WO2020250014A1 - Dispositif de réparation de valve cardiaque - Google Patents

Dispositif de réparation de valve cardiaque Download PDF

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Publication number
WO2020250014A1
WO2020250014A1 PCT/IB2019/054987 IB2019054987W WO2020250014A1 WO 2020250014 A1 WO2020250014 A1 WO 2020250014A1 IB 2019054987 W IB2019054987 W IB 2019054987W WO 2020250014 A1 WO2020250014 A1 WO 2020250014A1
Authority
WO
WIPO (PCT)
Prior art keywords
leaflets
fastening device
releasable fastening
head portion
grasping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2019/054987
Other languages
English (en)
Inventor
Marco MOSCARELLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dicandia Andrea
La Tegola Rodolfo
Nasso Giuseppe
Spedicati Andrea
Speziale Giuseppe
Original Assignee
Dicandia Andrea
La Tegola Rodolfo
Nasso Giuseppe
Spedicati Andrea
Speziale Giuseppe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dicandia Andrea, La Tegola Rodolfo, Nasso Giuseppe, Spedicati Andrea, Speziale Giuseppe filed Critical Dicandia Andrea
Priority to PCT/IB2019/054987 priority Critical patent/WO2020250014A1/fr
Publication of WO2020250014A1 publication Critical patent/WO2020250014A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2463—Implants forming part of the valve leaflets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/122—Clamps or clips, e.g. for the umbilical cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/128—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
    • A61B17/1285—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008—Fixation appliances for connecting prostheses to the body
    • A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes

