WO2024201329A1 - Nouvelles combinaisons comprenant du mannane de konjac, leurs compositions et leurs utilisations - Google Patents

Nouvelles combinaisons comprenant du mannane de konjac, leurs compositions et leurs utilisations Download PDF

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WO2024201329A1
WO2024201329A1 PCT/IB2024/052965 IB2024052965W WO2024201329A1 WO 2024201329 A1 WO2024201329 A1 WO 2024201329A1 IB 2024052965 W IB2024052965 W IB 2024052965W WO 2024201329 A1 WO2024201329 A1 WO 2024201329A1
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salts
water
kgm
drink
sodium
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Peter Bos
Jörg SCHREIBER
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Vivatis Pharma GmbH
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Vivatis Pharma GmbH
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
    • A23L19/115—Konjak; Konntaku
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/40—Effervescence-generating compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/68—Acidifying substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • the present invention relates to novel solid fast dissolving or fast dispersing combinations containing Konjac mannan, to processes for preparing drinkable compositions comprising them, to drinkable compositions comprising them and to their uses as a food supplement/beverage supplement, in particular,, but not limited to, in the managing of weight loss or overweight reduction, and in cholesterol and blood sugar levels control in a subject in need.
  • Konjac is an Asian plant with a starchy root rich in fiber called glucomannan.
  • Konjac mannan or Konjac glucomannan
  • Konjac Mannan is a high molecular weight, water-soluble, non-ionic glucomannan found in tubers of the Amorphophallus konjac plant (Konjac Mannan - an overview Science Direct Topics; Handbook of Hydrocolloids (Second Edition), 2009.
  • Konjac flour is produced from the corms of the Amorphophallus konjac plant, a tropical perennial crop.
  • the corms of the plant contain about 30%-50% glucomannan gum.
  • the resulting powder is konjac flour.
  • the flour constitutes 60%-80% of the dried root corm.
  • the corms grow below ground and are harvested at 2 kg for commercial processing. They are then washed and cut into thin slices, which are then dried and dry-milled into powder. The powder is separated, usually by cyclone or wind separation, producing crude konjac flour.
  • Glucomannans in which some of the mannose residues are replaced by D-glucose are found in softwoods, tubers, and bulbs.
  • Konjac glucomannan is a linear random copolymer of (1-4) linked beta-D-mannose and beta-D-glucose. It has mannose and glucose units at molar ratio of 1.6:1 with a low degree of acetyl groups (approximately 1 acetyl group per 17 residues) at the C-6 position. The degree of water solubility is controlled by the presence of the acetyl units.
  • KGM The natural polysaccharide Konjac glucomannan
  • KGM The natural polysaccharide Konjac glucomannan
  • Glucomannan whose glucose and mannose units are connected by p-1 ,4-linkages, with a low degree of acetyl groups at the side chain C-6 position, as shown in Formula (I):
  • the p-1 ,4-linkages are not digested by human enzymes of the microbiota in the human Gl tract. This is due to the p-glycosidic linkages between the mannose and glucose molecules, which cannot be hydrolysed by pancreatic amylase or salivary amylase. This means that it passes into the colon without being digested. Once it is in the colon, it is fermented by the native flora to produce glucomannan-oligosaccharides. Because it is not digested immediately, konjac glucomannan can increase feelings of satiety, leading the consumer to eat less.
  • KGM has been widely used in food industry as it has been authorized as a food additive in Europe and classified as GRAS (Generally Recognized as Safe) by the FDA (Food and Drug Administration.
  • the KGM powder used as such shows too many drawbacks.
  • 1g KGM powder (high molecular weight) in 99 g water at a temperature of 25°C under constant stirring with, for example, a spoon it can take up to 10-15 minutes to form a gel in water.
  • it is preferred to use a high molecular weight KGM and due to this high molecular weight the dissolution or gel formation of the KGM powder in water is time consuming for a consumer, and the formation of lumps (agglomeration of KGM in water) is a further disadvantage.
  • the resulting gel is very stiff and does not flow easily out of the drinking glass to the mouth.
  • the gel colour is grayish/grey, therefore it is not very appealing, and its viscosity makes difficult to swallow it.
  • EFSA to reduce overweight it has to be in-taken three times a day (at 1 g level, 3x1g/day); it is therefore self-evident that the above drawbacks are not in favour of the compliance.
  • the patent application CN1146867A discloses a Konjak jelly with a lipid-lowering and weight-reducing health-care function.
  • the preparation is complex: it involves a heating step followed by filtration and cooling.
  • the patent application CN105901269A discloses a Konjac tablet candy for weight management.
  • the patent application ON 101564123A discloses a konjac vinegar health jelly and a preparation method thereof.
  • the preparation is complex: it involves a pre-dissolution step followed by filtration and addition to hot water, stirring and subsequent heating to 80-90°C for a long time (40-50 minutes) to complete dissolution, and finally further filtration.
  • the patent application CN108041570A discloses a food additive comprising Konjac gum, Arabic gum and polyphosphate salts to be added to a food material for obtaining a good emulsification, stability, thickening, water retention.
  • the technical problem that the present invention addresses and solves is to provide a solid fast dissolving or fast dispersing combination or composition of high molecular weight KGM, useful for preparing, for example, RTD beverage or another water-based fluid product for oral use containing high molecular weight KGM, that is easy to prepare (also with the only aid of a spoon), stable, easy to swallow and with an appealing mouthfeel, taste and colour.
  • the solid (e.g, powder) compositions for instant (or RTD, ready to drink) beverage according to the present invention are particularly advantageous and offer great compliance for those taking them. They are easy to prepare, stable, easy to swallow and suitable for a wide range of individuals, including the elderly and children. Usually they can be poured into water, or another water-based fluid, and quickly and easily, with the only aid of a spoon, transformed into a drinkable fluid having an appealing mouthfeel, taste and colour.
  • Figure 1 shows a simulation of fluid KGM behaviour after ingestion. After the ingestion of a water formulation comprising KGM, the water penetrates into the tissue or blood stream in the body. To simulate the vanishing of water from the formulation a series of experiments was made; gel formation occurs again when the water is no longer a significant part of the formulation and gel formation lowers food craving.
  • the Applicant addresses and solves the above requirements by providing an innovative combination that allows KGM powder composition to be quickly and easily diluted in water, or another water-based fluid, resulting in a drinkable, stable and easy-to-take composition.
  • the KGM powder composition of the invention by adding a fluid leads preferably to:
  • an effervescent fluid KGM composition e.g., if the KGM powder composition contains an effervescent system
  • the term "fluid” may have, for example, the meaning of water, a translucent/transparent or colored water-based system, a milk (white fluid), a fluid similar to milk (milk substitute, plant-based milk, non dairy substitute, non-dairy beverage, instant milk), a beverage (non-alcoholic, alcoholic), a drink (fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink), a nectar, a juice a coffee, a cappuccino, a smoothie, a macchiato, a cafe au lait, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a caffee latte, a cacao.
  • fluid gel may have, for example, the meaning of a system that is not a stiff gel (not flowable) but a flowable system (e.g., from a beverage glass so that a consumer can easily drink it).
  • a fluid gel is a translucent/transparent gel (water based KGM system) or a white composition (milk-like appearance) with higher viscositiy so that a fluid gel-like KGM composition results that is drinkable) or a colored fluid gel KGM composition so that a colored fluid gel KGM composition results that is drinkable.
  • a fluid gel of the invention may contain an effervescent system (e.g., mousse-like transparent or white or colored appearance).
  • a mousse is a soft, light, and airy system, that may contain bubbles of C02 to give it a light and airy texture.
  • fluid composition and “fluid gel composition” mean that they flow easily out from the drinking glass (or other containers) to the mouth of a consumer or from a spoon to the mouth of the consumer.
  • fast dissolving or fast dispersing means that, when a solid powder combination or composition of the invention is poured into a water-based fluid at a temperature from 18 °C to 40°C, preferably from 18°C to 25 °C, and stirred, preferably with the aid of a spoon, it easily gives, within a time from 10 seconds to 5 minutes, preferably from 1 minute to 3 minutes, a solution or a homogeneous fine dispersion free of lumps, insoluble bottom residue, precipitates.
  • the Applicant has found a powder combination or composition comprising KGM that is able to be quickly and easily diluted in a water-based fluid (e.g., water) and to reduce the formation of lumps, improve the flow behaviour of a water-based composition out of a drinking glass, and the viscosity of KGM powder when diluted in water or another water-based fluid, improving the mouthfeel of KGM, its taste, and the colour of the final drinkable composition.
  • a water-based fluid e.g., water
  • the subject-matter of the present invention relates to a solid combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one further dissolving or dispersing aid component (i) to (ix) which is selected from group comprising or, alternatively, consisting of: i. at least one arabic gum, and at least one water-soluble salt, as defined in the present invention; and/or ii. at least one arabic gum, at least one water-soluble salt, as defined in the present invention, and at least one acid; preferably at least one hydroxy acid, as defined in the present invention; more preferably, citric acid and/or tartaric acid; and/or ill.
  • KGM Konjac glucomannan
  • ix which is selected from group comprising or, alternatively, consisting of: i. at least one arabic gum, and at least one water-soluble salt, as defined in the present invention; and/or ii. at least one arabic gum, at least one
  • At least one sugar alcohol preferably at least one sugar alcohol erythritol, as defined in the present invention, and at least one component selected from i. to ix. (not vii); and/or viii. at least one acid, preferably at least one hydroxy acid; and/or ix. at least one arabic gum and at least one acid, preferably at least one hydroxy acid, or their mixtures thereof, preferably in combination with one or more flavours and/or colorants and/or sweetener and/or oils (lipids) and/or surfactants and/or actives as defined above.
  • component herein includes either a single substance or mixture of substances thereof.
  • Konjac glucomannan is a known and commercially available compound having for example CAS RN No. 37220-17-0. It is also referred to as Konjac gum, Konjac Glucomannan, Glucomannan Konjac Jelly, Konnyaku and Amorphophallus Konjac Root Mannan. Preferably, KGM is for example in powder form.
  • Konjac gum may be indicated with E425(i) or E425(ii), both contain Konjac glucomannan.
  • a high molecular weight KGM (e.g., >10 6 Da, preferably e.g., from >10 6 Da to 10 8 Da, more preferably e.g., from >10 6 Da to 10 7 Da) forms a gel in water which leads to feeling of satiety after ingestion (e.g., 1 g KGM).
