8 of forming a first layer containing a silicone elastomer, and a step of forming a second layer having adhesiveness.
  • the tensile stress at 40% elongation of the laminate of the first layer and the second layer is ⁇ . ⁇ 02020/175681 19
  • the following is a method for producing a laminate for skin application (hereinafter, also referred to as a method for producing a laminate).
  • a first layer containing a silicone elastomer is formed.
  • the method for forming the first layer is not limited, but the following steps are preferable.
  • a coating liquid (hereinafter, also referred to as coating liquid!-1) containing a silicone polymer having a crosslinkable group, a crosslinking agent, and a solvent is applied onto the first support and dried to form a first coating.
  • coating liquid!-1 a coating liquid containing a silicone polymer having a crosslinkable group, a crosslinking agent, and a solvent is applied onto the first support and dried to form a first coating.
  • the eighth step of forming a layer is preferable.
  • Step 8 is to coat and dry a coating solution (hereinafter also referred to as coating solution 1-2) containing a silicone polymer having a crosslinkable group, a crosslinking agent, silica particles, and a silicone solvent on the first support. Then, the step of forming the first layer is preferable.
  • a coating solution hereinafter also referred to as coating solution 1-2
  • the step is formed by applying and drying the coating liquid !_ 1 or !_ 2 on the first support.
  • the first support that is continuously conveyed is used and that the steps and the steps described below are performed by a mouth-to-roll method.
  • silicone polymer having a crosslinkable group, the crosslinker, and the silica particles contained in 1 and 1_2 include the components described in the section of the first layer, and the preferred embodiments are also the same. ..
  • the solvent contained in 1 and !_ 2 is preferably a good solvent for a silicone polymer having a crosslinkable group.
  • the good solvent for the silicone polymer having a crosslinkable group include silicone solvents, ethyl acetate, heptane, tetrahydrofuran, methyl ethyl ketone, and the like.
  • the solvents contained in the coating liquids 1_1 and 1-2 may be used alone or in combination of two or more. Above all, a silicone-based solvent is preferable as the solvent contained in the coating liquids !_ 1 and !_ 2. ⁇ 0 2020/175681 20 ⁇ (: 171? 2020 /008363
  • Coating liquid! -1 and the silicone solvent contained in the coating liquid 1_2 are preferably cyclic siloxanes such as hexamethylcyclotrisiloxane, octamethylcyclotetrasiloxane, and decamethylcyclotetrasiloxane (also referred to as cyclopentasiloxane).
  • Coating liquid !_ 1 and coating liquid !_ 2 may each contain the other components described in the section of the first layer.
  • the coating liquid 1-1 and the coating liquid !_2 may contain a reaction retarder, a reaction inhibitor, etc. used in the reaction for obtaining the silicone elastomer.
  • the reaction retarder or reaction inhibitor is preferably a component that does not easily remain in the first layer, and is preferably a volatile (for example, boiling point is 100 ° C. or less) compound. It is more preferable that the compound has a boiling point lower than that of the solvent (eg, silicone-based solvent such as cyclic siloxane) contained in _ 1 and the coating liquid !_ 2.
  • the reaction retarder or reaction inhibitor include, for example, acetylene alcohols (eg, 2-methyl-3-butyne-2-yl), cyclic siloxanes (eg, tetravinyltetramethylcyclotetrasiloxane), etc. Is mentioned.
  • the solid content (total amount of components excluding the solvent) in the coating liquid !_ 1 and the coating liquid !_ 2 depends on the ease of applying the coating liquid, the ease of feeding and filtering the coating liquid, and the like. It may be determined according to the conditions, preferably 10% by mass to 70% by mass, more preferably 15% by mass to 65% by mass, further preferably 20% by mass to 50% by mass.
  • Examples of the first support used in step 8 include the above-mentioned first support, and the preferred embodiments are also the same.
  • the first support used in step 8 preferably has a silicone layer on the surface on the first layer side from the viewpoint of enhancing the releasability from the first layer.
