WO2024182232A2 - Système de conservation et de transport d'organe hyperbare modulaire - Google Patents

Système de conservation et de transport d'organe hyperbare modulaire Download PDF

Info

Publication number
WO2024182232A2
WO2024182232A2 PCT/US2024/017055 US2024017055W WO2024182232A2 WO 2024182232 A2 WO2024182232 A2 WO 2024182232A2 US 2024017055 W US2024017055 W US 2024017055W WO 2024182232 A2 WO2024182232 A2 WO 2024182232A2
Authority
WO
WIPO (PCT)
Prior art keywords
organ
module
monitoring
fluid
removable chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/017055
Other languages
English (en)
Other versions
WO2024182232A3 (fr
Inventor
Raymond Paul Reneau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Express LLC
Original Assignee
Life Express LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Express LLC filed Critical Life Express LLC
Publication of WO2024182232A2 publication Critical patent/WO2024182232A2/fr
Publication of WO2024182232A3 publication Critical patent/WO2024182232A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion

Definitions

  • This disclosure relates to modular systems for the preservation and transport of living organs and tissues extracorporeal ly such as is required pending transplantation of organs from one being to another.
  • the disclosed system allows for control of pressure, temperature, and fluid management in the environment surrounding the organ.
  • the present disclosure refers generally to “organs;” however, the present disclosure contemplates that the disclosed systems are useful for preservation and transportation of organs as well as other body tissues.
  • Organ transplantation and preservation is a field of increasing importance due to the advances in the medical arts and sciences related to organ transplants, which have made it possible to transplant a variety of living tissues and organs. It is generally recognized in the art that preservation of living tissue is most effective if the tissue is immersed in a perfusate, nutrient liquid, and is maintained in a thermally-controlled, hyperbaric environment.
  • the attending physician may require that the perfusate be modified as, for example, to include additives or change the basic composition of the fluid.
  • the perfusate and the preservation chamber were maintained at equilibrium pressures, either both under hyperbaric conditions or both at ambient pressure. Since it is desirable to provide a hyperbaric environment for the organ, prior preservation systems were closed, pressurized systems, wherein both the perfusate and the preservation chamber were maintained at elevated pressures. In these past systems, it is generally necessary to depressurize the entire system, including the organ preservation chamber, in order to change or modify the perfusate.
  • the present disclosure provides a modular system for preserving and transporting living organs extracorporeally, comprising an organ monitoring and support module configured to engage with a removable chamber for housing an organ to be transplanted at a pressure of greater than or equal to two to three bars atmospheric, a fluid module configured to store for supply to the organ monitoring and support module one or more fluids, and a power module for supplying power to the organ monitoring and support module and the fluid module.
  • the organ monitoring and support module, the fluid module, and the power module are movably coupled to each other.
  • FIG. 1 illustrates a first perspective view of a modular hyperbaric organ preservation and transportation system, according to certain embodiments of the present disclosure.
  • FIG. 2 illustrates a second perspective view of the modular hyperbaric organ preservation and transportation system in FIG. 1 , according to certain embodiments of the present disclosure.
  • FIG. 3 illustrates a cross-sectional side view of a portion of the modular hyperbaric organ preservation and transportation system in FIGs. 1 and 2, according to certain embodiments of the present disclosure.
  • FIG. 4A illustrates a side schematic view of a portion of the modular hyperbaric organ preservation and transportation system in FIGs. 1 and 2, according to certain embodiments of the present disclosure.
  • FIG. 4B illustrates a perspective view of the portion of the modular hyperbaric organ preservation and transportation system in FIG. 4A, according to certain embodiments of the present disclosure.
  • FIG. 5 illustrates a perspective view of a portion of the modular hyperbaric organ preservation and transportation system in FIGs. 1 and 2, according to certain embodiments of the present disclosure.
  • FIG. 6 illustrates a cross-sectional side view of a portion of the modular hyperbaric organ preservation and transportation system in FIGs. 1 and 2, according to certain embodiments of the present disclosure.