  • said high molecular weight Konjac glucomannan has a molecular weight equal to or bigger than 10 6 Da; preferably, has a molecular weight comprised from bigger than 10 6 Da to 10 8 Da; more preferably, has a molecular weight comprised from 10 7 Da to 10 8 Da.
  • a high molecular weight KGM with a viscosity value comprised from 20,000 cps to 100,000 cps, preferably comprised from 25,000 cps to 80,000 cps, more preferably comprised from 30,000 cps (30,000 mPas) to 60,000 cps, even more preferably comprised from 35,000 cps to 50,000 cps, for example bigger than 36,000 cps.
  • the solid fast dissolving or fast dispersing composition of the present invention can be mixed with a drinkable liquid or a drinkable fluid gel like composition, which may be selected from water, milk (e.g., cow milk), a milk substitute (plant based milk, non dairy substitute, dairy beverage), a carbonated fluid, a beverage, a drink (fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink), a nectar, a juice, a smoothie, a macchiato, a cafe au lait, a caffee latte, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a cacao without forming lumps.
  • milk e.g., cow milk
  • a milk substitute plant based milk, non dairy substitute, dairy beverage
  • a carbonated fluid e.g., a beverage
  • a drink fruit drink, energy drink, fortified drink, herbal drink, sport
  • Arabic gum is also a known and commercially available compound, and it is also referred to as acacia gum, and preferably it is also in powder form. Arabic gum is the dried resin of acacia Senegal and related species.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above is more preferably selected from the group comprising or, alternatively, consisting of citrate salts, ascorbate salts, gluconate salts, chloride salts, lactate salts, tartrate salts, sulfate salts, glycinate/bisglycinate salts, acetyl taurinate salts, or mixtures thereof; more preferably, said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above is selected from water-soluble alkali-metal salts and/or water soluble alkali-earth metal salts such as for example citrate salts, ascorbate salt, gluconate salts, chloride salts, lactate salts, tartrate salts, or their mixtures thereof.
  • chloride salts include sodium chloride, potassium chloride, calcium chloride and ammonium
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from a tripotassium citrate salt, more preferably may be a tripotassium citrate and/or tripotassium citrate monohydrate (company Pharmavit or from Magnesia/Jungbunzlauer) or trisodium citrate anhydrous (company Magnesia/Jungbunzlauer) or magnesium citrate (company Pharmavit) or zinc citrate or their mixtures thereof.
  • a tripotassium citrate salt more preferably may be a tripotassium citrate and/or tripotassium citrate monohydrate (company Pharmavit or from Magnesia/Jungbunzlauer) or trisodium citrate anhydrous (company Magnesia/Jungbunzlauer) or magnesium citrate (company Pharmavit) or zinc citrate or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill) and (iv) above may be selected from a sodium and/or potassium ascorbate salt ((Jebsen&Jessen) and/or calcium and/or magnesium ascorbate (company Global Calcium) and/or zinc ascorbate monohydrate (company BioIla Chemicals GmbH) or their mixtures thereof.
  • a sodium and/or potassium ascorbate salt (Jebsen&Jessen) and/or calcium and/or magnesium ascorbate (company Global Calcium) and/or zinc ascorbate monohydrate (company BioIla Chemicals GmbH) or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from a sodium and/or potassium gluconate salt (company Magnesia/Jungbunzlauer) and/or calcium and/or magnesium gluconate (company Global Calcium) and/or zinc gluconate salt (company Magnesia/Jungbunzlauer) or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from an alkali-earth metal halogenide salt; e.g., an alkali-earth chloride salt (e.g., CaCh x 2H2O, company Magnesia/Jungbunzlauer) or (e.g., MgCh x 6H2O, company Magnesia/Jungbunzlauer) or hydrate water free versions like calcium chloride salt or a magnesium chloride or their mixtures thereof.
  • an alkali-earth metal halogenide salt e.g., an alkali-earth chloride salt (e.g., CaCh x 2H2O, company Magnesia/Jungbunzlauer) or (e.g., MgCh x 6H2O, company Magnesia/Jungbunzlauer) or hydrate water free versions like calcium chloride salt or a magnesium
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from an alkali chloride salt, e.g., sodium chloride, potassium chloride, ammonium chloride, or their mixtures thereof.
  • an alkali chloride salt e.g., sodium chloride, potassium chloride, ammonium chloride, or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from lactate salts, more preferably may be a calcium lactate pentahydrate (company Global Calcium) and/or sodium lactate (company Magnesia/Jungbunzlauer) and/or potassium lactate and/or zinc lactate dihydrate, or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from tartrate salts, more preferably may be a potassium tartrate x 0.5 H2O (company Dr. Paul Lohmann) and/or potassium sodium tartrate x 4 H2O, or their mixtures thereof.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from sulfate salts, more preferably may be a sodium and/or potassium sulfate.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from glycinate salts, more preferably may be a sodium and/or potassium glycinate.
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from bisglycinate salts, more preferably may be a zinc bisglycinate or zinc bisglycinate monohydrate (company BioIla Chemicals GmbH).
  • said at least one water-soluble salt mentioned in the component (I), (II), (ill), (iv) and (v) above may be selected from acetyl taurinate salts, more preferably may be a calcium and/or magnesium acetyl taurinate (company Synapharm).
  • said at least one acid, more preferably at least one hydroxy acid, mentioned in the components (II), (ill), (in the components iv. and v., here is an acid that forms the effervescent system together with a base), (viii) and (lx) above may be selected from at least one organic and/or inorganic acids, more preferably may be a hydroxy acid such as, for example, citric acid, lactic acid, ascorbic acid, tartaric acid, malic acid or other acids like phosphoric acid or glucono-delta-lactone (GdL -is a lactone that rapidly dissolves in water, and subsequently slowly hydrolyses to gluconic acid) and/or mixtures thereof; more preferably, said an acid mentioned in the component (II), (ill), (in iv. and v., here is an acid that forms the effervescent system together with a base), (viii) and (ix) above may be a hydroxy acid, most preferably it may be
  • said an effervescent system mentioned in the components (iv) and (v) above comprises or, alternatively, consists of at least one base that can release carbon dioxide.
  • said an effervescent system comprises or, alternatively, consists of at least one basic substance (i.e., an organic and/or inorganic base) capable of releasing carbon dioxide in the presence of an acidic substance (i.e., an organic and/or inorganic acid) preferably in the presence of a composition or formulation containing water.
  • an organic and/or inorganic base i.e., an organic and/or inorganic base
  • an acidic substance i.e., an organic and/or inorganic acid
  • said base may be a carbonate and/or bicarbonate salt, more preferably may be a sodium and/or potassium carbonate salt or sodium and/or potassium bicarbonate salt.
  • said an effervescent system mentioned in the components (iv) and (v) above comprises or, alternatively, consists of a sodium and/or potassium bicarbonate salt (also referred to as sodium or potassium hydrogen carbonate salt, NaHCOs or KHCO3) and citric acid.
  • a sodium and/or potassium bicarbonate salt also referred to as sodium or potassium hydrogen carbonate salt, NaHCOs or KHCO3
  • citric acid also referred to as sodium or potassium hydrogen carbonate salt, NaHCOs or KHCO3
  • said at least one water-soluble salt mentioned in the components (iv) and (v) above may be selected from alkali-metal carbonate salts; more preferably, may be a sodium carbonate and/or sodium hydrogen carbonate salt (Solvay Chemicals International: BICAR® FOOD, A+E. Fischer-Chemie GmbH & Co. KG, Wiesbaden, Germany, Carl Dicke GmbH & Co KG, Mdnchengladbach, Germany) and/or potassium hydrogen carbonate (company Dr. Paul Lohmann) or their mixtures thereof.
  • alkali-metal carbonate salts more preferably, may be a sodium carbonate and/or sodium hydrogen carbonate salt (Solvay Chemicals International: BICAR® FOOD, A+E. Fischer-Chemie GmbH & Co. KG, Wiesbaden, Germany, Carl Dicke GmbH & Co KG, Mdnchengladbach, Germany) and/or potassium hydrogen carbonate (company Dr. Paul Lohmann) or their mixtures thereof.
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one arable gum, and at least one water-soluble salt, with the provision that said at least one water-soluble salt is not a phosphate or polyphosphate salt.
  • KGM Konjac glucomannan
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with an arable gum, at least one water-soluble salt, and at least one hydroxy acid, such as preferably citric acid, lactic acid, ascorbic acid, tartaric acid, malic acid or other acids like phosphoric acid or glucono-delta-lactone (GdL).
  • KGM Konjac glucomannan
  • GdL glucono-delta-lactone
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one water- soluble salt and, optionally, at least one acid, more preferably at leastone hydroxy acid, with the provision that said at least one water-soluble salt is not a phosphate or polyphosphate salt.
  • KGM Konjac glucomannan
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with an effervescent system and, optionally, at least one water-soluble salt.
  • KGM Konjac glucomannan
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with an effervescent system, an arable gum and, optionally, at least one water-soluble salt.
  • KGM Konjac glucomannan
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one sugar alcohol; more preferably, at least one sugar alcohol erythritol.
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one sugar alcohol; more preferably, at least one sugar alcohol erythritol, and at least one component selected from i. to ix., (not vii.).
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one acid, preferably at least one hydroxy acid; more preferably selected from citric acid and/or tartaric acid.
  • KGM Konjac glucomannan
  • the invention refers to a solid fast dissolving or fast dispersing combination (or composition) comprising or, alternatively, consisting of Konjac glucomannan (KGM) in combination with at least one arabic gum and at least one acid, preferably at least one hydroxy acid, selected from citric acid and/or tartaric acid.
  • KGM Konjac glucomannan
  • the solid fast dissolving or fast dispersing combination of the invention may be present in a composition for oral use such as a solid pharmaceutical, nutraceutical or food composition which comprises an aforementioned combination (i) to (ix) as above defined, and (x) optionally, at least one flavour and/or colorant and/or sweetener, and/or a carrier or at least one excipient pharma or food grade.
  • a composition for oral use such as a solid pharmaceutical, nutraceutical or food composition which comprises an aforementioned combination (i) to (ix) as above defined, and (x) optionally, at least one flavour and/or colorant and/or sweetener, and/or a carrier or at least one excipient pharma or food grade.
  • composition herein includes pharmaceutical, nutraceutical or food compositions or compositions for medical devices under the EU Reg. 745/2017.
