WO2023106971A1 - Dispositif de réduction pathogène des composants du sang - Google Patents

Dispositif de réduction pathogène des composants du sang Download PDF

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Publication number
WO2023106971A1
WO2023106971A1 PCT/RU2022/050378 RU2022050378W WO2023106971A1 WO 2023106971 A1 WO2023106971 A1 WO 2023106971A1 RU 2022050378 W RU2022050378 W RU 2022050378W WO 2023106971 A1 WO2023106971 A1 WO 2023106971A1
Authority
WO
WIPO (PCT)
Prior art keywords
cuvette
ultraviolet
ultraviolet radiation
ultraviolet light
irradiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2022/050378
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English (en)
Russian (ru)
Inventor
Гаррий Дмитриевич IVASHCHENKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2023106971A1 publication Critical patent/WO2023106971A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits

Definitions

  • the device refers to devices for irradiating donor blood components with ultraviolet light of a certain range.
  • Known apparatus for photophoresis includes a housing that houses a peristaltic pump, a container for blood cells and two blocks of irradiation with ultraviolet lamps. In each block, ultraviolet lamps are located in the same plane. Between the blocks there is a cuvette, which, together with a container for blood cells and tubes, is included in a disposable system. The planes of the ultraviolet lamps in the irradiation blocks are horizontal and parallel. Irradiation blocks are located one above the other and have rigid plates transparent for ultraviolet radiation in front of ultraviolet lamps. The cuvette, which is a film cuvette, is located between rigid plates. [EN 196 088 U1]
  • the disadvantage of this apparatus is the presence of covers of each body in which solid plates are installed that transmit ultraviolet light.
  • the bodies are connected by a hinge and racks of their fixation for the installation of a serpentine film cuvette.
  • the technical result is achieved by using a device for pathogenic reduction of blood components, separated from two sources ultraviolet radiation, two rigid plates that transmit ultraviolet, as well as a peristaltic pump, a film cuvette with serpentine channels and tubes, ultraviolet radiation sources are combined into one housing forming an irradiation chamber, which has an opening for introducing an irradiation unit into it, consisting of two rigid plates that transmit ultraviolet, located horizontally with a gap between the plates, while the gap serves to locate a film cuvette with serpentine channels in it.
  • the UV source can be located on one side only.
  • the source of ultraviolet radiation may have an element that provides a change in the intensity of the ultraviolet flux.
  • a node controlling the weight of the container with non-irradiated cell mass can be introduced into the device.
  • the source of ultraviolet radiation can change the distance to the cuvette by changing the intensity of irradiation.
  • Figure 1 shows the device from the front.
  • Figure 2 is a side view of the device without a wall.
  • Figure 3 - part of the irradiation node.
  • the device consists of the following elements.
  • the device works as follows.
  • the cell mass is placed in a container with non-irradiated cell mass 1 and a disposable system is installed, which includes a container with non-irradiated cell mass 1, a container with irradiated cell mass 2, tubes 4. From the container, the cell mass through tube 4 enters the peristaltic pump and from it through the tube into the inlet fitting of the cuvette and from the outlet fitting of the cuvette into a container with irradiated cell mass 2.
  • the tube 4 is connected to the container with the irradiated cell mass 2.
  • Position 5 in the device indicates the irradiation chamber.
  • ultraviolet sources are located at position 6.
  • Position 7 the irradiation unit, which includes position 8 - rigid plates that transmit ultraviolet.
  • Position 9 serpentine film cuvette
  • the device works as follows.
  • the peristaltic pump 3 is turned on and the cell mass from the container 1 through the tube 4 with the help of the pump 3 enters the cuvette, where it is irradiated using ultraviolet irradiation sources.
  • the cell mass is drained through tube 4 into the Container with irradiated cell mass 2.
  • the pump and radiation source are turned off.
  • Tube 4 on the fitting through which the serpentine 9 cell mass flows out of the cuvette is raised above the plane of the cuvette. Or at the outlet of the tube through which the cell mass flows out of the cuvette 9 is installed jet.
  • Each of these options creates an overpressure in the cuvette channels, which presses the film cuvette against both UV-transmitting plates.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Optical Measuring Cells (AREA)

