WO2020211399A1 - Procédé et appareil d'envoi de données, dispositif informatique, et support d'informations - Google Patents

Procédé et appareil d'envoi de données, dispositif informatique, et support d'informations Download PDF

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Publication number
WO2020211399A1
WO2020211399A1 PCT/CN2019/123444 CN2019123444W WO2020211399A1 WO 2020211399 A1 WO2020211399 A1 WO 2020211399A1 CN 2019123444 W CN2019123444 W CN 2019123444W WO 2020211399 A1 WO2020211399 A1 WO 2020211399A1
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WIPO (PCT)
Prior art keywords
sample
information sheet
processed
computer
target data
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Ceased
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PCT/CN2019/123444
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English (en)
Chinese (zh)
Inventor
葛毅
曹敏
顾思健
闵文波
郑秋艳
程志鹏
廖国娟
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Genewiz Suzhou Ltd
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Genewiz Suzhou Ltd
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Definitions

  • the present disclosure relates to the field of biotechnology, for example, to a data transmission method, device, device, and storage medium.
  • the embodiments of the present invention provide a data sending method, device, device, and storage medium to facilitate users to understand the meaning of data collected by the device, and send different data to users who need the data, thereby improving user experience.
  • the embodiment of the present invention provides a data sending method, including:
  • Determining the sample information sheet and the item information sheet according to the sample to be processed may include:
  • the sample information sheet and the project information sheet according to the sample to be processed may further include:
  • a working directory is created, and the working directory is used to store sample information sheets and project information sheets.
  • the embodiment of the present invention also provides a data sending device, which includes:
  • the acquisition module is set to acquire samples to be processed
  • a determining module configured to determine a sample information sheet and an item information sheet according to the sample to be processed
  • the analysis module is configured to perform biological analysis on the sample to be processed according to the sample information sheet and the item information sheet to obtain target data;
  • the sending module is configured to split the target data and send the split target data to the corresponding terminal devices respectively.
  • the determining module may be set to:
  • the device may also include:
  • the creation module is set to create a working directory, and the working directory is used to store sample information sheets and project information sheets.
  • the device may also include:
  • the setting module is set to set the computer parameters according to the preset rules.
  • the embodiment of the present invention also provides a computer device, including a memory, a processor, and a computer program stored in the memory and capable of running on the processor.
  • a computer device including a memory, a processor, and a computer program stored in the memory and capable of running on the processor.
  • any computer device can be implemented as in the embodiment of the present invention. 1.
  • the embodiment of the present invention also provides a computer-readable storage medium on which a computer program is stored.
  • the program is executed by a processor, the data sending method as described in any of the embodiments of the present invention is implemented.
  • the embodiment of the present invention obtains a sample to be processed, determines a sample information sheet and an item information sheet according to the sample to be processed, performs biological analysis on the sample to be processed according to the sample information sheet and the item information sheet, and obtains target data.
  • the data is split, and the split target data is sent to the corresponding terminal devices, which can improve the user experience.
  • FIG. 1 is a flowchart of a data sending method in Embodiment 1 of the present invention
  • FIG. 3 is a schematic structural diagram of a data sending device in Embodiment 3 of the present invention.
  • Fig. 4 is a schematic structural diagram of a computer device in the fourth embodiment of the present invention.
  • FIG. 1 is a flowchart of a data sending method provided in Embodiment 1 of the present invention. This embodiment is applicable to the situation of data sending. The method may be executed by the data sending device in the embodiment of the present invention, and the device may use software. And/or hardware implementation, as shown in Figure 1, the method includes the following steps:
  • the sample to be processed may be a cell sample sent by another company, or may be another sample that requires biological research, which is not limited in the embodiment of the present invention.
  • obtaining the sample to be processed may be to obtain the sample to be processed sent by company A, and obtain the sample to be processed sent by company B.
  • S120 Determine a sample information sheet and an item information sheet according to the sample to be processed.
  • the sample information sheet includes the number of samples, the name of the sample, other information of the sample, and the grouping situation of the sample, for example, a group of 10 cells.
  • the project information sheet includes the company name or company code corresponding to the sample, or other characteristics that can characterize the company to which the sample belongs.
  • the project information sheet may include: sample Q sent by company A and sample W sent by company B .
  • the method before determining the sample information sheet and the item information sheet according to the sample to be processed, the method further includes:
  • before creating the working directory it further includes:
  • S130 Perform biological analysis on the sample to be processed according to the sample information sheet and the item information sheet to obtain target data.
  • the biological analysis of the sample to be processed can be performed by the device for parameter collection of the sample to be processed, and then the collected data can be analyzed, or the biological analysis of the sample to be processed can be directly performed by the device, which is not limited in the embodiment of the present invention.
  • the target data is related to the sample information sheet and the item information sheet.
  • the analysis result of company A’s cells is marked with the label corresponding to company A
  • the analysis result of company B’s cells is marked with the label corresponding to company B.
  • the analysis result of the cells and the label corresponding to the labeled company A, the analysis results of the cells of the B company and the label corresponding to the labeled B company are all target data.