  • flavours and/or colorants and/or sweeteners may be of synthetic or natural origin.
  • components (x) may be selected from fruit flavours, such as vanilla, orange, blueberry, lemon, and the like; and sweeteners such as sucralose and/or stevia and/or erythritol.
  • Colorants may be any colorant which makes the more appealing the composition when mixed up with water, for instance yellow colorants, such as vanilla yellow and the like.
  • Colorants may also be selected from active-coloured ingredients, as it will be disclosed in detail in the following.
  • All the components used in the solid fast dissolving or fast dispersing combination and composition of the present invention are physiologically acceptable having a food or pharmaceutical grade.
  • All the components of the solid fast dissolving or fast dispersing composition of the present invention are in a in powder form and/or in a granular form, to give a solid fast dissolving or fast dispersing composition of the present invention in the form of a mixture of powders and/or granules.
  • solid fast dissolving or fast dispersing composition and “solid fast dissolving or fast dispersing combination” are intended to refer to and include any solid composition or combination of the present invention in the form of a loose and/or free-flowing mixture of powders and/or granules, i.e. it is not a in the form of a tablet, a chewable tablet, a pill, a candy, a capsule, etc.
  • composition of the invention comprises or, alternatively, consists of:
  • (F) at least one sugar alcohol erythritol and at least one composition selected from (A), (B), (0), (D'), (D"), (G) and/or (H); or
  • compositions from (A) to (H) in combination with one or more flavours and/or colorants and/or sweetener and/or oils (lipids) and/or surfactants and/or actives as defined above.
  • composition (A) comprises or, alternatively, consists of KGM, an arabic gum, and a tripotassium citrate salt; even more preferably, a tripotassium citrate monohydrate salt.
  • composition (B) comprises or, alternatively, consists of KGM, an arabic gum, a tripotassium citrate salt; more preferably, a tripotassium citrate monohydrate salt, and citric acid.
  • composition (C) comprises or, alternatively, consists of KGM, sodium and/or potassium gluconate salt and, optionally, a tripotassium citrate salt; more preferably, a tripotassium citrate monohydrate salt.
  • composition (D') comprises or, alternatively, consists of KGM, a sodium and/or potassium (bi)carbonate, and citric acid or tartraric acid (or a mixture citric acid/tartaric acid).
  • composition (D”) comprises or, alternatively, consists of KGM, an arabic gum, a sodium and/or potassium (bi)carbonate, and citric acid or tartraric acid (or a mixture citric acid/tartaric acid).
  • composition (E) comprises or, alternatively, consists of KGM and erythritol.
  • composition (F) comprises or, alternatively, consists of erythritol and at least one of the compositions selected from (A), (B), (C), (D'), (D"), (G) and/ or (H).
  • composition (G) comprises or, alternatively, consists of KGM and citric acid and/or tartaric acid. More preferably, composition (H) comprises or, alternatively, consists of KGM, arabic gum and citric acid and/or tartaric acid.
  • the weight ratio KGM/Arabic gum/salt is the range comprised from 1 :1 :0.1 to 1 : 15:7, more preferably in the range comprised from 1 : 1.5:0.5 to 1 :2:2, for instance in the range from 1 : 1 , 8:0, 8 to 1 : 1 , 8: 1.6, wherein the salt is preferably a tripotassium citrate, more preferably a tripotassium citrate monohydrate.
  • Tripotassium citrate salt may be replaced by the other salts as defined above, for instance gluconates and ascorbates, such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or hydrate water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • gluconates and ascorbates such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or hydrate water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be
  • the weight ratio KGM/arabic gum/salt/citric acid (or acid) is in the range comprised from 1/1/0.1/0.1 to 1/15/7/5, more preferably in the range comprised from 1/1/0.2/0.2 to 1/7.5/5/4, even more preferably in the range comprised from 1/1.5/0.3/0.3 to 1/2/4/3, for istance from 1/1.8/0.4/0.3 to 1/1 .8/1/2, or from 1/1 .8/0.4/0.4 to 1/1 .8/0.8/1 , for istance 1/1 .8/0.4/0.4, wherein the water soluble salt is preferably tripotassium citrate, more preferably tripotassium citrate monohydrate.
  • Tripotassium citrate salt may be replaced by the other salts as defined above, for instance gluconates and ascorbates, such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • gluconates and ascorbates such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • the citric acid may be replaced by other acids such as hydroxy acid like lactic acid, ascorbic acid, tartaric acid, malic acid or phosphoric acid or glucono-delta-lactone (GdL) which rapidly dissolves, and subsequently slowly hydrolyses to gluconic acid) or mixtures of acids.
  • acids such as hydroxy acid like lactic acid, ascorbic acid, tartaric acid, malic acid or phosphoric acid or glucono-delta-lactone (GdL) which rapidly dissolves, and subsequently slowly hydrolyses to gluconic acid) or mixtures of acids.
  • compositions (A) showed a more neutral pH
  • compositions (B) also comprising citric acid, showed pH ⁇ 6.5.
  • a fluid gel e.g., KGM/Arabic gum/tripotassium citrate monohydrate
  • arabic gum is a fibre
  • it is possible to use according to the present invention for example in a drink, 9 g for example of a powder composition of KGM/Arabic gum/ at least one water-soluble salt, preferably in a weight ratio of 1 :9:1.6.
  • Drinking this composition delivers 10 g fibre/drink or 30 g/day (3 drinks).
  • the composition of KGM/Arabic gum/tripotassium citrate monohydrate 1 :9:1.6 is fluid and delivers 10 g of fibre/or 30 g/day (3 drinks). Even higher amounts of Arabic gum in a drink are also possible.
  • lipophilic and/or surface-active components as a powder and/or granule (actives, oils, lipids and/or surfactants) to the system of (A) KGM/Arabic gum/at least one water-soluble salt leads to a milk-like product (instant milk) or milk alternatives product (milk substitute products, non dairy substitutes, plant-based milks, non-dairy beverage) or cocoa-like product at a approximately neutral pH range.
  • the lipophilic and/or surface-active component can be added a) as a powder and/or granule or b) as a liquid, more preferably as a powder and/or granule.
  • Examples of powders a1) full cream milk powder, a2) coffee powder, a3) wheat germs, a4) almond flour, a5) cacao powder, a6) MCT powder, a7) omega-3 powder, a8) oatmeal/oatflour powder, or a9) soymeal/soyflour powder.
  • Examples of liquid oils b1) Linseed oil + EPA +DHA (liquid omega 3, containing ALA, EPA and DHA).
  • liquid oils examples include flaxseed oil, fish oil, borage oil, blackcurrent seed oil, evening primrose oil, olive oil, MCT oils (e.g. coconut oil).
  • the weight ratio KGM/water soluble salt is in the range comprised from 1/0.5 to 1/15, more preferably in the range of 1 :6, even more preferably 1 :3 for example with tripotassium citrate monohydrate.
  • the pH of such a composition is around about 7.4 ⁇ 2 (at 20.5°C).
  • Tripotassium citrate monohydrate salt may be replaced by the other water-soluble salts as defined above, for instance gluconates and ascorbates, such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • gluconates and ascorbates such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also
  • composition D' comprises or, alternatively, consists of KGM and an effervescent system, as defined above, and optionally a salt as defined above.
  • said composition D' comprises or, alternatively, consists of KGM/sodium hydrogen carbonate/citric acid and/or tartaric acid, and/or KGM/potassium hydrogen carbonate/citric acid and/or tartaric acid.
  • the weight ratio of KGM/sodium and/or potassium hydrogen carbonate salt/citric and/or tartaric acid is in the range comprised from 1/0.1/0.06/ to 1/10/23, more preferably in the range comprised from 1/5/2.5 to 1/5/12, even more preferably in the range of 1.00/0.1/0.23, or more preferably 1/(0.1-0.60)/(0.1-1.8), or more preferably 1/0.6/(0.25-1.4), wherein the water-soluble salt in the composition D' is preferably tripotassium citrate, more preferably tripotassium citrate monohydrate.
  • the optional added salt is in the range from 0.1 g to 15 g.
  • Tripotassium citrate monohydrate salt may be replaced by the other water-soluble salts, as defined above, for instance gluconates and ascorbates, such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O, (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • gluconates and ascorbates such as gluconates (sodium, potassium, calcium), ascorbates (sodium), potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O, (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride. Mixtures of salt
  • said composition D comprises or, alternatively, consists of KGM/Arabic gum/sodium hydrogen carbonate/citric acid (and/or tartaric acid) and, optionally, at least one salt selected from the group comprising or, alternatevily, consisting of tripotassium citrate, preferably tripotassium citrate monohydrate, gluconates (sodium, potassium, calcium), ascorbates (sodium and/or potassium), sodium and/or potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate, preferably trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride X2H2O (or water free versions of magnesium chloride, calcium chloride), sodium chloride, potassium chloride; or said composition D” comprises or, alternatively, consists of KGM/Arabic gum/potassium hydrogen carbonate/citric acid (and/or tartaric acid) and, optionally, a salt selected from the group copm
  • the weight ratio of KGM/Arabic gum/sodium or potassium (bi)carbonate/citric acid (and/or tartaric acid) is in the range comprised from 1/0.1/0.15/0.1 to 1/15/0.8/1.8, more preferably:
  • the arable gum may be present at 1.4 or 1.5 or 1.6 or 1.7 weight ratio based on 100 g (e.g., 1.4 means 1.4%).
  • arable gum >1.7 gives a fluid composition.
  • a higher amount of arable gum which may be in the range (weight ratio) from 10 to 50, preferably from 15 to 40, more preferably from 20 to 30 by weight for 1 .0 KGM.
  • said composition D comprises or, alternatively, consists of KGM/arabic gum/sodium and/or potassium (bi)carbonate/citric acid (and/or tartaric acid)/at least one salt; preferably, with a weight ratio of:
  • Tripotassium citrate and tripotassium citrate monohydrate salt may be replaced by the other water-soluble salts, as defined above, selected from the group copmprising or, alternatevily, consisting of tripotassium citrate, preferably tripotassium citrate monohydrate, gluconates (sodium, potassium, calcium), ascorbates (sodium and/or potassium), sodium and/or potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate, preferably trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride) sodium chloride, potassium chloride. Mixtures of salts may also be used.