  • Coating liquid !_ 1 or coating liquid! As the coating method of -2, a known coating method can be applied. ⁇ 0 2020/175681 21 ⁇ (: 171? 2020 /008363
  • Specific coating methods include force-ten coating method, dip coating method, spin coating method, print coating method, spray coating method, slot coating method, mouth coating method, slide coating method, blade coating method. Method, gravure coating method, wire bar method and the like.
  • the slot coating method is preferable as the coating method when the step 8 is performed by the mouth toe roll method using the first support which is continuously conveyed.
  • drying method examples include a method using an oven, a warm air blower, an infrared ray (see [3 ⁇ 4] heater), and the like.
  • warm air may be applied from the surface of the first support opposite to the surface coated with the coating liquid.
  • the drying conditions e.g., in the range of 7 0 ° ⁇ ⁇ 1 1 0 ° ⁇ , between 1 0 minutes to 3 0 minutes is preferred.
  • the first layer after drying may be heated to remove the reaction delay agent, reaction inhibitor, etc. contained in the coating liquid !_ 1 and the coating liquid !_2. .. Heating conditions during this heating may, for example, in the range of 7 0 ° ⁇ ⁇ 1 5 0 ° ⁇ , preferably 3 0 minutes to 9 0 minutes.
  • the second layer having adhesiveness is formed.
  • the process step may be, for example, a step of forming the second layer on the second support described later, or a step of forming the second layer on the first layer formed in step 8. Good.
  • the process step is a process of forming the second layer on the second support
  • the first layer is formed on the formed second layer in step 8
  • the laminated body of the present disclosure is manufactured. Good.
  • the process step is a process of forming the second layer on the second support
  • the second layer formed and the first layer formed on the first support in step 8 are attached. match ⁇ 0 2020/175681 22 ⁇ (: 171? 2020 /008363
  • the laminated body of the present disclosure may be manufactured.
  • the process step is a step of forming the second layer on the first layer formed in step 8.
  • the process step is preferably a process of forming a second layer by applying a coating liquid containing an adhesive (hereinafter, also referred to as coating liquid 1-3) on the first layer and drying the coating liquid. ..
  • a coating liquid containing an adhesive hereinafter, also referred to as coating liquid 1-3
  • Examples of the adhesive contained in the coating liquids 1_3 include the adhesives described in the section of the second layer, and the preferred embodiments are also the same.
  • the coating liquids 1_3 preferably contain a solvent together with the adhesive.
  • the solvent contained in the coating liquids 1_3 is preferably a good solvent for the base polymer in the adhesive.
  • the adhesive contained in 1_3 is a silicone-based adhesive
  • silicone-based solvents include the silicone-based solvents contained in coating liquid !-1 and coating liquid !_2.
  • the solid content (total amount of components excluding the solvent) in the coating liquid 1-3 is determined according to the ease of applying the coating liquid, the ease with which the coating liquid is delivered and filtered. Of course, 10 mass% to 65 mass% is preferable, 15 mass% to 60 mass% is more preferable, and 25 mass% to 55 mass% is further preferable.
  • Examples of the coating method and the drying method used in the process step include the coating method and the drying method in the step, and preferred embodiments are also the same.
  • the first support to be conveyed be used to carry out the steps and steps in a mouth-to-roll method.
  • step 8 in order to protect the first layer, the following steps should be performed between step 8 and step ⁇ 0 2020/175681 23 ⁇ (: 171? 2020 /008363
  • step 81 and step 82 It is preferable to carry out step 81 and step 82.
  • the first support having the first layer may be wound after the process 8 but before the process. is there.
  • the first layer may be damaged. Therefore, it is preferable to protect the surface of the first layer by performing the following steps 81 and 82 between step 8 and step.
  • step 81 a protective film is attached to the surface of the first layer formed in step 8.
  • the protective film it is preferable that at least the surface in contact with the first layer has releasability from the first layer.
  • the protective film examples include a Mitsuhachi (ethylene-vinyl acetate copolymer resin) film (commercially available products include, for example, 803 series of Sanae Kaken Co., Ltd. 80 series), polyolefin film ( Examples of commercially available products include surface protective films of Toray Industries, Inc., Tretec (registered trademark) series, and the like.