  • FIGs. 1 and 2 depict perspective views of a modular hyperbaric organ preservation and transportation system 100 (sometimes referred to herein as “system 100”) for transporting and storing an organ (shown as 128 in FIG. 1 ) under pressure, which enables the organ 128 to reside extracorporeally for an increased period of time relative to an organ not stored under pressure.
  • system 100 for transporting and storing an organ (shown as 128 in FIG. 1 ) under pressure, which enables the organ 128 to reside extracorporeally for an increased period of time relative to an organ not stored under pressure.
  • the organ 128 can be transported greater distances and thus may be available to a wider range of individuals awaiting a necessary organ transplant.
  • medical personnel generally place an organ in the modular hyperbaric organ preservation and transport system 100 and then apply pressure to the organ.
  • the pressure profile to be applied to the organ is established before the organ is placed in the system 100.
  • medical personnel generally treat the organ, for example by administering fluids to the organ, and/or monitor the organ, during, e.g., transport. Then, at the appropriate time, medical personnel carefully decompress the modular hyperbaric organ preservation and transport system 100, remove the organ from the system 100, and proceed to place the organ in the patient, if appropriate.
  • the modular hyperbaric organ preservation and transportation system 100 includes an organ monitoring and support module 110, a fluid module 130, and a power module 140. As shown in FIGs. 1 and 2, each of the modules (110, 130, and 140) is coupled to a support column 150 at different positions along a length of the support column 150.
  • the support column 150 may be a single unitary piece or multiple, separable pieces.
  • the support column 150 is telescoping such that when extended, each of the modules 110, 130, and 140 is separated a distance apart for easy access to each of the modules.
  • each of the modules 110, 130, and 140 is rotatable around the support column 150 for easy access to each of the modules.
  • each of the modules 110, 130, and 140 may be detached from the modular hyperbaric organ preservation and transportation system 100 to operate independently.
  • the various components of the modular hyperbaric organ preservation and transportation system 100 are formed of robust and lightweight materials that facilitate easy transfer of the system into and out of, e.g., vehicles, and therefore facilitate easy transportation of the system between distant locations. Examples of such materials include lightweight metals, ceramics, polymers, and composites.
  • the materials of one or more components of the modular hyperbaric organ preservation and transportation system 100 are configured to be sterilized or chemically treated to allow the system to be transported into healthcare environments with reduced the risk of contamination.
  • Components of the modular hyperbaric organ preservation and transportation system 100 that may come into contact with the organ 128 are constructed of suitable biocompatible materials, such as medical grade thermoplastics, so that the environment for the organ 128 will not be contaminated.
  • the organ monitoring and support module 110 is designed to support and engage a pressure-tight pressure module 111 for storing the organ 128 at pressure.
  • the pressure module 111 comprises a cylindrical container, or chamber, manufactured from a rigid and transparent or translucent material capable of withstanding interior pressures around two to three bars or more above ambient atmospheric pressure, including but not limited to acrylic, so that the organ 128 disposed therein is viewable.
  • the pressure module 111 is configured to engage with the body 115 of the organ monitoring and support module 110, as well as an interface manifold plate 117.
  • the pressure module 111 includes rails attached thereto that slidingly engage with one or more tracks in the body 115 of the organ monitoring and support module 110.
  • the pressure module 111 includes a first end 112 and a second end 113, each of which may be reinforced with an aluminum ring 114 for mechanical support.
  • the first end 112 and the second end 113 are configured to sealingly engage with the container of the pressure module 111 to maintain the targeted pressure in the pressure module 111.
  • the second end 113 is designed to further engage interface manifold plate 117 and/or body 115.
  • the first end 112 and/or the second end 113 are removable such that the organ 128 may be easily put into, removed from, or manipulated within the pressure module 111.
  • the first end 112 or the second end 113 includes a transparent plate that is connected to the remainder of the container of pressure module 111 with one or more hinges such that the first end 112 or the second end 113 can be opened, like a door, for easy access to an organ disposed in the pressure module 111.
  • the pressure module 111 slides onto the body 115 to engage with the organ monitoring support module 110.