  • Citric acid may be replaced by other acids, preferred a hydroxy acid such as lactic acid, ascorbic acid, tartaric acid, malic acid or by other acids like phosphoric acid or glucono-delta-lactone (GdL) or mixtures of the acids mentioned above.
  • a hydroxy acid such as lactic acid, ascorbic acid, tartaric acid, malic acid or by other acids like phosphoric acid or glucono-delta-lactone (GdL) or mixtures of the acids mentioned above.
  • composition D may further comprises at least one lipophilic and/or surface-active component such as, for example, actives, oils, lipids and/or surfactants; for example, the composition D” may comprises:
  • KGM/arabic gum/sodium and/or potassium (bi) carbonate/hydroxy acid KGM/arabic gum/sodium and/or potassium (bi) carbonate/hydroxy acid
  • KGM/arabic gum/sodium and/or potassium (bi) carbonate/citric acid preferably with a weight ratio of:
  • KGM Arabic gum Carbonate Citric acid (Active, Oil, lipid, Surfactant) 1.0: (15.0-40): (0.15-0.8): (0.15-1.5): (0.5-80.0) or, KGM Arabic gum Carbonate Citric acid MCT-C8
  • the subject matter of the present invention relates to a solid fast dissolving or fast dispersing composition
  • a solid fast dissolving or fast dispersing composition comprising or, alternatively, consisting of, a high molecular weight Konjac glucomannan (KGM) and an arable gum in combination with at least one further dissolving or dispersing aid component which is selected from the group comprising or, alternatively, consisting of:
  • At least one water-soluble salt at least one water-soluble salt, with the provision that said at least one water-soluble salt is not a phosphate or polyphosphate salt;
  • an effervescent system comprising or, alternatively, consisting of at least one basic substance capable of releasing carbon dioxide in the presence of at least one acidic substance and, optionally, at least one water-soluble salt; or
  • (H) at least one organic acid, preferably at least one hydroxy acid; and/or their mixtures thereof.
  • said high molecular weight Konjac glucomannan has a molecular weight equal to or bigger than 10 6 Da; preferably, has a molecular weight comprised from bigger than 10 6 Da to 10 8 Da; more preferably, has a molecular weight comprised from 10 7 Da to 10 8 Da; and/or said high molecular weight Konjac glucomannan (KGM) has viscosity value preferably comprised from 20,000 cps to 100,000 cps, preferably comprised from 25,000 cps to 80,000 cps, more preferably comprised from 30,000 cps to 60,000 cps, even more preferably comprised from 35,000 cps to 50,000 cps, and preferably has glucomannan content comprised from bigger than 85% to 98%, more preferably from 90% and 95%.
  • said at least one water-soluble salt is preferably selected from the group comprising or, alternatively, consisting of:
  • citrate salts preferably, sodium and/or potassium citrate salts; more preferably tripotassium citrate salts, tripotassium citrate monohydrate salts, trisodium citrate salts, trisodium citate anhydrous salts, magnesium citrate, calcium citrate, zinc citrate, or their mixtures thereof;
  • - ascorbate salts preferably, sodium and/or potassium ascorbate salts, calcium and/or magnesium ascorbate salts, zinc ascorbate, zinc ascorbate monohydrate salts, or their mixtures thereof;
  • gluconate salts preferably, sodium and/or potassium gluconate salts, calcium and/or magnesium gluconate salts, zinc gluconate salt, or their mixtures thereof;
  • chloride salts preferably, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, ammonium chloride, or their mixture thereof.
  • lactate salts preferably, calcium lactate, calcium lactate pentahydrate, sodium and/or potassium lactate, zinc lactate, zinc lactate dihydrate, or their mixtures thereof;
  • - tartrate salts preferably, sodium and/or potassium tartrate, potassium sodium tartrate, or their mixtures thereof;
  • - sulfate salts preferably, sodium and/or potassium sulfate salts
  • - glycinate salts preferably, sodium and/or potassium glycinate salts
  • said at least one organic acid is selected from the group comprising or, alternatevily, consisting of citric acid, lactic acid, ascorbic acid, tartaric acid, malic acid, or phosphoric acid or glucono-delta-lactone (GdL).
  • said effervescent system comprises or, alternatively, consists of at least one basic substance capable of releasing carbon dioxide in the presence of at least one acidic substance, wherein said basic substance is selected from carbonate or bicarbonate salts; more preferably, sodium and/or potassium carbonate, sodium and/or potassium bicarbonate, or their mixtures thereof; and said at least one acidic substance is selected from organic acids; preferably, hydroxy acids such as citric acid and/or tartaric acid.
  • said solid fast dissolving or fast dispersing composition comprises or, altervatively, consists of (i) KGM, arabic gum, tripotassium citrate; more preferably, tripotassium citrate monohydrate, and citric acid, or (ii) KGM, arabic gum, sodium and/or potassium (bi)carbonate, and citric acid.
  • the subject matter of the present invention relates to a process for preparing a drinkable compositition comprising the steps of: a) putting into contact a solid fast dissolving or fast dispersing composition of the invention with a water-based fluid, which is selected from water, a beverage, a milk, a milk substitute, a plant-based milk, non dairy substitute, nondairy beverage, instant milk; non-alcoholic, alcoholic, a fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink, a nectar, a juice or a cappuccino, a smoothie, a coffee, a macchiato, a cafe au lait, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a caffee latte, a cacao, or mixtures thereof; b) mixing, preferably with the aid of a spoon, for a time from a water-based fluid
  • the subject matter of the present invention relates to a drinkable composition obtained by mixing the solid fast dissolving or fast dispersing combination, as described above, with water, a beverage, a milk, a milk substitute, a plant-based milk, non dairy substitute, non-dairy beverage, instant milk; nonalcoholic, alcoholic, a fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink, a nectar, a juice or a cappuccino, a smoothie, a coffee, a macchiato, a cafe au lait, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a caffee latte, a cacao, or mixture thereof.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method for managing weight loss or overweight reduction in a subject in need.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method to promote body weight loss in a healthy subject, or to reduce body weight in an overweight and/or obese subjects.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method for reducing cholesterol and blood sugar levels in a subject in need.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method for managing weight loss or overweight reduction in a subject in need.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method to promote body weight loss in a healthy subject, or to reduce body weight in an overweight and/or obese subjects.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method for reducing cholesterol and blood sugar levels in a subject in need.
  • the subject matter of the present invention relates to a solid fast dissolving or fast dispersing composition
  • a solid fast dissolving or fast dispersing composition comprising or, alternatively, consisting of, a high molecular weight Konjac glucomannan (KGM) in combination with at least one further dissolving or dispersing aid component which is selected from the group comprising or, alternatively, consisting of:
  • At least one effervescent system comprising or, alternatively, consisting of at least one basic substance capable of releasing carbon dioxide in the presence of at least one acidic substance and, optionally, at least one water- soluble salt;
  • (G) at least one acid, preferably at least one hydroxy acid; and/or their mixtures thereof.
  • said high molecular weight Konjac glucomannan has a molecular weight equal to or bigger than 10 6 Da; preferably, has a molecular weight comprised from bigger than 10 6 Da to 10 8 Da; more preferably, has a molecular weight comprised from 10 7 Da to 10 8 Da; and/or said high molecular weight Konjac glucomannan (KGM) has viscosity value preferably comprised from 20,000 cps to 100,000 cps, preferably comprised from 25,000 cps to 80,000 cps, more preferably comprised from 30,000 cps to 60,000 cps, even more preferably comprised from 35,000 cps to 50,000 cps, and preferably has glucomannan content comprised from bigger than 85% to 98%, more preferably from 90% and 95%.
  • said at least one water-soluble salt is preferably selected from the group comprising or, alternatively, consisting of:
  • citrate salts preferably, sodium and/or potassium citrate salts; more preferably tripotassium citrate salts, tripotassium citrate monohydrate salts, trisodium citrate salts, trisodium citate anhydrous salts, magnesium citrate, calcium citrate, zinc citrate, or their mixtures thereof;
  • - ascorbate salts preferably, sodium and/or potassium ascorbate salts, calcium and/or magnesium ascorbate salts, zinc ascorbate, zinc ascorbate monohydrate salts, or their mixtures thereof;
  • - gluconate salts preferably, sodium and/or potassium gluconate salts, calcium and/or magnesium gluconate salts, zinc gluconate salt, or their mixtures thereof;
  • chloride salts preferably, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, ammonium chloride, or their mixture thereof.
  • lactate salts preferably, calcium lactate, calcium lactate pentahydrate, sodium and/or potassium lactate, zinc lactate, zinc lactate dihydrate, or their mixtures thereof;
  • - tartrate salts preferably, sodium and/or potassium tartrate, potassium sodium tartrate, or their mixtures thereof;
  • - sulfate salts preferably, sodium and/or potassium sulfate salts
  • - glycinate salts preferably, sodium and/or potassium glycinate salts
  • said at least one organic acid is selected from the group comprising or, alternatevily, consisting of citric acid, lactic acid, ascorbic acid, tartaric acid, malic acid, or phosphoric acid or glucono-delta-lactone (GdL).
  • said effervescent system comprises or, alternatively, consists of at least one basic substance capable of releasing carbon dioxide in the presence of at least one acidic substance, wherein said basic substance is selected from carbonate or bicarbonate salts; more preferably, sodium and/or potassium carbonate, sodium and/or potassium bicarbonate, or their mixtures thereof; and said at least one acidic substance is selected from organic acids; more preferably, hydroxy acids such as citric acid and/or tartaric acid.
  • the subject matter of the present invention relates to a process for preparing a drinkable compositition comprising the steps of: a) putting into contact a solid fast dissolving or fast dispersing composition of the invention with a water-based fluid, which is selected from water, a beverage, a milk, a milk substitute, a plant-based milk, non dairy substitute, nondairy beverage, instant milk; non-alcoholic, alcoholic, a fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink, a nectar, a juice or a cappuccino, a smoothie, a coffee, a macchiato, a cafe au lait, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a caffee latte, a cacao, or mixtures thereof; b) mixing, preferably with the aid of a spoon, for a time from a water-based fluid
  • the subject matter of the present invention relates to a drinkable composition obtained by mixing the solid fast dissolving or fast dispersing combination, as described above, with water, a beverage, a milk, a milk substitute, a plant-based milk, non dairy substitute, non-dairy beverage, instant milk; nonalcoholic, alcoholic, a fruit drink, energy drink, fortified drink, herbal drink, sport drink, yogurt drink, buttermilk drink, probiotic drink, a nectar, a juice or a cappuccino, a smoothie, a coffee, a macchiato, a cafe au lait, a coffee milk, a frapuccino, an espresso, an espresso macchiato, a latte espresso, a flat white, a caffee latte, a cacao or mixtures thereof.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method for managing weight loss or overweight reduction in a subject in need.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method to promote body weight loss in a healthy subject, or to reduce body weight in an overweight and/or obese subjects.
