WO2021205372A3 - Lipopeptides antibactériens, composition pharmaceutique et composition cosmétique les comprenant, et leurs utilisations - Google Patents

Lipopeptides antibactériens, composition pharmaceutique et composition cosmétique les comprenant, et leurs utilisations Download PDF

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Publication number
WO2021205372A3
WO2021205372A3 PCT/IB2021/052911 IB2021052911W WO2021205372A3 WO 2021205372 A3 WO2021205372 A3 WO 2021205372A3 IB 2021052911 W IB2021052911 W IB 2021052911W WO 2021205372 A3 WO2021205372 A3 WO 2021205372A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipopeptides
composition
pharmaceutical composition
cosmetic composition
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2021/052911
Other languages
English (en)
Other versions
WO2021205372A2 (fr
Inventor
Slawomir SEK
Dagmara TYMECKA
Joanna JUHANIEWICZ-DEBINSKA
Dariusz BARTOSIK
Robert LASEK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uniwersytet Warszawski
Original Assignee
Uniwersytet Warszawski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Warszawski filed Critical Uniwersytet Warszawski
Priority to EP21727925.6A priority Critical patent/EP4132945A2/fr
Publication of WO2021205372A2 publication Critical patent/WO2021205372A2/fr
Publication of WO2021205372A3 publication Critical patent/WO2021205372A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des lipopeptides antimicrobiens synthétiques ayant une structure linéaire et des lipopeptides antimicrobiens ayant une structure ramifiée, des compositions pharmaceutiques comprenant de tels lipopeptides, des compositions cosmétiques comprenant de tels lipopeptides et des lipopeptides destinés à être utilisés en tant que médicament, ainsi que des lipopeptides destinés à être utilisés dans le traitement ou la prophylaxie d'une infection bactérienne.
PCT/IB2021/052911 2020-04-08 2021-04-08 Lipopeptides antibactériens, composition pharmaceutique et composition cosmétique les comprenant, et leurs utilisations Ceased WO2021205372A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21727925.6A EP4132945A2 (fr) 2020-04-08 2021-04-08 Lipopeptides antibactériens, composition pharmaceutique et composition cosmétique les comprenant, et leurs utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PLPL433503 2020-04-08
PL433503A PL246720B1 (pl) 2020-04-08 2020-04-08 Lipopeptydy o działaniu przeciwbakteryjnym, kompozycja farmaceutyczna i kompozycja kosmetyczna je zawierająca oraz zastosowania

Publications (2)

Publication Number Publication Date
WO2021205372A2 WO2021205372A2 (fr) 2021-10-14
WO2021205372A3 true WO2021205372A3 (fr) 2022-01-20

Family

ID=78022834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/052911 Ceased WO2021205372A2 (fr) 2020-04-08 2021-04-08 Lipopeptides antibactériens, composition pharmaceutique et composition cosmétique les comprenant, et leurs utilisations

Country Status (3)

Country Link
EP (1) EP4132945A2 (fr)
PL (1) PL246720B1 (fr)
WO (1) WO2021205372A2 (fr)

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Computational chemistry methods in structural biology", vol. 112, 2018, ELSEVIER, NL, ISBN: 978-0-12-386485-7, ISSN: 1876-1623, article GLOSSOP HUGH D. ET AL: "Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus", pages: 385 - 394, XP055835832, DOI: 10.1016/bs.apcsb.2018.03.004 *
DEY RAJIB ET AL: "Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus", MEDCHEMCOMM, vol. 10, no. 11, 13 November 2019 (2019-11-13), United Kingdom, pages 1907 - 1915, XP055867866, ISSN: 2040-2503, DOI: 10.1039/C9MD00329K *
GAYAN HERUKA DE ZOYSA ET AL: "Antimicrobial Peptides with Potential for Biofilm Eradication: Synthesis and Structure Activity Relationship Studies of Battacin Peptides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 2, 22 January 2015 (2015-01-22), pages 625 - 639, XP055758649, ISSN: 0022-2623, DOI: 10.1021/jm501084q *
GAYAN HERUKA DE ZOYSA ET AL: "Unexplored antifungal activity of linear battacin lipopeptides against planktonic and mature biofilms of C. albicans", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 146, February 2018 (2018-02-01), AMSTERDAM, NL, pages 344 - 353, XP055758662, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.01.023 *
KIHARA SHINJI ET AL: "Solution structure of linear battacin lipopeptides - the effect of lengthening fatty acid chain", SOFT MATTER, vol. 15, no. 37, 25 September 2019 (2019-09-25), pages 7501 - 7508, XP055835804, ISSN: 1744-683X, DOI: 10.1039/C9SM00932A *
MOON SUN HEE ET AL: "Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 23, 14 December 2017 (2017-12-14), US, pages 9630 - 9640, XP055797610, ISSN: 0022-2623, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01064> DOI: 10.1021/acs.jmedchem.7b01064 *
VARNAVA KYRIAKOS GABRIEL ET AL: "Design, Synthesis, Antibacterial Potential, and Structural Characterization of N-Acylated Derivatives of the Human Autophagy 16 Polypeptide", BIOCONJUGATE CHEMISTRY, vol. 30, no. 7, 17 July 2019 (2019-07-17), US, pages 1998 - 2010, XP055867862, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.9b00290 *

Also Published As

Publication number Publication date
PL433503A1 (pl) 2021-10-11
WO2021205372A2 (fr) 2021-10-14
PL246720B1 (pl) 2025-03-03
EP4132945A2 (fr) 2023-02-15

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