  • the pressure module 111 surrounds an organ support tray 116 and the second end 113 engages with the interface manifold plate 117, which serves as the system manifold.
  • the organ support tray 116 may removably couple to the interface manifold plate 117, the body 115, and/or the pressure module 111.
  • the interface manifold plate 117 may removably couple to the body 115.
  • the organ support tray 116 and connection plate 118 may be formed of any suitable rigid and biocompatible materials configured to be thermally and/or chemically sterilized.
  • the interface manifold plate 117 includes one or more ports 118 through which one or more cables and/or lines may be sealingly disposed for supplying the pressure module 111 and the organ 128 with fluids during operation, as well as for providing power and/or electrical signals to one or more sensors and/or other electronics within the pressure module 111.
  • the ports 118 may facilitate extension of one or more fluid lines 119 from an environment external to the pressure module 111 to an environment within the pressure module 111 when the pressure module 111 is engaged with the interface manifold plate 117.
  • the fluid lines 119 are configured to deliver liquids and/or gasses to the organ 128 in the pressure module 111.
  • the fluid lines 119 extend through the ports 118 and down into the fluid module 130, where they may removably couple to one or more liquid and/or gas sources for supplying the liquids and/or gasses.
  • the ports 118 may comprise one or more self- sealing features, thereby enabling the fluid lines 119 to be extended through the ports 118 one at a time during use.
  • the fluid lines 119 may be formed of any suitable flexible and biocompatible materials.
  • the fluid lines 119 are disposable and may be configured for single use.
  • the fluid lines 119 are disposed within protective sleeving to enable manipulation of the lines without causing damage or creasing thereto.
  • suitable types of protective sleeving include tube sleeving, braided sleeving, corrugated sleeving, spiral sleeving, wraparound sleeving, and drag chain sleeving. The interchangeability and disposability of these components of the system 100 beneficially reduce the need for system downtime to clean the components.
  • the organ monitoring and support module 110 further includes a dashboard 120 (e.g., a user interface) which may include a display screen 121 , buttons or knobs 122, and keys 123 (or other user input devices or mechanisms) for monitoring and controlling parameters of the modular hyperbaric organ preservation and transportation system 100, such as pressure, temperature, fluids, and gasses. Handles 124 may also be included to facilitate navigating the modular hyperbaric organ preservation and transportation system 100 when it is being transported.
  • a dashboard 120 e.g., a user interface
  • buttons or knobs 122 buttons or knobs 122
  • keys 123 or other user input devices or mechanisms
  • Handles 124 may also be included to facilitate navigating the modular hyperbaric organ preservation and transportation system 100 when it is being transported.
  • the organ monitoring and support module 110 also includes a monitoring tray 125 with a cavity 126 that facilitates mounting and support/storage for various monitoring devices, such as fluid and oxygen sensors or other devices for monitoring the condition of the organ 128.
  • the monitoring devices may be wired or wirelessly coupled to probes disposed within the pressure module 111 during operation, which may provide to the monitoring devices analogue or digital electrical signals indicative of organ environmental conditions such as organ temperature, transcutaneous gas pressure, and tissue oxygen partial pressure.
  • Data collected by the monitoring devices supported on monitoring tray 125 may be displayed for a user on the display screen 121 .
  • the monitoring tray 125 includes handles
  • the monitoring tray 125 may be pulled out of and pushed into the organ monitoring and support module 110, similar to a drawer, for space optimization and compactness of the organ monitoring and support module 110 during transport.
  • the fluid module 130 includes a cavity 131 for storing fluid sources (e.g., liquid and gas sources), as well as portions of the fluid lines 119 to supply the stored fluids to the organ monitoring and support module 110.
  • the cavity 131 may be temperature controlled, via a refrigeration unit, to accommodate the fluids being used. This provides for improved thermal regulation of the organ 128 by enabling control of the temperature of the fluids in which the organ
  • the refrigeration unit may include any suitable regulated fluid refrigeration apparatus which uses a coolant such as Freon circulated through a heat exchanger to effect and control the temperature of fluids in the cavity 131.
  • the refrigeration unit includes a temperature-sensing element to sense the temperature of fluids, such as perfusate, and a suitable thermostat to form a temperature control signal to maintain the temperature of fluids within a prescribed range.