  • the subject matter of the present invention relates to the solid fast dissolving or fast dispersing composition, as described above, for use in a method for reducing cholesterol and blood sugar levels in a subject in need.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method for managing weight loss or overweight reduction in a subject in need.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method to promote body weight loss in a healthy subject, or to reduce body weight in an overweight and/or obese subjects.
  • the subject matter of the present invention relates to the drinkable composition, as described above, for use in a method for reducing cholesterol and blood sugar levels in a subject in need.
  • KGM arable gum
  • at least one water-soluble salt as defined above.
  • Fullcream milk powder is added to a system of KGM/Arabic gum/water soluble salt.
  • Coffee powder is added to KGM/Arabic gum/water soluble salt and poured into milk.
  • a powder mixture of KGM/Arabic gum/Tripotassium citrate monohydrate/coffee powder (Robusta, mild, 23-10231, coffein content: 3.5-5.5% from Deutsche Ex Thermal Performance GmbH, Hamburg, Germany)/sucralose (1g/2.6g/0.8g/1.5g/0.015g) is added to 94.085g of a low fat homogenized milk (fat content: 1 ,5%, available in German supermarket EDEKA, https://www.super nucheck.de/edeka/fashion/h-milch-1-5/).
  • a fluid brown composition results (taste similar to a milk coffee from a fridge in a german supermarket (EDEKA), taste like e.g., "Starbucks” caffee latte, “Emmi” caffee latte, “Gut und gunstig” latte espresso, “Muller” latte macchiato, “Muller” espresso macchiato).
  • Oat powder is added to KGM/Arabic gum/water soluble salt
  • a powder mixture of KGM/Gum arabic/Tripotassium citrate monohydrate/oat meal powder/vanilla flavor/Sucralose (1.0g/2.7g/1.6g/2.5g/0.4g/0.015g) is added to water (91.585g) and stirred with a spoon.
  • a fluid composition results with a white appearance and neutral oatmeal taste impression.
  • Full cream milk powder and a freeze-dried fruit are added to KGM/Arabic gum/water soluble salt
  • a powder mixture of KGM, Gum Arabic, Tripotassium citrate/Full cream milk powder (1.0g/1.8g/0.8g/3.0g) was mixed and whole freeze-dried raspberries (2g) were added to the powder mixture.
  • This raspberry containing powder mixture (1 ,0g/1 .8g/0.8g/3.0g/2.0g) was added to water in a beverage glass and stirred with a spoon. The fluid mixture was allowed to stand for 10 min for the rehydration of the raspberries.
  • a red raspberry containing fluid milk drink (with KGM) was obtained (pH: 6.8, 25°C).
  • KGM arable gum, at least one water-soluble salt, as defined above, and at least one hydroxy acid, as defined above.
  • a powder mixture of KGM/Arabic gum/citric acid/ tripotassium citrate monohydrate makes easier the dissolving process of the KGM and arable gum in water by simply stirring the composition with a spoon in water. Immediately, a fluid is obtained (pH 3.95 (20.7°C)). No lump formation (compared to KGM pure in water). The consumer can drink it immediately. More neutral compositions (neutral aftertaste, e.g., pH 5.7 (21.1 °C) can be obtained by changing the relative ratios citrate/hydroxy acid ((1 .0:1 ,5:0.7:0.1).
  • the salt is preferably selected from the group copmprising or, alternatevily, consisting of tripotassium citrate, preferably tripotassium citrate monohydrate, gluconates (sodium, potassium, calcium), ascorbates (sodium and/or potassium), sodium and/or potassium tartrate x O.5H2O, potassium sodium tartrate-4-hydrate, trisodium citrate, preferably trisodium citrate anhydrous, magnesium chloride x 6H2O, calcium chloride x 2H2O (or water free versions of magnesium chloride, calcium chloride) sodium chloride, potassium chloride.
  • a powder mixture of KGM/Arabic gum/Tripotassium citrate monohydrate/citric acid/Full cream milk powder (1.00 g/1 .50 g/1 ,5g/0.1 g/3.00 g) was added to 92.9 g of water and stirred with a spoon.
  • a fluid composition results (pH 6.24, 19.6°C) with a white appearance. Increasing the citric acid content leads to more acidic formulations.
  • cacoa powder Plaine Arome (Fat content: 22-24%)
  • full cream milk powder 3.0g/1.2g
  • KGM/Arabic gum/water soluble salt /hydroxy acid e.g., citric acid
  • Cacao powder is available from e.g., Barry Callebout Anlagen GmbH, Im Mediapark 8a, 50670 Kbln (with different fat contents, e.g., "Noir Intense”: 10- 12%, "Plaine Arome” or “Extra brute”: 22-24%, “Rouge Ultime”20-22%, “Legere”: 1 %.
  • a powder mixture of KGM/Arabic gum/Tripotassium citrate monohydrate/citric acid/Full cream powder/Cacao powder (Plaine Arome (Fat content: 22-24%)) (1.0 g/1.5g/1.5g/0.1g/3.0g/1.2g) was added to 91.7 g of water and stirred with a spoon.
  • a fluid composition results (pH 6.6, 20.5°C) with a brown appearance. Due to the combination of full cream milk/cacao powder the product has a good cacao taste.
  • KGM a water-soluble salt and, optionally, a hydroxy acid as defined above.
  • Astonishingly powder mixtures of KGM/water soluble salt facilitates the dissolving process of the high molecular weight KGM in water.
  • a fluid is obtained by simply stirring the composition with a spoon. No lump formation (compared to KGM pure in water). Small KGM particles are visible in water directly after the mixture was prepared.
  • the formation of these small particles in comparison to the pure KGM/water system is an advantage because these particles are in fluid state (salt/water) instead of a thick gel that is formed in case of the KGM/water combination. After a while from these fluid particles starts the conversion to a fluid gel. The consumer can drink the fluid immediately.
  • a drinkable fluid gel results that he can drink.
  • Sodium and potassium gluconate or tripotassium citrate monohydrate, trisodium citrate anhydrous, sodium ascorbate, potassium tartrate x 0,5 H20, potassium sodium tartrate-4-hydrate or magnesium chloride x 6 H2O or the corresponding calcium chloride and sodium chloride or potassium chloride are examples that work very well.
  • combinations with water soluble salts are also possible. It is evident, that these salts or salt combinations have "very fast dissolver” or "very fast suspending” properties for KGM.
  • KGM/sodium gluconate/water (1g/3g/96g) has a pH of 7.43 (20.5°C) and a more neutral taste.
  • Adding citric acid (e.g., 0.25 g) gives a pH of 4.44 (20.1 °C) in a formulation of KGM/sodium gluconate/water/citric acid (1 g/3g/0.25g/95.50g/0.25g) and a little bit more acid taste perception.
  • a composition of KGM/Tripotassium citrate monohydrate/citric acid can be formulated at more neutral pH (citric acid: 0 g, pH: 7.4, 20.5°C) or by addition of citric acid the desired pH can be found (g water: 100g - g raw materials/ingredients).
  • a powder mixture of KGM/sodium chloride (1g/0.5g) up to KGM/sodium chloride (1 g/2g) leads to a fast-dissolving process of the KGM (water: 100 g - g of raw materials).
  • KGM/water soluble salt/water formulations are translucent to transparent, for example the high molecular weight KGM/sodium gluconate/water system is translucent to transparent. High molecular weight KGM/water systems are more greyish and translucent/not transparent (see introduction). Consumers that prefer a translucent to transparent KGM fluid or a more translucent/transparent KGM fluid gel will like such compositions. Adding a water soluble natural or synthetic color to such formulations results in the corresponding colored translucent to transparent fluids or colored translucent to transparent fluid gels. Adding a water-soluble flavour and/or a sweetener like sucralose, stevia is additionly possible.
  • Compositions (D) e.g., D' and D” become effervescent when mixed with water, through the CO2 development due to the following reaction: MeHCOs + (HOOCCH 2 ) 2 C(OH)COOH -> CO2 + Me-citrate; Me being Na or K.
  • Effervescent system Me Hydrogen carbonate + acid (e.g., citric acid).
  • KGM/Me hydrogen carbonate/citric acid such as for example: a) KGM/sodium hydrogen carbonate/citric acid.
  • a higher content of the effervescent system e.g., NaHCOs/citric acid
  • KGM/potassium hydrogen carbonate/citric acid e.g., NaHCOs/citric acid
  • the freedom to operate at different neutralisation levels and the usage of the corresponding sodium or potassium hydrogen carbonate salt is relevant for at least six reasons. 1) Some consumers prefer an acid taste of a product (or the combination acid combined with sweetness from a sweetener). The formulator will formulate the KGM product at a lower pH value in this case. 2) The stability of added actives is in some cases better in an acid (more neutral) than in a more neutral (acid) pH. The formulator will formulate at the corresponding preferred pH value (acid or more neutral pH value). 3) The color impression of an active is different at acid pH values versus a more neutral pH (e.g., for actives like antocyanins).
  • the color is brighter in an acid environment that the formulator will formulate at a lower pH value the KGM product.
  • the consumer (obese adult, obese child) is interested in a KGM product with (a lot of) foam and an acid aftertaste after dissolving the KGM powder mixture.
  • a high amount of the hydrogen carbonate salt e.g 0.4 g to 3.0 g potassium hydrogen carbonate
  • a foam development is observed in the presence of 1.00 g KGM; 0.77g citric acid (for 0.40 g potassium hydrogen carbonate) or in the presence of 5.80 g citric acid (for 3.00 g potassium hydrogen carbonate).
  • the pH of such formulations in the range of pH 3.7-4.0.
  • the consumer (obese adult, obese child) is interested in a KGM product with (a lot of) foam and a more neutral aftertaste after dissolving the KGM powder mixture.
  • a high amount of the hydrogen carbonate salt e.g. 0.4g to 3.0 g potassium hydrogen carbonate
  • a foam development and neutral aftertaste (pH 6.1) is observed.
