WO2022265604A2 - Poudre de traitement pour l'abrasion par air - Google Patents

Poudre de traitement pour l'abrasion par air Download PDF

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Publication number
WO2022265604A2
WO2022265604A2 PCT/TR2022/050550 TR2022050550W WO2022265604A2 WO 2022265604 A2 WO2022265604 A2 WO 2022265604A2 TR 2022050550 W TR2022050550 W TR 2022050550W WO 2022265604 A2 WO2022265604 A2 WO 2022265604A2
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Prior art keywords
bone
boron
air abrasion
treatment powder
abrasion treatment
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Ceased
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PCT/TR2022/050550
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WO2022265604A3 (fr
Inventor
Mustafa TUNALI
Esra ERCAN
Gulbahar USTAOGLU
Onder ALBAYRAK
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Priority claimed from TR2021/009677 external-priority patent/TR2021009677A2/tr
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Publication of WO2022265604A3 publication Critical patent/WO2022265604A3/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Definitions

  • the invention relates to the air abrasion powder that consists of substances with bioactive, osteogenic and antibacterial activity such as calcium phosphate compounds, nano-titanium and boron compounds in nanoparticle structure, and particles that increase antibacterial activity such as nanosilver, for air abrasion devices that can be used in the subgingival and submucosal (the groove below the gingival line, surrounding the tooth and dental implant) region.
  • substances with bioactive, osteogenic and antibacterial activity such as calcium phosphate compounds, nano-titanium and boron compounds in nanoparticle structure, and particles that increase antibacterial activity such as nanosilver
  • Air abrasion devices were first introduced to dentistry in 1945 and have been used for mechanical tooth cleaning since the 1980s.
  • Intraoral air abrasion is a technique in which abrasive particles are used. The underlying principle of this method is to create a stream in which compressed air and water are mixed and contain small particles. This method usually does not require anesthesia and reduces the risk of tooth fragmentation/microfracture.
  • Air abrasion is classically used in dental cavity preparation in dentistry to remove metal, porcelain and composite debris from tooth surfaces and to roughen the tooth surface before applying the adhesive resin. Apart from these, they are also widely used in the fields of periodontology and implantology. It is used to remove dental plaque biofilm from the surfaces of natural teeth and dental implants. In this technique, powders in different properties suitable for clinical use are used.
  • the application areas have expanded from supragingival (the area formed above the gingival level) to subgingival (the groove-shaped area surrounding the tooth, below the gingival line) using highly abrasive sodium bicarbonate powders. Later, less abrasive and degradable (degradable/soluble) erythrole and glycine powders were developed especially for use in subgingival areas. Amino acids such as glycine and erythrole powders are used on implant surfaces, which have a similar effect with sodium bicarbonate powders in terms of bacterial biofilm removal, but do not cause significant changes on the surface. Since these powders are not biocompatible for the body, residual powder particles can cause allergy/foreign body reactions and adversely affect the treatment results. BRIEF DESCRIPTION OF THE INVENTION
  • the invention relates to a new air abrasion powder created by gaining technical properties such as osteogenic potential, antibacterial properties, increasing clot adhesion and increasing osteogenic potential by using Sodium, Hydroxy Apatite and Boron, which are not found in air abrasion powders in known techniques.
  • the invention is an air abrasion powder consisting of nanoparticle calcium phosphate compounds and substances with bioactive, osteogenic and antibacterial activities such as nano-titanium and boron compounds in air abrasion devices, and particles that increase antibacterial activity such as nano-silver.
  • the invention makes the treated blood products such as Platelet Rich Fibrin (PRF), autogenous bone, autogenous dentin, autogenous cement, autogenous enamel usable in air abrasion devices.
  • PRF Platelet Rich Fibrin
  • autogenous bone autogenous dentin
  • autogenous cement autogenous enamel
  • Decontamination of implant surfaces is a prerequisite for treatment success in both surgical and non-surgical treatment of peri-implantitis. While substances such as boron/silver in our invention provide these antibacterial properties, calcium phosphate components will increase new bone formation. Thus, a serious contribution will be made to the success of the treatment.
  • the invention can also be used in implants and tissues in dentistry, orthopedics, plastic surgery and other medical fields.
  • the invention relates to air abrasion powder to be used in air abrasion devices;
  • the feature of the powder is that it is “highly biocompatible, osteogenic and antibacterial”:
  • Air abrasion powder contains nano-titanium and nano-sized calcium phosphate- based bioceramic material for high biocompatibility and osteogenic effect; At least one of the nanoscale hydroxyapatite, tricalcium phosphate, octacalcium phosphate, biphasic calcium phosphate, autogenous dentin, cement, enamel and bone powders will be used as matrix material (main material).
  • At least one of the “boron components, cerium components or stronium components” will be added to the main material as an additive material.
  • At least one of "silver nanoparticles, titanium dioxide nanoparticles, boron additive, cerium additive and stronium additive" will be added to the main material.
  • Solid state method or wet chemical method can be used for doping to the main material; Different from these methods, the additives determined can also be used directly by mixing them with the main material in certain proportions.
  • Example 1 Hydroxyapatite in nanosize (95% wt.) as base material (matrix material) for high biocompatibility and osteogenic effect, cerium additive in nanosize (Ce02, 4% wt.) to increase osteogenic effect, silver additive (AgN03, wt.
