WO2023190849A1 - Composition liquide à usage oral - Google Patents

Composition liquide à usage oral Download PDF

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Publication number
WO2023190849A1
WO2023190849A1 PCT/JP2023/013143 JP2023013143W WO2023190849A1 WO 2023190849 A1 WO2023190849 A1 WO 2023190849A1 JP 2023013143 W JP2023013143 W JP 2023013143W WO 2023190849 A1 WO2023190849 A1 WO 2023190849A1
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WO
WIPO (PCT)
Prior art keywords
water
aluminum
liquid oral
oral composition
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/013143
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English (en)
Japanese (ja)
Inventor
拓也 田淵
琢也 土屋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Healthcare Co Ltd
Original Assignee
Daiichi Sankyo Healthcare Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Healthcare Co Ltd filed Critical Daiichi Sankyo Healthcare Co Ltd
Priority to CN202380030418.4A priority Critical patent/CN118973543A/zh
Priority to JP2024512785A priority patent/JP7838077B2/ja
Publication of WO2023190849A1 publication Critical patent/WO2023190849A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a liquid oral composition.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 11-269073
  • Patent Document 2 Japanese Patent Application Laid-Open No. 2021-91654.
  • Patent Document 1 states that copper chlorophyllin is a compound obtained by replacing the magnesium atom in the molecule of chlorophyllin with a copper atom, and that chlorophyllin is effective as a medicine for preventing bad breath and treating wounds. It is stated that it has traditionally been incorporated into many products (paragraph 0002). The document also describes a preparation containing a copper chlorophyllin salt and an acid (Claim 1), and a method for adding an acid to prevent the tongue from being colored by the copper chlorophyllin salt (Claim 7). Are listed.
  • Example 1 The same document also describes that the degree of tongue coloring was observed for granules containing copper chlorophyllin potassium and citric acid (Example 1) and chewable tablets containing copper chlorophyllin potassium and citric acid. (Example 2, Table 1, etc.).
  • Patent Document 2 states that water-soluble polyvalent metal salts such as copper salts are medicinal ingredients that can be incorporated into dentifrice compositions, and that such ingredients can suppress hypersensitivity, suppress bad breath, and tighten gums. etc., and is described as being effective in preventing or suppressing oral diseases (paragraph 0002).
  • a water-soluble polyvalent metal salt such as copper salts
  • a water-soluble polyvalent metal salt is described as a technology for a dentifrice composition containing a water-soluble polyvalent metal salt, which is easy to put on a toothbrush, has excellent moldability, and has excellent dischargeability from a storage container even after storage.
  • a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound is described (Claim 1). .
  • the present inventors have found that when a water-soluble copper salt such as copper gluconate is blended into a liquid oral composition, discoloration may occur in the oral cavity, for example, on the tongue, oral mucosa, or teeth. .
  • the present invention provides a technique for suppressing coloring in the oral cavity when applying a liquid oral composition containing a water-soluble copper salt.
  • the present inventors have intensively investigated the cause of coloration when using a liquid oral composition containing a water-soluble copper salt.
  • one of the causes was found to be a reaction between the water-soluble copper salt in the liquid oral composition and components present in the oral cavity.
  • the present inventors conducted further studies to suppress the coloring caused by the water-soluble copper salt in the liquid oral composition and the components present in the oral cavity, and found that water-soluble aluminum was added to the liquid oral composition.
  • the present invention was completed based on the new discovery that incorporating salt is effective.
  • the following liquid oral cavity composition and method for suppressing tooth discoloration are provided.
  • the water-soluble copper salt is one or more selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin.
  • Composition [3] The liquid oral composition according to [1] or [2], wherein the water-soluble copper salt is copper gluconate.
  • the water-soluble aluminum salt is an aluminum salt of an organic acid.
  • the water-soluble aluminum salt is one or more selected from the group consisting of aluminum lactate, potassium aluminum sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride, aluminum benzoate, and aluminum allantoin chlorohydroxy.
  • [1 The liquid oral composition according to any one of ] to [3].
  • [6] The liquid oral composition according to any one of [1] to [5], wherein the water-soluble aluminum salt is aluminum lactate.
  • the liquid oral composition according to any one of [1] to [6] which contains copper gluconate and aluminum lactate.
  • the content of the copper gluconate is 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition
  • the content of the water-soluble aluminum salt to the content of the water-soluble copper salt in the liquid oral composition is 0.25 or more and 300 or less in mass ratio, [1] to [8] Liquid oral composition according to any one of the above.
  • a dentifrice containing a water-soluble copper salt and a water-soluble aluminum salt can also be provided.
  • composition may contain each component alone or in combination of two or more.
  • ⁇ indicating a numerical range represents the above or below, and includes both ends of the numerical value.
  • the composition is applied intraorally, and specifically is a liquid oral composition.
  • the liquid oral composition contains a water-soluble copper salt and a water-soluble aluminum salt. Each component will be explained below.
  • the water-soluble copper salt refers to a water-soluble one among an inorganic acid salt of copper and an organic acid salt of copper.
  • the water-soluble copper salt may be either anhydrous or hydrated.
  • the water-soluble copper salt may be one used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
  • a water-soluble copper salt from the viewpoint of improving the effect of combined use with a water-soluble aluminum salt, for example, one or two selected from the group consisting of copper gluconate, copper sulfate, copper citrate, copper chlorophyll, and sodium copper chlorophyllin. The above can be mentioned.
  • the water-soluble copper salt preferably contains at least one of copper gluconate and copper sulfate, and more preferably copper gluconate.
  • the water-soluble copper salt for example, commercially available products can be used.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 0.001 mass based on the entire liquid oral composition from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect. % or more, more preferably 0.01% by mass or more, still more preferably 0.03% by mass or more, even more preferably 0.08% by mass or more.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 10% by mass or less, more preferably The content is 1% by mass or less, more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, even more preferably 0.2% by mass or less.