  • the consumer (obese adult, obese child) consumes too much sodium or not enough potassium and/or has a high blood pressure problem.
  • an effervescent system e.g. sodium (potassium) hydrogen carbonate, a hydroxy acid (in this case: citric acid) and the formation of the resulting sodium citrate (or the resulting potassium citrate) are a "very fast dissolver” or a "very fast suspending” combination for a KGM composition.
  • a powder mixture of KGM/Arabic gum/sodium hydrogen carbonate/citric acid A powder mixture of KGM/Arabic gum/sodium hydrogen carbonate/citric acid.
  • the dissolved CO2, arable gum and the resulting formation of the salt lead to a fast dissolution process by simply stirring the composition with a spoon and the composition stays fluid or gives a fluid gel.
  • the resulting salt is potassium citrate instead of sodium citrate.
  • a) Weight ratios of 1.0/1.2/0.3/0.7 gives a foam that disappears after a while and dissolves quickly the powder ingredients.
  • a fluid is obtained (pH 3.92, 19.9°C) by simply stirring the composition with a spoon. The consumer can drink it immediately. If he prefers to wait a while (e.g., 10-15 min) a drinkable fluid gel results that he can drink.
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively “drink the fluid gel after 10 to 15 min after mixing”.
  • the composition has an acid aftertaste.
  • Weight ratios of 1 .0/1 .2/0.3/0.23 gives less foam that disappears after a while and dissolves quickly the powder ingredients.
  • a fluid is obtained by simply stirring the composition with a spoon. (pH 5.9, (19.6°C)).
  • the consumer can drink it immediately. If he prefers to wait a while (e.g., 10-15 min) a drinkable fluid gel results that he can drink.
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively “drink the fluid gel after 10 to 15 min after mixing”.
  • the composition has a more neutral aftertaste.
  • Weight ratios of 1.0/1.4/0.26/0.6 or 1.0/1.8/0.5/1.0 gives a foam that disappears after a while and dissolves quickly the powder ingredients by simply stirring the composition with a spoon. Immediately a fluid is obtained. (pH: 3.92 (20.7°C).
  • the composition has an acid aftertaste.
  • Higher concentrations of Arabic gum relative to KGM gives fluid systems (e.g., KGM/Gum Arabic: 1 : 1 .5 or 1 : 1 .6 or 1 : 1 .7 etc.).
  • an effervescent system e.g., sodium (potassium) hydrogen carbonate, a hydroxy acid (in this case: citric acid) and the resulting sodium citrate (or the resulting potassium citrate) are a "very fast dissolver” or a "very fast suspending” combination for a KGM/Arabic gum composition and reduces the viscosity of KGM (>1.4).
  • lipophilic and/or surface-active components as a powder (actives, oils, lipids and/or surfactants) to the effervescent system of KGM/Arabic gum/sodium or potassium (bi) carbonate/hydroxy acid (e.g., citric acid) and, optionally, a water-soluble salt (D") leads to a milk-like product or foamed milk-like product (instant milk, or foamed instant milk) or milk alternatives product (milk substitute products, non dairy substitutes, plant based milks, non- dairy beverage) or cocoa-like product.
  • the lipophilic (and/or surface active) component can be added as a) a powder or b) a liquid.
  • powders are: a1) full cream milk powder, a2) coffee powder (expresso etc.), a3) wheat germs, a4) almond flour, a5) cacao powder, a6) MCT powder, a7) omega-3 powder, a8) oatmeal/oatflour powder, a9) soymeal/soyflour powder.
  • liquid oils examples include: b1 ) Linseed oil + EPA + DHA (liquid omega 3, containing ALA, EPA and DHA); examples of other liquid oils are flaxseed oil, fish oil, borage oil, blackcurrent seed oil, evening primrose oil, olive oil, MCT oils (e.g., coconut oil).
  • Linseed oil + EPA + DHA liquid omega 3, containing ALA, EPA and DHA
  • examples of other liquid oils are flaxseed oil, fish oil, borage oil, blackcurrent seed oil, evening primrose oil, olive oil, MCT oils (e.g., coconut oil).
  • An instant full cream milk powder (lactose free) is available from Saputo, Australia (Instant Full cream Lactose Free powder 25 kg). It contains a mixture of fat (minimum 28%), proteins (at least 35%, calcium (1 g/100g).
  • a fluid composition results (pH: 6.2 (19.7°C) with a white appearance. Due to the full cream milk powder the product has a rich mouthfeeling.
  • the effervescent system was adjusted to a total content of 0.53g/100g so that a consumer may notice a small amount of foam.
  • Using higher amounts of the effervescent system gives a foaming milk like composition.
  • no external foam equipment or a small handheld electric mixer producing this foamed milk is necessary (the foam comes from the development of CO2).
  • a composition comprising KGM/Arabic gum/sodium or potassium (bi) carbon ate/hydroxy acid (e.g., citric acid) can be added to a full cream milk powder.
  • KGM/Arabic gum/sodium or potassium (bi) carbon ate/hydroxy acid e.g., citric acid
  • NaHCO3 part of the effervescent system
  • KHCO3 potassium can be delivered as potassium citrate.
  • a combination of NaHCO3/KHCO3 delivers both minerals for a consumer.
  • Typcial vitamins are B-vitamins like vitamin B2 (riboflavin) vitamin B12 (riboflavin), the B-vitamin complex (all B-Vitamins), vitamin A, vitamin D, vitamin E, vitamin K or vitamin C.
  • Proteins like whey (concentrates, isolates, hydrolysate) or from other protein sources (already mentioned in the patent) can be added.
  • the composition can be a foamed milk (total effervescent content (0.88 g/100 g or 0.53/100 g) or a milk were the foam is not visible for a consumer.
  • Other ingredients like skim milk, whole milk, anhydrous milk fat can be used and are also available from Saputo Dairy Australia Pty Ltd.
  • a ready to drink liquid coffee formulation with a powder composition of instant full cream milk powder, coffee powder (espresso) and an effervescent system that release CO2 for the development of a foam, KGM and arable gum can be prepared. Additional ingredients are usually sugars, a coffee flavour, caramel, salts, colorants.
  • KGM/Sugar (alcohol) (1g/0.25g-20g). These powder components were mixed and the resulting powder compositions were added to water (100g - raw materials) and stirred with a spoon.
  • sugar alcohols
  • dextrose monohydrate mannitol
  • mannitol xylitol
  • allulose maltitol
  • lactose monohydrate erythritol
  • a powder mixture of 1g KGM and 1 g erythritol was added to 98 g water and stirred with a spoon. This results in a homogenous composition without lumps (also 0.5 g works well or higher amounts of erythritol).
  • a drinkable fluid gel results that he can drink.
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively "drink the fluid gel 10 to 15 min after mixing.
  • citric acid suspends or dissolves the high molecular weight KGM very fast at room temperature without formation of lumps.
  • the consumer can drink it immediately. If he prefers to wait a while (e.g. 10-15 min) a drinkable fluid gel results that he can drink.
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively "drink the fluid gel 10 to 15 min after mixing”.
  • the Orange juice is available in a Germany supermarket (Aldi): Declaration: Orange juice from fruit juice concentrate, enriched with Vitamin C. Brand name: rio d'oro.
  • a fluid composition with orange juice taste results (pH: 3.2; 20.4°C).
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively “drink the fluid gel 10 to 15 min after mixing”.
  • a KGM/tartaric acid (1 .0g/0.5 g ) powder mixture dissolves in water (98.5g) very fast without lump formation (pH 2.5; 20.3°C).
  • the consumer can drink it immediately. If he prefers to wait a while (e.g. 10-15 min) a drinkable fluid gel results that he can drink.
  • the company selling the drink should disclose "drink immediately after mixing to get a fluid” or alternatively "drink the fluid gel 10 to 15 min after mixing”.
  • actives e.g., proteins like whey proteins or other proteins like milk, egg, casein, pea, animal, fish, poultry, soy, almond, chia, hemp, rice, collagen, vegan collagen, o-lactalbumin
  • actives e.g., proteins like whey proteins or other proteins like milk, egg, casein, pea, animal, fish, poultry, soy, almond, chia, hemp, rice, collagen, vegan collagen, o-lactalbumin
  • Body height 1.70 m, weight: 80 kg, BMI: 28 kg/m2;
  • the person would have a BMI of 22 kg/m2 at a body weight of 63 kg, i.e., normal weight.
  • 50 g of proteins can be supplemented with three drinks/day (16.6 g/drink).
  • Powder mixture comprising of KGM/Arabic gum/effervescent system/whey protein concentrate.
  • compositions of the invention can be easily used by the consumers at home. Indeed, a consumer may just use a spoon as "stirrer”, which is sufficient to make the KGM more fluid thanks to the further components of the composition.
  • An alternative to a spoon is a small handheld electric mixer. If a consumer has a problem to dissolve the KGM composition the company selling the KGM composition should give the advice to use a milk foamer, manual model or handheld stick frothers (e.g., Nursingaufschaumer FINO, rotation speed 12.000 U/Min, sacred-Nr. : 12720, GEFU GmbH, Braukweg 28, 59889 Eslohe, Germany). In this case the device is used to stir the composition (instead of foaming, in this case there is no foam development). On the other hand, in industrial processes, a typical industrial stirrer can be used.
  • composition of the invention may also comprise additional active ingredients or compositions, for instance, substances effective in promoting weight loss. All the components of the compositions of the invention are commercially available.
  • the water phase may be represented by tap water, sparkling water or still water.
  • the water phase may contain (e.g. for industrial processes) water soluble ingredients like polyols, sugars, acids (hydroxy acids, citric acid, lactic acid, tartartic acid, solutions (e.g. gluconic acid, 50%, lactic acid solutions) water soluble flavors, water soluble vitamins (e.g.
  • B-Vitamins, Vitamin C and derivatives water soluble salts, water soluble dextrins, water soluble proteins, protein concentrates, protein isolates, protein hydrolysates from whey, milk, egg, casein, pea, animal, fish, poultry, soy, almond, chia, hemp, rice, lentins, lupins, collagen, vegan collagen, water soluble amino acids, water soluble surfactants, water soluble colors, water soluble sweetener, (e.g.