Definitions

  • the present invention relates generally to the field of circulatory valve repair.
  • the present invention more specifically, relates to an apparatus useful in the field of repairing heart valves for patients suffering from regurgitation.
  • mitral regurgitation has become one of the most frequent heart valve disease.
  • a significant number of patients with mitral or tricuspid regurgitation are often deemed not operable because at higher risk for surgery.
  • such patients can be treated with valve repair procedures that results from "edge-to-edge” surgical techniques.
  • said procedures typically provide for a device that is, preferably percutaneously, introduced and implanted into the patient's body, positioned at the valve to be repaired. Edges (or leaflets) of the valve are grasped and clipped together by said device to significantly reduce (or even cancel) the regurgitation. In this way, it is allowed to repair a valve defect without subjecting the patient to a proper cardiac surgery.
  • MITRACLIP® from Abbot is a device that acts at the mitral leaflets. Although has reported to be safe, it is associated to suboptimal results, both in terms of reducing the degree of mitral regurgitation and increasing the expectation of live and heart related events in terms of hospital readmission/ heart failure. Summary of the Invention
  • the technical problem placed and solved by the present invention is then to provide an apparatus for repairing a valve, in particular a heart valve, that allows to overcome the above-illustrated drawbacks with reference to the prior art.
  • the apparatus according to the present invention is structurally simple, economical to be realized and allows to obtain a significant reduction of regurgitation of the valve to be treated.
  • the above-mentioned apparatus is composed of several adjustable components that allows to operate in a reversible manner until the detachment of a releasable fastening device equipped with grasping means is performed.
  • a preferred embodiment of the apparatus of the present invention is suitable for repairing a valve having leaflets, in particular a heart valve, and it is configured to be percutaneously inserted in a patient body.
  • Said apparatus comprises an elongated hollow body provided with a head portion at a longitudinal distal end thereof and a releasable fastening device, positioned within said head portion, provided with grasping means configured to grasp the leaflets.
  • the apparatus also comprises steering means configured to position and release said releasable fastening device.
  • the head portion is provided with at least an opening configured to receive leaflets therethrough and the apparatus further comprises suction means, selectively operable to catch the leaflets inside the head portion so as to grasp and coapt the leaflets by said grasping means.
  • the invention provides for the possibility of “bite” edges - or leaflets - of a valve of a patient body that are spaced apart from each other, either stationary and in motion, through the adjustable and remotely controllable releasable fastening device, decreasing the gap therebetween.
  • the apparatus is provided with a suction system which allows to foster the engaging of leaflets and to provide a precise positioning of the fastening device for grasping leaflets of the valve.
  • a preferred embodiment of the apparatus comprises means for orbiting the releasable fastening device about an axis, coaxial with a longitudinal direction of development of the elongated hollow body, the latter preferably being provided of two opposing openings at said head portion.
  • Such a solution reduces the need for a rotation and/or orbitational movement of the fastening device at the leaflets level, due to the 180°-degree oriented double catching openings. In this way, less rotational movements are needed accomplishing fast delivery and reduced operation time.
  • the apparatus according to the present invention is capable of insertion through multiple and simultaneous access sites so as that one or more releasable fastening device can be implanted, for example via pulmonary vein and/or trans-septal, in order to achieve a better catching and leaflets grasping.
  • FIG. 1 shows a longitudinal-section of a prospective view of a preferred embodiment of a terminal end of an apparatus for repairing a heart valve having leaflets according to the present invention partially about to engage with said leaflets;
  • figure 2A shows a longitudinal-section of a frontal view of the terminal end shown in figure 1 ;
  • figure 2B shows a longitudinal-section of the terminal end shown in figure 1 from a partially rotated side view
  • FIG. 3A-3F shows in sequence operative configurations of the releasable fastening device from an open position to a grasping position of leaflets of a heart valve through a preferred embodiment of the apparatus according to the present invention
  • figure 4 shows a prospective view of steering means and the releasable fastening device of the terminal end shown in figure 1 , wherein the elongated hollow body is not shown;
  • FIG. 5 shows a schematic view of a preferred embodiment of an apparatus according to the present invention in conjunction with further devices that can be associated with and/or implemented in it.
  • the invention is intended for the use in the field of surgical medical devices for operations at internal organs of the human body, in particular at the heart valves.
  • the present invention finds application for correcting both degenerative primary and secondary mitral regurgitation as well as tricuspid regurgitation.
  • the apparatus according to the present invention is composed of several adjustable components that allows to operate in a reversible manner until the detachment of a releasable fastening device equipped with grasping means is performed. Said apparatus will be described with reference to a preferred embodiment shown figure 1.
  • a method of treating regurgitation of a heart valve having leaflets is also provided. Preferred steps of such method are schematically shown with reference to figures 3A-3F and will be described in the following.
  • the present description primarily focuses on the terminal portion of the apparatus, i.e. the portion bearing the releasable fastening device.
  • the apparatus of the present invention is provided or associated with further components, schematically and partly illustrated in figure 5 and related to auxiliary units such as, for example, means for maneuvering the apparatus and intended for use by the health operator as well as further devices configured to be used in conjunction with the apparatus itself.
  • the apparatus is suitable to be percutaneously inserted in the human body, providing for a minimally invasive device for repairing regurgitation, preferably of the mitral valve, through a clipping-like mechanism of both anterior and posterior mitral leaflet on beating heart.
  • the apparatus is capable of different access sites for insertion, for example through the right upper pulmonary vein via right minimally invasive thoracotomy, mini stemotomy or median sternotomy or through the right atrium or the atrial septum as well as an insertion through the left ventricle apex via left mini minimally invasive thoracotomy.