  • the content of the water-soluble copper salt in the liquid oral composition is preferably 0.001% by mass as the copper content from the viewpoint of further improving the blending effect of the water-soluble copper salt such as the halitosis suppressing effect.
  • the content is more than 0.01% by mass, and more preferably 0.01% by mass or more.
  • the content of water-soluble copper salt in the liquid oral composition is preferably 0.06% by mass or less, more preferably 0.06% by mass or less, as the amount of copper blended. It is .03% by mass or less.
  • the water-soluble aluminum salt refers to a water-soluble one among inorganic acid salts of aluminum and organic acid salts of aluminum.
  • the water-soluble aluminum salt may be either anhydrous or hydrated. Any water-soluble aluminum salt may be used as long as it is used, for example, as a raw material for pharmaceuticals, foods, and cosmetics.
  • the water-soluble aluminum salt is preferably aluminum lactate, aluminum potassium sulfate, aluminum sulfate, aluminum nitrate, aluminum chloride (for example, aluminum chloride hexahydrate), benzoic acid. It is one or more selected from the group consisting of aluminum and allantoin chlorohydroxyaluminum, and more preferably at least one selected from the group consisting of aluminum lactate and aluminum chloride.
  • the water-soluble aluminum salt is preferably an aluminum salt of an organic acid.
  • the aluminum salt of an organic acid is, for example, one or more selected from the group consisting of aluminum lactate, aluminum citrate, and aluminum benzoate, and preferably aluminum lactate.
  • the content of the water-soluble aluminum salt in the liquid oral composition is preferably 0.01% by mass or more, more preferably The content is 0.03% by mass or more, more preferably 0.06% by mass or more, even more preferably 0.08% by mass or more, even more preferably 0.1% by mass or more.
  • the content of the water-soluble aluminum salt in the liquid oral composition is preferably 5% by mass or less based on the entire liquid oral composition. , more preferably 3.5% by mass or less, still more preferably 3% by mass or less, even more preferably 1.5% by mass or less.
  • the content of water-soluble aluminum salt in the liquid oral composition is preferably 0.002% by mass or more, more preferably 0.002% by mass or more, based on the aluminum content, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. It is .005% by mass or more. Further, from the viewpoint of improving the effect of suppressing coloring in the oral cavity and suppressing the metallic taste, the content of the water-soluble aluminum salt in the liquid oral composition may be, for example, 1% by mass or less as the amount of aluminum blended, Preferably it is 0.5% by mass or less, more preferably 0.2% by mass or less.
  • the content of water-soluble aluminum salt (water-soluble aluminum salt/water-soluble copper salt) with respect to the content of water-soluble copper salt in the liquid oral composition is determined by mass ratio, from the viewpoint of improving the effect of suppressing coloring in the oral cavity. Therefore, it is preferably 0.25 or more, more preferably 0.5 or more. Further, from the viewpoint of suppressing metallic taste, the mass ratio (water-soluble aluminum salt/water-soluble copper salt) is preferably 300 or less, more preferably 100 or less, and even more preferably 50 or less.
  • the liquid oral cavity composition preferably contains copper gluconate and aluminum lactate from the viewpoint of more stably suppressing intraoral coloration.
  • the content of copper gluconate is preferably 0.01% by mass or more and 0.2% by mass or less based on the entire liquid oral composition
  • the content of aluminum lactate is preferably 0.01% by mass or more and 0.2% by mass or less with respect to the entire liquid oral composition. It is preferably 0.01% by mass or more and 3% by mass or less based on the whole.
  • Liquid oral compositions specifically include water.
  • the content of water in the liquid oral composition can be, for example, the remainder after removing components other than water in the liquid oral composition.
  • the content of water in the liquid oral composition is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, based on the entire liquid oral composition. It is also preferably 99.99% by mass or less, more preferably 99.989% by mass or less, still more preferably 99.90% by mass or less.
  • compositions such as liquid oral compositions may contain components other than the above-mentioned components as long as the effects of the present invention are not impaired.
  • Such components include, for example, medicinal ingredients, abrasives, binders, thickeners, surfactants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, and detergents. agents, adsorbents, etc., and can be appropriately selected depending on the dosage form and the like. Specific examples of additive components are shown below, but the components that can be blended are not limited to these.
  • Examples of medicinal ingredients include one or two selected from the group consisting of bactericidal agents, anti-inflammatory agents, blood circulation promoters, tartar deposition inhibitors, stain removers, hypersensitivity inhibitors, vitamins, and plaque-degrading enzymes. The above can be mentioned. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals and the like.
  • the bactericidal agent is selected from the group consisting of, for example, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroylsarcosine, and triclosan.
  • isopropylmethylphenol cetylpyridinium chloride
  • benzalkonium chloride benzethonium chloride
  • hinokitiol chlorhexidine hydrochloride
  • alkyldiaminoethylglycine hydrochloride sodium lauroylsarcosine
  • triclosan One or more types may be mentioned.
  • anti-inflammatory agents examples include ⁇ -glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, tranexamic acid, and ⁇ -aminocaprone.
  • Examples include one or more selected from the group consisting of acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, and lysozyme hydrochloride.
  • blood circulation promoters examples include sodium chloride.
  • tartar deposition inhibitors include zeolite, disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, and phosphoric acid.
  • examples include one or more selected from the group consisting of sodium hydrogen hydrate, disodium hydrogen phosphate (crystal), trisodium phosphate, and sodium polyphosphate.
  • stain remover examples include Macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000). etc.), sodium polyphosphate, and polyvinylpyrrolidone.
  • hypersensitivity suppressant examples include at least one selected from the group consisting of potassium nitrate and aluminum salts other than water-soluble aluminum salts.