  • Mitsuhachi ethylene-vinyl acetate copolymer resin
  • commercially available products include, for example, 803 series of Sanae Kaken Co., Ltd. 80 series
  • polyolefin film examples include surface protective films of Toray Industries, Inc., Tretec (registered trademark) series, and the like.
  • a known film laminating method such as a mouth laminating method can be applied.
  • step 82 the protective film attached in step 81 is peeled from the surface of the first layer.
  • Examples of the hydrophilic treatment for the surface of the first layer performed in step 83 include corona treatment and plasma treatment. Particularly, from the viewpoint of productivity and the viewpoint of equipment maintenance, corona treatment is preferable.
  • the corona treatment device used for corona treatment is not particularly limited, for example, vetaphone, In addition to the corona treatment equipment that can be processed by the mouth-to-roll method such as manufactured by the company, there is a Tatsumi (3 _ 4) manufactured by Kasuga Electric Co., Ltd.
  • the conditions for the hydrophilization treatment may be appropriately determined, for example, so that the contact angle is as shown below.
  • the surface of the first layer hydrophilized in step 83 was 1 ⁇ 1-methyl-2-pyrrolidone (hereinafter, Also referred to as a contact angle) is preferably 60 degrees or less, and more preferably 50 degrees or less.
  • a contact angle meter for example, mouth 1 ⁇ /1 ⁇ _7101 of Kyowa Surface Science Co., Ltd.
  • the contact angle shall be measured at 25°°.
  • step ⁇ 3 of laminating the second support on the second layer after the second layer is formed in the step it is preferable to have a step ⁇ 3 of laminating the second support on the second layer after the second layer is formed in the step.
  • Examples of the second support used in the step ⁇ include the above-mentioned second support, and the preferred embodiments are also the same.
  • the second support used in the step ⁇ has a silicone layer on the surface on the second layer side from the viewpoint of enhancing the releasability from the second layer.
  • the laminate of the present disclosure can be manufactured as described above.
  • the application of the laminate of the present disclosure is not particularly limited as long as it is applied to the skin of the application target person. ⁇ 0 2020/175681 25 ⁇ (: 171? 2020 /008363
  • the laminate of the present disclosure is applied without feeling uncomfortable, follows the movement of the skin, and has excellent permeability of water vapor released from the skin, it is a use for a long time of application of the present disclosure. The effect of the laminated body is easily exhibited.
  • the laminate of the present disclosure is preferably used for a living body monitoring device, a display element, a wound dressing material, a transdermal preparation, or a cosmetic product.
  • a biological monitoring device it can be attached to the skin of the target person to obtain biological information of the target person (for example, skin temperature, blood pressure, blood oxygen concentration, heart rate, pulse rate, UV dose, activity level, heart rate, heart rate). Examples include electric monitors, wearable devices that measure sweat ( ⁇ ! ⁇ !, etc.).
  • the layered product of the present disclosure can be applied to a part to be attached to the skin that is a part of the biological monitoring device.
  • the display element has, for example, a display function (for example, an organic semiconductor 1_display, etc.), and by sticking it on the skin of the person to whom it is applied, by sticking it on the skin of the person to whom it is applied, Examples include wearable devices that display information (the same as above) and other information (for example, mobile terminal information).
  • the laminated body of the present disclosure can be applied to a part to be attached to the skin which is a part of the display element.
  • Wound dressings also called dressings, are laminates that are used to cover skin wounds, burns, etc. by applying them to the skin of the person to whom they are applied.
  • the laminate of the present disclosure may be used as a wound dressing itself, may be applied to the joining portion to the skin is a _ part of the wound dressing.
  • the transdermal preparation is a laminate used for percutaneously absorbing the drug contained in the transdermal preparation by applying it to the skin of the application subject.
  • the layered product of the present disclosure preferably contains a drug in the second layer and is used as a transdermal preparation itself.
  • the layered product of the present disclosure is applied to the skin of an application target, for example, as a cosmetic to beautify the skin. You may use.