  • S140 Split the target data, and send the split target data to corresponding terminal devices.
  • splitting according to the index is to find the serial number of the corresponding sample in the LIMS (Laboratory Information Management System, Laboratory Information Management System) through the index of the off-machine data, and perform fastq format conversion on the off-machine file. Find the corresponding BARCODE (label) according to the index, and then match it to the corresponding item, classify the off-machine data and transfer it to the corresponding RAWDATA (raw data) directory, generate QCsummary and perform final quality control operations.
  • LIMS Laboratory Information Management System
  • the target data is split, and the split target data are sent to the corresponding terminal devices.
  • the cell quality results corresponding to company A are The quality results are sent to the terminal device corresponding to company A, and company B needs to obtain the gene sequence of the cell, and then the gene sequence of the cell corresponding to company B is sent to the terminal device corresponding to company B.
  • the sample to be processed is acquired, the sample information sheet and the item information sheet are determined according to the sample to be processed, and the sample to be processed is subjected to biological analysis according to the sample information sheet and item information sheet to obtain target data.
  • Splitting the target data and sending the split target data to the corresponding terminal devices can improve the user experience.
  • FIG. 2 is a flowchart of a data sending method in the second embodiment of the present invention.
  • This embodiment is optimized based on the above-mentioned embodiment.
  • the sample information sheet and item information are determined according to the sample to be processed
  • the list includes: performing index optimization and reverse complementary deduplication on the samples to be processed to obtain optimized samples; obtaining sample information sheets and project information sheets according to the project type, computer parameters, platform type, package Lane type, and optimized samples.
  • the method of this embodiment includes the following steps:
  • S220 Perform index optimization and reverse complementary deduplication on the samples to be processed to obtain optimized samples.
  • inferior samples in the samples are removed to obtain optimized samples.
  • S230 Obtain a sample information sheet and a project information sheet according to the project type, computer parameters, platform type, package Lane type, and optimized sample.
  • Lanes will be arranged in the LIMS system, and multiple Lanes will be aggregated into a single Run (sequencing chip), the project and platform type will be configured according to the customer's requirements, and the computer parameters will be set according to the sample information And the package Lane type.
  • Run sequencing chip
  • S240 Perform biological analysis on the sample to be processed according to the sample information sheet and the item information sheet to obtain target data.
  • S250 Split the target data, and send the split target data to corresponding terminal devices.
  • the technical solution of this embodiment obtains samples to be processed, performs index optimization and reverse complementary deduplication on the samples to be processed, and obtains optimized samples, according to project type, computer parameters, platform type, package Lane type, and optimization
  • the sample obtains a sample information sheet and a project information sheet, performs biological analysis on the sample to be processed according to the sample information sheet and the project information sheet to obtain target data, splits the target data, and sends the split target data separately To the corresponding terminal device, it can improve the user experience.
  • FIG. 3 is a schematic structural diagram of a data sending device provided in Embodiment 3 of the present invention. This embodiment is applicable to the situation of data transmission, the device can be implemented in software and/or hardware, and the device can be integrated in any device that provides the function of data transmission. As shown in FIG. 3, the data sending device includes: an acquisition module 310, a determination module 320, an analysis module 330, and a sending module 340.
  • the obtaining module 310 is configured to obtain samples to be processed
  • the determining module 320 is configured to determine a sample information sheet and an item information sheet according to the sample to be processed;
  • the analysis module 330 is configured to perform biological analysis on the sample to be processed according to the sample information sheet and the item information sheet to obtain target data;
  • the sending module 340 is configured to split the target data, and send the split target data to corresponding terminal devices.
  • the determining module 320 is configured to:
  • the data sending device further includes:
  • the creation module is set to create a working directory, and the working directory is used to store sample information sheets and project information sheets.
  • the data sending device further includes:
  • the setting module is set to set the computer parameters according to the preset rules.
  • the above-mentioned device can execute the method provided by any embodiment of the present invention, and has corresponding functional modules and beneficial effects for executing the method.
  • the sample to be processed is acquired, the sample information sheet and the item information sheet are determined according to the sample to be processed, and the sample to be processed is subjected to biological analysis according to the sample information sheet and item information sheet to obtain target data.
  • Splitting the target data and sending the split target data to the corresponding terminal devices can improve the user experience.
  • FIG. 4 is a schematic structural diagram of a computer device in Embodiment 4 of the present invention.
  • Figure 4 shows a block diagram of an exemplary computer device 12 suitable for implementing embodiments of the present invention.
  • the computer device 12 shown in FIG. 4 is only an example, and should not bring any limitation to the function and application scope of the embodiment of the present invention.
  • the computer device 12 takes the form of a general-purpose computing device.
  • the components of the computer device 12 may include, but are not limited to: one or more processors or processing units 16, a system memory 28, and a bus 18 connecting different system components (including the system memory 28 and the processing unit 16).
  • the bus 18 represents one or more of several types of bus structures, including a memory bus or a memory controller, a peripheral bus, a graphics acceleration port, a processor, or a local bus using any bus structure among multiple bus structures.