  • stevia, sucralose, erythritol polymers like xanthan gum, sodium carboxymethylcellulose, pectins, high methoxyl pectin, carrageenans, cellulose gum, gellan gum, guar gum, locust bean gum, propylene glycol alginate, gum tragacanth, microcrystalline cellulose, distarch phosphate, acetylated starch, acetylated distarch adipate, hydroxypropyl distarch phosphate, hydroxypropyl starches, starch sodium octenyl succinate, fructooligosaccharide, galacto-oligosaccharides, water soluble powders (like cacao powder, milk powder etc.), carbonate salts, hydrogen carbonate salts, water soluble minerals, lactones like glucono deltalacton, dextrose monohydrate, mannitol, xylit, allulose, maltitol, lactose monohydrate, g
  • an arabic gum available in the market is for example a raw material that is water soluble, pH 4-5, loss of drying ⁇ 10%, Ash ⁇ 4%, viscosity (25% in water) of 60-180 mPas (Benecke GmbH, Hamburg, Germany, Norevo GmbH, Germany, Nexira, France).
  • a highly emulsifying Type 4810, or Type 4810, or Type 4810, or Type 4810 (Benecke GmbH) can be used in accordance with the present invention.
  • Other sources of Arabic gum are from the company Nexira (Tradenames: Efistab AA, SuperStab, Eficacia, InstaGum AX, Instagum AA, Instagum AP).
  • a KGM as a raw material with starch content ⁇ 1- 3%, preferred ⁇ 3%, protein content ⁇ 1.5-3.0%, preferred ⁇ 3,0%, pH 5-7, Ash ⁇ 5%, glucomannan content >85-90%, preferred >90%, more preferred from 90% to 98%, for example 92%-95%, viscosity from 26,000 to 36,000 mPas, preferred > 36,000 mPas, more preferred from 36,000 to 80,000 mPas, particle size from 90 to 200 mesh, preferably 120 to 200 mesh.
  • KGM is available from FH Diedrichs & Ludwig Post GmbH, Mannheim, Germany, Neupert Ingredients, Garstedt, Germany, G.E. Roeper GmbH, Hamburg, Germany, Baoji Konjac Chemical Co. Ltd, China.
  • a KGM E425(i) and/or E425(ii) can bused in accordance with the present invention.
  • a Konjac glucomannan (KGM) commercially available into the market having preferably CAS RN No. 37220-17-0.
  • KGM Konjac glucomannan
  • it may be used a Konjac gum preferably indicated with E425(i) or E425(ii), both containing Konjac glucomannan.
  • a high molecular weight KGM e.g., >10 6 Da, preferably e.g., from >10 6 Da to 10 8 Da, more preferably e.g., from >10 6 Da to 10 7 Da.
  • a high molecular weight KGM with a viscosity value comprised from 20,000 cps to 100,000 cps, preferably comprised from 25,000 cps to 80,000 cps, more preferably comprised from 30,000 cps (30,000 mPas) to 60,000 cps, even more preferably comprised from 35,000 cps to 50,000 cps, for example bigger than 36,000 cps.
  • Sodium hydrogen carbonate salt is available fromSolvay Chemicals International: BICAR® FOOD, A+E. Fischer- Chemie GmbH & Co. KG, Wiesbaden, Germany, Carl Dicke GmbH & Co KG, Mbnchengladbach, Germany) and potassium hydrogen carbonate is available from company Dr. Paul Lohmann).
  • vanilla flavor is available from Sensient, Geesthacht, Germany.
  • Blood orange flavour is available from OlbrichtArom GmbH & Co. KG, Leisnig, Germany.
  • Blue berry flavor is available from IMCD Kunststoff GmbH.
  • Citric acid (anhydrous) is available from Jungbunzlauer (“Citronensaure Anhydrat”).
  • Citric acid monohydrate is available from Atlantic Chemicals Trading GmbH, Hamburg, Germany.
  • Tartaric acid can be obtained by W. Ulrich GmbH, Chemische Erzeugnisse, Germany.
  • Erythritol (Erylite Erythritol) can be obtained from Magnesia (Jungbunzlauer), Germany.
  • subject-matter of the invention is a solid pharmaceutical, nutraceutical or food composition or a composition for medical device under EU Reg. 745/2017 which comprises the solid fast dissolving or fast dispersing combination of the invention, as above defined, and a) optionally, at least flavours and/or colorants and/or sweeteners; and b) optionally further (active) ingredients.
  • Illustrative and non-limiting examples of such (active) ingredients that can be combined with the solid fast dissolving or fast dispersing composition of the present invention containing KGM and Arabic gum are the following: Antocyanines such as ''Brainberry'' from company Bioactor, Aronia melanocarpa extract (25% Anthocyanins) or antocyanins/polyphenols mixtures ("Berriesence”) from MCB Ming Chyi Biotechnology Ltd.
  • Antocyanines such as ''Brainberry'' from company Bioactor, Aronia melanocarpa extract (25% Anthocyanins) or antocyanins/polyphenols mixtures ("Berriesence”) from MCB Ming Chyi Biotechnology Ltd.
  • Carob bean extract and fructooligosaccharide such as "CSAT+” is available from company Pharmactive Biotech Products.
  • Black garlic such as "ABG10+” is available from company Pharmactive Biotech Products.
  • Coffein such as "Caffeine, 98%” is available from company OmniActive Health Technologies or “CaffXtend” is available from Nutriventia (Mumbai, India) or from soluble coffee extracts such as “Arabica kraftig, 23-10234”, “Espresso, aromatisch (Arabica/Robusta-Blend), 23-10236”,” Arabica mild, 23-10232”, “Espresso, medium, Robusta, 23-10235”, “Robusta, kraftig, 23-10233”, “Robusta, mild, 23-10231” are available from Deutscheset Ex Cool GmbH, Hamburg, Germany.
  • Cacao powder such as “Noir Intense”, “Plaine Arome”, “Extra brute”, “Rouge Ultime”, “Legere”: 1 % are available from Barry Callebout Kunststoff GmbH, im Mediapark 8a, 50670 Kbln.
  • Actives in cacao are polyphenols like flavanols (epicatechin, catechin, and procyanidins) and flavonols (quercetin), anthocyanins, phenolic acids, and stilbenes.
  • coffein is in guarana (“Guarana Extract PDR & N.Caff BLDR22%-904”) is available from OmniActive Health Technologies.
  • Collagens are available from the companies Gelita AG, Rousselot, Weishardt, Nitta Gelatin. Abyss or vegan collagens are available from company MCB Ming Chyi Biotechnology Ltd (“CollaGem”) or from INB GmbH (“Vollagen”) or from Vecollal/TCI (“VeCollal”).
  • Chromium salts like "Chromium picolinate” are available from Vertellus, Indianapolis, USA Niacin is available from Wegochem Europe B.V., Netherlands.
  • Alpha Lipoic acid such as “Alipure” is available from Alzchem Group AG, Germany.
  • Whey hydrolysate with an active dipeptide AP (Alanine-Proline) which inhibits the alpha glucosidase's activity such as "Pep2Dia” is available from Ingredia Dairy experts.
  • Cinnamon or cinnamon extracts are available from Flavex Naturextrakte GmbH, Rehlingen, Germany (Zimtrinden Ceylanicum C02-se Exschreib, Nr. 034.001).
  • Curcumin is available from the company Gencor (“HydroCurc® Liquid Grade 10%”) or from company OmniActive Health Technologies (“Curcuwin Ultra+ Curcuminoids 20%” or “CurcuWIN Curcumin DNS HB Pdr 20%/EU”) or from company Natural remedies, India (“Turmacin”), or from company Nutriventia, Mumbai, India (“Water Dispersible Turmeric Extract Powder 60N” or “unstain”).
  • Vitamins lipophilic like Vitamin A, D, E, K
  • B-vitamins or the "B-vitamin complex” can be added to the formulations.
  • Thiamine Vitamin B-1
  • Vitamin B6 helps the body cells convert carbohydrates into energy.
  • Vitamin B6 can help with weight loss by boosting metabolism.
  • vitamin C, niacin, iron, calcium, and vitamin B5 can help to speed up metabolism.
  • a slow-release vitamin C formulation is "C-Fence” which is available from Nutriventia, Mumbai, India.
  • a heat stabilized vitamin C is "Stabilized Vitamin C 80” which is available from Nutriventia Mumbai, India.
  • Oat powder is available as Hafermehl Vollkorn (Art Nr. 4.1), Rubin Muhle GmbH, Germany.
  • Dried fruits and/or freeze dried fruits and/or individually quick frozen (IQF) fruits and/or frozen fruit products such as Agai, Acerola, Apple, Apricot, Aronia, Avocado, Banana, Berry mixes, Blackberry, Blackcurrant, Black Cherries, Blood Oranges, Blueberry, Boysenberry, Breadfruit, Camu Camu, Carambola, Carissa, Cherimoya, Cherries, Cherries Morello, Citrus, Cloudberry, Corinthians, Crabapples, Cranberries, Currants, Dates, Durian, Feijoa, Figs, Gooseberries, Grape, Grapefruit, Groundcherries, Guarana, Guava, Jackfruit, Juneberry, Kaffir Lime I Combava, Kiwi, Kumquats, Langsart, Lemon, Lime, Lingonberry, Longan, Loquats, Lychee, Mandarin, Mango, Mangosteen, Marionberry, Melon, Mint, Mulberries, Nectarine, Oranges, Papaya, Passion Fruit, Pawpaw, Peaches, Pe
  • Dried fruits and/or freeze-dried fruits and/or individually quick frozen (IQF) fruits and/or frozen fruit products are available, for example, from TALI e.K., Steinweg 1 , 34298 Helsa, Germany or Allfood GmbH-Handels-technik mbH, Bavariaring 2, D-80336 Munchen or FRUKTIA GmbH, Haferplanetary 10A, 28357 Bremen, Germany or Buxtrade GmbH, An den Geestergen 1 , 21614 Buxtehude.
  • Raspberries whole freeze dried (Himbeeren ganz gefriergetrocknet) are available from Buxtrade GmbH, Germany.
  • WATTS' UP Polyphenols and the like such as "WATTS' UP” are available from company Bioactor, Bioflavonoids from Citrus sinensis (Hesperidin).
  • Carnitin, Carnitin Hydrochloride such as "L-Carnitin HCI” are available from Liaoning Koncepnutra Co. Ltd.
  • Resveratrol such as "ResveraFen” is available from Akay Natural Ingredients Private Limited, containing resveratrol, de-bitterised fenugreek powder rich in soluble dietary fibre, Sunflower lecithin and/or Sunflower oil; or Resveratrol such as "Veri-Sperse®” from Gencor/pharmaco biotechnologies.