  • the refrigeration unit may be any suitable refrigeration system such as are known in the art which is capable of maintaining the temperature of fluids near freezing (e.g., 2-8 degrees C) at ambient pressure.
  • the heat exchanger of the refrigeration unit can be mounted on the body 115 and configured to be disposed within the pressure module 111 during operation rather than the cavity 131 , since the object and function of the refrigeration unit is to maintain the temperature of the organ 128 indirectly by cooling the fluids the organ 128 is immersed in.
  • Gas sources of the fluid module 130 may include any suitable apparatus for providing regulated high-pressure gas, such as oxygen, as is known in the art.
  • the gas sources include a source of high-pressure gas, such as a gas canister, a regulator, gas supply conduit, and gas vent conduit.
  • the regulator may include any suitable pressure gauges and control mechanisms to enable the operator to set, adjust and monitor the gas pressure in the pressure module 111 when engaged with the body 115.
  • the cavity 131 includes a fluid receptacle for perfusate constructed of any suitable material and in any particular shape or configuration as desired.
  • the fluid receptacle is constructed with material having a low thermal conductivity to facilitate the refrigeration of perfusate.
  • the temperature-sensing element of the refrigeration unit described above can alternatively be mounted within the cavity 131 or within/adjacent to the organ 128.
  • the fluid receptacle of the cavity 131 is provided with an outlet and a return inlet suitably located below the normal perfusate level to permit perfusate to circulate from the fluid receptacle to the pressure module 111 and back to the fluid receptacle via the fluid lines 119.
  • the modular hyperbaric organ preservation and transportation system 100 will include a supply system comprising at least two fluid and/or gas supply loops: one loop for managing fluid and/or gas supply to the organ 128, and one loop for managing fluid and/or gas supply to the environment surrounding the organ 128 within the pressure module 111.
  • the supply system of the modular hyperbaric organ preservation and transportation system 100 includes one or more pumps, check valves, backpressure regulators, and the fluid lines 119.
  • the pumps provide fluid pressure to circulate fluids, such as perfusate, from the fluid sources in the fluid module 130 to the pressure module 111 and may include any suitable pumps capable of providing sufficient fluid pressure to deliver fluids the pressure module 111 when the pressure module 111 is pressurized from around two (2) to three (3) bars or more above the ambient pressure of the fluid sources of the fluid module 130.
  • the pumps provide a steady flow of fluids to the pressure module 111 , but other types of pumps can be used to provide pulsating flow of fluids if desired. Selection of the particular type of pumps to be used is dependent upon the volume of fluids that is necessary to circulate via the fluid lines 119, as well as other factors that are known to those of ordinary skill in the art and thus need not be described herein.
  • the fluid lines 119 are in fluid communication with the fluid sources in the cavity 131 via one or more outlets and return inlets, and with the pressure module 111 via one or more check valves and the ports 118 of the interface manifold plate 117.
  • the check valves and ports 118 allow unidirectional flow of fluids, such as perfusate, from the fluid lines 119 into pressure module 111 in response to fluid pressure provided by the one or more pumps of the supply system.
  • the check valve(s) prevent fluid flow from the pressure module 111 and thus isolate hyperbaric pressure module 111 from the ambient pressure of the fluid sources in the fluid module 130.
  • the backpressure regulators may include any suitable pressure regulators and relief valve mechanisms which sense the pressure in the pressure module 111 and open to maintain a prescribed fluid pressure differential between pressure module 111 and the fluid sources in the fluid module 130.
  • the backpressure regulators permit return circulation of effluent fluids to the fluid module 130 via the fluid lines 119, the ports 118 in the interface manifold plate 117, and inlets of the fluid sources.
  • a filter unit or filtration means may be included interposed between the fluid lines 119 and the fluid sources to remove organ by-products and impurities from effluent fluids.
  • the backpressure regulators and fluid lines 119 form a perfusate return means of the present disclosure.
  • the perfusate return means may include fixed or variable in-line orifices that may be mounted in flow communication with the fluid lines 119 for providing backpressure control, eliminating the need for backpressure regulators if desired.