  • these architectures include, but are not limited to, Industry Standard Architecture (ISA) bus, Micro Channel Architecture (MAC) bus, enhanced ISA bus, Video Electronics Standard Association (Vedio Electronic Standard) Association, VESA) local bus and Peripheral Component Interconnect (PCI) bus.
  • the computer device 12 typically includes a variety of computer system readable media. These media can be any available media that can be accessed by the computer device 12, including volatile and non-volatile media, removable and non-removable media.
  • the system memory 28 may include computer system readable media in the form of volatile memory, such as random access memory (RAM) 30 and/or cache memory 32.
  • the computer device 12 may further include other removable/non-removable, volatile/nonvolatile computer system storage media.
  • the storage system 34 may be used to read and write non-removable, non-volatile magnetic media (not shown in FIG. 4, usually referred to as a "hard drive").
  • a disk drive for reading and writing to removable non-volatile disks such as "floppy disks”
  • a removable non-volatile optical disk such as CD-ROM, DVD-ROM
  • each drive can be connected to the bus 18 through one or more data media interfaces.
  • the memory 28 may include at least one program product having a set of (for example, at least one) program modules, which are configured to perform the functions of the embodiments of the present invention.
  • a program/utility tool 40 having a set of (at least one) program modules 42 may be stored in, for example, the memory 28.
  • Such program modules 42 include, but are not limited to, an operating system, one or more application programs, and other programs Modules and program data, each of these examples or some combination may include the realization of a network environment.
  • the program module 42 generally executes the functions and/or methods in the embodiments described in the present disclosure.
  • the computer device 12 can also communicate with one or more external devices 14 (such as keyboards, pointing devices, displays 24, etc.), and can also communicate with one or more devices that enable users to interact with the computer device 12, and/or communicate with Any device (such as a network card, modem, etc.) that enables the computer device 12 to communicate with one or more other computing devices.
  • This communication can be performed through an input/output (I/O) interface 22.
  • the display 24 does not exist as an independent entity, but is embedded in a mirror surface. When the display surface of the display 24 is not displayed, the display surface of the display 24 and the mirror surface are visually integrated.
  • the computer device 12 may also communicate with one or more networks (for example, a local area network (LAN), a wide area network (WAN), and/or a public network, such as the Internet) through the network adapter 20.
  • networks for example, a local area network (LAN), a wide area network (WAN), and/or a public network, such as the Internet
  • the network adapter 20 communicates with other modules of the computer device 12 through the bus 18.
  • other hardware and/or software modules can be used in conjunction with the computer device 12, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives And data backup storage system, etc.
  • the processing unit 16 executes various functional applications and data processing by running programs stored in the system memory 28, such as implementing the data sending method provided by the embodiment of the present invention: acquiring samples to be processed; determining samples based on the samples to be processed Information sheet and item information sheet; according to the sample information sheet and item information sheet, biological analysis is performed on the sample to be processed to obtain target data; the target data is split, and the split target data are sent to the corresponding Terminal Equipment.
  • the fifth embodiment of the present invention provides a computer-readable storage medium on which a computer program is stored.
  • the program is executed by a processor, the method for sending data as provided in all the embodiments of the invention is realized: obtaining samples to be processed; The sample information sheet and the item information sheet are determined by the sample to be processed; the sample to be processed is subjected to biological analysis according to the sample information sheet and the item information sheet to obtain target data; the target data is split, and the split target The data are respectively sent to the corresponding terminal equipment.
  • the computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium.
  • the computer-readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or device, or a combination of any of the above. More specific examples (non-exhaustive list) of computer-readable storage media include: electrical connections with one or more wires, portable computer disks, hard disks, random access memory (RAM), read-only memory (ROM), Erasable programmable read-only memory (EPROM or flash memory), optical fiber, portable compact disk read-only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above.
  • the computer-readable storage medium can be any tangible medium that contains or stores a program, and the program can be used by or in combination with an instruction execution system, apparatus, or device.
  • the computer-readable signal medium may include a data signal propagated in baseband or as a part of a carrier wave, and computer-readable program code is carried therein. This propagated data signal can take many forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing.
  • the computer-readable signal medium may also be any computer-readable medium other than the computer-readable storage medium.
  • the computer-readable medium may send, propagate, or transmit the program for use by or in combination with the instruction execution system, apparatus, or device .
  • the program code contained on the computer-readable medium can be transmitted by any suitable medium, including but not limited to wireless, wire, optical cable, RF, etc., or any suitable combination of the above.
  • the computer program code used to perform the operations of the present disclosure can be written in one or more programming languages or a combination thereof.
  • the programming languages include object-oriented programming languages-such as Java, Smalltalk, C++, and also conventional Procedural programming language-such as "C" language or similar programming language.
  • the program code can be executed entirely on the user's computer, partly on the user's computer, executed as an independent software package, partly on the user's computer and partly executed on a remote computer, or entirely executed on the remote computer or server.
  • the remote computer can be connected to the user's computer through any kind of network (including a local area network (LAN) or a wide area network (WAN)), or it can be connected to an external computer (for example, using an Internet service provider to pass the Internet connection).
  • LAN local area network
  • WAN wide area network