  • Example 2 Nanosized a-tricalcium phosphate (98% wt.) as base material (matrix material) for high biocompatibility and osteogenic effect, boron additive (H3B03, 2% wt.) to both increase osteogenic effect and impart antibacterial effect.
  • base material matrix material
  • boron additive H3B03, 2% wt.
  • Octocalcium phosphate (OCP) materials have a positive effect on bone forming cells, similar to autogenous bone. It has been suggested that OCP is a precursor to biological apatite crystals in bone and teeth. Calcium phosphate compounds positively support osteogenesis with their osteoinductive properties. OCP increases the activity of various bone cells, including osteoblasts, osteocytes, osteoclasts, and macrophages, during conversion to Hydroxy Apatite (HA). Changes in the physicochemical properties of OCP affect osteoclast formation, differentiation of osteocytes, and proliferation of osteoblasts. OCPs remodel (remodel) with bone.
  • HA Hydroxy Apatite
  • Up-regulation of osteoblast differentiation markers such as alkaline phosphatase (ALP) and osterix and RANKL is induced by OCP crystals.
  • ALP alkaline phosphatase
  • HA osterix and RANKL
  • the conversion process from OCP to HA happens very slowly and gradually. Meanwhile, it causes physicochemical changes, including the consumption of Calcium (Ca 2+) and the release of inorganic phosphate (P) ions, and the high adsorption affinity of serum proteins such as a2HS-glycoproteins. Thus, it contributes to the formation of new bone.
  • Adding an antimicrobial agent to small particles not only removes bacterial biofilm, but also reduces the occurrence of future biofilm-associated infections. Due to the reduced bacterial colonization, the success of surgical treatments is also increased. Antibacterial properties are gained by adding at least one of the silver nanoparticles and boron compounds. Thus, the development of infection in the region during and after the treatment is significantly reduced.
  • Nanohydroxyapatite (NHA) application increases free surface energy and wettability. It is also associated with platelet activation and increased bone formation.
  • Boron-containing nano-hydroxyapatite composites increase the osteogenic differentiation of mesenchymal stem cells by increasing alkaline phosphatase activity compared to nano-hydroxyapatite composite or boric acid alone.
  • Wnt appeared to affect TGF-related genes in response to stress signaling pathways compared to nano-hydroxyapatite composite, boric acid.
  • Octacalcium phosphate which is thought to be a deposit that accumulates in the first stage in the biological environment, is of increasing interest for biomedical applications.
  • OCP Octacalcium phosphate
  • the protein binding ability of octacalcium phosphate surfaces has been demonstrated in rat serum.
  • a total of 138 proteins were detected in OCP and 103 proteins in HA with similar surface area. Therefore, only proteins adsorbed on OCP surfaces were detected.
  • Boron (B) the fifth element in the periodic table, is the only nonmetal in the elements in group 3A, but contains properties of both metals and nonmetals. Boron is a bioactive element that positively affects bone formation, composition and physical properties and central nervous system function, relieves joint symptoms, facilitates hormone action, and is associated with a reduced risk for some types of cancer. Boron affects the production and activity of steroid hormones, the actions of this trace mineral in the prevention of calcium loss and bone demineralization. However, Boron plays an important role in osteogenesis and its deficiency has been shown to negatively affect bone development and regeneration. Especially due to its positive effects on bone, studies have been carried out on its use as a scaffold-scaffold in bone tissue engineering.
  • SAM-e S-adenosyl methionine
  • NAD+ nicotinamide adenine dinucleotide
  • Silver nanoparticles have a broad spectrum of antibacterial, antifungal and antiviral properties. Silver nanoparticles have the ability to penetrate bacterial cell walls, alter the structure of cell membranes and even result in cell death. Thanks to its electrostatic attraction and its affinity for sulfur proteins, silver ions can adhere to the cell wall and cytoplasmic membrane. Adhering ions increase the permeability of the cytoplasmic membrane and cause disruption of the bacterial membrane. After the free silver ions are taken into the cells, respiratory enzymes are deactivated to form reactive oxygen species and interrupt the production of adenosine triphosphate. Denaturation of the cytoplasmic membrane can degrade organelles and even cause cell lysis. Their effectiveness is due not only to their nanoscale size, but also to their large surface area/volume ratio.
  • Silver nanoparticles can increase the permeability of cell membranes by secreting silver ions, produce reactive oxygen species and interrupt the replication of deoxyribonucleic acid (DNA).
  • Silver nanoparticles can be used in dentistry as an antibacterial agent in the structure of removable dentures, in composite filling materials, as irrigation solution and obturation material in endodontic treatment, in adhesive materials in orthodontic treatment, in membranes used for directed tissue regeneration in periodontal treatment, and in the production of titanium coating in dental implant treatments.
  • Periodontitis is a chronic inflammatory disease in which various types of microorganisms are common. Infection control through biofilm degradation and suppression of inflammation is essential for periodontal treatment.
  • silver nanoparticles are advantageous because they have antibacterial properties without creating bacterial resistance.
  • Silver nanoparticles loaded up to about 8.2% by weight provide systems that can promote osteoblast viability and differentiation and inhibit the growth of multidrug resistant bacteria.
  • the smaller size silver nanoparticles offer a higher antibacterial property against oral anaerobic pathogenic bacteria.
  • the membrane containing silver nanoparticles is used in tissue regeneration, it can increase clinical success in the treatment of intraosseous defects, since it reduces the adhesion and penetration of bacteria.
  • silver nanoparticles reduce some inflammatory cytokines and angiogenesis parameters.