  • the apparatus is capable of insertion preferably through the jugular vein or the right atrium.
  • Multiple and/or simultaneous access sites can be used, e.g. pulmonary vein and atrial septum, so as both mitral and tricuspid valve can be advantageously treated at the same time.
  • two or more releasable fastening devices can be inserted (e.g. pulmonary vein and trans-septal) in order to achieve better leaflets catching and grasping.
  • the apparatus comprises an elongated hollow body 30 provided with a head portion 31 at a longitudinal distal end E thereof.
  • Said elongated hollow body 30 is preferably in the form of a tube manufactured so as to be suitable for use in medical applications for which an insertion in a patient body is envisaged.
  • said hollow body 30 has circular section and a thickness suitable for carrying out its function of rigidity and flexibility.
  • the hollow body 30 presents a length comprised between 20 and 50 cm and have a diameter of about 5 mm. It also performs the function of enclosing and protecting inside it steering means 20 that allows to transmit and/or control motion of the releasable fastening device 10 positioned within the head portion 31.
  • Said steering means 20 is preferably arranged inside said elongated hollow body 30 in such a way as to define an annulus 40 between the inner surface of the elongated hollow body 30 and the steering means 20.
  • the annulus 40 extends through terminal ends of the elongated hollow body 30.
  • Said steering means 20 is preferably disposed concentrically to the hollow body 30 and has a size suitable for containing for example transmission cables and, at the same time, leaving empty space inside the hollow body 30 to allow the passage of fluids, in particular blood, like in a catheterization system.
  • said steering means 20 is configured to position and release said releasable fastening device 10 which is provided with grasping means 11 configured to grasp the leaflets 2 of the valve to be treated or suffering from regurgitation.
  • the steering means 20 is steered and actuated by the use of control knobs, levers and fasteners located for example at the handles of the apparatus 100, if the latter were provided with.
  • the apparatus 100 may preferably include the use of control means, like a joystick, and the possible passage of fluids through the annulus 40 occurs by means of a suction provided by a unit arranged at a proximal end of said elongated hollow body 30, for example incorporated in said control means.
  • the apparatus 100 further comprises suction means 50 selectively operable to catch the leaflets 2 inside the head portion 31 so as to grasp and to coapt the leaflets 2 by said grasping means 11.
  • suction means 50 selectively operable to catch the leaflets 2 inside the head portion 31 so as to grasp and to coapt the leaflets 2 by said grasping means 11.
  • the head portion 31 of the hollow body 30 is provided with at least an opening 32 configured to receive leaflets 2 therethrough.
  • said annulus 40 is in a fluid communication with said at least an opening 32 and said suction means 50.
  • embodiments may provide a passage in the annulus 40 for the fluids to be sucked distinct from a passage dedicated to the vacuum with negative pressure supplied by said suction means 50 that attracts the leaflets 2 through said at least an opening 32.
  • a preferred embodiment of the apparatus 100 is provided with a pump, for example a roller pump 60, connected to the elongated hollow body 30 in order to wash undesired blood into a reservoir. Blood may be then processed and returned to the patient.
  • a pump for example a roller pump 60
  • the suction means 50 is configured to supply a high negative pressure, for example a vacuum system configured to supply a negative pressure up to 300 mmHg, and to be activated in response to a signal associated with the electrical activity of the heart, in particular a systole phase.
  • the apparatus 100 is configured to be associated with a device configured to detect the electrical activity of the heart, for example an ECG 70, and the suction can be activated during systole at the moment of the closure of the leaflets.
  • the suction can be activated in synchrony with the ECG in order to bite timely the mitral leaflets with the releasable fastening device.
  • Alert means 80 may also be envisaged so as to indicate to the health operator the engagement of the releasable fastening device 10 with the leaflets 2.
  • two different illuminable sensors can be provided at the head portion 31 of the hollow body 30, wherein a green light is emitted in case both leaflets are received into said at least an opening 32. Otherwise, for example a red light, would be emitted.
  • embodiment of the apparatus 100 may be provided with a blood filter 90 apt to reduce the suctioning capability of the elongated hollow body 30.
  • the sucking of the fluid may also be reduced by the walls of the hollow body, whose structure can preferably be configured to collapse in case the pressure exceeds, for example, a predetermined threshold value.
  • the head portion 31 has an opening 32 for each leaflet 2 to be received. More preferably the head portion 31 comprises two opposing openings 32 each configured to receive therethrough a leaflet of the valve. In such a way both anterior and posterior mitral leaflet can be engaged.
  • the releasable fastening device comprises a top and a bottom element 10A, 10B bearing respective coupling surfaces 10a, 10b facing each other and provided with said grasping means 11.
  • the grasping means 11 comprises barbs.
  • Said top and bottom element 10A, 10B are movable between an opening position wherein they are spaced from one another and a grasping position wherein the respective coupling surfaces 10a, 10b are configured to hold leaflets therebetween.
  • the top element 10A is also provided with one or more through hole or aperture 100A configured to allow a passage of the fluid to be sucked through the annulus 40 and of the negative pressure to be supplied in order to catch the leaflets 2 inside the head portion 31.
  • top and bottom element 10A, 10B each comprises a first 10A’, 10B’ and second 10A”, 10B" portion rotatably coupled to each other and arranged to form a substantially rhomboidal configuration of the releasable fastening device (10) in said opening position.
  • said top and bottom element are structurally shaped so as to form together two opposing “V-shaped” configuration in said opening position.
  • an atraumatic “bite” of the leaflets 2 with a double level fastening device can be obtained, wherein the leaflets 2 are grasped from above and below.
  • the releasable fastening device 10 may have two main material profiles.
  • a first profile wherein either said top and bottom element 10A, 10B allows no further movement to the valve leaflets 2 joined together once the fastening device is released.
  • a second profile wherein said top and bottom element 10A, 10B are made from flexible material that allows a certain degree of movements of both leaflets 2, once the fastening has occurred and the device 10 has been released.
  • the fastening device 10 results to be an implantable device that can be made for example from metal materials and/or metal alloys, like titanium, well-known and commonly used in cardiovascular implants.