  • Filters may be any suitable gas or liquid filters, such as plasma filters, as are commonly available.
  • flow meters are positioned in fluid communication with the fluid lines 119 for determining the volumetric amount of fluid, such as perfusate (hence the quantity of additives such as vitamins, minerals, antibiotics and all types of metabolic additives), available to the organ 128.
  • the power module 140 includes a power supply for the modular hyperbaric organ preservation and transportation system 100.
  • the power supply may be a battery, including but not limited to a rechargeable battery such as a lithium ion battery.
  • the modular hyperbaric organ preservation and transportation system 100 is AC/DC-powered and the power module 140 includes an AC/DC adapter or converter that may be plugged into an outlet via a power cord 142. It is further contemplated that the modular hyperbaric organ preservation and transportation system 100 may be both battery and AC/DC-powered.
  • the power module 140 is supported on a plurality of wheels 141 , which enable rolling of the modular hyperbaric organ preservation and transportation system 100 for easy transport thereof.
  • one or more gases to be supplied to the system 100 may be stored in the power module 140.
  • the power module 140 may store one or more oxygen tanks.
  • FIG. 3 a cross-sectional side view of the pressure module 111 and organ support tray 116 is illustrated, according to certain embodiments of the present disclosure.
  • the organ support tray 116 may removably couple to the pressure module 111 and/or the interface manifold plate 117.
  • the organ support tray 116 may include any suitable type of receptacle formed of rigid and biocompatible materials for supporting the organ 128 and/or a bath of perfusate 132, within which the organ 128 may be disposed.
  • the organ support tray 116 comprises a bin or tub having a horizontal bottom wall 160 sealingly coupled to one or more vertical side walls 161 for supporting the organ 128 in the bath of perfusate 132.
  • the perfusate 132 may be supplied via the internal fluid lines 119, which may have distal or terminal ends disposed within the organ support tray 116 during use.
  • FIGS. 4A and 4B illustrate various views of the organ monitoring and support module 110, including the monitoring tray 125, according to certain embodiments of the present disclosure.
  • the monitoring tray 125 includes a cavity 126 for mounting and support/storage of various monitoring devices 154 for monitoring the condition of the organ 128.
  • the monitoring devices 154 may be wired or wirelessly coupled to one or more probes 152 configured to be disposed within the pressure module 111 during operation of the modular hyperbaric organ preservation and transportation system 100.
  • probes 152 may include, for example, oxygen and other fluid sensors.
  • the monitoring devices 154 are coupled to probes 152 via cables 153 extending between the monitoring devices 154 and probes 152 and through the ports 118 in the interface manifold plate 117.
  • the cables 153 sheathe electrical wiring for transmitting signals between the probes
  • the cables 153 may be formed of suitable biocompatible materials.
  • the cavity 126 may include one or more cable management devices 155 for facilitating organization and extension/collapse of the cables 153 when sliding the monitoring tray 125.
  • the cables 153 may also be disposed within sleeving, such as collapsible drag chain sleeving, to prevent damage to the cables 153 as the monitoring tray 125 is extended from or retracted into the body 115. For easy access to the cables
  • the body 115 of the organ monitoring and support module 110 may include removable side panels 151.
  • other support systems and devices such as pumps, check/relief valves, and backpressure regulators, may also be mounted and/or stored in the cavity 126 of monitoring tray 125.
  • the fluid lines 119 may be operably coupled with pumps, check/relief valves, and/or backpressure regulators within the monitoring tray 125.
  • the system 100 may also be configured to support a robotic arm 170 having an end effector 171.
  • the robotic arm 170 may be removably coupled to the interface manifold plate 117 and/or the body 115 of organ monitoring and support module 110.
  • the end effector 171 may comprise any suitable end effector device for interacting with the organ 128, such as jaws, claws, grippers (e.g., Bernouilli grippers), or the like.
  • the robotic arm 170 can be used to stabilize, manipulate, or stimulate an organ disposed in the system 100 for preservation and transportation.
  • the robotic arm 170 is generally configured for at least rotational movement and lateral movement.
  • the robotic arm 170 comprises a serial robotic arm having a plurality of links 172 movably coupled by linear and/or revolute joints 174.