  • the laminate of the present disclosure may be used as a cosmetic for the purpose of concealing wounds, spots, tattoos, etc. on the skin, or as a cosmetic for the purpose of filling or extending wrinkles on the skin. Good. ⁇ How to use the laminate>
  • the layered product of the present disclosure is used by being attached to the skin of the person to whom it is applied, but the place of attachment is not particularly limited.
  • the laminate of the present disclosure may be attached, for example, a nail or the like, or may be attached across both the skin and the nail, as long as the adhesiveness can be exhibited.
  • the laminate of the present disclosure can be applied to a joint site such as a knee, an elbow, or a finger, since it can be applied without a feeling of strangeness and follows the movement of the skin.
  • the application time may be, for example, 48 hours or more.
  • the vial silica particles Alfa Corp., Si I icon (IV) oxide , amorphous fume d, surface treated, the specific surface area by the B ET method: 205 m 2 / g ⁇ 245 m 2 / g, CAS 7631-86-9 ), cyclopentasiloxane (manufactured by Shin-Etsu Chemical Co., Ltd., K F-995) loxane), vinyl terminated, weight average molecular weight ⁇ 25,000, viscosity 850-1 ,150 c St) and stir until the powder of silica particles dissolves.
  • a metal catalyst (abbreviated as Pt catalyst, platinum ( ⁇ ) — 1,3-divinyl-1,1,1,3,3-tetramethyldisiloxane complex solution ( Aldrich)) is added in an amount of 500 ppm with respect to the total mass of the coating solution, and the mixture is stirred for 30 minutes.
  • Pt catalyst platinum ( ⁇ ) — 1,3-divinyl-1,1,1,3,3-tetramethyldisiloxane complex solution ( Aldrich)
  • H — PDMS methylhydrosiloxane and dimethylsiloxane
  • Polv dimethylsi loxane-co-methy [hydros i loxane), tr imethy isiily terminated, number average molecular weight ⁇ 13,000, methy Ihydrosi loxane 3 ⁇ 4mol
  • number average molecular weight ⁇ 13,000, methy Ihydrosi loxane 3 ⁇ 4mol was added and stirred to obtain a coating solution for forming the first layer.
  • the coating liquid for forming the first layer was diluted with cyclopentasiloxane so that the solid content of silica particles, V-P DMS, and H-P D MS was 65% by mass.
  • a release film having a fluorosilicone layer on the surface of the PET film (manufactured by Fujiko, model number K1, thickness 50 Mm) was prepared.
  • the coating liquid for forming the first layer was applied onto the fluorosilicone layer of the first support by adjusting the thickness so that the coating amount was appropriate to obtain a desired film thickness.
  • the coating solution was applied 2 minutes after the copolymer of methylhydrosiloxane and dimethylsiloxane was added.
  • the cyclopentasiloxane was removed by performing a drying treatment for 1 hour in a blast dryer at 90°C to form a first layer.
  • the surface of the first layer was subjected to corona treatment to make the surface hydrophilic.
  • corona treatment device TEC-4AX manufactured by Kasuga Electric Co., Ltd. was used. Corona treatment conditions were 0.74 J/cm 2 .
  • the contact angle between the surface of the first layer and NMP after corona treatment was 60 degrees or less in all cases.
  • the contact angle between the surface of the first layer after corona treatment and NMP was measured by the method described above.
  • a silicone adhesive (Bio PSA 7 -4202, manufactured by Dow Corning) was diluted with ethyl acetate to prepare a coating solution for forming the second layer.
  • a second layer was formed by removing ethyl acetate by drying in a machine for 1 hour.
  • a release film having a fluorosilicone layer on the surface of the Mending film (manufactured by Fujico, model number [ ⁇ 1, thickness 50) was attached to obtain a laminate.
  • Example 14 A laminated body of Example 14 was obtained in the same manner as in Examples 1 to 13 except that the formation of the second layer was changed as follows.
  • Styrene-isoprene-styrene block copolymer a thermoplastic elastomer 3 I 3500 2 (trade name)) 50 parts by mass, and Alcon (registered trademark) which is an alicyclic saturated hydrocarbon resin as an adhesiveness-imparting agent.