  • vitamin preparations include ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, pyridoxine hydrochloride, DL- ⁇ -tocopherol acetate, tocopherol acetate, dl- ⁇ -tocopherol nicotinate, and tocopherol nicotine.
  • acid esters One or more types selected from the group consisting of acid esters can be mentioned.
  • dental plaque decomposing enzyme is dextranase.
  • abrasives examples include silica-based abrasives such as silicic anhydride, silica (crystalline silica or amorphous silica), silica gel, and aluminosilicate; zeolite, calcium hydrogen phosphate anhydrate, and calcium hydrogen phosphate dihydrate. selected from the group consisting of calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, quaternary calcium phosphate, and synthetic resin-based abrasives. One or more types may be mentioned.
  • binders include pullulan, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, polyvinyl Examples include one or more selected from the group consisting of organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.
  • organic binders such as pyrrolidone and carboxyvinyl polymers, thickening silicic anhydride, and bentonite.
  • the thickening agent may be one that is commercially available as a raw material for pharmaceuticals, foods, and cosmetics, such as polyhydric alcohols, more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3 - One or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lactit, trehalose, sodium hyaluronate, and hydrolyzed collagen. It will be done.
  • polyhydric alcohols more specifically sorbitol, glycerin, concentrated glycerin, ethylene glycol, propylene glycol, 1,3 - One or more selected from the group consisting of butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylit, maltit, lac
  • surfactant examples include anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and preferably anionic surfactants, nonionic surfactants, and amphoteric surfactants.
  • anionic surfactants cationic surfactants, nonionic surfactants, and amphoteric surfactants.
  • anionic surfactants, nonionic surfactants, and amphoteric surfactants One or more selected from the group consisting of:
  • Anionic surfactants include, for example, N-acylamino acid salts, ⁇ -olefin sulfonates, N-acyl sulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters.
  • N-acylamino acid salts e.g., N-acylamino acid salts
  • ⁇ -olefin sulfonates e.g., N-acyl sulfonates
  • alkyl sulfates e.g., sodium lauryl sulfate
  • sulfates of glycerin fatty acid esters e.g., sodium lauryl sulfate
  • nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and One or more types selected from the group consisting of glycerin fatty acid esters can be mentioned.
  • amphoteric surfactants include one or more selected from the group consisting of alkyl betaine surfactants, amine oxide surfactants, and imidazolinium betaine surfactants. Specific examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and coconut oil fatty acid amide alkyl betaine.
  • flavoring agents include monosodium L-glutamate, saccharin, sodium saccharin, disodium glycyrrhizinate, trisodium glycyrrhizinate, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, xylitol, inositol, D-sorbitol.
  • D-mannitol arabitol, raffinose, lactulose, lactitol, erythritol, reduced palatinose, palatinose, palatinite, acesulfame K, maltose, maltosyltrehalose or maltitol, neohesperidin dihydrochalcone, perillartin, p-methoxycinnamic aldehyde and thaumatin
  • preservatives include benzoates such as sodium benzoate; paraoxybenzoic acid esters such as methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol and ethanol; Examples include one or more selected from the group consisting of sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, and alkyldiaminoethylglycine hydrochloride.
  • Examples of the flavor include one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavor, and peppermint oil.
  • colorants include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red malt pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, coumarind pigment; A type selected from the group consisting of legal pigments such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1; riboflavin, and titanium dioxide. Or two or more types can be mentioned.
  • pH adjusting agents include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, sodium acetate hydroxide, potassium hydroxide, A group consisting of acids, alkalis, and buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.
  • buffers such as sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate.
  • solvent examples include, in addition to the water mentioned above, lower alcohols such as ethanol and propanol.
  • a solubilizer may be added to promote the dissolution of the above additives and medicinal ingredients in water.
  • solubilizers include polyhydric alcohols such as propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol.
  • Examples of the base include sodium hydrogen carbonate.
  • cleaning agent examples include sodium polyphosphate.
  • Examples of the adsorbent include ⁇ -cyclodextrin.
  • components suitable for use in oral compositions such as liquid oral compositions can also be appropriately blended within a range that does not impair the content of the present invention.
  • liquid oral composition is specifically a liquid preparation.
  • Liquid formulations are specifically oral formulations.
  • Specific embodiments of the liquid oral composition include one selected from the group consisting of mouthwashes, liquid toothpastes, and mouth fresheners. From the viewpoint of further improving the blending effect of the water-soluble copper salt and the water-soluble aluminum salt, the liquid oral composition is preferably a mouthwash.
  • the liquid oral composition includes a step of blending, for example, a water-soluble copper salt, a water-soluble aluminum salt, water, and other components as appropriate.
  • liquid oral composition obtained in this embodiment contains a water-soluble copper salt and a water-soluble aluminum salt, it effectively suppresses coloring when applied to the oral cavity, for example, to the tongue, oral mucosa, or teeth. can do.
  • the liquid oral composition obtained in this embodiment is suitably used as, for example, a tongue coloring inhibitor, an oral mucosa coloring inhibitor, or a tooth coloring inhibitor.
  • the method for inhibiting tongue discoloration, the method for inhibiting oral mucosa discoloration, and the method for inhibiting tooth discoloration all include applying a composition containing a water-soluble copper salt and a water-soluble aluminum salt to the oral cavity.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition liquide à usage oral, qui contient un sel de cuivre soluble dans l'eau et un sel d'aluminium soluble dans l'eau.
PCT/JP2023/013143 2022-03-31 2023-03-30 Composition liquide à usage oral Ceased WO2023190849A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202380030418.4A CN118973543A (zh) 2022-03-31 2023-03-30 液体口腔用组合物
JP2024512785A JP7838077B2 (ja) 2022-03-31 2023-03-30 液体口腔用組成物

