WO2024018084A3 - Particules - Google Patents

Particules Download PDF

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Publication number
WO2024018084A3
WO2024018084A3 PCT/EP2023/070373 EP2023070373W WO2024018084A3 WO 2024018084 A3 WO2024018084 A3 WO 2024018084A3 EP 2023070373 W EP2023070373 W EP 2023070373W WO 2024018084 A3 WO2024018084 A3 WO 2024018084A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic clusters
magnetic
clusters
particles
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2023/070373
Other languages
English (en)
Other versions
WO2024018084A2 (fr
Inventor
Maren JOHANSEN
Jan Paulsen
Daniel Firth
Talha GOKMEN
Geir Fonnum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies AS
Original Assignee
Life Technologies AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies AS filed Critical Life Technologies AS
Priority to EP23750558.1A priority Critical patent/EP4559009A2/fr
Priority to CN202380058757.3A priority patent/CN119698673A/zh
Publication of WO2024018084A2 publication Critical patent/WO2024018084A2/fr
Publication of WO2024018084A3 publication Critical patent/WO2024018084A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F216/10—Carbocyclic compounds
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K13/00—Use of mixtures of ingredients not covered by one single of the preceding main groups, each of these compounds being essential
    • C08K13/06—Pretreated ingredients and ingredients covered by the main groups C08K3/00 - C08K7/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2265—Oxides; Hydroxides of metals of iron
    • C08K2003/2272—Ferric oxide (Fe2O3)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/01—Magnetic additives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Power Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Compounds Of Iron (AREA)

Abstract

L'invention concerne également des amas magnétiques comprenant des nanocristaux d'oxyde de fer. Les amas magnétiques comprennent un acide carboxylique aromatique et/ou les amas magnétiques sont monodispersés. Les amas magnétiques peuvent être utiles dans des dosages biologiques et d'autres applications. L'invention concerne également des processus pour la préparation de tels amas magnétiques et des procédés d'utilisation des amas magnétiques, ainsi que des kits comprenant les amas magnétiques.
PCT/EP2023/070373 2022-07-22 2023-07-21 Particules Ceased WO2024018084A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP23750558.1A EP4559009A2 (fr) 2022-07-22 2023-07-21 Particules
CN202380058757.3A CN119698673A (zh) 2022-07-22 2023-07-21 粒子

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2210796.5A GB2620799A (en) 2022-07-22 2022-07-22 Particles
GB2210796.5 2022-07-22

Publications (2)

Publication Number Publication Date
WO2024018084A2 WO2024018084A2 (fr) 2024-01-25
WO2024018084A3 true WO2024018084A3 (fr) 2024-03-07

Family

ID=84540520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2023/070373 Ceased WO2024018084A2 (fr) 2022-07-22 2023-07-21 Particules

Country Status (4)

Country Link
EP (1) EP4559009A2 (fr)
CN (1) CN119698673A (fr)
GB (1) GB2620799A (fr)
WO (1) WO2024018084A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202315659D0 (en) 2023-10-12 2023-11-29 Life Tech As Nucleic acid preparation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247597A (en) * 1978-06-28 1981-01-27 Pitney Bowes, Inc. Electroscopic carrier particles having a carboxylic acid surface treatment
EP1362840A1 (fr) * 2002-05-15 2003-11-19 DSM Fine Chemicals Austria Nfg GmbH & Co KG Procédé de préparation des acides carboxyliques aromatiques et hétéroaromatiques par ozonolyse catalytique
EP2796153A1 (fr) * 2012-04-06 2014-10-29 SNU R & DB Foundation Nanocomposite d'oxyde de fer, produit de contraste d'imagerie par résonance magnétique pondérée en t2 le comprenant et leur procédé de fabrication
WO2020096631A2 (fr) * 2018-11-07 2020-05-14 Seer, Inc. Compositions, procédés et systèmes d'analyse de couronne protéique et leurs utilisations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003253D0 (en) 1990-02-13 1990-04-11 Amersham Int Plc Precipitating polymers
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
EP1985639B1 (fr) 1999-04-09 2013-08-14 Life Technologies AS Procédé pour la préparation de particules de polymère monodispersé
US8569477B2 (en) 2005-02-11 2013-10-29 Life Technologies As Method for isolating nucleic acids comprising the use of ethylene glycol multimers
GB0907372D0 (en) 2009-04-29 2009-06-10 Invitrogen Dynal As Particles
WO2012058635A1 (fr) 2010-10-29 2012-05-03 Life Technologies Corporation Dérivés de biotine
ITTO20130065A1 (it) * 2013-01-28 2014-07-29 Fond Istituto Italiano Di Tecnologia Sistema nanoparticellare sensibile al calore
CN105597686B (zh) * 2016-01-12 2018-06-26 郑州轻工业学院 Fe3O4@MIL-100（Fe）的制备方法及其应用
EP4226163B1 (fr) 2020-10-12 2025-12-24 Life Technologies AS Systèmes de traitement de particules magnétiques destinés à être utilisés avec des cellules biologiques et procédés associés
GB202017751D0 (en) 2020-11-10 2020-12-23 Life Tech As Sample protection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247597A (en) * 1978-06-28 1981-01-27 Pitney Bowes, Inc. Electroscopic carrier particles having a carboxylic acid surface treatment
EP1362840A1 (fr) * 2002-05-15 2003-11-19 DSM Fine Chemicals Austria Nfg GmbH & Co KG Procédé de préparation des acides carboxyliques aromatiques et hétéroaromatiques par ozonolyse catalytique
EP2796153A1 (fr) * 2012-04-06 2014-10-29 SNU R & DB Foundation Nanocomposite d'oxyde de fer, produit de contraste d'imagerie par résonance magnétique pondérée en t2 le comprenant et leur procédé de fabrication
WO2020096631A2 (fr) * 2018-11-07 2020-05-14 Seer, Inc. Compositions, procédés et systèmes d'analyse de couronne protéique et leurs utilisations

Also Published As

Publication number Publication date
GB2620799A (en) 2024-01-24
CN119698673A (zh) 2025-03-25
EP4559009A2 (fr) 2025-05-28
WO2024018084A2 (fr) 2024-01-25
GB2620799A8 (en) 2024-03-13
GB202210796D0 (en) 2022-09-07

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