WO2022031998A3 - Procédé de préparation d'intermédiaires utiles dans la préparation de composés qui modulent l'épissage - Google Patents

Procédé de préparation d'intermédiaires utiles dans la préparation de composés qui modulent l'épissage Download PDF

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Publication number
WO2022031998A3
WO2022031998A3 PCT/US2021/044794 US2021044794W WO2022031998A3 WO 2022031998 A3 WO2022031998 A3 WO 2022031998A3 US 2021044794 W US2021044794 W US 2021044794W WO 2022031998 A3 WO2022031998 A3 WO 2022031998A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
compounds
modulate splicing
intermediates useful
mrna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/044794
Other languages
English (en)
Other versions
WO2022031998A2 (fr
Inventor
Michael Luzzio
Tiansheng Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Skyhawk Therapeutics Inc
Original Assignee
Skyhawk Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Skyhawk Therapeutics Inc filed Critical Skyhawk Therapeutics Inc
Publication of WO2022031998A2 publication Critical patent/WO2022031998A2/fr
Publication of WO2022031998A3 publication Critical patent/WO2022031998A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés de préparation de composés utiles dans la préparation de composés modulateurs d'épissage de petites molécules qui modulent l'épissage d'ARNm, tels que des pré-ARNm, codés par des gènes, et des composés utilisés dans de tels procédés.
PCT/US2021/044794 2020-08-05 2021-08-05 Procédé de préparation d'intermédiaires utiles dans la préparation de composés qui modulent l'épissage Ceased WO2022031998A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063061744P 2020-08-05 2020-08-05
US63/061,744 2020-08-05
US202163161233P 2021-03-15 2021-03-15
US63/161,233 2021-03-15

Publications (2)

Publication Number Publication Date
WO2022031998A2 WO2022031998A2 (fr) 2022-02-10
WO2022031998A3 true WO2022031998A3 (fr) 2022-03-17

Family

ID=80120143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/044794 Ceased WO2022031998A2 (fr) 2020-08-05 2021-08-05 Procédé de préparation d'intermédiaires utiles dans la préparation de composés qui modulent l'épissage

Country Status (1)

Country Link
WO (1) WO2022031998A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7551629B2 (ja) 2019-02-05 2024-09-17 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
WO2020163405A1 (fr) * 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Procédés et compositions pour moduler l'épissage
JP7603594B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
JP7603595B2 (ja) 2019-02-06 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
MX2023001558A (es) * 2020-08-05 2023-04-26 Skyhawk Therapeutics Inc Composiciones para modular el corte y empalme.
GB202106871D0 (en) * 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160280721A1 (en) * 2013-11-03 2016-09-29 The Board Of Trustees Of The University Of Illinois Cross-coupling of unactivated secondary boronic acids
WO2019028440A1 (fr) * 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. Méthodes et compositions permettant de moduler l'épissageé
WO2019191229A1 (fr) * 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Composés permettant de traiter la maladie de huntington

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160280721A1 (en) * 2013-11-03 2016-09-29 The Board Of Trustees Of The University Of Illinois Cross-coupling of unactivated secondary boronic acids
WO2019028440A1 (fr) * 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. Méthodes et compositions permettant de moduler l'épissageé
WO2019191229A1 (fr) * 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Composés permettant de traiter la maladie de huntington

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE PubChem substance ANONYMOUS : "SID 151978989 ", XP055920099 *
ONO ET AL.: "Regioselective Preparation of Allylic Sulfones by Palladium-Catalyzed Reactions of Allylic Nitro Compounds with Sodium Benzenesulfinate", BULL. CHEM. SOC. JPN., vol. 59, 1986, pages 405 - 410, XP055915474 *

Also Published As

Publication number Publication date
WO2022031998A2 (fr) 2022-02-10

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