  • the total amount of the thermoplastic elastomer and the tackiness-imparting agent is 15% by mass with respect to the total mass of the rubber-based pressure-sensitive adhesive, and is dissolved in the above mixed solvent. , Sufficiently stirred.
  • the coating liquid for forming the second layer is applied on the first layer by adjusting the thickness so as to obtain an appropriate coating amount to obtain a desired film thickness, and then applied by a blast dryer at 90° ⁇ .
  • the above mixed solvent was removed by drying for 1 hour to form the second layer.
  • Example 15 a laminate of Example 15 was obtained.
  • the coating liquid for forming the second layer is applied on the first layer by adjusting the thickness so as to obtain an appropriate coating amount to obtain a desired film thickness, and then in a 90 ° blast dryer. Ethyl acetate was removed by drying for 1 hour to form a second layer.
  • Tegaderm registered trademark, 3M Japan KK, 1621, 1 0001X 1 20111 was used.
  • the numerical value shown in the column of “total thickness of the first layer and the second layer” is the thickness after peeling the release film from Tegaderm in Comparative Example 1, and in Comparative Example 2, It is the thickness of I 808.
  • the stress, the tensile stress at 40% elongation, and the tensile elongation at break were measured by the methods described above.
  • test piece was cut out so that the distance between them was 40, and the tensile stress at 40% elongation and the tensile elongation at break were measured by the method described above.
  • Comparative Example 1 Cut the laminated body in each example into 2 0 01 01 X 4 00! On the back of the right hand of 3 testers, then peel off the 1st support and the 2nd support, and the 1st layer and the 2nd layer. Was laminated.
  • Comparative Example 1 with regard to Tegaderm, the release film attached to the adhesive layer was removed to obtain 2 0 ⁇ 1 01 X 4 It was cut into pieces and attached to the backs of the right hands of the three testers.
  • Comparative Example 2 is ⁇ ⁇ 8_ It sticked out and stuck to the back of the right hand of the three testers.
  • Comparative Example 2 is ⁇ ⁇ 8_ It sticked out and stuck to the back of the right hand of the three testers.
  • Three testers evaluated the weight and the feeling of foreign matter (immediately, the feeling of foreign matter on the skin) at the location where the laminate was applied, according to the following three grades. The evaluation points of the three testers were averaged, and this was taken as the evaluation result of the feeling of foreign matter.
  • At least one of the weight and the feeling of foreign matter is not felt at all: 5 points
  • the laminated body in each example was cut into 2 0 01 01 X 400 !!! on the inner side of the upper arms of the three testers, and then the first support and the second support were peeled off, and the first layer and the second support were separated. A laminate of layers was applied.
  • Comparative Example 1 with regard to Tegaderm, the release film attached to the adhesive layer was removed to obtain 2 0 ⁇ 1 01 X 4 It was cut out and attached to the inside of the upper arms of the three testers.
  • Comparative Example 2 is ⁇ ⁇ 81 It sticked out and stuck to the inside of the upper arms of the three testers.

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Abstract

Un mode de réalisation de la présente invention concerne : un corps stratifié destiné à adhérer à la peau, qui comporte une première couche contenant un élastomère de silicone et une seconde couche qui est en contact avec la première couche et est adhésive, le produit stratifié de la première couche et de la seconde couche présentant une contrainte de traction, à 40% d'allongement, inférieure ou égale à 0,8 MPa et une épaisseur totale inférieure ou égale à 1 mm ; et un procédé de production du corps stratifié destiné à adhérer à la peau.
PCT/JP2020/008363 2019-02-28 2020-02-28 Corps stratifié destiné à adhérer à la peau et son procédé de production Ceased WO2020175681A1 (fr)

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JP2010132350A (ja) * 2008-10-01 2010-06-17 Nippon Electric Glass Co Ltd ガラスロール及びガラスロールの処理方法
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Publication number Priority date Publication date Assignee Title
JP2023045146A (ja) * 2021-09-21 2023-04-03 大日本印刷株式会社 積層シート、肌意匠シート及び肌意匠シート製造方法
JP7771588B2 (ja) 2021-09-21 2025-11-18 大日本印刷株式会社 肌意匠シート及び肌意匠シート製造方法

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