  • Said first and second profile can be associated not only with the type of material used for the releasable fastening device 10 but also to the presence of retaining means configured to maintain said top and bottom element 10A, 10B coupled therebetween in said grasping position.
  • the first 10A’, 10A” and the second portion 10B’, 10B” of each element 10A, 10B are connected by a central fulcrum 11A, 11 B.
  • Each fulcrum is provided with a spring element that allows an elastic return and guarantees the compression tightness between the top and bottom element 10A, 10B.
  • the fastening device 10 will have a more opened or closed “V-shape and, accordingly, will allow a greater or lower excursion of the fastened leaflets 2 in their front portions.
  • preferred dimension of the releasable fastening device 10 provides for a maximum height of about 15 mm and a maximum width of about 5 mm in said opening position. In said grasping position the releasable fastening device provides for a maximum height of about 5 mm and a maximum width of about 15 mm.
  • the apparatus 100 is also provided with means for indicating its positioning.
  • means for indicating its positioning For example, hyperechogenic markers may be envisaged on the releasable fastening device 10 in order to detect and provided a feedback in relation to the correct positioning of the head portion 31 of the elongated hollow body 30 in between the valve leaflets (3D echo guide).
  • said steering means 20 comprises adjustable coupling means configured to adjust a spacing between the grasping means 11. More in detail, in the example shown, the top and bottom element 10A and 10B forming the releasable fastening device 10 are connected by a screw-like activating element 21 which is activated synchronously with the EGG to move the fastening device 10 from the opening position to the grasping position at the right moment
  • the steering means 20 can also comprises means for orbiting the releasable fastening device 10 about an axis coaxial with a longitudinal direction of development a of said elongated hollow body 30.
  • orbiting is ensured by four rigid supports, rods 22 in example shown, symmetrically placed and configured to keep integral the movement of the top and bottom element 10A, 10B of the releasable fastening device 10.
  • Said rods 22 pass the top element 10A through the above-mentioned through hole 100A.
  • the orbiting means 22 preferably extends along the entire length of the elongated hollow body 30.
  • Said adjustable coupling means 21 and means for orbiting 22 results to be configured to advance and manipulate the releasable fastening device 10 for a proper positioning and placement on the mitral valve leaflets 2.
  • the present invention is also related to a method of treating regurgitation of a heart valve having leaflets 2.
  • the method is preferably carried out through the use of the apparatus 100 and the heart valve to be treated is preferably a mitral valve or a tricuspid valve.
  • an elongated hollow body 30 having a releasable fastening device 10 at a longitudinal distal end E thereof is provided, said releasable fastening device 10 is inserted and positioned in a patient body at the leaflets 2 of the heart valve to be treated.
  • the insertion is percutaneous.
  • the insertion may be through a pulmonary vein and/or the jugular vein.
  • the insertion may also be through the right atrium and/or the atrial septum and/or the left ventricle.
  • the steering means 20 is activated and the four rigid supports 22 are retracted from the releasable fastening device 10.
  • the screw-like activating element 21 that connects the top and bottom element 10A, 10B is then actuated.
  • a step of supplying a suction is provided by suction means 50 within said elongated hollow body 30, in order to catch leaflets 2 through at least an opening 32 obtained on said longitudinal distal end E.
  • suction means 50 within said elongated hollow body 30, in order to catch leaflets 2 through at least an opening 32 obtained on said longitudinal distal end E.
  • Preferred embodiment provides for the suction performed during systole phase at the moment of the closure of the leaflets 2.
  • the sucked leaflets 2 are grasped and coapted with grasping means 11 borne by said releasable fastening device 10.
  • said top and bottom elements 10A, 10B engage the leaflets 2 grasping them at corresponding terminal edge of the coupling surface 10a, 10b of respective first 10A’, 10B' and second 10A”, 10B” portions.
  • the coupling surfaces 10a, 10b are made coplanar and parallel each other in order to ensure the greatest gripping surface, holding the leaflets 2 therebetween.
  • the releasable fastening device is in the grasping position.
  • the grip of the top and bottom element 10A, 10B is guaranteed either by the retaining means generating an opposing force to the action of the activating element 21 and by the grasping means 11 of opposite coupling surfaces 10a, 10b that engage each other holding the leaflets 2 therebetween.
  • an activation of the screw-like activating element 21 in an opposite direction provides for a spacing away of the top and bottom element 10A and 10B, making the releasable fastening device 10 to retur to the opening position due to the action of their retaining means.
  • the orbiting means - in the form of four supporting rods 22 in the example shown - can be actuated axially along the longitudinal direction a, passing again through the releasable fastening device 10.
  • the detachment is realized by retracting the adjustable coupling means, preferably by uncoupling a pin inside the screw-like activating element 21 , controlled by the control means.
  • a joint element for example a cardan joint, provides for an uncoupling of a terminal end of the activating element 21 from the top and/or bottom element 10A, 10B of the releasable fastening device 10.
  • the retaining means of the bottom element 10B is activated, the latter having preferably an elastic coefficient greater than the retaining means borne by the top element 10A.
  • the bottom element 10B is capable to fold back the top element 10A in order to obtain the final V-shaped configuration of the releasable fastening device 10 in the grasping position.
  • FIG. 10A Further embodiment may provide for a folding back of the top element 10A without the above-described joint element, but only by virtue of the action expressed of the greater elastic coefficient of the retaining means borne by the bottom element 10B with respect to that one of the top element 10A. Then, the adjustable coupling means 21 can be fully retracted.
  • the elongated hollow body 30 is extracted from the patient body.
  • a method of treating regurgitation of a heart valve having leaflets 2 comprises the steps of: providing an elongated hollow body 30 having a releasable fastening device 10 at a longitudinal distal end E thereof, inserting and positioning in a patient body said releasable fastening device 10 at the leaflets 2 of the heart valve to be treated, supplying a suction within said elongated hollow body 30 to catch leaflets 2 through at least an opening 32 obtained on said longitudinal distal end