  • Capsaicin such as “Capsifen” is available from Akay Natural Ingredients Private Limited, chili extract, fenugreek powder, Cellulose powder and/or Lecithin, gum acacia; or “Capsimax” from OmniActive Health Technologies.
  • Omega-3 such as "DHA Algae Powder DAP' is available from MOB Ming Chyi Biotechnology Ltd
  • Citrus Sinensis fruit extract (Anthocyanins, Hydroxycinnamic acids, Flavanones, Vitamin 0) such as “Morosil” or “Red orange complex” are available from Bionap.
  • Weight Management Actives such as Flavonoids like Bioflavonoids are available from Citrus sinensis (Hesperidin) and Caffeine.
  • Bioflavonoids from citrus sinensis & citrus paradisi Hesperidin >80%; Naringin >5%
  • Bioflavonoids from citrus sinensis Hesperidin > 90%
  • Cordiart Bioactor
  • Vitamin D (Vitamin D3) powder 100000 IU/G is available from company Echemi.
  • Beta-glucane is available from company Leiber ("Yestimmun Beta Glucan”).
  • Green Tea extract (EGCG,” Teavigo”) or ECG (“Sunphenon ECG”), or EGC “Sunphenon XLB-100”) or EC (“Sunphenon EC”) all are available from Taiyo.
  • Oils, lipids like MCT Medium chain triglycerides
  • MCT-CTS or MCT-CPH Medium Chain Triglycerides
  • Sumbia - Keto-HiMCT high in C8 fatty acids
  • Carallum Fimbriata Extract such as "Slimaluma” are available from Gencor Pacific Limited.
  • Whey proteins hydrolysates, concentrates, isolates
  • Whey protein concentrate 80 Instant are available from Vivi Solution.
  • Milk protein concentrates like MPC 80/85 are available from Saputo Dairy Australia Pty Ltd.
  • Probiotics like B. psychraerophilum Q5 (DSM 33131) + L. hordei KLL19 (DSM 33127) + L. harbinensis G8 (DSM 33126) such as "premix novaMETABOLISM” are available from Probionova or Bifidobacterium breve B-3 from Morinaga Milk Industry, a mixture of Lacidophilus PBS066-DSM 24936 (Synbalance LA) and L. reuteri PBS072- DSM25175 (SynBalance LR) and L. plantarum PBS067-DSM24937 (Synbalance LP) with the tradename MetSyn are available from company Synbalance, Italy.
  • ROS reactive oxygen species
  • composition of the invention also solves this problem so that any other useful substance may be added to the composition of the invention, provided that said substance is chemically compatible with the other components of the composition of the invention.
  • the solid fast dissolving or fast dispersing composition of the invention may also comprise colorants, to improve the appearance of the composition when mixed with water.
  • composition of the invention having the correct pH, i.e. , pH ⁇ 6, so that said active-coloured ingredients may develop their nice red colour (both ingredients do not show a red colour at pH 7 or higher).
  • any further conventional excipient may be added to the composition, provided it is chemically compatible with the other components of the composition of the invention.
  • the solid fast dissolving or fast dispersing composition of the invention is a mixture of powders and/or granules which must be mixed with suitable water-based fluid, as above indicated, before intake.
  • the solid fast dissolving or fast dispersing composition of the invention is to be administered by oral route, after having been mixed with water or another water-based fluid.
  • a drinkable composition obtained by mixing the solid fast dissolving or fast dispersing composition of the invention with water or another water-based fluid is another subject-matter of the invention.
  • subject-matter of the invention is a liquid/fluid composition
  • a liquid/fluid composition comprising the solid fast dissolving or fast dispersing combination or the composition of the invention, and a suitable drinkable liquid, preferably, but not limited to, water.
  • the solid fast dissolving or fast dispersing compositions and/or the drinkable compositions of the invention are for use in a subject, said subject being a mammal, preferably a human being.
  • the mixture of powders and/or granules of the invention can be part of a two-part system (where the powder is separated from the fluid phase, e.g., in a cap of a biphase container), a can, a cardboard can, paper can, plastic packaging boxes, biodegradable packaging containers.
  • the solid fast dissolving or fast dispersing compositions and/or the drinkable compositions of the invention are useful in the management of body weight, especially in the treatment and/or prevention of overweight and obesity, and also for lowering cholesterol and blood sugar levels.
  • solid fast dissolving or fast dispersing compositions and/or the drinkable compositions of the invention for use in reducing body weight in overweight and obese subjects.
  • solid fast dissolving or fast dispersing compositions and/or the drinkable compositions of the invention for use in lowering cholesterol and blood sugar levels in a subject.
  • the solid fast dissolving or fast dispersing composition of the invention is generally administered at a dose of about 1-5 g/day of KGM, preferably 2-4 g/day of KGM, more preferably about 3g /day of KGM, preferably in the context of an energy restricted diet.
  • the solid fast dissolving or fast dispersing composition of the invention is administered at a dose of 1 g/day of KGM three times per day.
  • Figure 1 shows a simulation of fluid KGM behaviour after ingestion. With Reference to Figure 1, an increase in the viscosity is expected leading to a higher viscous composition/gel, depending on the amount of water.
  • a usually fluid composition e.g., KGM/Arabic gum/salt tripotassium citrate monohydrate/colorant Vanilla Yellow P-WS from Sensient/water 1g/1.8g/0.8g/0.06/96.3g
  • Konjac Glucomannan powder was added to water in a beverage glass and stirred with a spoon. Lump formation was observed. A greyish, lump containing gel formulation was obtained that is not appealing for a consumer. Drinking of this formulation is impossible due to the high viscosity of 36,000 mPas. The gel does not flow so that a consumer can not drink it from the beverage container. Furthermore the taste of this Konjac glucomannan gel is very bad.
  • Konjac Glucomannan Gum Arabic, Tripotassium Citrate Monohydrate, Citric acid anhydrous, Brainberry (Aronia melanocarpa extract), Sucralose and blueberry flavor were mixed and the powder mixture was added to water and stirred with a spoon.
  • the formulation has a lower viscosity then 1g pure Konjac Glucomannan in 99 g water (Comparative Example 1).
  • Konjac Glucomannan Gum Arabic, Tripotassium Citrate Monohydrate, Citric acid anhydrous, Watts'up (bioflavaonoids from citrus sinensis (Hesperidin), caffeine, sucralose the color additive (Vanilla Yellow), and orange flavor were mixed, and the powder mixture was added to water and stirred with a spoon.
  • the formulation has a lower viscosity then 1g pure Konjac Glucomannan in 99 g water (Comparative Example 1).
  • Konjac Glucomannan Gum Arabic, Capsifen (Chili extract, fenugreek powder, Cellulose powder, Lecithin, gum acacia), Sodium hydrogen carbonate, Citric acid anhydrous, Sucralose, Orange Flavour, Color additive (Vanilla Yellow) were mixed and the powder mixture was added to water and stirred with a spoon. The mixture gives a small foam (C02 release) that breaks down after a while. The formulation has a lower viscosity then 1g pure Konjac Glucomannan in 99 g water (Comparative Example 1). The Capsifen particles are homogenous suspended in the mixture directly after the preparation.
  • Konjac Glucomannan Gum Arabic, Tripotassium Citrate Monohydrate, Citric acid anhydrous, Bioflavonoids from citrus sinensis & citrus paradisi, Sucralose, Color additive (Vanilla Yellow) and Blood orange flavor were mixed and the powder mixture was added to water and stirred with a spoon. The mixture gives a small foam (CO2 release) that breaks down after a while. The formulation has a lower viscosity then 1g pure Konjac Glucomannan in 99 g water (Comparative Example 1).
  • Konjac Glucomannan, sodium hydrogen carbonate, Citric acid anhydrous were mixed and the powder mixture was added to water and stirred with a spoon. Very fast dissolution of Konjac Glucomannan. Due to the dissolved CO2 a creamy taste result. A smooth gel (drinkable) results.
  • Konjac Glucomannan Sodium hydrogen carbonate, Citric acid anhydrous and Tripotassium Citrate Monohydrate were mixed, and the powder mixture was added to water and stirred with a spoon. Very fast dissolution of Konjac. A fluid is obtained. After 15 min due to the dissolved CO2 a creamy taste result. A smooth gel (drinkable) result.
  • Example 18
  • a solid composition was prepared, in accordance with the present invention, containing 1 % KGM and a mild Robusta coffee powder (1.5 g/100 g; caffeine 52.5-82.5 mg/100 g). Subsequently, said composition was added to milk. A fluid composition of milk and coffee with good color, odor, taste and free of lumps was immediately obtained.
  • Konjac Glucomannan and Erythritol were mixed and the powder mixture was added to water and stirred with a spoon. Very fast dissolution of Konjac Glucomannan (homogenous composition without lumps).
  • Konjac Glucomannan and Erythritol were mixed and the powder mixture was added to water and stirred with a spoon. Very fast dissolution of Konjac Glucomannan (homogenous composition without lumps).
  • Konjac Glucomannan and Citric acid were mixed and the powder mixture was added to water and stirred with a spoon. Very fast dissolution of Konjac Glucomannan without lumps formation (small KGM particles are visible in water directly after the mixture was prepared; after a while from these fluid particles starts the conversion to a fluid gel).
  • Konjac Glucomannan and Tartaric acid were mixed and the powder mixture was added to water and stirred with a spoon.
  • Very fast dissolution of Konjac Glucomannan without lumps formation small KGM particles are visible in water directly after the mixture was prepared; after a while from these fluid particles starts the conversion to a fluid gel).

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Abstract

La présente invention concerne de nouvelles combinaisons solides à dissolution rapide ou à dispersion rapide contenant du mannane de Konjac, des procédés de préparation de compositions buvables les comprenant, des compositions buvables les comprenant et leurs utilisations en tant que complément alimentaire/complément de boisson, en particulier, mais de façon non limitative, utiles dans la gestion de la perte de poids ou la réduction de surpoids, et dans la régulation des taux de cholestérol et de glycémie chez un sujet en ayant besoin.
PCT/IB2024/052965 2023-03-27 2024-03-27 Nouvelles combinaisons comprenant du mannane de konjac, leurs compositions et leurs utilisations Ceased WO2024201329A1 (fr)

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