  • the linear and/or revolute joints 174 may linearly translate along and/or rotate about one or more axes, including horizontal axis Z and vertical axis Y shown in FIG. 5, to facilitate 1 -DOF, 2-DOF, 3-DOF, 4-DOF, 5-DOF, and/or 6-DOF for the robotic arm 170.
  • a fluid line 176 having a nozzle 178 at a terminal end thereof is coupled to, and in some examples, extends along, the robotic arm 170.
  • the fluid line 176 may be fluidically coupled, through a port 118 in the interface manifold plate 117, to a fluid source in the fluid module 130 for supplying and delivering one or more fluids to the organ 128 through the nozzle 178.
  • Such fluids may be utilized for stimulation of one or more tissues of the organ 128 during preservation and transport thereof.
  • the interface manifold plate 117 includes one or more ports 118 through which fluid lines 119 and cables 153 may be sealingly disposed for supplying the pressure module 111 and the organ 128 with fluids during operation, as well as for providing power and/or electrical signals to one or more probes 152 and/or other electronics within the pressure module 111.
  • Each of the ports 118 may comprise a self-sealing feature that fluidically seals the respective port 118 with or without a fluid line 119 or cable 153 disposed therethrough.
  • the self-sealing features facilitate an airtight seal around the environment within the pressure module 111 , thus enabling the pressure module 111 to be maintained at elevated pressures (e.g., two (2) to three (3) bars or more) during use.
  • the self-sealing features comprise taper seal connections 180, and/or the like.
  • the self-sealing features comprise gland-type connections 182, and/or the like.
  • the self-sealing features comprise push-in connectors, plugs, O-ring seals, sleeves, and/or the like.
  • the modular hyperbaric organ preservation and transportation system 100 provides a controlled hyperbaric environment for oxygen preservation wherein the organ 128 is bathed in fluids, including perfusate, provided from one or more ambient pressure fluid sources.
  • the organ 128 is placed on organ support tray 116 and the pressure module 111 is slid over and engaged with organ monitoring and support module 110.
  • a bath of perfusate may then be supplied to the organ support tray 116 and/or pressure module 111 from the fluid module 130 via fluid lines 119, and the organ 128 immersed in perfusate, which is generally life sustaining artificial blood plasma or similar liquid circulated from the fluid module 130 to the organ monitoring and support module 110.
  • the pressure module 111 is then pressurized via supply of gasses from the fluid module 130 to provide a prescribed, hyperbaric environment for the organ 128.
  • One or more regulators maintain the pressure inside the pressure module 111 at the prescribed level.
  • the pressure module 111 is maintained at a pressure of at least three (3) bars, which enhances preservation of the organ 128.
  • the perfusate is circulated under pressure from the fluid module 130 to the pressure module 111 to provide oxygen, nutrients, and treatment to the organ 128 as is required.
  • the temperature of the organ 128 is also controlled indirectly by controlling the temperature of the perfusate and/or other fluids supplied to the pressure module 111. These and other conditions of the organ 128 may be monitored via the dashboard 120.
  • the embodiments of the system 100 disclosed herein are configured to allow for easy accessibility and interchangeability of various components thereof making the disclosed system 100 beneficial not only in terms of organ preservation and transportation, but also in terms of ease of use for medical professionals operating under high stress conditions during organ transplant procedures. System downtime is significantly reduced as a result of the accessibility and interchangeability of many components of the system 100.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente divulgation propose un système modulaire pour conserver et transporter des organes vivants de manière extracorporelle, comprenant un module de surveillance et de support d'organe configuré pour venir en prise avec une chambre amovible pour loger un organe à transplanter à une pression supérieure ou égale à deux à trois bars atmosphériques, un module de fluide configuré pour stocker pour fournir au module de surveillance et de support d'organe un ou plusieurs fluides, et un module de puissance pour fournir de l'énergie au module de surveillance et de support d'organe et au module de fluide. Le module de surveillance et de support d'organe, le module de fluide et le module de puissance sont couplés de façon mobile l'un à l'autre. Le système divulgué permet de réguler la pression, la température et la gestion de fluide dans l'environnement entourant l'organe.
PCT/US2024/017055 2023-02-27 2024-02-23 Système de conservation et de transport d'organe hyperbare modulaire Ceased WO2024182232A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363448385P 2023-02-27 2023-02-27
US63/448,385 2023-02-27