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un dispositif (100) permettant de réparer une valve cardiaque ayant des valvules (2) et conçu pour être inséré par voie percutanée dans le corps d'un patient, ledit dispositif (100) comprenant * un corps creux allongé (30) pourvu d'une partie tête (31) au niveau d'une extrémité distale longitudinale (E) de ce dernier, * un dispositif de fixation libérable (10) positionné à l'intérieur de ladite partie tête (31) et pourvu d'un moyen de préhension (11) conçu pour saisir les valvules (2), * un moyen de direction (20) conçu pour positionner et libérer ledit dispositif de fixation libérable (10), ladite partie tête (31) étant pourvue d'au moins une ouverture (32) conçue pour recevoir des valvules (2) à travers cette dernière et ledit dispositif comprenant en outre un moyen d'aspiration (50) actionnable sélectivement permettant de saisir les valvules (2) à l'intérieur de la partie tête (31) de façon à saisir et à centrer les valvules (2) par ledit moyen de préhension (11).
PCT/IB2019/054987 2019-06-14 2019-06-14 Dispositif de réparation de valve cardiaque Ceased WO2020250014A1 (fr)

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PCT/IB2019/054987 WO2020250014A1 (fr) 2019-06-14 2019-06-14 Dispositif de réparation de valve cardiaque

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PCT/IB2019/054987 WO2020250014A1 (fr) 2019-06-14 2019-06-14 Dispositif de réparation de valve cardiaque

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023124541A1 (fr) * 2021-12-30 2023-07-06 杭州德晋医疗科技有限公司 Dispositif de réparation de valve apte à un serrage secondaire

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060089671A1 (en) * 1999-04-09 2006-04-27 Evalve, Inc. Fixation devices for variation in engagement of tissue
WO2014138482A1 (fr) * 2013-03-07 2014-09-12 Cedars-Sinai Medical Center Procédé et appareil pour la pose et le déploiement percutanés d'une prothèse cardiovasculaire
WO2018195215A2 (fr) * 2017-04-18 2018-10-25 Edwards Lifesciences Corporation Dispositifs d'étanchéité pour valves cardiaques et dispositifs de pose associés

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060089671A1 (en) * 1999-04-09 2006-04-27 Evalve, Inc. Fixation devices for variation in engagement of tissue
WO2014138482A1 (fr) * 2013-03-07 2014-09-12 Cedars-Sinai Medical Center Procédé et appareil pour la pose et le déploiement percutanés d'une prothèse cardiovasculaire
WO2018195215A2 (fr) * 2017-04-18 2018-10-25 Edwards Lifesciences Corporation Dispositifs d'étanchéité pour valves cardiaques et dispositifs de pose associés

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023124541A1 (fr) * 2021-12-30 2023-07-06 杭州德晋医疗科技有限公司 Dispositif de réparation de valve apte à un serrage secondaire

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