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Abstract

Procédé et appareil d'envoi de données, dispositif et support d'informations. Ledit procédé consiste à : acquérir un échantillon à traiter (S110) ; déterminer une feuille d'informations d'échantillon et une feuille d'informations d'article selon ledit échantillon (S120) ; réaliser, en fonction de la feuille d'informations d'échantillon et de la feuille d'informations d'article, une analyse biologique sur ledit échantillon pour obtenir des données cibles (S130) ; et diviser les données cibles, et envoyer les données cibles divisées à un dispositif terminal correspondant respectivement (S140). La procédé améliore l'expérience d'usage d'un utilisateur.
PCT/CN2019/123444 2019-04-16 2019-12-05 Procédé et appareil d'envoi de données, dispositif informatique, et support d'informations Ceased WO2020211399A1 (fr)

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CN110033830A (zh) * 2019-04-16 2019-07-19 苏州金唯智生物科技有限公司 一种数据发送方法、装置、设备及存储介质
CN111767256B (zh) * 2020-05-22 2023-10-20 北京和瑞精湛医学检验实验室有限公司 一种从fastq文件分离出样本read数据的方法
CN112800147A (zh) * 2021-02-02 2021-05-14 北京明略昭辉科技有限公司 一种数据处理方法、装置、设备及存储介质

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