Publications (2)

Publication Number Publication Date
WO2024182232A2 true WO2024182232A2 (fr) 2024-09-06
WO2024182232A3 WO2024182232A3 (fr) 2025-01-16

Family

ID=92590397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/017055 Ceased WO2024182232A2 (fr) 2023-02-27 2024-02-23 Système de conservation et de transport d'organe hyperbare modulaire

Country Status (1)

Country Link
WO (1) WO2024182232A2 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837390A (en) * 1983-05-11 1989-06-06 Keyes Offshore, Inc. Hyperbaric organ preservation apparatus and method for preserving living organs
US5586438A (en) * 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6794182B2 (en) * 2000-03-13 2004-09-21 E. George Wolf, Jr. Hyperbaric oxygen organ preservation system (HOOPS)
WO2003026419A1 (fr) * 2001-09-28 2003-04-03 Hull Harry F Dispositif simple, entierement transportable, de maintien en condition optimale de coeur excise destine a etre transplante
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods

Also Published As

Publication number Publication date
WO2024182232A3 (fr) 2025-01-16

Similar Documents

Publication Publication Date Title
US4837390A (en) Hyperbaric organ preservation apparatus and method for preserving living organs
US10695249B2 (en) Premature neonate closed life support system
EP0586489B1 (fr) Chambre de compression
EP1667762B1 (fr) Dispositif de raccordement et procede de raccordement de sous-systemes medicaux
CN105451704B (zh) 病人保持医院单元、病人运输系统以及病人运输和生命支持系统
EP3243384B1 (fr) Dispositif de perfusion d'organe
CN107183005A (zh) 器官灌注的设备与方法
US8563234B2 (en) Critical point drying systems and methods for in situ tissue preservation
JP3223817U (ja) 多器官保存装置
WO2024182232A2 (fr) Système de conservation et de transport d'organe hyperbare modulaire
CN111771870B (zh) 具有氧生成的器官运送器
US20160066565A1 (en) Isolator devices for collection, parametrical characterization and long-term preservation of organic fluids and/or materials containing stem cells
JP2019048776A (ja) 臓器及び生体組織の輸送装置
CN110573011A (zh) 具有补充充氧系统的器官运输设备
JP6988286B2 (ja) 臓器及び生体組織の輸送装置
EP4285849A1 (fr) Système cryogénique à pompes immergées multiples
JPH0269401A (ja) 臓器保存装置
US6395550B1 (en) Method and apparatus for tissue treatment
JPH02124801A (ja) 臟器保存装置
JP2025502937A (ja) 自動細胞操作システムのための支持構造
HK40019050A (en) Organ transporter with supplemental oxygenation system
HK40039070A (en) Organ transporter with oxygen generation
ITBO20000225A1 (it) Apparecchiatuta per il trasporto di organi da trapiantare .

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24764382

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 24764382

Country of ref document: EP

Kind code of ref document: A2