Abstract

L'invention concerne un appareil pour la réduction pathogène des composants du sang, qui comprend deux sources de rayonnement ultraviolet, deux plaques rigides laissant passer les ultraviolets, ainsi qu'une pompe péristaltique, une cuvette de type film avec des canaux en serpentin et un système de tubes; les sources de rayonnement ultraviolet sont regroupées en un corps formant une chambre d'émission qui comprend une ouverture pour y insérer une unité d'émission se composant de deux plaques rigides laissant passer les ultraviolets qui sont disposées horizontalement avec un jour entre elles; le jour est destiné à recevoir la cuvette de type film avec les canaux en serpentin. Ce dispositif est caractérisé en ce que la source de rayonnement est disposée uniquement d'un côté. Le dispositif est caractérisé en ce que la source de rayonnement ultraviolet comprend un élément assurant une modification de la valeur d'intensité du flux d'ultraviolets. Le dispositif est caractérisé en ce que l'appareil comporte une unité contrôlant le poids du conteneur avec une masse cellules non éclairée. Le dispositif est caractérisé en ce que la source de rayonnement ultraviolet peut changer la distance la séparant de la cuvette, changeant ainsi l'intensité de l'émission. Le résultat consiste en une simplification de la structure.
PCT/RU2022/050378 2021-12-07 2022-12-05 Dispositif de réduction pathogène des composants du sang Ceased WO2023106971A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2021136011 2021-12-07
RU2021136011 2021-12-07

Publications (1)

Publication Number Publication Date
WO2023106971A1 true WO2023106971A1 (fr) 2023-06-15

Family

ID=86730852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2022/050378 Ceased WO2023106971A1 (fr) 2021-12-07 2022-12-05 Dispositif de réduction pathogène des composants du sang

Country Status (1)

Country Link
WO (1) WO2023106971A1 (fr)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507482A1 (fr) * 1981-06-12 1982-12-17 Edelson Richard Procede et dispositif pour le traitement extracorporel du sang
US4464166A (en) * 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US5459322A (en) * 1993-12-14 1995-10-17 Therakos, Inc. Ultraviolet light chamber
RU2083375C1 (ru) * 1995-08-11 1997-07-10 Константин Петрович Шашкин Устройство вакуумного прижима печатной формы к фотоформе при копировании
US6312593B1 (en) * 1999-04-23 2001-11-06 Thomas R. Petrie Ultraviolet blood irradiation chamber
WO2002038191A2 (fr) * 2000-11-13 2002-05-16 Bayer Aktiengesellschaft Procede d'inactivation de micro-organismes presents dans un fluide au moyen de rayonnement ultraviolet
US6586172B1 (en) * 1998-10-02 2003-07-01 Iatros Limited Device for treatment of biological fluids
US20130078142A1 (en) * 2011-09-22 2013-03-28 Eugene I. Gordon Method and Apparatus for Sterilization of Medical Instruments and Devices by Ultraviolet Sterilization
US20170021042A1 (en) * 2015-07-23 2017-01-26 Terumo Bct Biotechnologies, Llc Flow-Through Pathogen Reduction
RU176288U1 (ru) * 2017-09-21 2018-01-15 Общество С Ограниченной Ответственностью "Электронные Приборы" (Ооо "Электронные Приборы") Ультрафиолетовый облучатель мононуклеарных клеток крови
RU196088U1 (ru) * 2017-08-30 2020-02-14 Гаррий Дмитриевич Иващенко Аппарат для фотофореза
WO2021188624A1 (fr) * 2020-03-20 2021-09-23 Barnett Eugene Dispositif et procédé de photothérapie polychromatique

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507482A1 (fr) * 1981-06-12 1982-12-17 Edelson Richard Procede et dispositif pour le traitement extracorporel du sang
US4464166A (en) * 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US5459322A (en) * 1993-12-14 1995-10-17 Therakos, Inc. Ultraviolet light chamber
RU2083375C1 (ru) * 1995-08-11 1997-07-10 Константин Петрович Шашкин Устройство вакуумного прижима печатной формы к фотоформе при копировании
US6586172B1 (en) * 1998-10-02 2003-07-01 Iatros Limited Device for treatment of biological fluids
US6312593B1 (en) * 1999-04-23 2001-11-06 Thomas R. Petrie Ultraviolet blood irradiation chamber
WO2002038191A2 (fr) * 2000-11-13 2002-05-16 Bayer Aktiengesellschaft Procede d'inactivation de micro-organismes presents dans un fluide au moyen de rayonnement ultraviolet
US20130078142A1 (en) * 2011-09-22 2013-03-28 Eugene I. Gordon Method and Apparatus for Sterilization of Medical Instruments and Devices by Ultraviolet Sterilization
US20170021042A1 (en) * 2015-07-23 2017-01-26 Terumo Bct Biotechnologies, Llc Flow-Through Pathogen Reduction
RU196088U1 (ru) * 2017-08-30 2020-02-14 Гаррий Дмитриевич Иващенко Аппарат для фотофореза
RU176288U1 (ru) * 2017-09-21 2018-01-15 Общество С Ограниченной Ответственностью "Электронные Приборы" (Ооо "Электронные Приборы") Ультрафиолетовый облучатель мононуклеарных клеток крови
WO2021188624A1 (fr) * 2020-03-20 2021-09-23 Barnett Eugene Dispositif et procédé de photothérapie polychromatique

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