  • silver nanoparticles can also increase anti-inflammatory cytokine synthesis. It is biocompatible with fibroblasts and keratinocytes. The silver accumulated in the organs is cleared in 8 weeks. It is phagocytosed by macrophages. However, systemic toxicity of ingested silver nanoparticles has not been reported.
  • Bone is a nano-apatite composite, a mostly natural nanostructured calcium phosphate (CaP) ceramic composed of approximately 60% mineral by dry weight. CaP materials most closely mimic the mineral phase of bone and due to its high osteoinductivity, CaP is a common material of choice for bone grafts.
  • Calcium phosphate is a family of minerals. It contains calcium phosphate, orthophosphate, metaphosphate or pyrophosphate and especially calcium ions with hydrogen ions or hydroxide. Calcium phosphates have a very important place in biology. For example, tooth enamel is largely calcium phosphate. Calcium phosphate based materials, Ca/P ratios, chemical formulas and abbreviations are presented in Table 1 .
  • Tricalcium phosphate and Hydroxyapatite are the most well-known calcium phosphate compounds. It is important that these two calcium compounds occur in skeletal structure, similar crystallographic structure and chemical composition. Calcium phosphate compounds are used as graft material, scaffold scaffolding (roof and carrier) or to increase implant osseointegration. However, Biphasic calcium phosphate is a good alternative to bone grafts for use around implants and replaces living bone as it is absorbable.
  • nanoparticles In air abrasion powder in the form of nanoparticles, the effect of contributing to the stabilization of osteogenic/clots that will be displayed by the particles remaining on the tooth/implant surface after the application is also important.
  • nanoparticles reduce proinflammatory cytokines such as IL1 b and TNF-a, while increasing the adhesion of osteoblasts to the surface.
  • Calcium is the most abundant mineral found in the body. It is the main component of bones and teeth. Adequate calcium intake is a critical factor for a healthy skeletal system. It is known that calcium phosphate is biocompatible and non-toxic to the body due to its chemical similarity to bones and teeth. In addition, calcium is very important as a coagulation factor in hemostasis and clot formation. In order for physiological functions to be performed, calcium levels in the blood must be within a certain concentration range.
  • Titanium shows excellent surface reactivity with high in vitro/vivo osteoconductivity when in contact with biological fluids.
  • the nano topography produced by the deposition of nano-structured Ti02 on Titanium alloy surfaces increases corrosion resistance, biocompatibility and cell integration for implants made of Ti alloys.
  • the high biocompatibility and bioactivity of nano-structured Ti02 increases bone formation with its osteoconductive properties.
  • Ag - Ti02 nanoparticles exhibit excellent antimicrobial activity against Gram-positive and Gram-negative bacterial cultures and Candida albicans. Complete inhibition of microorganisms was achieved at a very low Ag - Ti02 concentration. Its mesoporous nature and antimicrobial activity at low concentrations without photoactivation make this material an excellent potential candidate for application as a disinfectant and/or antimicrobial agent.
  • Dentin is covered by a crown made of highly mineralized and protective enamel and is covered by cementum, a structure at the root that plays a role in the attachment of teeth to the bone socket. 70% of its weight consists of minerals. The remaining 30% consists of organic matrix and water. Its inorganic material is calcium and phosphate ions, which form hydroxyapatite crystals, as in enamel, but the crystals are 30 times smaller, which makes dentin slightly softer than enamel. Cement; It covers the root dentin, its structure is similar to bone, but without Haversian system and blood vessels. Mesenchymal is calcified tissue.
  • the organic matrix of cement consists of 90% Type I and 5% Type III collagen. Sharpey's fibers, which make up most of the cement volume, are mostly composed of Type I collagen. Considering the inorganic component of cement, it is seen that it contains less hydroxyapatite than bone, enamel or dentin. Hydroxyapatite ratios: Cement 45-50%, bone 65%, enamel 97%, dentin 70%.
  • Bone; 2/3 of the bone is inorganic and the remaining 1/3 is organic matter.
  • the main component of the mineralized matrix is hydroxy apatite crystals.
  • Type 1 collagen fibrils constitute the majority of the intercellular fibrillar matrix.
  • Enamel It is the hardest and most durable tissue in the human body. Enamel contains morphologically parallel, ⁇ 50 nm wide, nanocrystals. About 95% to 98% of enamel is made up of calcium and phosphate ions that form strong hydroxyapatite crystals. However, they are not pure crystals because they are carbonated and contain trace minerals such as strontium, magnesium, lead and fluoride. Millions of carbonated hydroxyapatite crystals are arranged in long, slender structures from 4 pm to 8 pm in diameter. These factors make “biological hydroxyapatite” more soluble than pure hydroxyapatite.
  • Lyophilized PRF Platelet-rich fibrin
  • PRF is a second generation platelet concentrate developed for tissue repair and regeneration.
  • PRF is used in many tissue engineering fields as a highly biocompatible and inductive bioscaffold. As a fresh plasma preparation, PRF was originally developed for immediate autologous use. It is especially important to apply on the same day to keep the release of growth factors at the highest level.
  • Freeze-drying is a commonly used process for the long-term storage of proteins used for increasing stability and tissue regeneration. Freeze-dried, protein-based materials not only have the advantage of better stability and storage potential, but are also important for the immediate access of new growing cells and tissues to growth factors.
  • Lyophilized PRF can be used as a biomimetic scaffold for bone regeneration and mineralized tissue engineering. When PRF is applied as lyophilized, it has better tissue integration and increased osteogenic benefit to the wound area compared to fresh PRF.
  • our invention is aimed to apply the autogenous products by pulverizing (freeze drying, grinding, etc.) by spraying on the dental implant/tooth root surface and to obtain a biologically compatible surface that will support regeneration.

