WO2022162012A3 - Anticorps ciblant sur un large spectre des coronavirus et leurs utilisations - Google Patents

Anticorps ciblant sur un large spectre des coronavirus et leurs utilisations Download PDF

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Publication number
WO2022162012A3
WO2022162012A3 PCT/EP2022/051776 EP2022051776W WO2022162012A3 WO 2022162012 A3 WO2022162012 A3 WO 2022162012A3 EP 2022051776 W EP2022051776 W EP 2022051776W WO 2022162012 A3 WO2022162012 A3 WO 2022162012A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
coronaviruses
relates
protein
antigen binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2022/051776
Other languages
English (en)
Other versions
WO2022162012A2 (fr
Inventor
Federica SALLUSTO
Antonio Lanzavecchia
Antonino Cassotta
Jun Siong LOW
Josipa JERAK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Institute for Research in Biomedicine IRB
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Institute for Research in Biomedicine IRB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2021/051745 external-priority patent/WO2022161598A1/fr
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ, Institute for Research in Biomedicine IRB filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of WO2022162012A2 publication Critical patent/WO2022162012A2/fr
Publication of WO2022162012A3 publication Critical patent/WO2022162012A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des anticorps et des fragments de liaison à l'antigène de ceux-ci, qui se lient à la protéine de spicule (S) des coronavirus. Les anticorps, et des fragments de liaison à l'antigène de ceux-ci, ciblent sur un large spectre des coronavirus, comprenant différents alpha-et bêta-coronavirus. L'invention concerne également des acides nucléiques qui codent pour de tels anticorps et fragments d'anticorps et des cellules qui expriment de tels anticorps et fragments d'anticorps. De plus, l'invention concerne l'utilisation des anticorps et des fragments d'anticorps dans le traitement et le diagnostic d'une infection à coronavirus. En outre, l'invention concerne un peptide, un polypeptide ou une protéine de recombinaison comprenant l'épitope, auquel les anticorps se lient, et pouvant être utile dans la vaccination.
PCT/EP2022/051776 2021-01-26 2022-01-26 Anticorps ciblant sur un large spectre des coronavirus et leurs utilisations Ceased WO2022162012A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPPCT/EP2021/051745 2021-01-26
PCT/EP2021/051745 WO2022161598A1 (fr) 2021-01-26 2021-01-26 Anticorps ciblant largement des coronavirus et leurs utilisations
EP2021078062 2021-10-11
EPPCT/EP2021/078062 2021-10-11

Publications (2)

Publication Number Publication Date
WO2022162012A2 WO2022162012A2 (fr) 2022-08-04
WO2022162012A3 true WO2022162012A3 (fr) 2022-09-09

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WO (1) WO2022162012A2 (fr)

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Publication number Priority date Publication date Assignee Title
CN118440186A (zh) * 2023-01-05 2024-08-06 郴州市第一人民医院 一种广谱抗SARS-like冠状病毒和/或新冠突变株的抗体及其应用
CN118852420B (zh) * 2024-08-16 2025-11-11 东北农业大学 一种猪δ冠状病毒中和性单克隆抗体及其应用
CN119592517B (zh) * 2024-10-08 2025-09-19 河南农业大学 一种抗猪δ冠状病毒S2亚基的单克隆抗体及其杂交瘤细胞株和应用

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AU7924598A (en) 1998-06-08 1999-12-30 Sca Emballage France Fast flattening packaging
CN1168702C (zh) 1998-06-30 2004-09-29 Om药业 酰基-二肽类化合物,其制备方法以及含有前述化合物的药物组合物
WO2001046127A1 (fr) 1999-12-22 2001-06-28 Om Pharma Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise
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EP2158318A2 (fr) 2007-05-14 2010-03-03 Biogen Idec MA, Inc. Régions fc simple chaîne, polypeptides de liaison comportant de telles régions, et procédés correspondants
PL2350128T3 (pl) 2008-10-22 2015-03-31 Inst Res Biomedicine Sposoby wytwarzania przeciwciał z komórek plazmatycznych
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