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Application Number Priority Date Filing Date Title
JP2022058491 2022-03-31
JP2022-058491 2022-03-31

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WO2023190849A1 true WO2023190849A1 (fr) 2023-10-05

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189358A (ja) * 2009-02-20 2010-09-02 Lion Corp 口腔用組成物
WO2022131147A1 (fr) * 2020-12-14 2022-06-23 ライオン株式会社 Composition pour cavité buccale
JP2022099622A (ja) * 2020-12-23 2022-07-05 小林製薬株式会社 口腔用組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02157210A (ja) * 1988-12-07 1990-06-18 Sansho Seiyaku Co Ltd 皮膚着色料
JP3734360B2 (ja) * 1998-03-18 2006-01-11 エーザイ株式会社 銅クロロフィリンの塩を含有してなる製剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010189358A (ja) * 2009-02-20 2010-09-02 Lion Corp 口腔用組成物
WO2022131147A1 (fr) * 2020-12-14 2022-06-23 ライオン株式会社 Composition pour cavité buccale
JP2022099622A (ja) * 2020-12-23 2022-07-05 小林製薬株式会社 口腔用組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE GNPD MINTEL; 23 June 2021 (2021-06-23), "Toothpaste", XP093093926, Database accession no. 8810077 *
DATABASE GNPD MINTEL; December 2021 (2021-12-01), "Herbal Toothpaste for Bad Breath & Gum Disease", XP093093913, Database accession no. 9238786 *

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JP7838077B2 (ja) 2026-03-31
JPWO2023190849A1 (fr) 2023-10-05

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