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Inorganic Chemistry (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne la poudre pour l'abrasion par air qui est constituée de substances ayant une activité bioactive, ostéogénique et antibactérienne telles que des composés de phosphate de calcium, des composés de nano-titane et de bore dans une structure nanoparticulaire, et des particules qui augmentent l'activité antibactérienne telles que le nanoargent, pour des dispositifs d'abrasion par air qui peuvent être utilisés dans la région sous-gingivale et sous-mucosale (la rainure sous la ligne gingivale, entourant la dent et l'implant dentaire).
PCT/TR2022/050550 2021-06-14 2022-06-09 Poudre de traitement pour l'abrasion par air Ceased WO2022265604A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021009677 2021-06-14
TR2021/009677 TR2021009677A2 (tr) 2021-06-14 Hava abrazyon tedavi̇ tozu

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WO2022265604A2 true WO2022265604A2 (fr) 2022-12-22
WO2022265604A3 WO2022265604A3 (fr) 2023-02-09

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* Cited by examiner, † Cited by third party
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WO2008008184A2 (fr) * 2006-07-07 2008-01-17 Dentsply International Inc. Compositions à base de gutta-percha pour l'obturation de canaux radiculaires dentaires
CN115137653A (zh) * 2018-03-30 2022-10-04 徐崇明 一种用于牙髓保守治疗的填充糊剂及其制备方法
IT201800006721A1 (it) * 2018-06-27 2019-12-27 Composizione in polvere a base di un poliidrossialcanoato e relativo uso nella profilassi dentale.

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